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Neuroscience Bulletin

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01.02.2018 | Review

Spinal Mechanisms of Itch Transmission

verfasst von: Devin M. Barry, Admire Munanairi, Zhou-Feng Chen

Erschienen in: Neuroscience Bulletin | Ausgabe 1/2018

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Abstract

Peripheral itch stimuli are transmitted by sensory neurons to the spinal cord dorsal horn, which then transmits the information to the brain. The molecular and cellular mechanisms within the dorsal horn for itch transmission have only been investigated and identified during the past ten years. This review covers the progress that has been made in identifying the peptide families in sensory neurons and the receptor families in dorsal horn neurons as putative itch transmitters, with a focus on gastrin-releasing peptide (GRP)—GRP receptor signaling. Also discussed are the signaling mechanisms, including opioids, by which various types of itch are transmitted and modulated, as well as the many conflicting results arising from recent studies.

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Titel: Spinal Mechanisms of Itch Transmission
verfasst von: Devin M. Barry
Admire Munanairi
Zhou-Feng Chen
Publikationsdatum: 01.02.2018
Verlag: Springer Singapore
Erschienen in: Neuroscience Bulletin / Ausgabe 1/2018
Print ISSN: 1673-7067
Elektronische ISSN: 1995-8218
DOI: https://doi.org/10.1007/s12264-017-0125-2

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