Risk factors for 1-year hospital readmissions in patients with systemic lupus erythematosus

To reveal the characteristics of and risk factors for systemic lupus erythematosus (SLE) patients with frequent readmission aiming at intervening early and improve the quality of care during initial hospitalizations. This was a single-center, retrospective case–control study involving 521 hospitalized patients with SLE from January 2014 to December 2016 in the Affiliated Hospital of Guangdong Medical University. A total of 521 patients were enrolled, including 400 patients who were hospitalized once and 121 patients who were hospitalized repeatedly, and 23.2% of the patients were readmitted within 1 year. The results showed that the age of SLE onset (odds ratio [OR] 1.022, 95% confidence interval [CI] 1.007–1.036), serum albumin (OR 0.965, 95% CI 0.942–0.989), and cystatin C (OR 1.404, 95% CI 1.180–1.670) were closely related to readmission. The most common causes of readmission were infections (52 cases, 28.4%), especially respiratory tract infections, and lupus activity or recurrence (45 cases, 24.6%). Special attention should be paid to SLE patients with older age of onset, low serum albumin levels, and high cystatin C levels to avoid infection and recurrence with the aim of reducing the hospital readmission rate.