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Medical Oncology

Erschienen in:

01.05.2023 | Review Article

The impact of hypoxia on extracellular vesicle secretome profile of cancer

verfasst von: Keywan Mortezaee, Jamal Majidpoor

Erschienen in: Medical Oncology | Ausgabe 5/2023

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Abstract

Extracellular vesicles (EVs) are emerging as key mediators of cell-to-cell communications and signal transporters between tumor and stroma, and hypoxia is a critical characteristic of tumor microenvironment (TME) in solid cancers. Hypoxia stimulates tumor cells to generate and secrete more EVs, and the EVs shed from cancer transfer biological information to boost hypoxia and hypoxia inducible factor (HIF) functionality. Hypoxia alters EV secretome profile to carry pro-tumorigenic factors for promoting numerous tumor-related processes including increased cancer cell proliferation and survival, immune escape, aberrant angiogenesis, and invasion and metastasis. Exosomal hypoxia inducible factor (HIF)-1α is an essential driver of epithelial-mesenchymal transition (EMT) and stemness profile in cancer. Hypoxic cancer-derived EVs are also contributed to therapy resistance. In fact, EVs are messengers of hypoxic tolerance in cancer, which enable adaptation of tumor cells to changes occurring within TME for their further resistance and metastasis. Tracing EVs shed from hypoxic tumor cells into plasma provide important information about the genomic signature of cancer. In this review, we aimed to discuss about key tumorigenic events promoted by inter-connections between hypoxia and EVs, mainly exosomes, secreted into tumor area focusing on key hallmarks of cancer.

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Titel: The impact of hypoxia on extracellular vesicle secretome profile of cancer
verfasst von: Keywan Mortezaee
Jamal Majidpoor
Publikationsdatum: 01.05.2023
Verlag: Springer US
Erschienen in: Medical Oncology / Ausgabe 5/2023
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI: https://doi.org/10.1007/s12032-023-01995-x

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

The impact of hypoxia on extracellular vesicle secretome profile of cancer

Abstract

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

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