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Seminars in Immunopathology
Erschienen in: Seminars in Immunopathology 5/2016

11.05.2016 | Review

Roles of basophils and mast cells in cutaneous inflammation

verfasst von: Atsushi Otsuka, Yumi Nonomura, Kenji Kabashima

Erschienen in: Seminars in Immunopathology | Ausgabe 5/2016

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Abstract

Mast cells and basophils are associated with T helper 2 (Th2) immune responses. Newly developed mast cell-deficient mice have provided evidence that mast cells initiate contact hypersensitivity via activating dendritic cells. Studies using basophil-deficient mice have also revealed that basophils are responsible for cutaneous Th2 skewing to haptens and peptide antigens but not to protein antigens. Recently, several studies reported the existence of innate lymphoid cells (ILCs), which differ from classic T cells in that they lack the T cell receptor. Mast cells and basophils can interact with ILCs and play some roles in the pathogenesis of Th2 responses. Basophil-derived interleukin (IL)-4 enhances the expression of the chemokine CCL11, as well as IL-5, IL-9, and IL-13 in ILC2s, leading to the accumulation of eosinophils in allergic reactions. IL-33-stimulated mast cells can play a regulatory role in the development of ILC2-mediated non-antigen-specific protease-induced acute inflammation. In this review, we discuss the recent advances in our understanding of mast cells and basophils in immunity and inflammation.
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Metadaten
Titel
Roles of basophils and mast cells in cutaneous inflammation
verfasst von
Atsushi Otsuka
Yumi Nonomura
Kenji Kabashima
Publikationsdatum
11.05.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Seminars in Immunopathology / Ausgabe 5/2016
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI
https://doi.org/10.1007/s00281-016-0570-4

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