nach oben

Neurological Sciences

Erschienen in:

25.10.2023 | Review Article

The effects of rTMS on motor recovery after stroke: a systematic review of fMRI studies

verfasst von: Zhiqing Tang, Tianhao Liu, Kaiyue Han, Ying Liu, Wenlong Su, Rongrong Wang, Hao Zhang

Erschienen in: Neurological Sciences | Ausgabe 3/2024

Einloggen, um Zugang zu erhalten

Abstract

Repetitive transcranial magnetic stimulation (rTMS) has been widely used in motor rehabilitation after stroke, and functional magnetic resonance imaging (fMRI) has been used to investigate the neural mechanisms of motor recovery during stroke therapy. However, there is no review on the mechanism of rTMS intervention for motor recovery after stroke based on fMRI explicitly. We aim to reveal and summarize the neural mechanism of the effects of rTMS on motor function after stroke as measured by fMRI. We carefully performed a literature search using PubMed, EMBASE, Web of Science, and Cochrane Library databases from their respective inceptions to November 2022 to identify any relevant randomized controlled trials. Researchers independently screened the literature, extracted data, and qualitatively described the included studies. Eleven studies with a total of 420 poststroke patients were finally included in this systematic review. A total of 338 of those participants received fMRI examinations before and after rTMS intervention. Five studies reported the effects of rTMS on activation of brain regions, and four studies reported results related to brain functional connectivity (FC). Additionally, five studies analyzed the correlation between fMRI and motor evaluation. The neural mechanism of rTMS in improving motor function after stroke may be the activation and FCs of motor-related brain areas, including enhancement of the activation of motor-related brain areas in the affected hemisphere, inhibition of the activation of motor-related brain areas in the unaffected hemisphere, and changing the FCs of intra-hemispheric and inter-hemispheric motor networks.

Nur mit Berechtigung zugänglich

Kuriakose D, Xiao Z (2020) Pathophysiology and treatment of stroke: present status and future perspectives. Int J Mol Sci 21(20). https://doi.org/10.3390/ijms21207609

Peisker T, Koznar B, Stetkarova I, Widimsky P (2017) Acute stroke therapy: a review. Trends Cardiovasc Med 27(1):59–66. https://doi.org/10.1016/j.tcm.2016.06.009CrossRefPubMed

Gou X, Xu D, Li F, Hou K, Fang W, Li Y (2021) Pyroptosis in stroke-new insights into disease mechanisms and therapeutic strategies. J Physiol Biochem 77(4):511–529. https://doi.org/10.1007/s13105-021-00817-wCrossRefPubMed

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 (2019) Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 18(5):439–458. https://doi.org/10.1016/S1474-4422(19)30034-1CrossRef

Langhorne P, Coupar F, Pollock A (2009) Motor recovery after stroke: a systematic review. Lancet Neurol 8(8):741–754. https://doi.org/10.1016/S1474-4422(09)70150-4CrossRefPubMed

Stinear CM (2017) Prediction of motor recovery after stroke: advances in biomarkers. Lancet Neurol 16(10):826–836. https://doi.org/10.1016/S1474-4422(17)30283-1CrossRefPubMed

Somaa FA, de Graaf TA, Sack AT (2022) Transcranial magnetic stimulation in the treatment of neurological diseases. Front Neurol 13:793253. https://doi.org/10.3389/fneur.2022.793253CrossRefPubMedPubMedCentral

Fisicaro F, Lanza G, Grasso AA, Pennisi G, Bella R, Paulus W, Pennisi M (2019) Repetitive transcranial magnetic stimulation in stroke rehabilitation: review of the current evidence and pitfalls. Ther Adv Neurol Disord 12:1278099885. https://doi.org/10.1177/1756286419878317CrossRef

Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, Filipović SR, Grefkes C, Hasan A, Hummel FC, Jääskeläinen SK, Langguth B, Leocani L, Londero A, Nardone R, Nguyen JP, Nyffeler T, Oliveira-Maia AJ, Oliviero A, Padberg F, Palm U, Paulus W, Poulet E, Quartarone A, Rachid F, Rektorová I, Rossi S, Sahlsten H, Schecklmann M, Szekely D, Ziemann U (2020) Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014–2018). Clin Neurophysiol 131(2):474–528. https://doi.org/10.1016/j.clinph.2019.11.002CrossRefPubMed

10.

Schambra HM (2018) Repetitive transcranial magnetic stimulation for upper extremity motor recovery: does it help? Curr Neurol Neurosci Rep 18(12):97. https://doi.org/10.1007/s11910-018-0913-8CrossRefPubMedPubMedCentral

11.

Kobayashi M, Pascual-Leone A (2003) Transcranial magnetic stimulation in neurology. Lancet Neurol 2(3):145–156. https://doi.org/10.1016/s1474-4422(03)00321-1CrossRefPubMed

12.

Gilio F, Conte A, Vanacore N, Frasca V, Inghilleri M, Berardelli A (2007) Excitatory and inhibitory after-effects after repetitive magnetic transcranial stimulation (rTMS) in normal subjects. Exp Brain Res 176(4):588–593. https://doi.org/10.1007/s00221-006-0638-9CrossRefPubMed

13.

Tang Z, Han K, Wang R, Zhang Y, Zhang H (2022) Excitatory repetitive transcranial magnetic stimulation over the ipsilesional hemisphere for upper limb motor function after stroke: a systematic review and meta-analysis. Front Neurol 13:918597. https://doi.org/10.3389/fneur.2022.918597CrossRefPubMedPubMedCentral

14.

Bai Z, Zhang J, Fong K (2022) Effects of transcranial magnetic stimulation in modulating cortical excitability in patients with stroke: a systematic review and meta-analysis. J Neuroeng Rehabil 19(1):24. https://doi.org/10.1186/s12984-022-00999-4CrossRefPubMedPubMedCentral

15.

Gutiérrez-Muto AM, Castilla J, Freire M, Oliviero A, Tornero J (2020) Theta burst stimulation: technical aspects about TMS devices. Brain Stimul 13(3):562–564. https://doi.org/10.1016/j.brs.2020.01.002CrossRefPubMed

16.

Suppa A, Huang YZ, Funke K, Ridding MC, Cheeran B, Di Lazzaro V, Ziemann U, Rothwell JC (2016) Ten years of theta burst stimulation in humans: established knowledge, unknowns and prospects. Brain Stimul 9(3):323–335. https://doi.org/10.1016/j.brs.2016.01.006CrossRefPubMed

17.

Huang YZ, Edwards MJ, Rounis E, Bhatia KP, Rothwell JC (2005) Theta burst stimulation of the human motor cortex. Neuron 45(2):201–206. https://doi.org/10.1016/j.neuron.2004.12.033CrossRefPubMed

18.

Di Pino G, Pellegrino G, Assenza G, Capone F, Ferreri F, Formica D, Ranieri F, Tombini M, Ziemann U, Rothwell JC, Di Lazzaro V (2014) Modulation of brain plasticity in stroke: a novel model for neurorehabilitation. Nat Rev Neurol 10(10):597–608. https://doi.org/10.1038/nrneurol.2014.162CrossRefPubMed

19.

Simonetta-Moreau M (2014) Non-invasive brain stimulation (NIBS) and motor recovery after stroke. Ann Phys Rehabil Med 57(8):530–542. https://doi.org/10.1016/j.rehab.2014.08.003CrossRefPubMed

20.

Stefan K, Kunesch E, Cohen LG, Benecke R, Classen J (2000) Induction of plasticity in the human motor cortex by paired associative stimulation. Brain 123(Pt 3):572–584. https://doi.org/10.1093/brain/123.3.572CrossRefPubMed

21.

Guidali G, Roncoroni C, Bolognini N (2021) Modulating frontal networks’ timing-dependent-like plasticity with paired associative stimulation protocols: recent advances and future perspectives. Front Hum Neurosci 15:658723. https://doi.org/10.3389/fnhum.2021.658723CrossRefPubMedPubMedCentral

22.

Stefan K, Kunesch E, Benecke R, Cohen LG, Classen J (2002) Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation. J Physiol 543(Pt 2):699–708. https://doi.org/10.1113/jphysiol.2002.023317CrossRefPubMedPubMedCentral

23.

Hu Y, Guo TC, Zhang XY, Tian J, Lu YS (2019) Paired associative stimulation improves synaptic plasticity and functional outcomes after cerebral ischemia. Neural Regen Res 14(11):1968–1976. https://doi.org/10.4103/1673-5374.259618CrossRefPubMedPubMedCentral

24.

Carson RG, Kennedy NC (2013) Modulation of human corticospinal excitability by paired associative stimulation. Front Hum Neurosci 7:823. https://doi.org/10.3389/fnhum.2013.00823CrossRefPubMedPubMedCentral

25.

Du J, Tian L, Liu W, Hu J, Xu G, Ma M, Fan X, Ye R, Jiang Y, Yin Q, Zhu W, Xiong Y, Yang F, Liu X (2016) Effects of repetitive transcranial magnetic stimulation on motor recovery and motor cortex excitability in patients with stroke: a randomized controlled trial. Eur J Neurol 23(11):1666–1672. https://doi.org/10.1111/ene.13105CrossRefPubMed

26.

Moslemi HF, Kordi YA, Razeghi M, Shariat A, Bagheri Z, Rezaei K (2021) The effect of high-frequency repetitive transcranial magnetic stimulation on functional indices of affected upper limb in patients with subacute stroke. J Biomed Phys Eng 11(2):175–184. https://doi.org/10.31661/jbpe.v0i0.879CrossRef

27.

Luk KY, Ouyang HX, Pang M (2022) Low-frequency rTMS over contralesional M1 increases ipsilesional cortical excitability and motor function with decreased interhemispheric asymmetry in subacute stroke: a randomized controlled study. Neural Plast 2022:3815357. https://doi.org/10.1155/2022/3815357CrossRefPubMedPubMedCentral

28.

Avenanti A, Coccia M, Ladavas E, Provinciali L, Ceravolo MG (2012) Low-frequency rTMS promotes use-dependent motor plasticity in chronic stroke: a randomized trial. Neurology 78(4):256–264. https://doi.org/10.1212/WNL.0b013e3182436558CrossRefPubMed

29.

Guo Z, Jin Y, Bai X, Jiang B, He L, McClure MA, Mu Q (2021) Distinction of high- and low-frequency repetitive transcranial magnetic stimulation on the functional reorganization of the motor network in stroke patients. Neural Plast 2021:8873221. https://doi.org/10.1155/2021/8873221CrossRefPubMedPubMedCentral

30.

Zhang JJ, Bai Z, Fong K (2022) Priming intermittent theta burst stimulation for hemiparetic upper limb after stroke: a randomized controlled trial. Stroke 53(7):2171–2181. https://doi.org/10.1161/STROKEAHA.121.037870CrossRefPubMed

31.

Park CH, Chang WH, Ohn SH, Kim ST, Bang OY, Pascual-Leone A, Kim YH (2011) Longitudinal changes of resting-state functional connectivity during motor recovery after stroke. Stroke 42(5):1357–1362. https://doi.org/10.1161/STROKEAHA.110.596155CrossRefPubMedPubMedCentral

32.

Golestani AM, Tymchuk S, Demchuk A, Goodyear BG (2013) Longitudinal evaluation of resting-state FMRI after acute stroke with hemiparesis. Neurorehabil Neural Repair 27(2):153–163. https://doi.org/10.1177/1545968312457827CrossRefPubMed

33.

Lam TK, Dawson DR, Honjo K, Ross B, Binns MA, Stuss DT, Black SE, Chen JJ, Levine BT, Fujioka T, Chen JL (2018) Neural coupling between contralesional motor and frontoparietal networks correlates with motor ability in individuals with chronic stroke. J Neurol Sci 384:21–29. https://doi.org/10.1016/j.jns.2017.11.007CrossRefPubMed

34.

Peng Y, Liu J, Hua M, Liang M, Yu C (2019) Enhanced effective connectivity from ipsilesional to contralesional M1 in well-recovered subcortical stroke patients. Front Neurol 10:909. https://doi.org/10.3389/fneur.2019.00909CrossRefPubMedPubMedCentral

35.

Frahm J, Bruhn H, Merboldt KD, Hänicke W (1992) Dynamic MR imaging of human brain oxygenation during rest and photic stimulation. J Magn Reson Imaging 2(5):501–505. https://doi.org/10.1002/jmri.1880020505CrossRefPubMed

36.

Kwong KK, Belliveau JW, Chesler DA, Goldberg IE, Weisskoff RM, Poncelet BP, Kennedy DN, Hoppel BE, Cohen MS, Turner R, Et A (1992) Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci USA 89(12):5675–5679. https://doi.org/10.1073/pnas.89.12.5675ADSCrossRefPubMedPubMedCentral

37.

Turner R, Howseman A, Rees GE, Josephs O, Friston K (1998) Functional magnetic resonance imaging of the human brain: data acquisition and analysis. Exp Brain Res 123(1–2):5–12. https://doi.org/10.1007/s002210050538CrossRefPubMed

38.

Li B, Deng S, Sang B, Zhu W, Zhuo B, Zhang M, Qin C, Lyu Y, Du Y, Meng Z (2022) Revealing the neuroimaging mechanism of acupuncture for poststroke aphasia: a systematic review. Neural Plast 2022:5635596. https://doi.org/10.1155/2022/5635596CrossRefPubMedPubMedCentral

39.

Fox MD, Raichle ME (2007) Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat Rev Neurosci 8(9):700–711. https://doi.org/10.1038/nrn2201CrossRefPubMed

40.

Moher D, Liberati A, Tetzlaff J, Altman DG (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Plos Med 6(7):e1000097. https://doi.org/10.1371/journal.pmed.1000097CrossRefPubMedPubMedCentral

41.

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R, Glanville J, Grimshaw JM, Hróbjartsson A, Lalu MM, Li T, Loder EW, Mayo-Wilson E, McDonald S, McGuinness LA, Stewart LA, Thomas J, Tricco AC, Welch VA, Whiting P, Moher D (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https://doi.org/10.1136/bmj.n71CrossRefPubMedPubMedCentral

42.

Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M (2003) Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther 83(8):713–721CrossRefPubMed

43.

de Morton NA (2009) The PEDro scale is a valid measure of the methodological quality of clinical trials: a demographic study. Aust J Physiother 55(2):129–133. https://doi.org/10.1016/s0004-9514(09)70043-1CrossRefPubMed

44.

Ameli M, Grefkes C, Kemper F, Riegg FP, Rehme AK, Karbe H, Fink GR, Nowak DA (2009) Differential effects of high-frequency repetitive transcranial magnetic stimulation over ipsilesional primary motor cortex in cortical and subcortical middle cerebral artery stroke. Ann Neurol 66(3):298–309. https://doi.org/10.1002/ana.21725CrossRefPubMed

45.

Chang WH, Kim YH, Yoo WK, Goo KH, Park CH, Kim ST, Pascual-Leone A (2012) rTMS with motor training modulates cortico-basal ganglia-thalamocortical circuits in stroke patients. Restor Neurol Neurosci 30(3):179–189. https://doi.org/10.3233/RNN-2012-110162CrossRefPubMedPubMedCentral

46.

Chen Q, Shen W, Sun H, Zhang H, Liu C, Chen Z, Yu L, Cai X, Ke J, Li L, Zhang L, Fang Q (2022) The effect of coupled inhibitory-facilitatory repetitive transcranial magnetic stimulation on shaping early reorganization of the motor network after stroke. Brain Res 1790:147959. https://doi.org/10.1016/j.brainres.2022.147959CrossRefPubMed

47.

Du J, Yang F, Hu J, Hu J, Xu Q, Cong N, Zhang Q, Liu L, Mantini D, Zhang Z, Lu G, Liu X (2019) Effects of high- and low-frequency repetitive transcranial magnetic stimulation on motor recovery in early stroke patients: evidence from a randomized controlled trial with clinical, neurophysiological and functional imaging assessments. Neuroimage Clin 21:101620. https://doi.org/10.1016/j.nicl.2018.101620CrossRefPubMed

48.

Juan D, Yao W, Li J, Yang F, Hu J, Xu Q, Liu L, Lv Q, Liu R, Ye R, Ma M, Zhu W, Zhang Z, Liu X (2022) Motor network reorganization after repetitive transcranial magnetic stimulation in early stroke patients: a resting state fMRI study. Neurorehabil Neural Repair 36(1):61–68. https://doi.org/10.1177/15459683211054184CrossRef

49.

Gottlieb A, Boltzmann M, Schmidt SB, Gutenbrunner C, Krauss JK, Stangel M, Höglinger GU, Wallesch CW, Rollnik JD (2021) Treatment of upper limb spasticity with inhibitory repetitive transcranial magnetic stimulation: a randomized placebo-controlled trial. NeuroRehabilitation 49(3):425–434. https://doi.org/10.3233/NRE-210088CrossRefPubMed

50.

Li J, Zhang XW, Zuo ZT, Lu J, Meng CL, Fang HY, Xue R, Fan Y, Guan YZ, Zhang WH (2016) Cerebral functional reorganization in ischemic stroke after repetitive transcranial magnetic stimulation: an fMRI study. Cns Neurosci Ther 22(12):952–960. https://doi.org/10.1111/cns.12593CrossRefPubMedPubMedCentral

51.

Nowak DA, Grefkes C, Dafotakis M, Eickhoff S, Küst J, Karbe H, Fink GR (2008) Effects of low-frequency repetitive transcranial magnetic stimulation of the contralesional primary motor cortex on movement kinematics and neural activity in subcortical stroke. Arch Neurol 65(6):741–747. https://doi.org/10.1001/archneur.65.6.741CrossRefPubMed

52.

Qin Y, Liu X, Guo X, Liu M, Li H, Xu S (2021) Low-frequency repetitive transcranial magnetic stimulation restores dynamic functional connectivity in subcortical stroke. Front Neurol 12:771034. https://doi.org/10.3389/fneur.2021.771034CrossRefPubMedPubMedCentral

53.

Allen EA, Damaraju E, Plis SM, Erhardt EB, Eichele T, Calhoun VD (2014) Tracking whole-brain connectivity dynamics in the resting state. Cereb Cortex 24:663–676. https://doi.org/10.1093/cercor/bhs352CrossRefPubMed

54.

Dekhil O, Shalaby A, Soliman A, Mahmoud A, Kong M, Barnes G, Elmaghraby A, El-Baz A (2021) Identifying brain areas correlated with ADOS raw scores by studying altered dynamic functional connectivity patterns. Med Image Anal 68:101899. https://doi.org/10.1016/j.media.2020.101899CrossRefPubMed

55.

Rosso C, Moulton EJ, Kemlin C, Leder S, Corvol JC, Mehdi S, Obadia MA, Obadia M, Yger M, Meseguer E, Perlbarg V, Valabregue R, Magno S, Lindberg P, Meunier S, Lamy JC (2022) Cerebello-motor paired associative stimulation and motor recovery in stroke: a randomized, sham-controlled, double-blind pilot trial. Neurotherapeutics 19(2):491–500. https://doi.org/10.1007/s13311-022-01205-yCrossRefPubMedPubMedCentral

56.

Tosun A, Türe S, Askin A, Yardimci EU, Demirdal SU, Kurt IT, Tosun O, Kocyigit H, Akhan G, Gelal FM (2017) Effects of low-frequency repetitive transcranial magnetic stimulation and neuromuscular electrical stimulation on upper extremity motor recovery in the early period after stroke: a preliminary study. Top Stroke Rehabil 24(5):361–367. https://doi.org/10.1080/10749357.2017.1305644CrossRefPubMed

57.

Zhang L, Xing G, Fan Y, Guo Z, Chen H, Mu Q (2017) Short- and long-term effects of repetitive transcranial magnetic stimulation on upper limb motor function after stroke: a systematic review and meta-analysis. Clin Rehabil 31(9):1137–1153. https://doi.org/10.1177/0269215517692386CrossRefPubMed

58.

Xiang H, Sun J, Tang X, Zeng K, Wu X (2019) The effect and optimal parameters of repetitive transcranial magnetic stimulation on motor recovery in stroke patients: a systematic review and meta-analysis of randomized controlled trials. Clin Rehabil 33(5):847–864. https://doi.org/10.1177/0269215519829897CrossRefPubMed

59.

Fan H, Song Y, Cen X, Yu P, Bíró I, Gu Y (2021) The effect of repetitive transcranial magnetic stimulation on lower-limb motor ability in stroke patients: a systematic review. Front Hum Neurosci 15:620573. https://doi.org/10.3389/fnhum.2021.620573CrossRefPubMedPubMedCentral

60.

Gao B, Wang Y, Zhang D, Wang Z, Wang Z (2022) Intermittent theta-burst stimulation with physical exercise improves poststroke motor function: a systemic review and meta-analysis. Front Neurol 13:964627. https://doi.org/10.3389/fneur.2022.964627CrossRefPubMedPubMedCentral

61.

Liepert J, Hamzei F, Weiller C (2000) Motor cortex disinhibition of the unaffected hemisphere after acute stroke. Muscle Nerve 23(11):1761–1763. https://doi.org/10.1002/1097-4598(200011)23:11%3c1761::aid-mus14%3e3.0.co;2-mCrossRefPubMed

62.

Shimizu T, Hosaki A, Hino T, Sato M, Komori T, Hirai S, Rossini PM (2002) Motor cortical disinhibition in the unaffected hemisphere after unilateral cortical stroke. Brain 125(Pt 8):1896–1907. https://doi.org/10.1093/brain/awf183CrossRefPubMed

63.

Cicinelli P, Pasqualetti P, Zaccagnini M, Traversa R, Oliveri M, Rossini PM (2003) Interhemispheric asymmetries of motor cortex excitability in the postacute stroke stage: a paired-pulse transcranial magnetic stimulation study. Stroke 34(11):2653–2658. https://doi.org/10.1161/01.STR.0000092122.96722.72CrossRefPubMed

64.

Murase N, Duque J, Mazzocchio R, Cohen LG (2004) Influence of interhemispheric interactions on motor function in chronic stroke. Ann Neurol 55(3):400–409. https://doi.org/10.1002/ana.10848CrossRefPubMed

65.

Koski L, Mernar TJ, Dobkin BH (2004) Immediate and long-term changes in corticomotor output in response to rehabilitation: correlation with functional improvements in chronic stroke. Neurorehabil Neural Repair 18(4):230–249. https://doi.org/10.1177/1545968304269210CrossRefPubMed

66.

Lin YL, Potter-Baker KA, Cunningham DA, Li M, Sankarasubramanian V, Lee J, Jones S, Sakaie K, Wang X, Machado AG, Plow EB (2020) Stratifying chronic stroke patients based on the influence of contralesional motor cortices: an inter-hemispheric inhibition study. Clin Neurophysiol 131(10):2516–2525. https://doi.org/10.1016/j.clinph.2020.06.016CrossRefPubMedPubMedCentral

67.

Bocci T, Pietrasanta M, Cerri C, Restani L, Caleo M, Sartucci F (2014) Visual callosal connections: role in visual processing in health and disease. Rev Neurosci 25(1):113–127. https://doi.org/10.1515/revneuro-2013-0025CrossRefPubMed

68.

Bocci T, Nasini F, Caleo M, Restani L, Barloscio D, Ardolino G, Priori A, Maffei L, Nardi M, Sartucci F (2018) Unilateral application of cathodal tDCS reduces transcallosal inhibition and improves visual acuity in amblyopic patients. Front Behav Neurosci 12:109. https://doi.org/10.3389/fnbeh.2018.00109CrossRefPubMedPubMedCentral

69.

Wang Q, Zhang D, Zhao Y, Hai H, Ma Y (2020) Effects of high-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex on motor recovery in severe hemiplegic stroke: a randomized clinical trial. Brain Stimul 13:979–986. https://doi.org/10.1016/j.brs.2020.03.020CrossRefPubMed

70.

Grefkes C, Fink GR (2012) Disruption of motor network connectivity post-stroke and its noninvasive neuromodulation. Curr Opin Neurol 25(6):670–675. https://doi.org/10.1097/WCO.0b013e3283598473CrossRefPubMed

71.

Paul T, Hensel L, Rehme AK, Tscherpel C, Eickhoff SB, Fink GR, Grefkes C, Volz LJ (2021) Early motor network connectivity after stroke: an interplay of general reorganization and state-specific compensation. Hum Brain Mapp 42(16):5230–5243. https://doi.org/10.1002/hbm.25612CrossRefPubMedPubMedCentral

72.

Olafson ER, Jamison KW, Sweeney EM, Liu H, Wang D, Bruss JE, Boes AD, Kuceyeski A (2021) Functional connectome reorganization relates to post-stroke motor recovery and structural and functional disconnection. Neuroimage 245:118642. https://doi.org/10.1016/j.neuroimage.2021.118642CrossRefPubMed

73.

Hartwigsen G, Volz LJ (2021) Probing rapid network reorganization of motor and language functions via neuromodulation and neuroimaging. Neuroimage 224:117449. https://doi.org/10.1016/j.neuroimage.2020.117449CrossRefPubMed

74.

Binder E, Leimbach M, Pool EM, Volz LJ, Eickhoff SB, Fink GR, Grefkes C (2021) Cortical reorganization after motor stroke: a pilot study on differences between the upper and lower limbs. Hum Brain Mapp 42(4):1013–1033. https://doi.org/10.1002/hbm.25275CrossRefPubMed

75.

Rogers BP, Morgan VL, Newton AT, Gore JC (2007) Assessing functional connectivity in the human brain by fMRI. Magn Reson Imaging 25(10):1347–1357. https://doi.org/10.1016/j.mri.2007.03.007CrossRefPubMedPubMedCentral

76.

van den Heuvel MP, Hulshoff PH (2010) Exploring the brain network: a review on resting-state fMRI functional connectivity. Eur Neuropsychopharmacol 20(8):519–534. https://doi.org/10.1016/j.euroneuro.2010.03.008CrossRefPubMed

77.

Desowska A, Turner DL (2019) Dynamics of brain connectivity after stroke. Rev Neurosci 30(6):605–623. https://doi.org/10.1515/revneuro-2018-0082CrossRefPubMed

78.

Xia Y, Huang G, Quan X, Qin Q, Li H, Xu C, Liang Z (2021) Dynamic structural and functional reorganizations following motor stroke. Med Sci Monit 27:e929092. https://doi.org/10.12659/MSM.929092CrossRefPubMedPubMedCentral

79.

Volz LJ, Rehme AK, Michely J, Nettekoven C, Eickhoff SB, Fink GR, Grefkes C (2016) Shaping early reorganization of neural networks promotes motor function after stroke. Cereb Cortex 26(6):2882–2894. https://doi.org/10.1093/cercor/bhw034CrossRefPubMedPubMedCentral

80.

Li S, Francisco GE, Rymer WZ (2021) A new definition of poststroke spasticity and the interference of spasticity with motor recovery from acute to chronic stages. Neurorehabil Neural Repair 35(7):601–610. https://doi.org/10.1177/15459683211011214CrossRefPubMed

Titel: The effects of rTMS on motor recovery after stroke: a systematic review of fMRI studies
verfasst von: Zhiqing Tang
Tianhao Liu
Kaiyue Han
Ying Liu
Wenlong Su
Rongrong Wang
Hao Zhang
Publikationsdatum: 25.10.2023
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 3/2024
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-023-07123-x

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Hirnblutung unter DOAK und VKA ähnlich bedrohlich

17.05.2024 Direkte orale Antikoagulanzien Nachrichten

Kommt es zu einer nichttraumatischen Hirnblutung, spielt es keine große Rolle, ob die Betroffenen zuvor direkt wirksame orale Antikoagulanzien oder Marcumar bekommen haben: Die Prognose ist ähnlich schlecht.

Was nützt die Kraniektomie bei schwerer tiefer Hirnblutung?

17.05.2024 Hirnblutung Nachrichten

Eine Studie zum Nutzen der druckentlastenden Kraniektomie nach schwerer tiefer supratentorieller Hirnblutung deutet einen Nutzen der Operation an. Für überlebende Patienten ist das dennoch nur eine bedingt gute Nachricht.

Thrombektomie auch bei großen Infarkten von Vorteil

16.05.2024 Ischämischer Schlaganfall Nachrichten

Auch ein sehr ausgedehnter ischämischer Schlaganfall scheint an sich kein Grund zu sein, von einer mechanischen Thrombektomie abzusehen. Dafür spricht die LASTE-Studie, an der Patienten und Patientinnen mit einem ASPECTS von maximal 5 beteiligt waren.

Schwindelursache: Massagepistole lässt Otholiten tanzen

14.05.2024 Benigner Lagerungsschwindel Nachrichten

Wenn jüngere Menschen über ständig rezidivierenden Lagerungsschwindel klagen, könnte eine Massagepistole der Auslöser sein. In JAMA Otolaryngology warnt ein Team vor der Anwendung hochpotenter Geräte im Bereich des Nackens.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 3/2024

Neurological complications due to copper deficiency in the context of Wilson disease treatment: a case report with long-term follow-up and review of the literature

Influenza B-induced longitudinally extensive transverse myelitis and bithalamic acute disseminated encephalomyelitis

Marked neuropsychiatric involvement and dysmorphic features in nemaline myopathy

The role of plasma neurofilament light chain and glial fibrillary acidic protein in subjective cognitive decline and mild cognitive impairment

Five-year stroke prognosis. Influence of post-stroke delirium and post-stroke dementia on mortality and disability (Research Study – Part of the PROPOLIS Study)