Erschienen in:
01.06.2007 | Poster presentation
The critical role of heme oxygenase in neutrophil migration impairment in polymicrobial sepsis
verfasst von:
A Freitas, JC Alves-Filho, D Dal-Secco, F Spiller, FQ Cunha
Erschienen in:
Critical Care
|
Sonderheft 3/2007
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Excerpt
During severe sepsis a marked impairment of neutrophil migration into the infectious focus occurs, which is associated with dissemination of infection resulting in high mortality. We recently showed that heme oxygenase (HO) products, carbon monoxide and biliverdin, downregulate neutrophil recruitment by reducing the neutrophil/endothelium rolling and adhesion in a noninfectious inflammatory model. This study aimed to investigate a possible role of the HO-1 pathway on the failure of neutrophil recruitment in mice subjected to severe (S-CLP) polymicrobial sepsis induced by cecal ligation and puncture (CLP). …