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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 3/2020

14.03.2020 | Skeletal Development (R Marcucio and J Feng, Section Editors)

Skeletal Stem Cells for Bone Development and Repair: Diversity Matters

verfasst von: Yuki Matsushita, Wanida Ono, Noriaki Ono

Erschienen in: Current Osteoporosis Reports | Ausgabe 3/2020

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Abstract

Purpose of Review

Skeletal stem cells (SSCs) are considered to play important roles in bone development and repair. These cells have been historically defined by their in vitro potential for self-renewal and differentiation into “trilineage” cells; however, little is known about their in vivo identity. Here, we discuss recent progress on SSCs and how they potentially contribute to bone development and repair.

Recent Findings

Bone is composed of diverse tissues, which include cartilage and its perichondrium, cortical bone and its periosteum, and bone marrow and its trabecular bone and stromal compartment. We are now at the initial stage of understanding the precise identity of SSCs in each bone tissue. The emerging concept is that functionally dedicated SSCs are encased by their own unique cellular and extracellular matrix microenvironment, and locally support its own compartment.

Summary

Diverse groups of SSCs are likely to work in concert to achieve development and repair of the highly functional skeletal organ.
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Metadaten
Titel
Skeletal Stem Cells for Bone Development and Repair: Diversity Matters
verfasst von
Yuki Matsushita
Wanida Ono
Noriaki Ono
Publikationsdatum
14.03.2020
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 3/2020
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-020-00572-9

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