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22.11.2019 | Review and Perspectives

The broad and challenging landscape of extranodal lymphoproliferations

verfasst von: Snjezana Dotlic, Maurilio Ponzoni, Rebecca L. King, Ilske Oschlies, Judith Ferry, Maria Calaminici, Santiago Montes-Moreno, John R. Goodlad, German Ott, Alexandra Traverse-Glehen

Erschienen in: Virchows Archiv | Ausgabe 5/2020

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Abstract

Two sessions in the workshop of the 19th meeting of the European Association for Haematopathology termed “challenging extranodal lymphoproliferations” and “extranodal non-site-specific lymphoproliferations”, dealt with a series of heterogenous cases. These included lymphoproliferations of all cell lineages, from reactive lesions mimicking lymphomas through indolent lymphoid neoplasia and tumours with unclear biological behaviour to aggressive and transformed lymphomas. The themes addressed included cases with borderline features between hyperplastic and neoplastic lesions, the diagnostic spectrum of IgG4-related disease, T cell lymphoproliferations arising in extranodal sites with presumed indolent behaviour, diverse clinical presentations of intravascular large B cell lymphoma, diagnostic problems encountered with tumours displaying plasmablastic morphology, pitfalls concerning rare entities like adult T cell lymphoma/leukaemia (ATLL) and extranodal natural killer/T cell (NK/T) lymphomas, and unusual clinical presentations of various lymphomas. Altogether, within the frame of these two sessions, 75 cases remarkably differing in their clinical background, genetic features and overall need for a meticulous diagnostic approach were presented and discussed. In this paper, the salient points raised during the discussion of the cases, current diagnostic concepts and recommendations relevant to the diagnosis of these lymphoproliferations are described.

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Titel: The broad and challenging landscape of extranodal lymphoproliferations
verfasst von: Snjezana Dotlic
Maurilio Ponzoni
Rebecca L. King
Ilske Oschlies
Judith Ferry
Maria Calaminici
Santiago Montes-Moreno
John R. Goodlad
German Ott
Alexandra Traverse-Glehen
Publikationsdatum: 22.11.2019
Verlag: Springer Berlin Heidelberg
Erschienen in: Virchows Archiv / Ausgabe 5/2020
Print ISSN: 0945-6317
Elektronische ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-019-02702-w

Springer Medizin

The broad and challenging landscape of extranodal lymphoproliferations

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

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