Skip to main content
Erschienen in: Head and Neck Pathology 1/2014

01.03.2014 | Proceedings of the North American Society of Head and Neck Pathology Companion Meeting, March 2, 2014, San Diego, California

Salivary Gland Tumor “Wishes” to Add to the Next WHO Tumor Classification: Sclerosing Polycystic Adenosis, Mammary Analogue Secretory Carcinoma, Cribriform Adenocarcinoma of the Tongue and Other Sites, and Mucinous Variant of Myoepithelioma

verfasst von: Douglas R. Gnepp

Erschienen in: Head and Neck Pathology | Ausgabe 1/2014

Einloggen, um Zugang zu erhalten

Abstract

This review is a continuation of suggested tumor additions to the next WHO Tumor Classification. The author will focus on four salivary gland entities that have recently become accepted in the literature as new neoplastic entities: sclerosing polycystic adenosis, mammary analogue secretory carcinoma, cribriform adenocarcinoma of the tongue and other sites, and mucinous variant of myoepithelioma.
Literatur
1.
Zurück zum Zitat Smith BC, Ellis GL, Slater LJ, Foss RD. Sclerosing polycystic adenosis of major salivary glands: a clinicopathologic analysis of nine cases. Am J Surg Pathol. 1996;20:161–70.PubMedCrossRef Smith BC, Ellis GL, Slater LJ, Foss RD. Sclerosing polycystic adenosis of major salivary glands: a clinicopathologic analysis of nine cases. Am J Surg Pathol. 1996;20:161–70.PubMedCrossRef
2.
Zurück zum Zitat Gnepp DR, Wang LJ, Brandwein-Gensler M, et al. Sclerosing polycystic adenosis of the salivary gland. Am J Surg Pathol. 2006;30:154–64.PubMedCrossRef Gnepp DR, Wang LJ, Brandwein-Gensler M, et al. Sclerosing polycystic adenosis of the salivary gland. Am J Surg Pathol. 2006;30:154–64.PubMedCrossRef
3.
Zurück zum Zitat Skálová A, Gnepp DR, Simpson RH, et al. Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker. Am J Surg Pathol. 2006;30:939–44.PubMedCrossRef Skálová A, Gnepp DR, Simpson RH, et al. Clonal nature of sclerosing polycystic adenosis of salivary glands demonstrated by using the polymorphism of the human androgen receptor (HUMARA) locus as a marker. Am J Surg Pathol. 2006;30:939–44.PubMedCrossRef
5.
Zurück zum Zitat Park IH, Hong SM, Choi H, et al. Sclerosing polycystic adenosis of the nasal septum: the risk of misdiagnosis. Clin Exp Otorhinolaryngol. 2013;6:107–9.PubMedCentralPubMedCrossRef Park IH, Hong SM, Choi H, et al. Sclerosing polycystic adenosis of the nasal septum: the risk of misdiagnosis. Clin Exp Otorhinolaryngol. 2013;6:107–9.PubMedCentralPubMedCrossRef
6.
Zurück zum Zitat Petersson F, Tan PH, Hwang JS. Sclerosing polycystic adenosis of the parotid gland: report of a bifocal, paucicystic variant with ductal carcinoma in situ and pronounced stromal distortion mimicking invasive carcinoma. Head Neck Pathol. 2011;5:188–92.PubMedCentralPubMedCrossRef Petersson F, Tan PH, Hwang JS. Sclerosing polycystic adenosis of the parotid gland: report of a bifocal, paucicystic variant with ductal carcinoma in situ and pronounced stromal distortion mimicking invasive carcinoma. Head Neck Pathol. 2011;5:188–92.PubMedCentralPubMedCrossRef
7.
Zurück zum Zitat Kim BC, Yang DH, Kim J, et al. Sclerosing polycystic adenosis of the parotid gland. J Craniofac Surg. 2012;23:e451–2.PubMedCrossRef Kim BC, Yang DH, Kim J, et al. Sclerosing polycystic adenosis of the parotid gland. J Craniofac Surg. 2012;23:e451–2.PubMedCrossRef
8.
Zurück zum Zitat Tokyol C, Aktepe F, Hastürk GS, et al. Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. Kulak Burun Bogaz Ihtis Derg. 2012;22:288–92.PubMedCrossRef Tokyol C, Aktepe F, Hastürk GS, et al. Sclerosing polycystic adenosis of the parotid gland presenting with a Warthin tumor. Kulak Burun Bogaz Ihtis Derg. 2012;22:288–92.PubMedCrossRef
9.
Zurück zum Zitat Su A, Bhuta SM, Berke GS, Lai CK. A unique case of sclerosing polycystic adenosis of the sinonasal tract. Hum Pathol. 2013;44:1937–40.PubMedCrossRef Su A, Bhuta SM, Berke GS, Lai CK. A unique case of sclerosing polycystic adenosis of the sinonasal tract. Hum Pathol. 2013;44:1937–40.PubMedCrossRef
10.
Zurück zum Zitat Swelam W. The pathogenic role of Epstein–Barr virus (EBV) in sclerosing polycystic adenosis. Pathol Res Pract. 2010;206:565–71.PubMedCrossRef Swelam W. The pathogenic role of Epstein–Barr virus (EBV) in sclerosing polycystic adenosis. Pathol Res Pract. 2010;206:565–71.PubMedCrossRef
11.
Zurück zum Zitat Beato Martínez A, Moreno Juara A, Candia Fernández A. Sclerosing polycystic adenosis of the submandibular gland. Acta Otorrinolaringol Esp. 2013;64:78–80.PubMedCrossRef Beato Martínez A, Moreno Juara A, Candia Fernández A. Sclerosing polycystic adenosis of the submandibular gland. Acta Otorrinolaringol Esp. 2013;64:78–80.PubMedCrossRef
12.
Zurück zum Zitat Pfeiffer ML, Yin VT, Bell D, et al. Sclerosing polycystic adenosis of the lacrimal gland. Ophthalmology. 2013;120:873–873.e1.PubMedCrossRef Pfeiffer ML, Yin VT, Bell D, et al. Sclerosing polycystic adenosis of the lacrimal gland. Ophthalmology. 2013;120:873–873.e1.PubMedCrossRef
13.
Zurück zum Zitat Petersson F. Sclerosing polycystic adenosis of salivary glands: a review with some emphasis on intraductal epithelial proliferations. Head Neck Pathol. 2013;7(Suppl 1):S97–106.PubMedCrossRef Petersson F. Sclerosing polycystic adenosis of salivary glands: a review with some emphasis on intraductal epithelial proliferations. Head Neck Pathol. 2013;7(Suppl 1):S97–106.PubMedCrossRef
14.
Zurück zum Zitat Canas Marques A, Felix A. Invasive carcinoma arising in sclerosing polycystic adenosis of the salivary gland. European Society of Pathology Meeting Lisbon, Portugal, Poster number PS-03-015, 31 Aug to 4 Sept 2013. Canas Marques A, Felix A. Invasive carcinoma arising in sclerosing polycystic adenosis of the salivary gland. European Society of Pathology Meeting Lisbon, Portugal, Poster number PS-03-015, 31 Aug to 4 Sept 2013.
15.
Zurück zum Zitat Michal M, Skálová A, Simpson RHW, et al. Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue. Histopathology. 1999;35:495–501.PubMedCrossRef Michal M, Skálová A, Simpson RHW, et al. Cribriform adenocarcinoma of the tongue: a hitherto unrecognized type of adenocarcinoma characteristically occurring in the tongue. Histopathology. 1999;35:495–501.PubMedCrossRef
16.
Zurück zum Zitat Yajima M, Yamazaki T, Minemura T, Kotani A. Tubular adenocarcinoma of the apex of the tongue. J Oral Maxillofac Surg. 1989;47:86–8.PubMedCrossRef Yajima M, Yamazaki T, Minemura T, Kotani A. Tubular adenocarcinoma of the apex of the tongue. J Oral Maxillofac Surg. 1989;47:86–8.PubMedCrossRef
17.
Zurück zum Zitat Crocker TP, Kreutner A, Otherson HB, Garvin J. Papillary adenocarcinoma of minor salivary gland origin in a child. Arch Otolaryngol. 1983;109:827–31.PubMedCrossRef Crocker TP, Kreutner A, Otherson HB, Garvin J. Papillary adenocarcinoma of minor salivary gland origin in a child. Arch Otolaryngol. 1983;109:827–31.PubMedCrossRef
18.
Zurück zum Zitat Prasad KC, Kaniyur V, Pai RR, Nesari SS. Pedunculated cribriform adenocarcinoma of the base of the tongue. ENT-Ear Nose Throat J. 2004;83:62–4. Prasad KC, Kaniyur V, Pai RR, Nesari SS. Pedunculated cribriform adenocarcinoma of the base of the tongue. ENT-Ear Nose Throat J. 2004;83:62–4.
19.
Zurück zum Zitat Skalova A, Sima R, Kaspirkova-Nemcova J, et al. Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. Am J Surg Pathol. 2011;35:1168–76.PubMedCrossRef Skalova A, Sima R, Kaspirkova-Nemcova J, et al. Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. Am J Surg Pathol. 2011;35:1168–76.PubMedCrossRef
20.
Zurück zum Zitat Skalova A, Vanecek T, Sima R, et al. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: A hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34:599–608.PubMed Skalova A, Vanecek T, Sima R, et al. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: A hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34:599–608.PubMed
21.
Zurück zum Zitat Skálová A, Vanecek T, Majewska H, et al. Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, β-catenin, EGFR, and CCND1 genes. Am J Surg Pathol. 2014;38:23–33.PubMedCrossRef Skálová A, Vanecek T, Majewska H, et al. Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, β-catenin, EGFR, and CCND1 genes. Am J Surg Pathol. 2014;38:23–33.PubMedCrossRef
22.
Zurück zum Zitat Patel KR, Solomon IH, El-Mofty SK, Lewis JS Jr, Chernock RD. Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma. Hum Pathol. 2013;44:2501–8.PubMedCrossRef Patel KR, Solomon IH, El-Mofty SK, Lewis JS Jr, Chernock RD. Mammaglobin and S-100 immunoreactivity in salivary gland carcinomas other than mammary analogue secretory carcinoma. Hum Pathol. 2013;44:2501–8.PubMedCrossRef
23.
Zurück zum Zitat Hwang MJ, Wu PR, Chen CM, Chen CY, Chen CJ. A rare malignancy of the parotid gland in a 13-year-old Taiwanese boy: case report of a mammary analogue secretory carcinoma of the salivary gland with molecular study. Med Mol Morphol. 18 Aug 2013. (Epub ahead of print). Hwang MJ, Wu PR, Chen CM, Chen CY, Chen CJ. A rare malignancy of the parotid gland in a 13-year-old Taiwanese boy: case report of a mammary analogue secretory carcinoma of the salivary gland with molecular study. Med Mol Morphol. 18 Aug 2013. (Epub ahead of print).
24.
Zurück zum Zitat Mariano FV, Dos Santos HT, Azañero WD, et al. Mammary analogue secretory carcinoma of salivary glands is a lipid-rich tumour, and adipophilin can be valuable in its identification. Histopathology, 17 May 2013. doi:10.1111/his.12192. (Epub ahead of print). Mariano FV, Dos Santos HT, Azañero WD, et al. Mammary analogue secretory carcinoma of salivary glands is a lipid-rich tumour, and adipophilin can be valuable in its identification. Histopathology, 17 May 2013. doi:10.​1111/​his.​12192. (Epub ahead of print).
25.
Zurück zum Zitat Woo J, Seethala RR, Sirintrapun SJ. Mammary analogue secretory carcinoma of the parotid gland as a secondary malignancy in a childhood survivor of atypical teratoid rhabdoid tumor. Head Neck Pathol, 7 Aug 2013. (Epub ahead of print). Woo J, Seethala RR, Sirintrapun SJ. Mammary analogue secretory carcinoma of the parotid gland as a secondary malignancy in a childhood survivor of atypical teratoid rhabdoid tumor. Head Neck Pathol, 7 Aug 2013. (Epub ahead of print).
26.
Zurück zum Zitat Skalova A. Mammary analogue secretory carcinoma of salivary gland origin: an update and expanded morphologic and immunohistochemical spectrum of recently described entity. Head Neck Pathol. 2013;7(Suppl 1):S30–6.PubMedCrossRef Skalova A. Mammary analogue secretory carcinoma of salivary gland origin: an update and expanded morphologic and immunohistochemical spectrum of recently described entity. Head Neck Pathol. 2013;7(Suppl 1):S30–6.PubMedCrossRef
27.
Zurück zum Zitat Bishop JA, Yonescu R, Batista D, et al. Utility of mammaglobin immunohistochemistry as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma. Hum Pathol. 2013;44:1982–8.PubMedCrossRef Bishop JA, Yonescu R, Batista D, et al. Utility of mammaglobin immunohistochemistry as a proxy marker for the ETV6-NTRK3 translocation in the diagnosis of salivary mammary analogue secretory carcinoma. Hum Pathol. 2013;44:1982–8.PubMedCrossRef
28.
Zurück zum Zitat Williams L, Chiosea SI. Mammary analogue secretory carcinoma mimicking salivary adenoma. Head Neck Pathol. 2013;7:316–9.PubMedCrossRef Williams L, Chiosea SI. Mammary analogue secretory carcinoma mimicking salivary adenoma. Head Neck Pathol. 2013;7:316–9.PubMedCrossRef
29.
Zurück zum Zitat Jung MJ, Song JS, Kim SY, et al. Finding and characterizing mammary analogue secretory carcinoma of the salivary gland. Korean J Pathol. 2013;47:36–43.PubMedCentralPubMedCrossRef Jung MJ, Song JS, Kim SY, et al. Finding and characterizing mammary analogue secretory carcinoma of the salivary gland. Korean J Pathol. 2013;47:36–43.PubMedCentralPubMedCrossRef
30.
Zurück zum Zitat Bishop JA. Unmasking MASC: bringing to light the unique morphologic, immunohistochemical and genetic features of the newly recognized mammary analogue secretory carcinoma of salivary glands. Head Neck Pathol. 2013;7:35–9.PubMedCentralPubMedCrossRef Bishop JA. Unmasking MASC: bringing to light the unique morphologic, immunohistochemical and genetic features of the newly recognized mammary analogue secretory carcinoma of salivary glands. Head Neck Pathol. 2013;7:35–9.PubMedCentralPubMedCrossRef
31.
Zurück zum Zitat Griffith CC, Stelow EB, Saqi A, et al. The cytological features of mammary analogue secretory carcinoma: a series of 6 molecularly confirmed cases. Cancer Cytopathol. 2013;121:234–41.PubMedCrossRef Griffith CC, Stelow EB, Saqi A, et al. The cytological features of mammary analogue secretory carcinoma: a series of 6 molecularly confirmed cases. Cancer Cytopathol. 2013;121:234–41.PubMedCrossRef
32.
Zurück zum Zitat Bishop JA, Yonescu R, Batista DA, Westra WH, Ali SZ. Cytopathologic features of mammary analogue secretory carcinoma. Cancer Cytopathol. 2013;121:228–33.PubMedCrossRef Bishop JA, Yonescu R, Batista DA, Westra WH, Ali SZ. Cytopathologic features of mammary analogue secretory carcinoma. Cancer Cytopathol. 2013;121:228–33.PubMedCrossRef
33.
Zurück zum Zitat Levine P, Fried K, Krevitt LD, Wang B, Wenig BM. Aspiration biopsy of mammary analogue secretory carcinoma of accessory parotid gland: another diagnostic dilemma in matrix-containing tumors of the salivary glands. Diagn Cytopathol. 2014;42:49–53.PubMedCrossRef Levine P, Fried K, Krevitt LD, Wang B, Wenig BM. Aspiration biopsy of mammary analogue secretory carcinoma of accessory parotid gland: another diagnostic dilemma in matrix-containing tumors of the salivary glands. Diagn Cytopathol. 2014;42:49–53.PubMedCrossRef
34.
Zurück zum Zitat Chiosea SI, Griffith C, Assaad A, Seethala RR. Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands. Histopathology. 2012;61:387–94.PubMedCrossRef Chiosea SI, Griffith C, Assaad A, Seethala RR. Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands. Histopathology. 2012;61:387–94.PubMedCrossRef
35.
Zurück zum Zitat Fehr A, Löning T, Stenman G. Mammary analogue secretory carcinoma of the salivary glands with ETV6-NTRK3 gene fusion. Am J Surg Pathol. 2011;35:1600–2.PubMedCrossRef Fehr A, Löning T, Stenman G. Mammary analogue secretory carcinoma of the salivary glands with ETV6-NTRK3 gene fusion. Am J Surg Pathol. 2011;35:1600–2.PubMedCrossRef
36.
Zurück zum Zitat Rastatter JC, Jatana KR, Jennings LJ, Melin-Aldana H. Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient. Otolaryngol Head Neck Surg. 2012;146:514–5.PubMedCrossRef Rastatter JC, Jatana KR, Jennings LJ, Melin-Aldana H. Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient. Otolaryngol Head Neck Surg. 2012;146:514–5.PubMedCrossRef
37.
Zurück zum Zitat Petersson F, Lian D, Chau YP, Yan B. Mammary analogue secretory carcinoma: the first submandibular case reported including findings on fine needle aspiration cytology. Head Neck Pathol. 2012;6:135–9.PubMedCentralPubMedCrossRef Petersson F, Lian D, Chau YP, Yan B. Mammary analogue secretory carcinoma: the first submandibular case reported including findings on fine needle aspiration cytology. Head Neck Pathol. 2012;6:135–9.PubMedCentralPubMedCrossRef
38.
Zurück zum Zitat Griffith C, Seethala R, Chiosea SI. Mammary analogue secretory carcinoma: a new twist to the diagnostic dilemma of zymogen granule poor acinic cell carcinoma. Virchows Arch. 2011;459:117–8.PubMedCrossRef Griffith C, Seethala R, Chiosea SI. Mammary analogue secretory carcinoma: a new twist to the diagnostic dilemma of zymogen granule poor acinic cell carcinoma. Virchows Arch. 2011;459:117–8.PubMedCrossRef
39.
Zurück zum Zitat Connor A, Perez-Ordonez B, Shago M, et al. Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity. Am J Surg Pathol. 2012;36:27–34.PubMedCrossRef Connor A, Perez-Ordonez B, Shago M, et al. Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity. Am J Surg Pathol. 2012;36:27–34.PubMedCrossRef
40.
Zurück zum Zitat Sethi R, Kozin E, Remenschneider A, et al. Mammary analogue secretory carcinoma: update on a new diagnosis of salivary gland malignancy. Laryngoscope. 2014;124:188–95.PubMedCrossRef Sethi R, Kozin E, Remenschneider A, et al. Mammary analogue secretory carcinoma: update on a new diagnosis of salivary gland malignancy. Laryngoscope. 2014;124:188–95.PubMedCrossRef
41.
Zurück zum Zitat Ellis GL, Auclair PL. Atlas of tumor pathology: tumors of the salivary glands. Benign epithelial neoplasms. Armed Forces Institute of Pathology, Washington, DC, p 57, 1996. Ellis GL, Auclair PL. Atlas of tumor pathology: tumors of the salivary glands. Benign epithelial neoplasms. Armed Forces Institute of Pathology, Washington, DC, p 57, 1996.
42.
Zurück zum Zitat Esteva CJ, Slater LJ, Gnepp DR. Mucinous myoepithelioma, a previously unrecognized variant. Mod Pathol. 2012; 25(Suppl 2):308A, 1297. Esteva CJ, Slater LJ, Gnepp DR. Mucinous myoepithelioma, a previously unrecognized variant. Mod Pathol. 2012; 25(Suppl 2):308A, 1297.
43.
Zurück zum Zitat Ghannoun JE. PD Freedman PD. Signet-ring cell (mucin-producing) adenocarcinomas of minor salivary glands. Am J Surg Pathol. 2004;28:89–93.CrossRef Ghannoun JE. PD Freedman PD. Signet-ring cell (mucin-producing) adenocarcinomas of minor salivary glands. Am J Surg Pathol. 2004;28:89–93.CrossRef
44.
Zurück zum Zitat Singh M, Khurana N, Wadhwa R, Gulati A. Signet ring carcinoma parotid gland: a case report. Head Neck. 2011;33:1656–9.PubMedCrossRef Singh M, Khurana N, Wadhwa R, Gulati A. Signet ring carcinoma parotid gland: a case report. Head Neck. 2011;33:1656–9.PubMedCrossRef
45.
Zurück zum Zitat Bastaki J, Summersgill K. Signet-ring cell (mucin-producing) adenocarcinoma of minor salivary glands: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:e33–6.PubMedCrossRef Bastaki J, Summersgill K. Signet-ring cell (mucin-producing) adenocarcinoma of minor salivary glands: report of a case. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:e33–6.PubMedCrossRef
46.
Zurück zum Zitat Bastaki JM, Purgina BM, Dacic S, Seethala RR. Primary signet-ring cell (mucin-producing) adenocarcinoma of minor salivary glands: a clinicopathologic, immunohistochemical and molecular survey. Mod Pathol. 2012; 25(Suppl 2):304A, 1279. Bastaki JM, Purgina BM, Dacic S, Seethala RR. Primary signet-ring cell (mucin-producing) adenocarcinoma of minor salivary glands: a clinicopathologic, immunohistochemical and molecular survey. Mod Pathol. 2012; 25(Suppl 2):304A, 1279.
47.
Zurück zum Zitat Zamecnik M, Gogora M. Signet-ring cells simulating carcinomas in minor salivary gland of the lip. Pathol Res Pract. 1999;195:723–4.PubMedCrossRef Zamecnik M, Gogora M. Signet-ring cells simulating carcinomas in minor salivary gland of the lip. Pathol Res Pract. 1999;195:723–4.PubMedCrossRef
48.
Zurück zum Zitat Foschini MP, Baldovini C, Pennesi MG, Cocchi R, Simpson RH. Signet ring cell tumor of the minor salivary gland exhibiting benign behavior. Hum Pathol. 2012;43:303–6.PubMedCrossRef Foschini MP, Baldovini C, Pennesi MG, Cocchi R, Simpson RH. Signet ring cell tumor of the minor salivary gland exhibiting benign behavior. Hum Pathol. 2012;43:303–6.PubMedCrossRef
49.
Zurück zum Zitat Franquemont DW, Mills SE. Plasmacytoid monomorphic adenoma of salivary glands. Absence of myogenous differentiation and comparison to spindle cell myoepithelioma. Am J Surg Pathol. 1993;17:146–53.PubMedCrossRef Franquemont DW, Mills SE. Plasmacytoid monomorphic adenoma of salivary glands. Absence of myogenous differentiation and comparison to spindle cell myoepithelioma. Am J Surg Pathol. 1993;17:146–53.PubMedCrossRef
Metadaten
Titel
Salivary Gland Tumor “Wishes” to Add to the Next WHO Tumor Classification: Sclerosing Polycystic Adenosis, Mammary Analogue Secretory Carcinoma, Cribriform Adenocarcinoma of the Tongue and Other Sites, and Mucinous Variant of Myoepithelioma
verfasst von
Douglas R. Gnepp
Publikationsdatum
01.03.2014
Verlag
Springer US
Erschienen in
Head and Neck Pathology / Ausgabe 1/2014
Elektronische ISSN: 1936-0568
DOI
https://doi.org/10.1007/s12105-014-0532-x

Weitere Artikel der Ausgabe 1/2014

Head and Neck Pathology 1/2014 Zur Ausgabe

Proceedings of the North American Society of Head and Neck Pathology Companion Meeting, March 2, 2014, San Diego, California

Human Papillomavirus and Epstein Barr Virus in Head and Neck Carcinomas: Suggestions for the New WHO Classification

Proceedings of the North American Society of Head and Neck Pathology Companion Meeting, March 2, 2014, San Diego, California

Current Views and Perspectives on Classification of Squamous Intraepithelial Lesions of the Head and Neck

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Open Access Biomarker Leitthema

Um auch an kleinen Gewebeproben zuverlässige und reproduzierbare Ergebnisse zu gewährleisten ist eine strenge Qualitätskontrolle in jedem Schritt des Arbeitsablaufs erforderlich. Eine nicht ordnungsgemäße Prüfung oder Behandlung des …

Vergleichende Pathologie in der onkologischen Forschung

Pathologie Leitthema

Die vergleichende experimentelle Pathologie („comparative experimental pathology“) ist ein Fachbereich an der Schnittstelle von Human- und Veterinärmedizin. Sie widmet sich der vergleichenden Erforschung von Gemeinsamkeiten und Unterschieden von …

Gastrointestinale Stromatumoren

Open Access GIST CME-Artikel

Gastrointestinale Stromatumoren (GIST) stellen seit über 20 Jahren ein Paradigma für die zielgerichtete Therapie mit Tyrosinkinaseinhibitoren dar. Eine elementare Voraussetzung für eine mögliche neoadjuvante oder adjuvante Behandlung bei …

Personalisierte Medizin in der Onkologie

Aufgrund des erheblichen technologischen Fortschritts in der molekularen und genetischen Diagnostik sowie zunehmender Erkenntnisse über die molekulare Pathogenese von Krankheiten hat in den letzten zwei Jahrzehnten ein grundlegender …