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Neurological Sciences

Erschienen in:

01.11.2014 | Original Article

Single dose varenicline may trigger epileptic activity

verfasst von: Haydar Ali Erken, Gülten Erken, Hasan Şimşek, Oğuzhan Korkut, Emine Rabia Koç, Özlem Yavuz, Osman Genç

Erschienen in: Neurological Sciences | Ausgabe 11/2014

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Abstract

Varenicline is a new drug for smoking cessation, and its effect on epilepsy is not clear. The aim of this study was to investigate whether different doses of varenicline cause epileptic activity. Forty rats were randomly assigned to the following eight groups: control, saline, and 0.025, 0.04, 0.1, 0.5, 1, and 2 mg kg⁻¹ varenicline (single dose, i.p.). EEGs were recorded before the varenicline injection and during the following 240 min. While epileptic discharges were observed on the EEGs of the rats in all of the varenicline-treated groups, motor findings of epileptic seizure were not observed in some rats in these groups except the 1 and 2 mg kg⁻¹ groups. These findings indicate that different single doses of varenicline cause epileptic activity in rats.

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Titel: Single dose varenicline may trigger epileptic activity
verfasst von: Haydar Ali Erken
Gülten Erken
Hasan Şimşek
Oğuzhan Korkut
Emine Rabia Koç
Özlem Yavuz
Osman Genç
Publikationsdatum: 01.11.2014
Verlag: Springer Milan
Erschienen in: Neurological Sciences / Ausgabe 11/2014
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-014-1845-y

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