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01.12.2012 | Correspondence | Ausgabe 1/2012 Open Access

BMC Health Services Research 1/2012

Specific guidelines for assessing and improving the methodological quality of economic evaluations of newborn screening

Zeitschrift:
BMC Health Services Research > Ausgabe 1/2012
Autoren:
Astrid Langer, Rolf Holle, Jürgen John
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1472-6963-12-300) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

AL conducted the searches and the review of economic evaluations, participated in study appraisal, and took the lead in writing the manuscript. JJ initiated the project, developed the guideline, provided methodological supervision throughout the study and contributed to writing the manuscript. RH participated in the development of the guideline and contributed to methodological discussions. All authors read and approved the final manuscript.

Abstract

Background

Economic evaluation of newborn screening poses specific methodological challenges. Amongst others, these challenges refer to the use of quality adjusted life years (QALYs) in newborns, and which costs and outcomes need to be considered in a full evaluation of newborn screening programmes. Because of the increasing scale and scope of such programmes, a better understanding of the methods of high-quality economic evaluations may be crucial for both producers/authors and consumers/reviewers of newborn screening-related economic evaluations. The aim of this study was therefore to develop specific guidelines designed to assess and improve the methodological quality of economic evaluations in newborn screening.

Methods

To develop the guidelines, existing guidelines for assessing the quality of economic evaluations were identified through a literature search, and were reviewed and consolidated using a deductive iterative approach. In a subsequent test phase, these guidelines were applied to various economic evaluations which acted as case studies.

Results

The guidelines for assessing and improving the methodological quality of economic evaluations in newborn screening are organized into 11 categories: “bibliographic details”, “study question and design”, “modelling”, “health outcomes”, “costs”, “discounting”, “presentation of results”, “sensitivity analyses”, “discussion”, “conclusions”, and “commentary”.

Conclusions

The application of the guidelines highlights important issues regarding newborn screening-related economic evaluations, and underscores the need for such issues to be afforded greater consideration in future economic evaluations. The variety in methodological quality detected by this study reveals the need for specific guidelines on the appropriate methods for conducting sound economic evaluations in newborn screening.
Zusatzmaterial
Additional file 1 : Overview of economic evaluations in newborn hearing screening. Data extraction of selected economic evaluations of newborn hearing screening. (DOC 168 KB)
12913_2011_2118_MOESM1_ESM.doc
Additional file 2 : Overview of economic evaluations in newborn screening for inherited metabolic disorders including MCADD by MS/MS. Data extraction of selected economic evaluations of newborn screening for inherited metabolic disorders including MCADD by MS/MS. (DOC 74 KB)
12913_2011_2118_MOESM2_ESM.doc
Literatur
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