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European Archives of Oto-Rhino-Laryngology
Erschienen in: European Archives of Oto-Rhino-Laryngology 9/2017

01.07.2017 | Head and Neck

The presence of aberrant p53 pattern is a negative prognostic predictor in squamous cell carcinoma of the nasal vestibule

verfasst von: Domenic Vital, Gerhard F. Huber, David Holzmann, Holger Moch, Kristian Ikenberg

Erschienen in: European Archives of Oto-Rhino-Laryngology | Ausgabe 9/2017

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Abstract

The aim of this study was to analyze the role of Ki-67, p53, and the “aberrant p53 pattern” in squamous cell carcinomas of the nasal vestibule. Patients between 1995 and 2014 were included. Baseline characteristics and outcome were analyzed with respect to immunohistochemical staining of Ki-67 and p53. “Aberrant p53 pattern” was represented by a moderate or strong staining of at least 60% of the tumor cells or a complete absence of immunoreactivity. Forty-six patients were included of whom 31 (67.4%) were available for Ki-67 and 32 (69.9%) for p53 immunohistochemistry. The “aberrant pattern” of p53 was present in 50% of the patients. While immunoreactivity for both Ki-67 and p53 was not related to each other or outcome, the “aberrant p53 pattern” was associated with a worse disease-free survival (p = 0.014). The “aberrant p53 pattern” is a negative prognostic factor in squamous cell carcinoma of the nasal vestibule and might enable a patient-tailored treatment.
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Metadaten
Titel
The presence of aberrant p53 pattern is a negative prognostic predictor in squamous cell carcinoma of the nasal vestibule
verfasst von
Domenic Vital
Gerhard F. Huber
David Holzmann
Holger Moch
Kristian Ikenberg
Publikationsdatum
01.07.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
European Archives of Oto-Rhino-Laryngology / Ausgabe 9/2017
Print ISSN: 0937-4477
Elektronische ISSN: 1434-4726
DOI
https://doi.org/10.1007/s00405-017-4659-8

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