The online version of this article (doi:10.1186/1477-7827-10-107) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
Hong-Bo Qi was responsible for designing and coordinating the study. All authors were responsible for data collection, data analysis, and data interpretation. Xi-Ru Liu, Hua-Qiao Mu, and Qi Shi were responsible for the statistical analysis and for writing the manuscript. Xiao-Qiu Xiao was responsible for reviewing the manuscript. All authors read and approved the final manuscript.
Progesterone supplementation after in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI) can improve the rates of clinical pregnancy and live birth, but the optimal duration of treatment remains controversial. The objective of this meta-analysis was to investigate the effects of early progesterone cessation on pregnancy outcomes in women undergoing IVF/ICSI.
We searched MEDLINE, EMBASE, the Cochrane Central Register of Controlled Trials (CENTRAL), the Chinese biomedicine (CBM) literature database, and the Wanfang database. The final search was performed in July 2012. All available randomised trials that compared the effects of early progesterone cessation with progesterone continuation during early pregnancy after IVF/ICSI were included. The main outcome measures were live birth rate, miscarriage rate and ongoing pregnancy rate. Fixed or random-effects models were chosen to calculate the risk ratio (RR).
Six eligible studies with a total of 1,201 randomised participants were included in the final analysis. No statistically significant differences were detected between patients who underwent early progesterone cessation and those who received progesterone continuation for luteal phase support in terms of live birth rate (RR: 0.95, 95% CI: 0.86–1.05), miscarriage rate (RR: 1.01, 95% CI: 0.74–1.38) or ongoing pregnancy rate (RR: 0.97, 95% CI: 0.90–1.05). These results did not change after a sensitivity analysis.
The currently available evidence suggests that progesterone supplementation beyond the first positive hCG test after IVF/ICSI might generally be unnecessary, although large-scale randomised controlled trials are needed to strengthen this conclusion.
Additional file 1: Search strategy in MEDLINE, EMBASE, and CENTRAL databases. (PDF 27 KB)12958_2012_1039_MOESM1_ESM.pdf
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- The optimal duration of progesterone supplementation in pregnant women after IVF/ICSI: a meta-analysis
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