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European Radiology
Erschienen in: European Radiology 9/2015

01.09.2015 | Gastrointestinal

The precision of textural analysis in 18F-FDG-PET scans of oesophageal cancer

verfasst von: Georgia Doumou, Musib Siddique, Charalampos Tsoumpas, Vicky Goh, Gary J. Cook

Erschienen in: European Radiology | Ausgabe 9/2015

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Abstract

Objectives

Measuring tumour heterogeneity by textural analysis in 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) provides predictive and prognostic information but technical aspects of image processing can influence parameter measurements. We therefore tested effects of image smoothing, segmentation and quantisation on the precision of heterogeneity measurements.

Methods

Sixty-four 18F-FDG PET/CT images of oesophageal cancer were processed using different Gaussian smoothing levels (2.0, 2.5, 3.0, 3.5, 4.0 mm), maximum standardised uptake value (SUVmax) segmentation thresholds (45 %, 50 %, 55 %, 60 %) and quantisation (8, 16, 32, 64, 128 bin widths). Heterogeneity parameters included grey-level co-occurrence matrix (GLCM), grey-level run length matrix (GLRL), neighbourhood grey-tone difference matrix (NGTDM), grey-level size zone matrix (GLSZM) and fractal analysis methods. The concordance correlation coefficient (CCC) for the three processing variables was calculated for each heterogeneity parameter.

Results

Most parameters showed poor agreement between different bin widths (CCC median 0.08, range 0.004–0.99). Segmentation and smoothing showed smaller effects on precision (segmentation: CCC median 0.82, range 0.33–0.97; smoothing: CCC median 0.99, range 0.58–0.99).

Conclusions

Smoothing and segmentation have only a small effect on the precision of heterogeneity measurements in 18F-FDG PET data. However, quantisation often has larger effects, highlighting a need for further evaluation and standardisation of parameters for multicentre studies.

Key points

• Heterogeneity measurement precision in 18 F-FDG PET is influenced by image processing methods.
• Quantisation shows large effects on precision of heterogeneity parameters in 18 F-FDG PET/CT.
• Smoothing and segmentation show comparatively smaller effects on precision of heterogeneity parameters.
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Metadaten
Titel
The precision of textural analysis in 18F-FDG-PET scans of oesophageal cancer
verfasst von
Georgia Doumou
Musib Siddique
Charalampos Tsoumpas
Vicky Goh
Gary J. Cook
Publikationsdatum
01.09.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
European Radiology / Ausgabe 9/2015
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-015-3681-8

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