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01.12.2015 | Research article | Ausgabe 1/2015 Open Access

BMC Endocrine Disorders 1/2015

Role of enteral nutrition in nonthyroidal illness syndrome: a retrospective observational study

BMC Endocrine Disorders > Ausgabe 1/2015
Ranran Li, Jianan Ren, Qin Wu, Gefei Wang, Xiuwen Wu, Jun Chen, Guanwei Li, Zhiwu Hong, Huajian Ren, Yunzhao Zhao, Jieshou Li
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​s12902-015-0061-y) contains supplementary material, which is available to authorized users.
The work was supported by grants from the National Nature Science Foundation of China (81270478).

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

QW, JR and JL designed the whole study. JR, YZ and JL supervised the whole project. QW, GW and XW performed data analysis. RL, GW, XW, JC, GL, ZH and HR supervised patient diagnosis and recruitment. QW, JR and GL conducted data analyses and drafted the manuscript. RL, QW and XW participated in the manuscript writing. RL revised the manuscript after the first round revision. All authors critically reviewed the article and approved the final manuscript.



The nonthyroidal illness syndrome (NTIS) is prevalent among patients with enterocutaneous fistula and is associated with poor outcomes. The present study aimed to explore the role of enteral nutrition (EN) therapy on thyroid function among patients with enterocutaneous fistula and NTIS.


We conducted a retrospective observational study among patients with enterocutaneous fistula between January 2013 and April 2014. All enrolled patients received EN therapy. Thyroid function and other parameters were measured.


After administration of 4 weeks of EN therapy, NTIS was resolved in 66 patients (Group A), while it persisted in 14 patients (Group B). The overall treatment success rate was 82.50 %. There were no significant differences between groups A and B at baseline for all parameters, except for the time from admission to start of EN therapy. The logistic analysis revealed that the time from admission to start of EN therapy was a significant independent indicator for achieving resolution of NTIS in our cohort.


This retrospective observational cohort study demonstrated that EN therapy can aid in the resolution of NTIS among patients with enterocutaneous fistula. These findings confirm the benefit of EN in the treatment of enterocutaneous fistula.
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