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Current Osteoporosis Reports

Erschienen in:

21.04.2020 | Orthopedic Management of Fractures (M Kacena and L Gerstenfeld, Section Editors)

Epidemiology, Clinical Assessments, and Current Treatments of Nonunions

verfasst von: G. Bradley Reahl, Louis Gerstenfeld, Michael Kain

Erschienen in: Current Osteoporosis Reports | Ausgabe 3/2020

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Abstract

Purpose of Review

The failure of bony union following a fracture, termed a fracture nonunion, has severe patient morbidity and economic consequences. This review describes current consensuses and future directions of investigation for determining why, detecting when, and effective treatment if this complication occurs.

Recent Findings

Current nonunion investigation is emphasizing an expanded understanding of the biology of healing. This has led to assessments of the immune environment, multiple cytokines and morphogenetic factors, and the role of skeletogenic stem cells in the development of nonunion. Detecting biological markers and other objective diagnostic criteria is also a current objective of nonunion research. Treatment approaches in the near future will likely be dominated by the development of specific adjunct therapies to the nonunion surgical management, which will be informed by an expanded mechanistic understanding of nonunion biology.

Summary

Current consensus among orthopedists is that improved diagnosis and treatment of nonunion hinges first on discoveries at the bench side with later translation to the clinic.

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Titel: Epidemiology, Clinical Assessments, and Current Treatments of Nonunions
verfasst von: G. Bradley Reahl
Louis Gerstenfeld
Michael Kain
Publikationsdatum: 21.04.2020
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 3/2020
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-020-00575-6

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