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Current Treatment Options in Neurology
Erschienen in: Current Treatment Options in Neurology 11/2018

01.11.2018 | Sleep Disorders (A Iranzo, Section Editor)

Sleep Abnormalities in Wilson’s Disease

verfasst von: Valérie Cochen De Cock, MD, PhD, Nadège Girardot-Tinant, PhD, France Woimant, MD, Aurélia Poujois, MD, PhD

Erschienen in: Current Treatment Options in Neurology | Ausgabe 11/2018

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Abstract

Purpose of review

The aim of this article was to review the different sleep disorders associated with Wilson’s disease (WD), their mechanisms and their treatments.

Recent findings

Some of these disorders such as REM sleep behavior disorder or sleepiness can appear as a prodromal phase phenomenon in WD allowing an early treatment of the disease and sometimes a resolution of the sleep disorder.

Summary

Sleep disorders in WD are frequent combining insomnia, daytime sleepiness, restless legs syndrome (RLS), cataplexy-like episodes, and REM sleep behavior disorder (RBD). Sleep recordings confirm these disorders. Mechanisms involved in these disorders are complex associating (a) lesions of the pathways regulating sleep and wake or mood but also controlling movement, (b) iatrogenic effects of the treatments, and (3) consequences of the motor or dysautonomic or metabolic disorders.
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Metadaten
Titel
Sleep Abnormalities in Wilson’s Disease
verfasst von
Valérie Cochen De Cock, MD, PhD
Nadège Girardot-Tinant, PhD
France Woimant, MD
Aurélia Poujois, MD, PhD
Publikationsdatum
01.11.2018
Verlag
Springer US
Erschienen in
Current Treatment Options in Neurology / Ausgabe 11/2018
Print ISSN: 1092-8480
Elektronische ISSN: 1534-3138
DOI
https://doi.org/10.1007/s11940-018-0531-4

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