Erschienen in:
08.02.2018 | Editorials
The curious tale of perioperative precision medicine: a story of hydroxocobalamin and cardiac surgery-associated vasoplegia
verfasst von:
Miklos D. Kertai, MD, PhD, Andrew D. Shaw, MB, FRCA, FFICM, FCCM
Erschienen in:
Canadian Journal of Anesthesia/Journal canadien d'anesthésie
|
Ausgabe 5/2018
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Excerpt
Currently, most prevention strategies and therapies are designed for the average patient, and patients are generally not matched with the prevention or treatment strategies that will work best for them. The problem with this approach is that patients are not clones of each other and do not respond in the same way to any given treatment. Clinical trials generally report average treatment effects and are not sensitive to heterogeneity whereby a treatment may be beneficial in one subgroup but ineffective, or even harmful, in another. …