Introduction
Methods
Study population
Epidemiological survey
Biochemical measurements
Genetic analyses
SNP | Primer sequence | Restriction enzyme | PCR product | Allele |
---|---|---|---|---|
ABCA-1 V825I | F: 5′-GGTAGCCCACCACTCTCCCCTATAAAG-3′ | Tag I | 525 bp | G |
(rs2066715) | R: 5′-ATCAGCTGCCTGTCCTTGGACTA-3′ | A | ||
ACAT-1 | F: 5′-TATATTAAGGGGATCAGAAGT-3′ | Rsa I | 389 bp | A |
(rs1044925) | R: 5′-CCACCTAAAAACATACTACC-3′ | C | ||
LDL-R Ava II | F: 5′-GTCATCTTCCTTGCTGCCTGTTTAG-3′ | Ava II | 228 bp | A- |
R: 5′-GTTTCCACAAGGAGGTTTCAAGGTT-3′ | A+ | |||
LIPC -250G>A | F: 5′-GGCAAGGGCATCTTTGCTTC-3′ | Dra I | 411-bp | G |
(rs2070895) | R: 5′-GGTCGATTTACAGAAGTGCTTC-3′ | A | ||
LIPG 584C>T | F: 5′-CATGAGCTGAGATTGTTGTCAGTGC-3′ | Nde I | 254 bp | C |
(rs2000813) | R: 5′-CAGTCAACCACAACTACATTGGCGTCTTTCTCTCAT-3′ | T | ||
MTHFR 677C>T | F: 5′-CAAAGGCCACCCCGAAGC-3′ | Hinf I | 254 bp | C |
(rs1801133) | R: 5′-AGGACGGTGCGGTGAGAGTG-3′ | T | ||
MYLIP | F: 5′-ACAGAGCAAAAGACCCTGTCTC-3′ | Hae III | 387 bp | G |
(rs3757354) | R: 5′-AAAGAACTGTGTGTGGGAGGAT-3′ | T | ||
PCSK9 E670G | F: 5′-CACGGTTGTGTCCCAAATGG-3′ | Eam 1104I | 440 bp | A |
(rs505151) | R: 5′-GAGAGGGACAAGTCGGAACC-3′ | G | ||
PPARD +294T>C | F: 5′-CATGGTATAGCACTGCAGGAA-3′ | Bsl I | 269 bp | T |
(rs2016520) | R: 5′-CTTCCTCCTGTGGCTGCTC-3′ | C | ||
SCARB1 | F: 5′-CCTTGTTTCTCTCCCATCCTCACTTCCTCGACGC-3′ | Hin I1 | 218 bp | C |
(rs5888) | R: 5′-CACCACCCCAGCCCACAGCAGC-3′ | T |
DNA sequencing
Diagnostic criteria
Statistical analysis
Results
General characteristics
Characteristics | Normal weight | Overweight/obesity | t(χ2) |
P
|
---|---|---|---|---|
Number | 978 | 751 | – | – |
Male/female | 490/488 | 378/373 | 0.009 | 0.924 |
Age, years | 41.48±16.21 | 41.25±12.50 | 0.332 | 0.740 |
Education level, years | 3.71±3.89 | 4.71±4.49 | −4.170 | 0.000 |
Height, cm | 153.73±7.57 | 154.29±8.49 | −1.461 | 0.144 |
Weight, kg | 50.28±6.20 | 63.19±8.86 | −34.042 | 0.000 |
Body mass index, kg/m2 | 21.23±1.68 | 26.48±2.59 | −48.285 | 0.000 |
Waist circumference, cm | 70.58±6.56 | 82.90±7.39 | −30.766 | 0.000 |
Alcohol consumption, n (%) | 373 (38.1) | 362 (48.2) | 23.034 | 0.000 |
Cigarette smoking, n (%) | 305 (31.2) | 178 (23.7) | 15.036 | 0.001 |
Systolic blood pressure, mmHg | 119.69±17.40 | 125.84±17.64 | −7.242 | 0.000 |
Diastolic blood pressure, mmHg | 75.11±9.98 | 80.57±11.13 | −10.563 | 0.000 |
Pulse pressure, mmHg | 44.60±12.87 | 45.36±12.11 | −1.251 | 0.211 |
Total cholesterol, mmol/L | 4.46±0.94 | 5.01±1.05 | −11.325 | 0.000 |
Triglyceride, mmol/L | 1.21±1.02 | 1.74±1.50 | −8.837 | 0.000 |
HDL-C, mmol/L | 1.80±0.47 | 1.73±0.41 | 3.099 | 0.002 |
LDL-C, mmol/L | 2.52±0.73 | 2.96±0.85 | −11.180 | 0.000 |
Apolipoprotein (Apo) A1, g/L | 1.37±0.31 | 1.40±0.27 | −2.009 | 0.045 |
ApoB, g/L | 0.84±0.22 | 0.98±0.24 | −12.466 | 0.000 |
ApoA1/ApoB | 1.75±0.70 | 1.53±0.58 | 7.256 | 0.000 |
Electrophoresis and genotypes
Nucleotide sequences
Genotypic and allelic frequencies
SNP | Genotype (Allele) | Normal weight (n = 978) | Overweight/obesity (n = 751) | χ2 |
P
|
---|---|---|---|---|---|
ABCA-1 V825I | GG | 326 (33.3) | 269 (35.8) | ||
(rs2066715) | GA | 480 (49.1) | 334 (44.5) | ||
AA | 172 (17.6) | 148 (19.7) | 3.708 | 0.157 | |
G | 1132 (57.9) | 872 (58.1) | |||
A | 824 (42.1) | 630 (41.9) | 0.012 | 0.914 | |
ACAT-1 | AA | 662 (67.7) | 527 (70.2) | ||
(rs1044925) | AC | 279 (28.5) | 205 (27.3) | ||
CC | 37 (3.8) | 19 (2.5) | 2.671 | 0.263 | |
A | 1603 (82.0) | 1259 (83.8) | |||
C | 353 (18.0) | 243 (16.2) | 2.080 | 0.149 | |
LDL-R Ava II | A-A- | 527 (53.9) | 389 (51.8) | ||
A-A+ | 371 (37.9) | 295 (39.3) | |||
A+A+ | 80 (8.2) | 67 (8.9) | 0.824 | 0.662 | |
A- | 1425 (72.9) | 1073 (71.4) | |||
A+ | 531 (27.1) | 429 (28.6) | 0.848 | 0.357 | |
LIPC -250G>A | GG | 480 (49.1) | 233 (31.0) | ||
(rs2070895) | GA | 425 (43.5) | 432 (57.5) | ||
AA | 73 (7.5) | 86 (11.5) | 57.882 | 0.000 | |
G | 1385 (70.8) | 898 (59.8) | |||
A | 571 (29.2) | 604 (40.2) | 45.999 | 0.000 | |
LIPG 584C>T | CC | 454 (46.4) | 308 (41.0) | ||
(rs2000813) | CT | 477 (48.8) | 412 (54.9) | ||
TT | 47 (4.8) | 31 (4.1) | 6.314 | 0.043 | |
C | 1385 (70.8) | 1028 (68.4) | |||
T | 571 (29.2) | 474 (31.6) | 2.255 | 0.133 | |
MTHFR 677C>T | CC | 471 (48.2) | 354 (47.1) | ||
(rs1801133) | CT | 441 (45.1) | 341 (45.4) | ||
TT | 66 (6.7) | 56 (7.5) | 0.404 | 0.817 | |
C | 1383 (70.7) | 1049 (69.8) | |||
T | 573 (29.3) | 453 (30.2) | 0.305 | 0.581 | |
MYLIP | AA | 230 (23.5) | 148 (19.7) | ||
(rs3757354) | AG | 477 (48.8) | 363 (48.3) | ||
GG | 271 (27.7) | 240 (32.0) | 5.431 | 0.066 | |
A | 937 (47.9) | 659 (43.9) | |||
G | 1019 (52.1) | 843 (56.1) | 5.550 | 0.018 | |
PCSK9 E670G | AA | 916 (93.7) | 721 (96.0) | ||
(rs505151) | AG | 62 (6.3) | 30 (4.0) | ||
GG | 0 | 0 | 4.636 | 0.031 | |
A | 1894 (96.8) | 1472 (98.0) | |||
G | 62 (3.2) | 30 (2.0) | 4.509 | 0.034 | |
PPARD +294T>C | TT | 559 (57.2) | 396 (52.7) | ||
(rs2016520) | TC | 354 (36.2) | 312 (41.5) | ||
CC | 65 (6.6) | 43 (5.7) | 5.239 | 0.073 | |
T | 1472 (75.3) | 1104 (73.5) | |||
C | 484 (24.7) | 398 (26.5) | 1.375 | 0.241 | |
SCARB1 | CC | 548 (56.0) | 417 (55.5) | ||
(rs5888) | CT | 390 (39.9) | 311 (41.4) | ||
TT | 40 (4.1) | 23 (3.1) | 1.497 | 0.473 | |
C | 1486 (76.0) | 1145 (76.2) | |||
T | 470 (24.0) | 357 (23.8) | 0.032 | 0.859 |
Genotypes and serum lipid levels
Interactions of the SNPs and overweight/obesity on serum lipid levels
SNP | Genotype | TC (mmol/L) | TG (mmol/L) | HDL-C (mmol/L) | LDL-C (mmol/L) | ApoA1 (g/L) | ApoB (g/L) | ApoA1/ ApoB |
---|---|---|---|---|---|---|---|---|
ABCA-1 V825I | GG | – | – | – | – | – | – | – |
(rs2066715) | GA | – | – | – | ↑ | – | – | ↓ |
AA | – | – | – | ↑ | – | – | ↓ | |
F
| 1.473 | 2.937 | 1.717 | 3.687 | 1.913 | 2.941 | 6.485 | |
P
| 0.230 | 0.053 | 0.180 | 0.005c | 0.148 | 0.053 | 0.000c | |
ACAT-1 rs1044925 | AA | – | – | – | – | – | – | – |
(rs1044925) | AC | – | – | – | – | – | – | – |
CC | – | – | – | – | – | – | – | |
F
| 0.475 | 1.457 | 0.341 | 0.320 | 1.635 | 1.071 | 1.944 | |
P
| 0.622 | 0.233 | 0.711 | 0.726 | 0.195 | 0.343 | 0.143 | |
LDL-R Ava II | A-A- | – | – | – | – | – | – | – |
A-A+ | – | – | – | – | – | – | – | |
A+A+ | – | – | – | – | – | – | – | |
F
| 1.681 | 0.242 | 0.553 | 0.857 | 1.377 | 0.430 | 0.462 | |
P
| 0.186 | 0.785 | 0.576 | 0.425 | 0.253 | 0.650 | 0.630 | |
LIPC -250G>A | GG | ↑ | – | – | ↑ | – | ↑ | – |
(rs2070895) | GA | – | – | – | – | – | ↑ | – |
AA | – | – | – | – | ↑ | – | – | |
F
| 3.733 | 0.266 | 1.584 | 3.345 | 3.292 | 4.138 | 2.116 | |
P
| 0.005c | 0.766 | 0.205 | 0.007c | 0.007c | 0.003c | 0.121 | |
LIPG 584C>T | CC | – | – | – | – | – | – | – |
(rs2000813) | CT | – | – | – | – | – | – | – |
TT | – | – | – | – | – | ↑ | – | |
F
| 1.286 | 0.210 | 0.357 | 1.452 | 2.195 | 3.616 | 1.812 | |
P
| 0.277 | 0.810 | 0.700 | 0.234 | 0.112 | 0.005c | 0.164 | |
MTHFR 677C>T | CC | – | – | – | ↑ | – | – | – |
(rs1801133) | CT | ↑ | – | – | – | – | – | – |
TT | – | ↑ | – | ↓ | – | – | – | |
F
| 3.110 | 3.463 | 0.627 | 9.236 | 0.058 | 2.684 | 0.675 | |
P
| 0.009c | 0.006c | 0.534 | 0.000c | 0.944 | 0.069 | 0.509 | |
MYLIP | AA | – | – | – | – | – | – | – |
(rs3757354) | AG | ↑ | ↑ | – | – | – | – | – |
GG | – | – | – | – | – | – | – | |
F
| 6.864 | 4.325 | 1.818 | 2.495 | 0.684 | 1.895 | 1.388 | |
P
| 0.000c | 0.003c | 0.307 | 0.083 | 0.505 | 0.151 | 0.250 | |
PCSK9 E670G | AA | – | – | – | – | – | – | – |
(rs505151) | AG | – | ↑ | ↓ | – | – | ↑ | ↓ |
F
| 0.980 | 25.662 | 7.831 | 0.002 | 1.371 | 6.319 | 4.357 | |
P
| 0.322 | 0.000c | 0.001c | 0.968 | 0.242 | 0.002c | 0.007c | |
PPARD +294T>C | TT | – | – | – | – | – | – | – |
(rs2016520) | TC | – | ↑ | – | – | – | – | – |
CC | – | – | – | – | – | – | ↑ | |
F
| 1.832 | 5.737 | 1.235 | 1.087 | 0.171 | 1.362 | 3.985 | |
P
| 0.160 | 0.001c | 0.291 | 0.337 | 0.843 | 0.257 | 0.004c | |
SCARB1 | CC | – | – | – | – | – | ↑ | – |
(rs5888) | CT | – | – | – | – | ↓ | – | – |
TT | – | ↑ | – | – | ↓ | – | – | |
F
| 1.809 | 4.396 | 1.720 | 2.211 | 3.226 | 3.118 | 0.051 | |
P
| 0.164 | 0.002c | 0.179 | 0.110 | 0.008c | 0.009c | 0.778 |
Correlation between genotypes or alleles and serum lipid parameters
Lipid | Genotype/allele | Unstandardized coefficient | Std. error | Standardized coefficient |
t
|
P
|
---|---|---|---|---|---|---|
TC | ACAT-1 rs1044925 genotype | −0.099 | 0.043 | −0.053 | −2.287 | 0.022 |
LIPC -250G>A allele | 0.101 | 0.046 | 0.050 | 2.170 | 0.030 | |
LIPG 584C>T genotype | 0.149 | 0.043 | 0.079 | 3.503 | 0.000 | |
LIPG 584C>T allele | 0.169 | 0.049 | 0.077 | 3.425 | 0.001 | |
MTHFR 677C>T genotype | 0.218 | 0.037 | 0.133 | 5.854 | 0.000 | |
MTHFR 677C>T allele | 0.269 | 0.046 | 0.133 | 5.841 | 0.000 | |
PPARD +294T>C allele | 0.147 | 0.050 | 0.068 | 2.963 | 0.003 | |
TG | MTHFR 677C>T genotype | 0.146 | 0.054 | 0.062 | 2.701 | 0.007 |
MYLIP rs3757354 genotype | −0.102 | 0.042 | −0.057 | −2.456 | 0.014 | |
PPARD +294T>C allele | 0.321 | 0.086 | 0.087 | 3.732 | 0.000 | |
SCARB1 rs5888 genotype | −0.041 | 0.023 | −0.049 | −2.039 | 0.042 | |
HDL-C | ACAT-1 rs1044925 genotype | −0.057 | 0.022 | −0.062 | −2.643 | 0.008 |
ACAT-1 rs1044925 allele | −0.051 | 0.025 | −0.048 | −2.024 | 0.043 | |
LIPC -250G>A genotype | 0.038 | 0.016 | 0.055 | 2.366 | 0.018 | |
LIPG 584C>T genotype | 0.086 | 0.018 | 0.108 | 4.667 | 0.000 | |
LIPG 584C>T allele | 0.080 | 0.021 | 0.087 | 3.762 | 0.000 | |
MTHFR 677C>T genotype | 0.097 | 0.017 | 0.132 | 5.718 | 0.000 | |
MTHFR 677C>T allele | 0.123 | 0.021 | 0.136 | 5.868 | 0.000 | |
MYLIP rs3757354 genotype | 0.036 | 0.015 | 0.058 | 2.465 | 0.014 | |
LDL-C | ABCA-1 V825I genotype | 0.075 | 0.025 | 0.068 | 2.954 | 0.003 |
MTHFR 677C>T genotype | 0.075 | 0.029 | 0.059 | 2.562 | 0.010 | |
MTHFR 677C>T allele | 0.120 | 0.036 | 0.077 | 3.334 | 0.001 | |
ApoA1 | ACAT-1 rs1044925 genotype | −0.042 | 0.013 | −0.074 | −3.143 | 0.002 |
ACAT-1 rs1044925 allele | −0.042 | 0.016 | −0.063 | −2.672 | 0.008 | |
LIPC -250G>A genotype | 0.036 | 0.012 | 0.068 | 3.020 | 0.003 | |
LIPG 584C>T genotype | 0.040 | 0.012 | 0.076 | 3.303 | 0.001 | |
LIPG 584C>T allele | 0.039 | 0.014 | 0.064 | 2.781 | 0.005 | |
MTHFR 677C>T genotype | 0.053 | 0.010 | 0.118 | 5.130 | 0.000 | |
MTHFR 677C>T allele | 0.068 | 0.013 | 0.123 | 5.338 | 0.000 | |
ApoB | MTHFR 677C>T genotype | 0.032 | 0.008 | 0.086 | 3.781 | 0.000 |
MTHFR 677C>T allele | 0.042 | 0.010 | 0.092 | 4.049 | 0.000 | |
ApoA1/ApoB | LIPC -250G>A genotype | 0.070 | 0.026 | 0.063 | 2.649 | 0.008 |
Lipid | Genotype/allele | Unstandardized coefficient | Std. error | Standardized coefficient |
t
|
P
|
---|---|---|---|---|---|---|
TC | ACAT-1 rs1044925 genotype | −0.131 | 0.053 | −0.078 | −2.477 | 0.013 |
LDL-R Ava II genotype | −0.089 | 0.043 | −0.062 | −2.049 | 0.041 | |
LDL-R Ava II allele | −0.121 | 0.056 | −0.066 | −2.178 | 0.030 | |
LIPC -250G>A genotype | 0.156 | 0.045 | 0.106 | 3.443 | 0.001 | |
LIPC -250G>A allele | 0.204 | 0.057 | 0.111 | 3.593 | 0.000 | |
MTHFR 677C>T genotype | 0.266 | 0.046 | 0.179 | 5.768 | 0.000 | |
MTHFR 677C>T allele | 0.290 | 0.057 | 0.158 | 5.089 | 0.000 | |
PPARD +294T>C genotype | 0.101 | 0.048 | 0.066 | 2.104 | 0.036 | |
TG | LIPC -250G>A allele | 0.149 | 0.065 | 0.072 | 2.292 | 0.022 |
MYLIP rs3757354 genotype | −0.101 | 0.045 | −0.071 | −2.251 | 0.025 | |
SCARB1 rs5888 genotype | −0.142 | 0.066 | −0.068 | −2.157 | 0.031 | |
HDL-C | ACAT-1 rs1044925 genotype | −0.061 | 0.028 | −0.068 | −2.177 | 0.030 |
LIPC -250G>A genotype | 0.045 | 0.022 | 0.062 | 2.040 | 0.042 | |
LIPG 584C>T genotype | 0.085 | 0.025 | 0.104 | 3.364 | 0.001 | |
LIPG 584C>T allele | 0.085 | 0.030 | 0.089 | 2.877 | 0.004 | |
MTHFR 677C>T genotype | 0.105 | 0.024 | 0.134 | 4.361 | 0.000 | |
MTHFR 677C>T allele | 0.129 | 0.030 | 0.134 | 4.352 | 0.000 | |
MYLIP rs3757354 genotype | 0.054 | 0.021 | 0.082 | 2.609 | 0.009 | |
LDL-C | LIPC -250G>A genotype | 0.080 | 0.037 | 0.067 | 2.171 | 0.030 |
LIPC -250G>A allele | 0.125 | 0.046 | 0.084 | 2.713 | 0.007 | |
MTHFR 677C>T genotype | 0.146 | 0.036 | 0.126 | 4.016 | 0.000 | |
MTHFR 677C>T allele | 0.156 | 0.045 | 0.109 | 3.493 | 0.000 | |
ApoA1 | ACAT-1 rs1044925 genotype | −0.047 | 0.018 | −0.080 | −2.606 | 0.009 |
LIPC -250G>A genotype | 0.048 | 0.016 | 0.087 | 2.969 | 0.003 | |
LIPC -250G>A allele | 0.051 | 0.020 | 0.074 | 2.516 | 0.012 | |
LIPG 584C>T genotype | 0.040 | 0.016 | 0.075 | 2.467 | 0.014 | |
LIPG 584C>T allele | 0.049 | 0.019 | 0.079 | 2.608 | 0.009 | |
MTHFR 677C>T genotype | 0.057 | 0.014 | 0.121 | 3.965 | 0.000 | |
MTHFR 677C>T allele | 0.071 | 0.018 | 0.122 | 4.019 | 0.000 | |
SCARB1 rs5888 genotype | −0.034 | 0.012 | −0.065 | −2.742 | 0.006 | |
ApoB | LIPC -250G>A allele | 0.033 | 0.013 | 0.078 | 2.498 | 0.013 |
MTHFR 677C>T genotype | 0.037 | 0.011 | 0.105 | 3.359 | 0.001 | |
MTHFR 677C>T allele | 0.039 | 0.013 | 0.091 | 2.904 | 0.004 | |
SCARB1 rs5888 allele | −0.012 | 0.010 | −0.048 | −2.043 | 0.041 |
Lipid | Genotype/allele | Unstandardized coefficient | Std. cp error | Standardized coefficient |
t
|
P
|
---|---|---|---|---|---|---|
TC | ABCA-1 V825I all`ele | 0.162 | 0.078 | 0.074 | 2.078 | 0.038 |
LIPG 584C>T genotype | 0.228 | 0.073 | 0.109 | 3.122 | 0.002 | |
LIPG 584C>T allele | 0.251 | 0.084 | 0.105 | 2.993 | 0.003 | |
MTHFR 677C>T genotype | 0.158 | 0.060 | 0.092 | 2.624 | 0.009 | |
MTHFR 677C>T allele | 0.245 | 0.075 | 0.115 | 3.267 | 0.001 | |
MYLIP rs3757354 genotype | −0.121 | 0.054 | −0.082 | −2.264 | 0.024 | |
PPARD +294T>C allele | 0.222 | 0.083 | 0.096 | 2.666 | 0.008 | |
SCARB1 rs5888 allele | −0.182 | 0.069 | −0.095 | −2.633 | 0.009 | |
TG | MTHFR 677C>T genotype | 0.272 | 0.106 | 0.090 | 2.556 | 0.011 |
PCSK9 E670G genotype | 1.251 | 0.309 | 0.137 | 4.053 | 0.000 | |
PPARD +294T>C allele | 0.675 | 0.179 | 0.133 | 3.763 | 0.000 | |
SCARB1 rs5888 genotype | 0.232 | 0.099 | 0.084 | 2.337 | 0.020 | |
HDL-C | ABCA-1 V825I genotype | −0.048 | 0.022 | −0.077 | −2.193 | 0.029 |
LIPG 584C>T genotype | 0.087 | 0.026 | 0.114 | 3.337 | 0.001 | |
LIPG 584C>T allele | 0.068 | 0.030 | 0.078 | 2.270 | 0.024 | |
MTHFR 677C>T genotype | 0.097 | 0.023 | 0.146 | 4.122 | 0.000 | |
MTHFR 677C>T allele | 0.138 | 0.029 | 0.167 | 4.721 | 0.000 | |
PCSK9 E670G genotype | −0.167 | 0.075 | −0.076 | −2.234 | 0.026 | |
SCARB1 rs5888 genotype | −0.069 | 0.029 | −0.084 | −2.265 | 0.018 | |
LDL-C | ABCA-1 V825I genotype | 0.134 | 0.040 | 0.119 | 3.308 | 0.001 |
ABCA-1 V825I allele | 0.228 | 0.061 | 0.134 | 3.726 | 0.000 | |
LIPG 584C>T genotype | 0.115 | 0.054 | 0.076 | 2.106 | 0.035 | |
LIPG 584C>T allele | 0.131 | 0.062 | 0.077 | 2.116 | 0.035 | |
ApoA1 | ABCA-1 V825I allele | −0.044 | 0.020 | −0.075 | −2.138 | 0.033 |
LIPG 584C>T genotype | 0.036 | 0.018 | 0.071 | 2.038 | 0.042 | |
MTHFR 677C>T genotype | 0.057 | 0.015 | 0.137 | 3.862 | 0.000 | |
MTHFR 677C>T allele | 0.076 | 0.018 | 0.145 | 4.099 | 0.000 | |
SCARB1 rs5888 genotype | −0.062 | 0.018 | −0.122 | −3.523 | 0.000 | |
ApoB | ABCA-1 V825I genotype | 0.023 | 0.011 | 0.074 | 2.041 | 0.042 |
ABCA-1 V825I allele | 0.046 | 0.017 | 0.096 | 2.652 | 0.008 | |
LIPC -250G>A genotype | −0.034 | 0.012 | −0.101 | −2.777 | 0.006 | |
MTHFR 677C>T genotype | 0.028 | 0.013 | 0.077 | 2.147 | 0.032 | |
MTHFR 677C>T allele | 0.048 | 0.016 | 0.107 | 2.992 | 0.003 | |
MYLIP rs3757354 genotype | −0.026 | 0.012 | −0.079 | −2.190 | 0.029 | |
SCARB1 rs5888 allele | −0.052 | 0.015 | −0.129 | −3.587 | 0.000 | |
ApoA1/ApoB | ABCA-1 V825I genotype | −0.093 | 0.029 | −0.114 | −3.168 | 0.002 |
ABCA-1 V825I allele | −0.185 | 0.044 | −0.149 | −4.172 | 0.000 | |
LIPC -250G>A genotype | 0.132 | 0.036 | 0.132 | 3.698 | 0.000 | |
LIPC -250G>A allele | 0.114 | 0.048 | 0.085 | 2.361 | 0.018 | |
MYLIP rs3757354 genotype | 0.058 | 0.030 | 0.071 | 1.965 | 0.050 |