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Erschienen in: European Radiology 2/2024

25.08.2023 | Computed Tomography

Stent-specific fat attenuation index is associated with target vessel revascularization after PCI

verfasst von: Feng Xu, Chengcheng Wang, Qing Tao, Jian Zhang, Mingming Zhao, Shiwei Shi, Mengmeng Zhu, Chunxiang Tang, Longjiang Zhang, Changsheng Zhou, Chunhong Hu

Erschienen in: European Radiology | Ausgabe 2/2024

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Abstract

Objectives

To explore the clinical relevance of stent-specific perivascular fat attenuation index (FAI) in patients with stent implantation.

Methods

A total of 162 consecutive patients who underwent coronary computed tomography angiography (CCTA) following stent implantation were retrospectively included. The stent-specific FAI at 2 cm adjacent to the stent edge was calculated. The endpoints were defined as target vessel revascularization (TVR) on the stented vessel after CCTA and readmission times due to chest pain after stent implantation. Binary logistic regression analysis for TVR and ordinal regression models were conducted to identify readmission times (0, 1, and ≥ 2) with generalized estimating equations on a per-stent basis.

Results

On a per-stent basis, 9 stents (4.5%) experienced TVR after PCI at a median 30 months’ follow-up duration. Stent-specific FAI differed significantly among subgroups of patients with stent implantation and different readmission times (p = 0.002); patients with at least one readmission had higher stent-specific FAI than those without readmission (p < 0.001). Bifurcated stents (odds ratio [OR]: 11.192, p = 0.001) and stent-specific FAI (OR: 1.189, p = 0.04) were independently associated with TVR. With no readmission as a reference, stent-specific FAI (OR: 0.984, p = 0.007) was an independent predictor for hospital readmission times ≥ 2 (p = 0.003).

Conclusion

Non-invasive stent-specific FAI derived from CCTA was found to be associated with TVR, which was a promising imaging marker for functional assessment in patients who underwent stent implantation.

Clinical relevance statement

Noninvasive fat attenuation index adjacent to the stents edge derived from CCTA, an imaging marker reflecting the presence of inflammation acting on the neointimal tissue at the sites of coronary stenting, might be relevant clinically with target vessel revascularization.

Key Points

• Non-invasive stent-specific FAI derived from CCTA was associated with TVR (OR: 1.189 [95% CI: 1.007–1.043], p = 0.04) in patients who underwent stent implantation.
• Stent-specific FAI significantly differed among a subgroup of patients with chest pain after stent implantation and with different readmission times (p = 0.002); the patients with at least one readmission had higher stent-specific FAI than those without readmission (p < 0.001).
• Non-invasive stent-specific FAI derived from CCTA could be used as an imaging maker for the functional assessment of patients following stent implantation.
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Metadaten
Titel
Stent-specific fat attenuation index is associated with target vessel revascularization after PCI
verfasst von
Feng Xu
Chengcheng Wang
Qing Tao
Jian Zhang
Mingming Zhao
Shiwei Shi
Mengmeng Zhu
Chunxiang Tang
Longjiang Zhang
Changsheng Zhou
Chunhong Hu
Publikationsdatum
25.08.2023
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 2/2024
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-023-10111-6

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