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Current Osteoporosis Reports

Erschienen in:

15.03.2021 | Skeletal Biology and Regulation (MR Forwood and A Robling, Section Editors)

Skeletal Functions of Voltage Sensitive Calcium Channels

verfasst von: Christian S. Wright, Alexander G. Robling, Mary C. Farach-Carson, William R. Thompson

Erschienen in: Current Osteoporosis Reports | Ausgabe 2/2021

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Abstract

Summary

Voltage-sensitive calcium channels (VSCCs) are ubiquitous multimeric protein complexes that are necessary for the regulation of numerous physiological processes. VSCCs regulate calcium influx and various intracellular processes including muscle contraction, neurotransmission, hormone secretion, and gene transcription, with function specificity defined by the channel’s subunits and tissue location.

The functions of VSCCs in bone are often overlooked since bone is not considered an electrically excitable tissue. However, skeletal homeostasis and adaptation relies heavily on VSCCs. Inhibition or deletion of VSCCs decreases osteogenesis, impairs skeletal structure, and impedes anabolic responses to mechanical loading.

Recent Findings

While the functions of VSCCs in osteoclasts are less clear, VSCCs have distinct but complementary functions in osteoblasts and osteocytes.

Purpose of Review

This review details the structure, function, and nomenclature of VSCCs, followed by a comprehensive description of the known functions of VSCCs in bone cells and their regulation of bone development, bone formation, and mechanotransduction.

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Titel: Skeletal Functions of Voltage Sensitive Calcium Channels
verfasst von: Christian S. Wright
Alexander G. Robling
Mary C. Farach-Carson
William R. Thompson
Publikationsdatum: 15.03.2021
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 2/2021
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-020-00647-7

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Skeletal Functions of Voltage Sensitive Calcium Channels

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