Skip to main content
Erschienen in: Archives of Dermatological Research 2/2012

01.03.2012 | Original Paper

The association of PASI scores with CRH-R1 expression in patients with psoriasis

verfasst von: Bengü Çevirgen Cemil, Filiz Canpolat, Demet Yılmazer, Fatma Eskioğlu, Murat Alper

Erschienen in: Archives of Dermatological Research | Ausgabe 2/2012

Einloggen, um Zugang zu erhalten

Abstract

Stress is a well-known triggering factor along with genetic predisposition on the onset and during the course of psoriasis by altering the cellular constituents of the immune system. In the skin, there is a local hypothalamic–pituitary–adrenal (HPA) axis which is the equivalent of the central HPA axis. Corticotropin-releasing hormone (CRH) is a major regulator of the HPA axis in response to stress. This study was planned to show the role of CRH receptor type 1 (CRH-R1) in pathogenesis of psoriasis, the relation with the severity of psoriasis, and interpersonal variance in skin biopsy specimens of the psoriasis patient. Study involved 46 patients with psoriasis and 20 healthy control subjects who were older than 18 years. The clinical sign and PASI scores of psoriasis patients were recorded. Immunohistochemically, expression of CRH-R1 was investigated in psoriatic lesions and control group skin. A statistically significant increase of the expression of CRH-R1 was found in the skin biopsies of psoriasis patients compared with the control group patients. In patients with psoriasis, there was a positive correlation between the expressions of CRH-R1 and PASI scores (p = 0.001, r = +0.572). In addition, a statistically significant increase of PASI scores was found in the intense-stained CRH-R1 group compared with the weakly stained CRH-R1 patient group. The present study has demonstrated that CRH-R1 could have a role in pathogenesis of the psoriasis and stress may increase the intensity of psoriasis.
Literatur
1.
Zurück zum Zitat Arck PC, Slominski A, Theoharides TC, Peters EMJ, Paus R (2006) Neuroimmunology of stress: skin takes center stage. J Invest Dermatol 126:1697–1704PubMedCrossRef Arck PC, Slominski A, Theoharides TC, Peters EMJ, Paus R (2006) Neuroimmunology of stress: skin takes center stage. J Invest Dermatol 126:1697–1704PubMedCrossRef
2.
Zurück zum Zitat Arbiser JL, Karalis K, Viswanathan A et al (1999) Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin. J Invest Dermatol 113:838–842PubMedCrossRef Arbiser JL, Karalis K, Viswanathan A et al (1999) Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin. J Invest Dermatol 113:838–842PubMedCrossRef
3.
Zurück zum Zitat Bale TL, Giordano FJ, Hickey RP, Huang Y, Nath AK, Peterson KL, Vale WW, Lee KF (2002) Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization. Proc Natl Acad Sci USA 99:7734–7739PubMedCrossRef Bale TL, Giordano FJ, Hickey RP, Huang Y, Nath AK, Peterson KL, Vale WW, Lee KF (2002) Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization. Proc Natl Acad Sci USA 99:7734–7739PubMedCrossRef
4.
Zurück zum Zitat Buske-Kirschbaum A, Kern S, Ebrecht M, Hellhammer DH (2007) Altered distribution of leukocyte subsets and cytokine production in response to acute psychosocial stress in patients with psoriasis vulgaris. Brain Behav Immun 21:92–99PubMedCrossRef Buske-Kirschbaum A, Kern S, Ebrecht M, Hellhammer DH (2007) Altered distribution of leukocyte subsets and cytokine production in response to acute psychosocial stress in patients with psoriasis vulgaris. Brain Behav Immun 21:92–99PubMedCrossRef
5.
Zurück zum Zitat Cao J, Papadopoulou N, Kempuraj D et al (2005) Human mast cells express corticotrophin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J Immunol 174:7665–7675PubMed Cao J, Papadopoulou N, Kempuraj D et al (2005) Human mast cells express corticotrophin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J Immunol 174:7665–7675PubMed
6.
Zurück zum Zitat Chen R, Lewis KA, Perrin MH, Vale WW (1993) Expression cloning of a human corticotropin-releasing factor 2 receptor. Proc Natl Acad Sci USA 90:8967–8971PubMedCrossRef Chen R, Lewis KA, Perrin MH, Vale WW (1993) Expression cloning of a human corticotropin-releasing factor 2 receptor. Proc Natl Acad Sci USA 90:8967–8971PubMedCrossRef
7.
Zurück zum Zitat Chrousos GP, Gold PW (1992) The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 267:1244–1252PubMedCrossRef Chrousos GP, Gold PW (1992) The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 267:1244–1252PubMedCrossRef
8.
Zurück zum Zitat Devrimci-Özgüven H, Kundakçı N, Kumbasar H, Boyvat A (2000) The depression, anxiety, life satisfaction and affective expression levels in psoriasis patients. J Eur Acad Dermatol Venereol 14:267–271PubMedCrossRef Devrimci-Özgüven H, Kundakçı N, Kumbasar H, Boyvat A (2000) The depression, anxiety, life satisfaction and affective expression levels in psoriasis patients. J Eur Acad Dermatol Venereol 14:267–271PubMedCrossRef
9.
Zurück zum Zitat Fredriksson T, Pettersson U (1978) Severe psoriasis—oral therapy with a new retinoid. Dermatologica 157:238–244PubMedCrossRef Fredriksson T, Pettersson U (1978) Severe psoriasis—oral therapy with a new retinoid. Dermatologica 157:238–244PubMedCrossRef
10.
Zurück zum Zitat Kim JE, Park HJ (2011) Stress hormone and skin disease. In: Khopkar U (ed) Skin biopsy—perspectives. InTech, pp 209–224 Kim JE, Park HJ (2011) Stress hormone and skin disease. In: Khopkar U (ed) Skin biopsy—perspectives. InTech, pp 209–224
11.
Zurück zum Zitat Kim JE, Cho DH, Kim HS et al (2007) Expression of the corticotropin-releasing hormone-proopiomelanocortin axis in the various clinical types of psoriasis. Exp Dermatol 16:104–109PubMedCrossRef Kim JE, Cho DH, Kim HS et al (2007) Expression of the corticotropin-releasing hormone-proopiomelanocortin axis in the various clinical types of psoriasis. Exp Dermatol 16:104–109PubMedCrossRef
12.
Zurück zum Zitat Kishimoto T, Pearse RV 2nd, Lin CR, Rosenfeld MG (1995) A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc Natl Acad Sci USA 92:1108–1112PubMedCrossRef Kishimoto T, Pearse RV 2nd, Lin CR, Rosenfeld MG (1995) A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc Natl Acad Sci USA 92:1108–1112PubMedCrossRef
13.
Zurück zum Zitat Kono M, Nagata H, Umemura S, Kawana S, Yoshiki Osamura R (2001) In situ expression of corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin. FASEB J 15:2297–2299PubMed Kono M, Nagata H, Umemura S, Kawana S, Yoshiki Osamura R (2001) In situ expression of corticotropin-releasing hormone (CRH) and proopiomelanocortin (POMC) genes in human skin. FASEB J 15:2297–2299PubMed
14.
Zurück zum Zitat Liaw CW, Lovenberg TW, Barry G, Oltersdorf T, Grigoriadis DE, de Souza EB (1996) Cloning and characterization of the human corticotropin releasing factor-2 receptor complementary deoxyribonucleic acid. Endocrinology 137:72–77PubMedCrossRef Liaw CW, Lovenberg TW, Barry G, Oltersdorf T, Grigoriadis DE, de Souza EB (1996) Cloning and characterization of the human corticotropin releasing factor-2 receptor complementary deoxyribonucleic acid. Endocrinology 137:72–77PubMedCrossRef
15.
Zurück zum Zitat O’Kane M, Murphy EP, Kirby B (2006) The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease. Exp Dermatol 15:143–153PubMedCrossRef O’Kane M, Murphy EP, Kirby B (2006) The role of corticotropin-releasing hormone in immune-mediated cutaneous inflammatory disease. Exp Dermatol 15:143–153PubMedCrossRef
16.
Zurück zum Zitat Perrin MH, Vale WW (1999) Corticotropin releasing factor receptors and their ligand family. Ann NY Acad Sci 885:312–328PubMedCrossRef Perrin MH, Vale WW (1999) Corticotropin releasing factor receptors and their ligand family. Ann NY Acad Sci 885:312–328PubMedCrossRef
17.
Zurück zum Zitat Picardi A, Mazzotti E, Gaetano P et al (2005) Stress, social support, emotional regulation, and exacerbation of diffuse plaque psoriasis. Psychomatics 46:556–564CrossRef Picardi A, Mazzotti E, Gaetano P et al (2005) Stress, social support, emotional regulation, and exacerbation of diffuse plaque psoriasis. Psychomatics 46:556–564CrossRef
18.
Zurück zum Zitat Quevedo ME, Slominski A, Pinto W, Wei E, Wortsman J (2001) Pleiotropic effects of corticotropin releasing hormone on normal human skin keratinocytes. In Vitro Cell Dev Biol Anim 37:50–54PubMedCrossRef Quevedo ME, Slominski A, Pinto W, Wei E, Wortsman J (2001) Pleiotropic effects of corticotropin releasing hormone on normal human skin keratinocytes. In Vitro Cell Dev Biol Anim 37:50–54PubMedCrossRef
19.
Zurück zum Zitat Singh LK, Boucher W, Pang X et al (1999) Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors. J Pharmacol Exp Ther 288:1349–1356PubMed Singh LK, Boucher W, Pang X et al (1999) Potent mast cell degranulation and vascular permeability triggered by urocortin through activation of corticotropin-releasing hormone receptors. J Pharmacol Exp Ther 288:1349–1356PubMed
20.
Zurück zum Zitat Slominski A, Pisarchik A, Tobin DJ, Mazurkiewicz JE, Wortsman J (2004) Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology 145:941–950PubMedCrossRef Slominski A, Pisarchik A, Tobin DJ, Mazurkiewicz JE, Wortsman J (2004) Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology 145:941–950PubMedCrossRef
21.
Zurück zum Zitat Slominski A, Wortsman J, Luger T et al (2000) Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 80:979–1020PubMed Slominski A, Wortsman J, Luger T et al (2000) Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 80:979–1020PubMed
22.
Zurück zum Zitat Slominski AT, Botchkarev V, Choudhry M et al (1999) Cutaneous expression of CRH and CRH-R: is there a ‘skin stress response system?’. Ann NY Acad Sci 885:287–311PubMedCrossRef Slominski AT, Botchkarev V, Choudhry M et al (1999) Cutaneous expression of CRH and CRH-R: is there a ‘skin stress response system?’. Ann NY Acad Sci 885:287–311PubMedCrossRef
23.
Zurück zum Zitat Slominski AT, Roloff B, Zbytek B et al (2000) Corticotropin releasing hormone and related peptides can act as bioregulatory factors in human keratinocytes. In Vitro Cell Dev Biol Anim 36:211–216PubMedCrossRef Slominski AT, Roloff B, Zbytek B et al (2000) Corticotropin releasing hormone and related peptides can act as bioregulatory factors in human keratinocytes. In Vitro Cell Dev Biol Anim 36:211–216PubMedCrossRef
24.
Zurück zum Zitat Suda T, Tomori N, Tozawa F, Mouri T, Demura H, Shizume K (1984) Distribution and characterization of immunoreactive corticotropin-releasing factor in human tissues. J Clin Endocrinol Metab 59:861–866PubMedCrossRef Suda T, Tomori N, Tozawa F, Mouri T, Demura H, Shizume K (1984) Distribution and characterization of immunoreactive corticotropin-releasing factor in human tissues. J Clin Endocrinol Metab 59:861–866PubMedCrossRef
25.
Zurück zum Zitat Tagen M, Stiles L, Kalogeromitros D et al (2007) Skin corticotropin-releasing hormone receptor expression in psoriasis. J Invest Dermatol 127:1789–1791PubMed Tagen M, Stiles L, Kalogeromitros D et al (2007) Skin corticotropin-releasing hormone receptor expression in psoriasis. J Invest Dermatol 127:1789–1791PubMed
26.
Zurück zum Zitat Theoharides TC, Singh LK, Boucher W et al (1998) Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Endocrinology 139:403–413PubMedCrossRef Theoharides TC, Singh LK, Boucher W et al (1998) Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Endocrinology 139:403–413PubMedCrossRef
27.
Zurück zum Zitat Zbytek B, Mysliwski A, Slominski A et al (2002) Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes. Life Sci 70:1013–1021PubMedCrossRef Zbytek B, Mysliwski A, Slominski A et al (2002) Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes. Life Sci 70:1013–1021PubMedCrossRef
28.
Zurück zum Zitat Zbytek B, Pikula M, Slominski RM et al (2005) Corticotropin-releasing hormone triggers differentiation in HaCaT keratinocytes. Br J Dermatol 152:474–480PubMedCrossRef Zbytek B, Pikula M, Slominski RM et al (2005) Corticotropin-releasing hormone triggers differentiation in HaCaT keratinocytes. Br J Dermatol 152:474–480PubMedCrossRef
29.
Zurück zum Zitat Zhou C, Yu X, Cai D, Liu C, Li C (2009) Role of corticotropin-releasing hormone and receptor in the pathogenesis of psoriasis. Med Hypotheses 73:513–515PubMedCrossRef Zhou C, Yu X, Cai D, Liu C, Li C (2009) Role of corticotropin-releasing hormone and receptor in the pathogenesis of psoriasis. Med Hypotheses 73:513–515PubMedCrossRef
Metadaten
Titel
The association of PASI scores with CRH-R1 expression in patients with psoriasis
verfasst von
Bengü Çevirgen Cemil
Filiz Canpolat
Demet Yılmazer
Fatma Eskioğlu
Murat Alper
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
Archives of Dermatological Research / Ausgabe 2/2012
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-012-1218-4

Weitere Artikel der Ausgabe 2/2012

Archives of Dermatological Research 2/2012 Zur Ausgabe

Leitlinien kompakt für die Dermatologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Dermatologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.