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Head and Neck Pathology

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21.08.2021 | Case Reports

Sinonasal SMARCB1 (INI1) Deficient Carcinoma with Yolk Sac Tumor Differentiation: A Case Report and Treatment Options

verfasst von: Burak Hazir, Berkay Şímșek, Arzu Erdemír, Fatih Gürler, Ozan Yazici, Yusuf Kizil, Utku Aydíl

Erschienen in: Head and Neck Pathology | Ausgabe 2/2022

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Abstract

SMARCB1 (INI1) deficient carcinoma (SDC) is a newly-described, aggressive, high-grade malignancy of the adult population. Rarely, these tumors demonstrate yolk sac differentiation. Treatment protocols are not defined due to the rarity of this entity. A 55 year-old-male presented with a tumor originating in the maxillary sinus. He was treated with neoadjuvant therapy followed by radical surgery and adjuvant treatment. We review the literature and discuss the course of disease and treatments of sinonasal SDC with yolk sac tumor differentiation. To our knowledge, this is the sixth reported case of sinonasal SDC with yolk sac tumor differentiation. This is the first publication describing the clinical course and efficacy of therapeutic interventions.

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Titel: Sinonasal SMARCB1 (INI1) Deficient Carcinoma with Yolk Sac Tumor Differentiation: A Case Report and Treatment Options
verfasst von: Burak Hazir
Berkay Şímșek
Arzu Erdemír
Fatih Gürler
Ozan Yazici
Yusuf Kizil
Utku Aydíl
Publikationsdatum: 21.08.2021
Verlag: Springer US
Erschienen in: Head and Neck Pathology / Ausgabe 2/2022
Elektronische ISSN: 1936-0568
DOI: https://doi.org/10.1007/s12105-021-01375-9

Springer Medizin

Sinonasal SMARCB1 (INI1) Deficient Carcinoma with Yolk Sac Tumor Differentiation: A Case Report and Treatment Options

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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