Erschienen in:
Open Access
01.09.2012 | Meeting abstract
SLE patients and autoantibody-positive healthy individuals display unique cytokine profiles: shared features of inflammation as well as select features of immunosuppression in autoantibody-positive healthy individuals
verfasst von:
LL Ritterhouse, HT Maecker, CG Fathman, JT Merrill, JM Guthridge, JA James
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 3/2012
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Excerpt
Antinuclear antibodies can be detected in up to 25% of the population; however, only 5 to 7% are afflicted with an autoimmune disease. Therefore, many individuals are capable of mitigating the presence of autoantibodies and avoiding clinical disease. The objective of this study was to investigate unique features of SLE patients compared with autoantibody-positive (aAb+) healthy immune systems and to examine roles that cytokines play in maintaining immune equilibrium in ANA-positive healthy individuals. …