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Seminars in Immunopathology

Erschienen in:

01.09.2009 | Review

The immunopathology of human biliary cell epithelium

verfasst von: Ya-Hui Chuang, Ruth Y. Lan, M. Eric Gershwin

Erschienen in: Seminars in Immunopathology | Ausgabe 3/2009

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Abstract

Bile ducts lined with biliary epithelial cells, or cholangiocytes, are the main components of the biliary system in liver. Cholangiocytes participate in the production and transport of bile substances, as well as participate in immune responses. Cholangiocytes protect against pathogens by expressing toll-like receptors and anti-microbial peptides; act as antigen-presenting cells by expressing human leukocyte antigen molecules and costimulatory molecules; recruit leukocytes to the target site by expressing adhesion molecules, cytokines, and chemokines; and induce apoptosis of leukocytes to limit the immune responses. Several cholangiopathies result from dysfunctions of the biliary system. They can broadly be divided into autoimmune, genetic, infectious, drug, and ischemic-injury-induced categories. The pathogenesis of many of these cholangiopathies is unclear and treatment is limited. Further understanding of the complexity of the biliary system is critical for medical advancements in this field.

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Titel: The immunopathology of human biliary cell epithelium
verfasst von: Ya-Hui Chuang
Ruth Y. Lan
M. Eric Gershwin
Publikationsdatum: 01.09.2009
Verlag: Springer-Verlag
Erschienen in: Seminars in Immunopathology / Ausgabe 3/2009
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-009-0172-5

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