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Current Addiction Reports

Erschienen in:

01.12.2019 | Adolescent/Young Adult Addiction (M Heitzeg, Section Editor)

The Impact of Genes on Adolescent Substance Use: a Developmental Perspective

verfasst von: Elisa M. Trucco, Brigitte Madan, Michelle Villar

Erschienen in: Current Addiction Reports | Ausgabe 4/2019

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Abstract

Purpose of Review

This review discusses the importance of understanding the impact of genetic factors on adolescent substance use within a developmental framework. Methods for identifying genetic factors, relevant endophenotypes and intermediate phenotypes, and gene-environment interplay effects will be reviewed.

Recent Findings

Prior work supports the role of polygenic variation on adolescent substance use. Mechanisms through which genes impact adolescent phenotypes consist of differences in neural structure and function, early temperamental differences, and problem behavior. Gene-environment interactions are characterized by increased vulnerability to both maladaptive and adaptive contexts.

Summary

Developmental considerations in genetic investigations highlight the critical role that polygenic variation has on adolescent substance use. Yet, determining what to do with this information, especially in terms of personalized medicine, poses ethical and logistic challenges.

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Titel: The Impact of Genes on Adolescent Substance Use: a Developmental Perspective
verfasst von: Elisa M. Trucco
Brigitte Madan
Michelle Villar
Publikationsdatum: 01.12.2019
Verlag: Springer International Publishing
Erschienen in: Current Addiction Reports / Ausgabe 4/2019
Elektronische ISSN: 2196-2952
DOI: https://doi.org/10.1007/s40429-019-00273-z

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

The Impact of Genes on Adolescent Substance Use: a Developmental Perspective

Abstract

Purpose of Review

Recent Findings

Summary

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