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19.08.2021 | Magnetic Resonance

T₁ and T₂ quantification using magnetic resonance fingerprinting in mild traumatic brain injury

verfasst von: Teresa Gerhalter, Martijn Cloos, Anna M. Chen, Seena Dehkharghani, Rosemary Peralta, James S. Babb, Alejandro Zarate, Tamara Bushnik, Jonathan M. Silver, Brian S. Im, Stephen Wall, Steven Baete, Guillaume Madelin, Ivan I. Kirov

Erschienen in: European Radiology | Ausgabe 2/2022

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Abstract

Objectives

To assess whether MR fingerprinting (MRF)–based relaxation properties exhibit cross-sectional and prospective correlations with patient outcome and compare the results with those from DTI.

Methods

Clinical imaging, MRF, and DTI were acquired in patients (24 ± 10 days after injury (timepoint 1) and 90 ± 17 days after injury (timepoint 2)) and once in controls. Patient outcome was assessed with global functioning, symptom profile, and neuropsychological testing. ADC and fractional anisotropy (FA) from DTI and T₁ and T₂ from MRF were compared in 12 gray and white matter regions with Mann–Whitney tests. Bivariate associations between MR measures and outcome were assessed using the Spearman correlation and logistic regression.

Results

Data from 22 patients (38 ± 12 years; 17 women) and 18 controls (32 ± 8 years; 12 women) were analyzed. Fourteen patients (37 ± 12 years; 11 women) returned for timepoint 2, while two patients provided only timepoint 2 clinical outcome data. At timepoint 1, there were no differences between patients and controls in T₁, T₂, and ADC, while FA was lower in mTBI frontal white matter. T₁ at timepoint 1 and the change in T₁ exhibited more (n = 18) moderate to strong correlations (|r|= 0.6–0.85) with clinical outcome at timepoint 2 than T₂ (n = 3), FA (n = 7), and ADC (n = 2). High T₁ at timepoint 1, and serially increasing T₁, accounted for five of the six MR measures with the highest utility for identification of non-recovered patients at timepoint 2 (AUC > 0.80).

Conclusion

T₁ derived from MRF was found to have higher utility than T₂, FA, and ADC for predicting 3-month outcome after mTBI.

Key Points

• In a region-of-interest approach, FA, ADC, and T₁ and T₂ all showed limited utility in differentiating patients from controls at an average of 24 and 90 days post-mild traumatic brain injury.

• T₁ at 24 days, and the serial change in T₁, revealed more and stronger predictive correlations with clinical outcome at 90 days than did T₂, ADC, or FA.

• T₁ showed better prospective identification of non-recovered patients at 90 days than ADC, T₂, and FA.

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Titel: T1 and T2 quantification using magnetic resonance fingerprinting in mild traumatic brain injury
verfasst von: Teresa Gerhalter
Martijn Cloos
Anna M. Chen
Seena Dehkharghani
Rosemary Peralta
James S. Babb
Alejandro Zarate
Tamara Bushnik
Jonathan M. Silver
Brian S. Im
Stephen Wall
Steven Baete
Guillaume Madelin
Ivan I. Kirov
Publikationsdatum: 19.08.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 2/2022
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-021-08235-8

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T₁ and T₂ quantification using magnetic resonance fingerprinting in mild traumatic brain injury