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Current Rheumatology Reports
Erschienen in: Current Rheumatology Reports 6/2015

01.06.2015 | Health Economics and Quality of Life (M Harrison, Section Editor)

The Prediction and Monitoring of Toxicity Associated with Long-Term Systemic Glucocorticoid Therapy

verfasst von: Emma Harris, Ana Tiganescu, Sandy Tubeuf, Sarah Louise Mackie

Erschienen in: Current Rheumatology Reports | Ausgabe 6/2015

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Abstract

Glucocorticoids are often required for adequate control of inflammation in many serious inflammatory diseases; common indications for long-term treatment include polymyalgia rheumatica, giant cell arteritis, asthma and chronic obstructive pulmonary disease. Long-term glucocorticoid therapy is, however, associated with many adverse effects involving skin, gastro-intestinal, eye, skeletal muscle, bone, adrenal, cardio-metabolic and neuropsychiatric systems. This balance between benefits and risks of glucocorticoids is important for clinical practice and glucocorticoid-related adverse effects can significantly impair health-related quality of life. Understanding the nature and mechanisms of glucocorticoid-related adverse effects may inform how patients are monitored for toxicity and identify those groups, such as older people, that may need closer monitoring. For clinical trials in diseases commonly treated with glucocorticoids, standardised measurement of glucocorticoid-related adverse effects would facilitate future evidence synthesis and meta-analysis.
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Metadaten
Titel
The Prediction and Monitoring of Toxicity Associated with Long-Term Systemic Glucocorticoid Therapy
verfasst von
Emma Harris
Ana Tiganescu
Sandy Tubeuf
Sarah Louise Mackie
Publikationsdatum
01.06.2015
Verlag
Springer US
Erschienen in
Current Rheumatology Reports / Ausgabe 6/2015
Print ISSN: 1523-3774
Elektronische ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-015-0513-4

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