Salivary duct carcinoma with neuroendocrine features

Excerpt

Sir, Salivary duct carcinoma (SDC) is a highly aggressive salivary gland neoplasm affecting older, male patients and arising in the major salivary glands. The most frequent location is the parotid gland, followed by submandibular glands or minor salivary-gland sites [10]. Clinically, these tumors are characterized by aggressive behavior with early distant metastasis, local recurrence, and high mortality. Some studies, including three large series [1, 2, 6], characterized the clinical pathological features as a distinct entity. We describe a SDC with oncocytic-like appearance and morphological and immunohistochemical features of endocrine differentiation, studied by means of fine-needle aspiration (FNA) and immunohistochemistry. …