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Pediatric Surgery International

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11.11.2017 | Original Article

The initial prophylactic antibiotic usage and subsequent necrotizing enterocolitis in high-risk premature infants: a systematic review and meta-analysis

verfasst von: Xue Fan, Li Zhang, Jun Tang, Chao Chen, Juan Chen, Yi Qu, Dezhi Mu

Erschienen in: Pediatric Surgery International | Ausgabe 1/2018

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Abstract

Objective

To investigate the correlation between the initial prophylactic antibiotic use and the subsequent NEC in high-risk premature infants.

Methods

We performed a literature search of PubMed, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), and the Web of Science, and nine studies with a total of 5207 infants were selected for inclusion in this study.

Results

The pooled estimate for the seven studies combined indicating that prophylactic antibiotic usage was associated with a non-significant trend toward increased incidence of NEC [odds ratio (OR) 0.75; 95% confidence interval (CI) 0.26–2.17], and prolonged exposure to prophylactic antibiotics, compared with limited prophylactic antibiotic use, was associated with a significant trend toward the risk of increasing incidence of NEC (OR 1.31; 95% CI 1.08–1.59).

Conclusion

Current evidence does not support the use of prophylactic antibiotics to reduce the incidence of NEC for high-risk premature infants.

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Titel: The initial prophylactic antibiotic usage and subsequent necrotizing enterocolitis in high-risk premature infants: a systematic review and meta-analysis
verfasst von: Xue Fan
Li Zhang
Jun Tang
Chao Chen
Juan Chen
Yi Qu
Dezhi Mu
Publikationsdatum: 11.11.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Surgery International / Ausgabe 1/2018
Print ISSN: 0179-0358
Elektronische ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-017-4207-z

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The initial prophylactic antibiotic usage and subsequent necrotizing enterocolitis in high-risk premature infants: a systematic review and meta-analysis

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Objective

Methods

Results

Conclusion

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