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European Journal of Nutrition

Erschienen in:

11.06.2020 | Review

The effect of soy isoflavones on arterial stiffness: a systematic review and meta-analysis of randomized controlled trials

verfasst von: Brian Man, Chendi Cui, Xiao Zhang, Daisuke Sugiyama, Emma Barinas-Mitchell, Akira Sekikawa

Erschienen in: European Journal of Nutrition | Ausgabe 2/2021

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Abstract

Purpose

Some but not all randomized controlled trials (RCTs) of soy isoflavones showed their beneficial effect on arterial stiffness, a predictor of cardiovascular events, dementia, and all-cause mortality, independent of traditional risk factors. To test the hypothesis that supplementation of soy isoflavones reduces arterial stiffness, we performed a systematic review and meta-analysis of RCTs of soy isoflavones on arterial stiffness.

Methods

The protocol of this systematic review was registered with PROSPERO (CRD42019126128) and written in accordance with PRISMA. The PubMed, Embase, and clinicaltrials.gov databases were searched using the following criteria: human subjects, soy isoflavones as intervention, and arterial stiffness as primary outcome. A random-effects meta-analysis was used to pool estimates across studies. Standardized mean difference (SMD) was used to synthesize quantitative results.

Results

Among 998 articles retrieved, 8 articles met our criteria. Duration of intervention was relatively short (maximum of 12 weeks). Outcome measurements extracted were pulse wave velocity (PWV), systemic arterial compliance (SAC), augmentation index (AI), and cardio-ankle vascular index (CAVI). Soy isoflavones reduced arterial stiffness compared to placebo (standardized mean difference − 0.33, 95% confidence interval − 0.47, − 0.19). Subgroup analyses showed no difference between treatment effects for intervention duration (< 6 weeks vs. ≥ 6 weeks) or gender (women only vs. men only vs. combined). Sensitivity analysis showed no difference in the effect of soy isoflavones between PWV, CAVI, SAC, and AI.

Conclusion

Supplementation of soy isoflavones reduced arterial stiffness. Longer duration trials with larger number of participants are warranted.

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Titel: The effect of soy isoflavones on arterial stiffness: a systematic review and meta-analysis of randomized controlled trials
verfasst von: Brian Man
Chendi Cui
Xiao Zhang
Daisuke Sugiyama
Emma Barinas-Mitchell
Akira Sekikawa
Publikationsdatum: 11.06.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 2/2021
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-020-02300-6

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