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European Journal of Pediatrics

Erschienen in:

03.03.2023 | RESEARCH

Risk factors of brain abscess in neonatal meningitis: a propensity score–matched study

verfasst von: Nan Peng, Lizhen Fu, Xiaohua Liang, Qi Lu

Erschienen in: European Journal of Pediatrics | Ausgabe 5/2023

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Abstract

Brain abscess is a rare but life-threatening complication of meningitis. The purpose of this study was to identify clinical features and potentially relevant factors of brain abscess in neonates with meningitis. This study was a propensity score–matched case–control study of neonates with brain abscess and meningitis in a tertiary pediatric hospital between January 2010 and December 2020. A total of 16 neonates with brain abscess were matched to 64 patients with meningitis. Demography, clinical characteristics, laboratory results, and pathogens were collected. Conditional logistic regression analyses were performed to identify the independent risk factors associated with brain abscess. The most common pathogen we found in the brain abscess group was Escherichia coli. Risk factors of brain abscess were identified: multidrug-resistant bacterial infection (OR, 11.204; 95% CI, 2.315–54.234; p = 0.003), C-reactive protein (CRP) > 50 mg/L (OR, 11.652; 95% CI, 1.799–75.470; p = 0.010).

Conclusion: The risk factors of brain abscess are multidrug-resistant bacterial infection and CRP > 50 mg/L. Monitoring the level of CRP is essential. Bacteriological culture and rational use of antibiotics are necessary for the prevention of MDR bacterial infection as well as the occurrence of brain abscess.

What is Known: • Morbidity and mortality of neonatal meningitis have declined, but brain abscess associated with neonatal meningitis is still life-threatening.
What is New: • This study investigated relevant factors related to brain abscess. • It is important for neonatologists to perform prevention, early identification, and appropriate interventions for neonates with meningitis.

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Titel: Risk factors of brain abscess in neonatal meningitis: a propensity score–matched study
verfasst von: Nan Peng
Lizhen Fu
Xiaohua Liang
Qi Lu
Publikationsdatum: 03.03.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Pediatrics / Ausgabe 5/2023
Print ISSN: 0340-6199
Elektronische ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-023-04860-1

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Risk factors of brain abscess in neonatal meningitis: a propensity score–matched study

Abstract

Neu im Fachgebiet Pädiatrie

Mit dem Seitenschneider gegen das Reißverschluss-Malheur

Reanimation bei Kindern – besser vor Ort oder während Transport?

Alter der Mutter beeinflusst Risiko für kongenitale Anomalie

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Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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Abstract

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