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European Archives of Psychiatry and Clinical Neuroscience

Erschienen in:

01.12.2009 | Original Paper

The effect of the COMT val¹⁵⁸met polymorphism on neural correlates of semantic verbal fluency

verfasst von: Axel Krug, Valentin Markov, Abigail Sheldrick, Sören Krach, Andreas Jansen, Klaus Zerres, Thomas Eggermann, Tony Stöcker, N. Jon Shah, Tilo Kircher

Erschienen in: European Archives of Psychiatry and Clinical Neuroscience | Ausgabe 8/2009

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Abstract

Variation in the val¹⁵⁸met polymorphism of the COMT gene has been found to be associated with cognitive performance. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal areas. Given the complex modulation and functional heterogeneity of frontal lobe systems, further specification of COMT gene-related phenotypes differing in prefrontally mediated cognitive performance are of major interest. Eighty healthy individuals (54 men, 26 women; mean age 23.3 years) performed an overt semantic verbal fluency task while brain activation was measured with functional magnetic resonance imaging (fMRI). COMT val¹⁵⁸met genotype was determined and correlated with brain activation measured with fMRI during the task. Although there were no differences in performance, brain activation in the left inferior frontal gyrus [Brodmann area 10] was positively correlated with the number of val alleles in the COMT gene. COMT val¹⁵⁸met status modulates brain activation during the language production on a semantic level in an area related to executive functions.

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Titel: The effect of the COMT val158met polymorphism on neural correlates of semantic verbal fluency
verfasst von: Axel Krug
Valentin Markov
Abigail Sheldrick
Sören Krach
Andreas Jansen
Klaus Zerres
Thomas Eggermann
Tony Stöcker
N. Jon Shah
Tilo Kircher
Publikationsdatum: 01.12.2009
Verlag: D. Steinkopff-Verlag
Erschienen in: European Archives of Psychiatry and Clinical Neuroscience / Ausgabe 8/2009
Print ISSN: 0940-1334
Elektronische ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-009-0010-8

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