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Erschienen in: Heart Failure Reviews 5/2014

01.09.2014

Takotsubo cardiomyopathy

verfasst von: Tatsuji Kono, Hani N. Sabbah

Erschienen in: Heart Failure Reviews | Ausgabe 5/2014

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Abstract

Takotsubo cardiomyopathy (TC) is characterized by transient left ventricular apical wall motion abnormalities, chest pain with electrocardiographic changes, and modest myocardial enzymatic release mimicking acute coronary syndrome, but without significant coronary artery disease. TC is an increasingly recognized type of acquired cardiomyopathy occurring commonly after a recent stressful event, in particular emotional stress, and is relatively common in middle-aged and older women. The pathogenetic mechanism remains unknown. Catecholamine surge related to emotional distress seems to play a major role in the pathogenesis of this cardiomyopathy, rendering TC a type of neurocardiological disorder that manifests as acute but reversible heart failure. Clinicians should consider this syndrome in the differential diagnosis of patients presenting with clinical findings suggestive of acute coronary syndrome, especially in postmenopausal women with a recent history of acute emotional or physical stress.
Literatur
1.
Zurück zum Zitat Sato H, Tateishi H, Uchida T (1990) Takotsubo-like left ventricular dysfunction due to multivessel coronary spasm. Clinical aspect of myocardial injury: from ischemia to heart failure. Kagakuhyoronsha Press, Tokyo Sato H, Tateishi H, Uchida T (1990) Takotsubo-like left ventricular dysfunction due to multivessel coronary spasm. Clinical aspect of myocardial injury: from ischemia to heart failure. Kagakuhyoronsha Press, Tokyo
2.
Zurück zum Zitat Bybee KA, Prasad A, Barsness GW, Lerman A, Jaffe AS, Murphy JG, Wright RS, Rihal CS (2004) Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome. Am J Cardiol 94(3):343–346PubMedCrossRef Bybee KA, Prasad A, Barsness GW, Lerman A, Jaffe AS, Murphy JG, Wright RS, Rihal CS (2004) Clinical characteristics and thrombolysis in myocardial infarction frame counts in women with transient left ventricular apical ballooning syndrome. Am J Cardiol 94(3):343–346PubMedCrossRef
4.
Zurück zum Zitat Tsuchihashi K, Ueshima K, Uchida T, Oh-mura N, Kimura K, Owa M, Yoshiyama M, Miyazaki S, Haze K, Ogawa H, Honda T, Hase M, Kai R-i, Morii I (2001) Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. J Am Coll Cardiol 38(1):11–18PubMedCrossRef Tsuchihashi K, Ueshima K, Uchida T, Oh-mura N, Kimura K, Owa M, Yoshiyama M, Miyazaki S, Haze K, Ogawa H, Honda T, Hase M, Kai R-i, Morii I (2001) Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. J Am Coll Cardiol 38(1):11–18PubMedCrossRef
8.
Zurück zum Zitat Bybee KA, Kara T, Prasad A, Lerman A, Barsness GW, Wright RS, Rihal CS (2004) Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med 141(11):858–865PubMedCrossRef Bybee KA, Kara T, Prasad A, Lerman A, Barsness GW, Wright RS, Rihal CS (2004) Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Intern Med 141(11):858–865PubMedCrossRef
10.
11.
Zurück zum Zitat Kurowski V, Kaiser A, von Hof K, Killermann DP, Mayer Bn, Hartmann F, Schunkert H, Radke PW (2007) Apical and midventricular transient left ventricular dysfunction syndrome (tako-tsubo cardiomyopathy): frequency, mechanisms, and prognosis. Chest 132(3):809–816PubMedCrossRef Kurowski V, Kaiser A, von Hof K, Killermann DP, Mayer Bn, Hartmann F, Schunkert H, Radke PW (2007) Apical and midventricular transient left ventricular dysfunction syndrome (tako-tsubo cardiomyopathy): frequency, mechanisms, and prognosis. Chest 132(3):809–816PubMedCrossRef
12.
Zurück zum Zitat Kurisu S, Sato H, Kawagoe T, Ishihara M, Shimatani Y, Nishioka K, Kono Y, Umemura T, Nakamura S (2002) Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute myocardial infarction. Am Heart J 143(3):448–455PubMedCrossRef Kurisu S, Sato H, Kawagoe T, Ishihara M, Shimatani Y, Nishioka K, Kono Y, Umemura T, Nakamura S (2002) Tako-tsubo-like left ventricular dysfunction with ST-segment elevation: a novel cardiac syndrome mimicking acute myocardial infarction. Am Heart J 143(3):448–455PubMedCrossRef
13.
Zurück zum Zitat Wittstein IS, Thiemann DR, Lima JAC, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC (2005) Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352(6):539–548. doi:10.1056/NEJMoa043046 PubMedCrossRef Wittstein IS, Thiemann DR, Lima JAC, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC (2005) Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 352(6):539–548. doi:10.​1056/​NEJMoa043046 PubMedCrossRef
16.
Zurück zum Zitat Lambert G, Naredi S, Eden E, Rydenhag B, Friberg P (2002) Monoamine metabolism and sympathetic nervous activation following subarachnoid haemorrhage: influence of gender and hydrocephalus. Brain Res Bull 58(1):77–82PubMedCrossRef Lambert G, Naredi S, Eden E, Rydenhag B, Friberg P (2002) Monoamine metabolism and sympathetic nervous activation following subarachnoid haemorrhage: influence of gender and hydrocephalus. Brain Res Bull 58(1):77–82PubMedCrossRef
19.
Zurück zum Zitat Bybee KA, Motiei A, Syed IS, Kara T, Prasad A, Lennon RJ, Murphy JG, Hammill SC, Rihal CS, Wright RS (2007) Electrocardiography cannot reliably differentiate transient left ventricular apical ballooning syndrome from anterior ST-segment elevation myocardial infarction. J Electrocardiol 40(1):38.e1–38.e6CrossRef Bybee KA, Motiei A, Syed IS, Kara T, Prasad A, Lennon RJ, Murphy JG, Hammill SC, Rihal CS, Wright RS (2007) Electrocardiography cannot reliably differentiate transient left ventricular apical ballooning syndrome from anterior ST-segment elevation myocardial infarction. J Electrocardiol 40(1):38.e1–38.e6CrossRef
20.
Zurück zum Zitat Prasad A, Lerman A, Rihal CS (2008) Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J 155(3):408–417PubMedCrossRef Prasad A, Lerman A, Rihal CS (2008) Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J 155(3):408–417PubMedCrossRef
21.
Zurück zum Zitat Eitel I, von Knobelsdorff-Brenkenhoff F, Bernhardt P, Carbone I, Muellerleile K, Aldrovandi A, Francone M, Desch S, Gutberlet M, Strohm O, Schuler G, Schulz-Menger J, Thiele H, Friedrich MG (2011) Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy. JAMA 306(3):277–286. doi:10.1001/jama.2011.992 PubMedCrossRef Eitel I, von Knobelsdorff-Brenkenhoff F, Bernhardt P, Carbone I, Muellerleile K, Aldrovandi A, Francone M, Desch S, Gutberlet M, Strohm O, Schuler G, Schulz-Menger J, Thiele H, Friedrich MG (2011) Clinical characteristics and cardiovascular magnetic resonance findings in stress (takotsubo) cardiomyopathy. JAMA 306(3):277–286. doi:10.​1001/​jama.​2011.​992 PubMedCrossRef
22.
Zurück zum Zitat Eitel I, Behrendt F, Schindler K, Kivelitz D, Gutberlet M, Schuler G, Thiele H (2008) Differential diagnosis of suspected apical ballooning syndrome using contrast-enhanced magnetic resonance imaging. Eur Heart J 29(21):2651–2659. doi:10.1093/eurheartj/ehn433 PubMedCrossRef Eitel I, Behrendt F, Schindler K, Kivelitz D, Gutberlet M, Schuler G, Thiele H (2008) Differential diagnosis of suspected apical ballooning syndrome using contrast-enhanced magnetic resonance imaging. Eur Heart J 29(21):2651–2659. doi:10.​1093/​eurheartj/​ehn433 PubMedCrossRef
23.
Zurück zum Zitat Haghi D, Fluechter S, Suselbeck T, Kaden JJ, Borggrefe M, Papavassiliu T (2007) Cardiovascular magnetic resonance findings in typical versus atypical forms of the acute apical ballooning syndrome (Takotsubo cardiomyopathy). Int J Cardiol 120(2):205–211PubMedCrossRef Haghi D, Fluechter S, Suselbeck T, Kaden JJ, Borggrefe M, Papavassiliu T (2007) Cardiovascular magnetic resonance findings in typical versus atypical forms of the acute apical ballooning syndrome (Takotsubo cardiomyopathy). Int J Cardiol 120(2):205–211PubMedCrossRef
25.
Zurück zum Zitat Aretz HT, Billingham ME, Edwards WD, Factor SM, Fallon JT, Fenoglio JJ Jr, Olsen EG, Schoen FJ (1987) Myocarditis. A histopathologic definition and classification. Am J Cardiovasc Pathol 1(1):3–14PubMed Aretz HT, Billingham ME, Edwards WD, Factor SM, Fallon JT, Fenoglio JJ Jr, Olsen EG, Schoen FJ (1987) Myocarditis. A histopathologic definition and classification. Am J Cardiovasc Pathol 1(1):3–14PubMed
26.
Zurück zum Zitat Akashi YJ, Nakazawa K, Sakakibara M, Miyake F, Musha H, Sasaka K (2004) 123I-MIBG myocardial scintigraphy in patients with ‘’ takotsubo ‘’ cardiomyopathy. J Nucl Med 45(7):1121–1127PubMed Akashi YJ, Nakazawa K, Sakakibara M, Miyake F, Musha H, Sasaka K (2004) 123I-MIBG myocardial scintigraphy in patients with ‘’ takotsubo ‘’ cardiomyopathy. J Nucl Med 45(7):1121–1127PubMed
27.
Zurück zum Zitat Kume T, Kawamoto T, Okura H, Toyota E, Neishi Y, Watanabe N, Hayashida A, Okahashi N, Yoshimura Y, Saito K, Nezuo S, Yamada R, Yoshida K (2008) Local release of catecholamines from the hearts of patients with tako-tsubo-like left ventricular dysfunction. Circ J 72(1):106–108PubMedCrossRef Kume T, Kawamoto T, Okura H, Toyota E, Neishi Y, Watanabe N, Hayashida A, Okahashi N, Yoshimura Y, Saito K, Nezuo S, Yamada R, Yoshida K (2008) Local release of catecholamines from the hearts of patients with tako-tsubo-like left ventricular dysfunction. Circ J 72(1):106–108PubMedCrossRef
28.
Zurück zum Zitat Movahed A, Reeves WC, Mehta PM, Gilliland MG, Mozingo SL, Jolly SR (1994) Norepinephrine-induced left ventricular dysfunction in anesthetized and conscious, sedated dogs. Int J Cardiol 45(1):23–33PubMedCrossRef Movahed A, Reeves WC, Mehta PM, Gilliland MG, Mozingo SL, Jolly SR (1994) Norepinephrine-induced left ventricular dysfunction in anesthetized and conscious, sedated dogs. Int J Cardiol 45(1):23–33PubMedCrossRef
29.
Zurück zum Zitat Frustaci A, Loperfido F, Gentiloni N, Caldarulo M, Morgante E, Russo MA (1991) Catecholamine-induced cardiomyopathy in multiple endocrine neoplasia. A histologic, ultrastructural, and biochemical study. Chest 99(2):382–385PubMedCrossRef Frustaci A, Loperfido F, Gentiloni N, Caldarulo M, Morgante E, Russo MA (1991) Catecholamine-induced cardiomyopathy in multiple endocrine neoplasia. A histologic, ultrastructural, and biochemical study. Chest 99(2):382–385PubMedCrossRef
30.
Zurück zum Zitat Kono T, Morita H, Kuroiwa T, Onaka H, Takatsuka H, Fujiwara A (1994) Left ventricular wall motion abnormalities in patients with subarachnoid hemorrhage: neurogenic stunned myocardium. J Am Coll Cardiol 24(3):636–640. doi:10.1016/0735-1097(94)90008-6 PubMedCrossRef Kono T, Morita H, Kuroiwa T, Onaka H, Takatsuka H, Fujiwara A (1994) Left ventricular wall motion abnormalities in patients with subarachnoid hemorrhage: neurogenic stunned myocardium. J Am Coll Cardiol 24(3):636–640. doi:10.​1016/​0735-1097(94)90008-6 PubMedCrossRef
31.
Zurück zum Zitat Takizawa M, Kobayakawa N, Uozumi H, Yonemura S, Kodama T, Fukusima K, Takeuchi H, Kaneko Y, Kaneko T, Fujita K, Honma Y, Aoyagi T (2007) A case of transient left ventricular ballooning with pheochromocytoma, supporting pathogenetic role of catecholamines in stress-induced cardiomyopathy or takotsubo cardiomyopathy. Int J Cardiol 114(1):E15–E17PubMedCrossRef Takizawa M, Kobayakawa N, Uozumi H, Yonemura S, Kodama T, Fukusima K, Takeuchi H, Kaneko Y, Kaneko T, Fujita K, Honma Y, Aoyagi T (2007) A case of transient left ventricular ballooning with pheochromocytoma, supporting pathogenetic role of catecholamines in stress-induced cardiomyopathy or takotsubo cardiomyopathy. Int J Cardiol 114(1):E15–E17PubMedCrossRef
32.
35.
Zurück zum Zitat Huang MT, Lee CF, Dobson GP (1997) Epinephrine enhances glycogen turnover and depresses glucose uptake in vivo in rat heart. FASEB J 11(12):973–980PubMed Huang MT, Lee CF, Dobson GP (1997) Epinephrine enhances glycogen turnover and depresses glucose uptake in vivo in rat heart. FASEB J 11(12):973–980PubMed
36.
Zurück zum Zitat Kume T, Akasaka T, Kawamoto T, Yoshitani H, Watanabe N, Neishi Y, Wada N, Yoshida K (2005) Assessment of coronary microcirculation in patients with takotsubo-like left ventricular dysfunction. Circ J 69(8):934–939PubMedCrossRef Kume T, Akasaka T, Kawamoto T, Yoshitani H, Watanabe N, Neishi Y, Wada N, Yoshida K (2005) Assessment of coronary microcirculation in patients with takotsubo-like left ventricular dysfunction. Circ J 69(8):934–939PubMedCrossRef
37.
Zurück zum Zitat Elesber A, Lerman A, Bybee KA, Murphy JG, Barsness G, Singh M, Rihal CS, Prasad A (2006) Myocardial perfusion in apical ballooning syndrome correlate of myocardial injury. Am Heart J 152(3):469.e9–469.e13CrossRef Elesber A, Lerman A, Bybee KA, Murphy JG, Barsness G, Singh M, Rihal CS, Prasad A (2006) Myocardial perfusion in apical ballooning syndrome correlate of myocardial injury. Am Heart J 152(3):469.e9–469.e13CrossRef
39.
Zurück zum Zitat Gauthier C, Langin D, Balligand J-L (2000) Beta3-adrenoceptors in the cardiovascular system. Trends Pharmacol Sci 21(11):426–431PubMedCrossRef Gauthier C, Langin D, Balligand J-L (2000) Beta3-adrenoceptors in the cardiovascular system. Trends Pharmacol Sci 21(11):426–431PubMedCrossRef
40.
Zurück zum Zitat Heubach JF, Rau T, Eschenhagen T, Ravens U, Kaumann AJ (2002) Physiological antagonism between ventricular β1-adrenoceptors and α1-adrenoceptors but no evidence for β2- and β3-adrenoceptor function in murine heart. Br J Pharmacol 136(2):217–229. doi:10.1038/sj.bjp.0704700 PubMedCentralPubMedCrossRef Heubach JF, Rau T, Eschenhagen T, Ravens U, Kaumann AJ (2002) Physiological antagonism between ventricular β1-adrenoceptors and α1-adrenoceptors but no evidence for β2- and β3-adrenoceptor function in murine heart. Br J Pharmacol 136(2):217–229. doi:10.​1038/​sj.​bjp.​0704700 PubMedCentralPubMedCrossRef
41.
Zurück zum Zitat Niu X, Watts VL, Cingolani OH, Sivakumaran V, Leyton-Mange JS, Ellis CL, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Paolocci N, Kass DA, Barouch LA (2012) Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase. J Am Coll Cardiol 59(22):1979–1987PubMedCentralPubMedCrossRef Niu X, Watts VL, Cingolani OH, Sivakumaran V, Leyton-Mange JS, Ellis CL, Miller KL, Vandegaer K, Bedja D, Gabrielson KL, Paolocci N, Kass DA, Barouch LA (2012) Cardioprotective effect of beta-3 adrenergic receptor agonism: role of neuronal nitric oxide synthase. J Am Coll Cardiol 59(22):1979–1987PubMedCentralPubMedCrossRef
43.
Zurück zum Zitat Haghi D, Roehm S, Hamm K, Harder N, Suselbeck T, Borggrefe M, Papavassiliu T (2010) Takotsubo Cardiomyopathy is not due to plaque rupture: an intravascular ultrasound study. Clin Cardiol 33(5):307–310. doi:10.1002/clc.20747 PubMedCrossRef Haghi D, Roehm S, Hamm K, Harder N, Suselbeck T, Borggrefe M, Papavassiliu T (2010) Takotsubo Cardiomyopathy is not due to plaque rupture: an intravascular ultrasound study. Clin Cardiol 33(5):307–310. doi:10.​1002/​clc.​20747 PubMedCrossRef
45.
Zurück zum Zitat Ito K, Sugihara H, Kawasaki T, Yuba T, Doue T, Tanabe T, Adachi Y, Katoh S, Azuma A, Nakagawa M (2001) Assessment of ampulla (Takotsubo) cardiomyopathy with coronary angiography, two-dimensional echocardiography and 99mTc-tetrofosmin myocardial single photon emission computed tomography. Ann Nucl Med 15(4):351–355PubMedCrossRef Ito K, Sugihara H, Kawasaki T, Yuba T, Doue T, Tanabe T, Adachi Y, Katoh S, Azuma A, Nakagawa M (2001) Assessment of ampulla (Takotsubo) cardiomyopathy with coronary angiography, two-dimensional echocardiography and 99mTc-tetrofosmin myocardial single photon emission computed tomography. Ann Nucl Med 15(4):351–355PubMedCrossRef
46.
Zurück zum Zitat Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nishioka K, Umemura T, Nakamura S, Yoshida M, Sato H (2003) Myocardial perfusion and fatty acid metabolism in patients with tako-tsubo-like left ventricular dysfunction. J Am Coll Cardiol 41(5):743–748. doi:10.1016/S0735-1097(02)02924-8 PubMedCrossRef Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nishioka K, Umemura T, Nakamura S, Yoshida M, Sato H (2003) Myocardial perfusion and fatty acid metabolism in patients with tako-tsubo-like left ventricular dysfunction. J Am Coll Cardiol 41(5):743–748. doi:10.​1016/​S0735-1097(02)02924-8 PubMedCrossRef
47.
Zurück zum Zitat Galiuto L, De Caterina AR, Porfidia A, Paraggio L, Barchetta S, Locorotondo G, Rebuzzi AG, Crea F (2010) Reversible coronary microvascular dysfunction: a common pathogenetic mechanism in Apical Ballooning or Tako-Tsubo Syndrome. Eur Heart J 31(11):1319–1327. doi:10.1093/eurheartj/ehq039 PubMedCrossRef Galiuto L, De Caterina AR, Porfidia A, Paraggio L, Barchetta S, Locorotondo G, Rebuzzi AG, Crea F (2010) Reversible coronary microvascular dysfunction: a common pathogenetic mechanism in Apical Ballooning or Tako-Tsubo Syndrome. Eur Heart J 31(11):1319–1327. doi:10.​1093/​eurheartj/​ehq039 PubMedCrossRef
48.
Zurück zum Zitat Meimoun P, Malaquin D, Sayah S, Benali T, Luycx-Bore A, Levy F, Zemir H, Tribouilloy C (2008) The coronary flow reserve is transiently impaired in tako-tsubo cardiomyopathy: a prospective study using serial Doppler transthoracic echocardiography. J Am Soc Echocardiogr 21(1):72–77PubMedCrossRef Meimoun P, Malaquin D, Sayah S, Benali T, Luycx-Bore A, Levy F, Zemir H, Tribouilloy C (2008) The coronary flow reserve is transiently impaired in tako-tsubo cardiomyopathy: a prospective study using serial Doppler transthoracic echocardiography. J Am Soc Echocardiogr 21(1):72–77PubMedCrossRef
49.
Zurück zum Zitat Meimoun P, Malaquin D, Benali T, Tribouilloy C (2008) Assessment of coronary flow reserve by transthoracic Doppler echocardiography in left apical ballooning syndrome. Eur J Echocardiogr 9(1):78–79. doi:10.1016/j.euje.2007.01.002 PubMed Meimoun P, Malaquin D, Benali T, Tribouilloy C (2008) Assessment of coronary flow reserve by transthoracic Doppler echocardiography in left apical ballooning syndrome. Eur J Echocardiogr 9(1):78–79. doi:10.​1016/​j.​euje.​2007.​01.​002 PubMed
50.
Zurück zum Zitat Lacy CR, Contracta RJ, Robbins ML, Tannenbaum AK, Moreyra AE, Chelton S, Kostis JB (1995) Coronary vasoconstriction induced by mental stress (simulated public speaking). Am J Cardiol 75(7):503–505PubMedCrossRef Lacy CR, Contracta RJ, Robbins ML, Tannenbaum AK, Moreyra AE, Chelton S, Kostis JB (1995) Coronary vasoconstriction induced by mental stress (simulated public speaking). Am J Cardiol 75(7):503–505PubMedCrossRef
53.
Zurück zum Zitat Chilian WM (1990) Adrenergic vasomotion in the coronary microcirculation. Basic Res Cardiol 85(Suppl 1):111–120PubMed Chilian WM (1990) Adrenergic vasomotion in the coronary microcirculation. Basic Res Cardiol 85(Suppl 1):111–120PubMed
56.
Zurück zum Zitat Mori H, Ishikawa S, Kojima S, Hayashi J, Watanabe Y, Hoffman JIE, Okino H (1993) Increased responsiveness of left ventricular apical myocardium to adrenergic stimuli. Cardiovasc Res 27(2):192–198. doi:10.1093/cvr/27.2.192 PubMedCrossRef Mori H, Ishikawa S, Kojima S, Hayashi J, Watanabe Y, Hoffman JIE, Okino H (1993) Increased responsiveness of left ventricular apical myocardium to adrenergic stimuli. Cardiovasc Res 27(2):192–198. doi:10.​1093/​cvr/​27.​2.​192 PubMedCrossRef
57.
Zurück zum Zitat Pierpont GL, DeMaster EG, Cohn JN (1984) Regional differences in adrenergic function within the left ventricle. Am J Physiol Heart Circ Physiol 246(6):H824–H829 Pierpont GL, DeMaster EG, Cohn JN (1984) Regional differences in adrenergic function within the left ventricle. Am J Physiol Heart Circ Physiol 246(6):H824–H829
59.
Zurück zum Zitat Hernandez-Pampaloni M, Keng FYJ, Kudo T, Sayre JS, Schelbert HR (2001) Abnormal longitudinal, base-to-apex myocardial perfusion gradient by quantitative blood flow measurements in patients with coronary risk factors. Circulation 104(5):527–532. doi:10.1161/hc3001.093503 PubMedCrossRef Hernandez-Pampaloni M, Keng FYJ, Kudo T, Sayre JS, Schelbert HR (2001) Abnormal longitudinal, base-to-apex myocardial perfusion gradient by quantitative blood flow measurements in patients with coronary risk factors. Circulation 104(5):527–532. doi:10.​1161/​hc3001.​093503 PubMedCrossRef
60.
Zurück zum Zitat Broadley AJ, Korszun A, Abdelaal E, Moskvina V, Jones CJ, Nash GB, Ray C, Deanfield J, Frenneaux MP (2005) Inhibition of cortisol production with metyrapone prevents mental stress-induced endothelial dysfunction and baroreflex impairment. J Am Coll Cardiol 46(2):344–350. doi:10.1016/j.jacc.2005.03.068 PubMedCrossRef Broadley AJ, Korszun A, Abdelaal E, Moskvina V, Jones CJ, Nash GB, Ray C, Deanfield J, Frenneaux MP (2005) Inhibition of cortisol production with metyrapone prevents mental stress-induced endothelial dysfunction and baroreflex impairment. J Am Coll Cardiol 46(2):344–350. doi:10.​1016/​j.​jacc.​2005.​03.​068 PubMedCrossRef
Metadaten
Titel
Takotsubo cardiomyopathy
verfasst von
Tatsuji Kono
Hani N. Sabbah
Publikationsdatum
01.09.2014
Verlag
Springer US
Erschienen in
Heart Failure Reviews / Ausgabe 5/2014
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI
https://doi.org/10.1007/s10741-013-9404-9

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