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European Journal of Nutrition

Erschienen in:

03.11.2019 | Review

The association between glycemic index, glycemic load, and metabolic syndrome: a systematic review and dose–response meta-analysis of observational studies

verfasst von: Jia-Yu Zhang, Yu-Ting Jiang, Ya-Shu Liu, Qing Chang, Yu-Hong Zhao, Qi-Jun Wu

Erschienen in: European Journal of Nutrition | Ausgabe 2/2020

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Abstract

Purpose

The association of glycemic index (GI) and glycemic load (GL) with metabolic syndrome (MetS) is controversial. Therefore, we conducted this first systematic review and dose–response meta-analysis of observational studies to quantify these associations.

Methods

We searched PubMed, EMBASE, Web of Science, and the Cochrane Library for relevant studies up to 1 April 2019. Summary odds ratios (OR) and 95% confidence intervals (CI) were calculated by a random-effects model. This study was registered with PROSPERO (CRD42019131788).

Results

We included eight high-quality (n = 5) or medium-quality (n = 3) cross-sectional studies in the final meta-analysis, comprising 6058 MetS events and 28,998 participants. The summary ORs of MetS for the highest versus lowest categories were 1.23 (95% CI 1.10–1.38, I² = 0, tau² = 0, n = 5) for dietary GI, 1.06 (95% CI 0.89–1.25, I² = 36.2%, tau² = 0.0151, n = 6) for dietary GL. The summary OR was 1.12 (95% CI 1.00–1.26, I² = 0, tau² = 0, n = 3) per 5 GI units, 0.96 (95% CI 0.83–1.10, I² = 33.4%, tau² = 0.0059, n = 2) per 20 GL units.

Conclusions

Dietary GI was positively associated with the prevalence of MetS. However, no significant association was found between dietary GL and the prevalence of MetS. Further studies with prospective design are needed to establish potential causal relationship between dietary GI and the MetS.

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Titel: The association between glycemic index, glycemic load, and metabolic syndrome: a systematic review and dose–response meta-analysis of observational studies
verfasst von: Jia-Yu Zhang
Yu-Ting Jiang
Ya-Shu Liu
Qing Chang
Yu-Hong Zhao
Qi-Jun Wu
Publikationsdatum: 03.11.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 2/2020
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-019-02124-z

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