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Erschienen in: European Radiology 5/2020

30.01.2020 | Cardiac

Surgically implanted aortic valve bioprostheses deform after implantation: insights from computed tomography

verfasst von: Marguerite E. Faure, Dominika Suchá, Fides R. Schwartz, Petr Symersky, Ad J. J. C. Bogers, Jeffrey G. Gaca, Lynne M. Koweek, Linda M. de Heer, Ricardo P. J. Budde

Erschienen in: European Radiology | Ausgabe 5/2020

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Abstract

Objective

Little is known about the prevalence and degree of deformation of surgically implanted aortic biological valve prostheses (bio-sAVRs). We assessed bio-sAVR deformation using multidetector-row computed tomography (MDCT).

Methods

Three imaging databases were searched for patients with MDCT performed after bio-sAVR implantation. Minimal and maximal valve ring diameters were obtained in systole and/or diastole, depending on the acquired cardiac phase(s). The eccentricity index (EI) was calculated as a measure of deformation as (1 − (minimal diameter/maximal diameter)) × 100%. EI of < 5% was considered none or trivial deformation, 5–10% mild deformation, and > 10% non-circular. Indications for MDCT and implanted valve type were retrieved.

Results

One hundred fifty-two scans of bio-sAVRs were included. One hundred seventeen measurements were performed in systole and 35 in diastole. None or trivial deformation (EI < 5%) was seen in 67/152 (44%) of patients. Mild deformation (EI 5–10%) was seen in 59/152 (39%) and non-circularity was found in 26/152 (17%) of cases. Overall, median EI was 5.5% (IQR 3.4–7.8). In 77 patients, both systolic and diastolic measurements were performed from the same scan. For these scans, the median EI was 6.5% (IQR 3.4–10.2) in systole and 5.1% (IQR3.1–7.6) in diastole, with a significant difference between both groups (p = 0.006).

Conclusions

Surgically implanted aortic biological valve prostheses show mild deformation in 39% of cases and were considered non-circular in 17% of studied valves.

Key Points

• Deformation of surgically implanted aortic valve bioprostheses (bio-sAVRs) can be adequately assessed using MDCT.
• Bio-sAVRs show at least mild deformation (eccentricity index > 5%) in 56% of studied cases and were considered non-circular (eccentricity index > 10%) in 17% of studied valves.
• The higher deformity rate found in bio-sAVRs with (suspected) valve pathology could suggest that geometric deformity may play a role in leaflet malformation and thrombus formation similar to that of transcatheter heart valves.
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Literatur
1.
Zurück zum Zitat Brown JM, O'Brien SM, Wu C, Sikora JA, Griffith BP, Gammie JS (2009) Isolated aortic valve replacement in North America comprising 108,687 patients in 10 years: changes in risks, valve types, and outcomes in the Society of Thoracic Surgeons National Database. J Thorac Cardiovasc Surg 137:82–90 Brown JM, O'Brien SM, Wu C, Sikora JA, Griffith BP, Gammie JS (2009) Isolated aortic valve replacement in North America comprising 108,687 patients in 10 years: changes in risks, valve types, and outcomes in the Society of Thoracic Surgeons National Database. J Thorac Cardiovasc Surg 137:82–90
2.
Zurück zum Zitat Samad Z, Vora AN, Dunning A et al (2016) Aortic valve surgery and survival in patients with moderate or severe aortic stenosis and left ventricular dysfunction. Eur Heart J 37:2276–2286CrossRef Samad Z, Vora AN, Dunning A et al (2016) Aortic valve surgery and survival in patients with moderate or severe aortic stenosis and left ventricular dysfunction. Eur Heart J 37:2276–2286CrossRef
3.
Zurück zum Zitat Côté N, Pibarot P, Clavel MA (2017) Incidence, risk factors, clinical impact, and management of bioprosthesis structural valve degeneration. Curr Opin Cardiol 32:123–129CrossRef Côté N, Pibarot P, Clavel MA (2017) Incidence, risk factors, clinical impact, and management of bioprosthesis structural valve degeneration. Curr Opin Cardiol 32:123–129CrossRef
4.
Zurück zum Zitat Hoffmann G, Lutter G, Cremer J (2008) Durability of bioprosthetic cardiac valves. Dtsch Arztebl Int 105:143–148PubMedPubMedCentral Hoffmann G, Lutter G, Cremer J (2008) Durability of bioprosthetic cardiac valves. Dtsch Arztebl Int 105:143–148PubMedPubMedCentral
5.
Zurück zum Zitat Binder RK, Webb JG, Toggweiler S et al (2013) Impact of post-implant Sapien XT geometry and position on conduction disturbances, hemodynamic performance, and paravalvular regurgitation. JACC Cardiovasc Interv 6:462–468CrossRef Binder RK, Webb JG, Toggweiler S et al (2013) Impact of post-implant Sapien XT geometry and position on conduction disturbances, hemodynamic performance, and paravalvular regurgitation. JACC Cardiovasc Interv 6:462–468CrossRef
6.
Zurück zum Zitat Delgado V, Ng AC, van de Veire NR et al (2010) Transcatheter aortic valve implantation: role of multi-detector row computed tomography to evaluate prosthesis positioning and deployment in relation to valve function. Eur Heart J 31:1114–1123CrossRef Delgado V, Ng AC, van de Veire NR et al (2010) Transcatheter aortic valve implantation: role of multi-detector row computed tomography to evaluate prosthesis positioning and deployment in relation to valve function. Eur Heart J 31:1114–1123CrossRef
7.
Zurück zum Zitat Willson AB, Webb JG, Gurvitch R et al (2012) Structural integrity of balloon-expandable stents after transcatheter aortic valve replacement: assessment by multidetector computed tomography. JACC Cardiovasc Interv 5:525–532CrossRef Willson AB, Webb JG, Gurvitch R et al (2012) Structural integrity of balloon-expandable stents after transcatheter aortic valve replacement: assessment by multidetector computed tomography. JACC Cardiovasc Interv 5:525–532CrossRef
8.
Zurück zum Zitat Fuchs A, De Backer O, Brooks M et al (2017) Subclinical leaflet thickening and stent frame geometry in self-expanding transcatheter heart valves. EuroIntervention 13:1067–1075CrossRef Fuchs A, De Backer O, Brooks M et al (2017) Subclinical leaflet thickening and stent frame geometry in self-expanding transcatheter heart valves. EuroIntervention 13:1067–1075CrossRef
9.
Zurück zum Zitat Caudron J, Fares J, Hauville C et al (2011) Evaluation of multislice computed tomography early after transcatheter aortic valve implantation with the Edwards Sapien bioprosthesis. Am J Cardiol 108:873–881CrossRef Caudron J, Fares J, Hauville C et al (2011) Evaluation of multislice computed tomography early after transcatheter aortic valve implantation with the Edwards Sapien bioprosthesis. Am J Cardiol 108:873–881CrossRef
10.
Zurück zum Zitat Schultz CJ, Weustink A, Piazza N et al (2009) Geometry and degree of apposition of the corevalve revalving system with multislice computed tomography after implantation in patients with aortic stenosis. J Am Coll Cardiol 54:911–918CrossRef Schultz CJ, Weustink A, Piazza N et al (2009) Geometry and degree of apposition of the corevalve revalving system with multislice computed tomography after implantation in patients with aortic stenosis. J Am Coll Cardiol 54:911–918CrossRef
11.
Zurück zum Zitat Wood DA, Tops LF, Mayo JR et al (2009) Role of multislice computed tomography in transcatheter aortic valve replacement. Am J Cardiol 103:1295–1301CrossRef Wood DA, Tops LF, Mayo JR et al (2009) Role of multislice computed tomography in transcatheter aortic valve replacement. Am J Cardiol 103:1295–1301CrossRef
12.
Zurück zum Zitat Abbasi M, Azadani AN (2015) Leaflet stress and strain distributions following incomplete transcatheter aortic valve expansion. J Biomech 48:3663–3671CrossRef Abbasi M, Azadani AN (2015) Leaflet stress and strain distributions following incomplete transcatheter aortic valve expansion. J Biomech 48:3663–3671CrossRef
13.
Zurück zum Zitat Rodríguez-Olivares R, Rahhab Z, El Faquir N et al (2016) Differences in frame geometry between balloon-expandable and self-expanding transcatheter heart valves and association with aortic regurgitation. Rev Esp Cardiol (Engl Ed) 69:392–400 Rodríguez-Olivares R, Rahhab Z, El Faquir N et al (2016) Differences in frame geometry between balloon-expandable and self-expanding transcatheter heart valves and association with aortic regurgitation. Rev Esp Cardiol (Engl Ed) 69:392–400
14.
Zurück zum Zitat Schoen FJ, Levy RJ (2005) Calcification of tissue heart valve substitutes: progress toward understanding and prevention. Ann Thorac Surg 79:1072–1080CrossRef Schoen FJ, Levy RJ (2005) Calcification of tissue heart valve substitutes: progress toward understanding and prevention. Ann Thorac Surg 79:1072–1080CrossRef
15.
Zurück zum Zitat Thubrikar MJ, Deck JD, Aouad J, Nolan SP (1983) Role of mechanical stress in calcification of aortic bioprosthetic valves. J Thorac Cardiovasc Surg 86:115–125CrossRef Thubrikar MJ, Deck JD, Aouad J, Nolan SP (1983) Role of mechanical stress in calcification of aortic bioprosthetic valves. J Thorac Cardiovasc Surg 86:115–125CrossRef
16.
Zurück zum Zitat Sritharan D, Fathi P, Weaver JD, Retta SM, Wu C, Duraiswamy N (2018) Impact of clinically relevant elliptical deformations on the damage patterns of sagging and stretched leaflets in a bioprosthetic heart valve. Cardiovasc Eng Technol 9:351–364CrossRef Sritharan D, Fathi P, Weaver JD, Retta SM, Wu C, Duraiswamy N (2018) Impact of clinically relevant elliptical deformations on the damage patterns of sagging and stretched leaflets in a bioprosthetic heart valve. Cardiovasc Eng Technol 9:351–364CrossRef
17.
Zurück zum Zitat Bernacca GM, Fisher AC, Wilkinson R, Mackay TG, Wheatley DJ (1992) Calcification and stress distribution in bovine pericardial heart valves. J Biomed Mater Res 26:959–966CrossRef Bernacca GM, Fisher AC, Wilkinson R, Mackay TG, Wheatley DJ (1992) Calcification and stress distribution in bovine pericardial heart valves. J Biomed Mater Res 26:959–966CrossRef
18.
Zurück zum Zitat Smith DB, Sacks MS, Pattany PM, Schroeder R (1999) Fatigue-induced changes in bioprosthetic heart valve three-dimensional geometry and the relation to tissue damage. J Heart Valve Dis 8:25–33PubMed Smith DB, Sacks MS, Pattany PM, Schroeder R (1999) Fatigue-induced changes in bioprosthetic heart valve three-dimensional geometry and the relation to tissue damage. J Heart Valve Dis 8:25–33PubMed
19.
Zurück zum Zitat van Nooten G, Ozaki S, Herijgers P, Segers P, Verdonck P, Flameng W (1999) Distortion of the stentless porcine valve induces accelerated leaflet fibrosis and calcification in juvenile sheep. J Heart Valve Dis 8:34–41PubMed van Nooten G, Ozaki S, Herijgers P, Segers P, Verdonck P, Flameng W (1999) Distortion of the stentless porcine valve induces accelerated leaflet fibrosis and calcification in juvenile sheep. J Heart Valve Dis 8:34–41PubMed
20.
Zurück zum Zitat Binder RK, Rodes-Cabau J, Wood DA et al (2013) Transcatheter aortic valve replacement with the Sapien 3: a new balloon-expandable transcatheter heart valve. JACC Cardiovasc Interv 6:293–300CrossRef Binder RK, Rodes-Cabau J, Wood DA et al (2013) Transcatheter aortic valve replacement with the Sapien 3: a new balloon-expandable transcatheter heart valve. JACC Cardiovasc Interv 6:293–300CrossRef
21.
Zurück zum Zitat Blanke P, Reinohl J, Schlensak C et al (2012) Prosthesis oversizing in balloon-expandable transcatheter aortic valve implantation is associated with contained rupture of the aortic root. Circ Cardiovasc Interv 5:540–548CrossRef Blanke P, Reinohl J, Schlensak C et al (2012) Prosthesis oversizing in balloon-expandable transcatheter aortic valve implantation is associated with contained rupture of the aortic root. Circ Cardiovasc Interv 5:540–548CrossRef
22.
Zurück zum Zitat Willson AB, Rodes-Cabau J, Wood DA et al (2012) Transcatheter aortic valve replacement with the St. Jude medical portico valve: first-in-human experience. J Am Coll Cardiol 60:581–586CrossRef Willson AB, Rodes-Cabau J, Wood DA et al (2012) Transcatheter aortic valve replacement with the St. Jude medical portico valve: first-in-human experience. J Am Coll Cardiol 60:581–586CrossRef
23.
Zurück zum Zitat Haziza F, Papouin G, Barratt-Boyes B, Christie G, Whitlock R (1996) Tears in bioprosthetic heart valve leaflets without calcific degeneration. J Heart Valve Dis 5:35–39PubMed Haziza F, Papouin G, Barratt-Boyes B, Christie G, Whitlock R (1996) Tears in bioprosthetic heart valve leaflets without calcific degeneration. J Heart Valve Dis 5:35–39PubMed
24.
Zurück zum Zitat Vesely I, Barber JE, Ratliff NB (2001) Tissue damage and calcification may be independent mechanisms of bioprosthetic heart valve failure. J Heart Valve Dis 10:471–477PubMed Vesely I, Barber JE, Ratliff NB (2001) Tissue damage and calcification may be independent mechanisms of bioprosthetic heart valve failure. J Heart Valve Dis 10:471–477PubMed
25.
Zurück zum Zitat Schoen FJ, Levy RJ (1999) Founder's Award, 25th Annual Meeting of the Society for Biomaterials, perspectives. Providence, RI, April 28-May 2, 1999. Tissue heart valves: current challenges and future research perspectives. J Biomed Mater Res 47:439–465 Schoen FJ, Levy RJ (1999) Founder's Award, 25th Annual Meeting of the Society for Biomaterials, perspectives. Providence, RI, April 28-May 2, 1999. Tissue heart valves: current challenges and future research perspectives. J Biomed Mater Res 47:439–465
26.
Zurück zum Zitat de Heer LM, Budde RP, van Prehn J et al (2012) Pulsatile distention of the nondiseased and stenotic aortic valve annulus: analysis with electrocardiogram-gated computed tomography. Ann Thorac Surg 93:516–522CrossRef de Heer LM, Budde RP, van Prehn J et al (2012) Pulsatile distention of the nondiseased and stenotic aortic valve annulus: analysis with electrocardiogram-gated computed tomography. Ann Thorac Surg 93:516–522CrossRef
27.
Zurück zum Zitat Sucha D, Tuncay V, Prakken NH et al (2015) Does the aortic annulus undergo conformational change throughout the cardiac cycle? A systematic review. Eur Heart J Cardiovasc Imaging 16:1307–1317PubMed Sucha D, Tuncay V, Prakken NH et al (2015) Does the aortic annulus undergo conformational change throughout the cardiac cycle? A systematic review. Eur Heart J Cardiovasc Imaging 16:1307–1317PubMed
28.
Zurück zum Zitat Suchá D, Daans CG, Symersky P et al (2015) Reliability, agreement, and presentation of a reference standard for assessing implanted heart valve sizes by multidetector-row computed tomography. Am J Cardiol 116:112–120CrossRef Suchá D, Daans CG, Symersky P et al (2015) Reliability, agreement, and presentation of a reference standard for assessing implanted heart valve sizes by multidetector-row computed tomography. Am J Cardiol 116:112–120CrossRef
29.
Zurück zum Zitat Ac N, Delgado V, van der Kley F et al (2010) Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2- and 3-dimensional transesophageal echocardiography and multislice computed tomography. Circ Cardiovasc Imaging 3:94–102CrossRef Ac N, Delgado V, van der Kley F et al (2010) Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation by 2- and 3-dimensional transesophageal echocardiography and multislice computed tomography. Circ Cardiovasc Imaging 3:94–102CrossRef
Metadaten
Titel
Surgically implanted aortic valve bioprostheses deform after implantation: insights from computed tomography
verfasst von
Marguerite E. Faure
Dominika Suchá
Fides R. Schwartz
Petr Symersky
Ad J. J. C. Bogers
Jeffrey G. Gaca
Lynne M. Koweek
Linda M. de Heer
Ricardo P. J. Budde
Publikationsdatum
30.01.2020
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 5/2020
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-019-06634-6

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