Erschienen in:
01.04.2014 | Letter
The renal angiopoietin/Tie2 system in lethal human sepsis
verfasst von:
Adnan Aslan, Rianne M Jongman, Jill Moser, Coen A Stegeman, Harry van Goor, Arjan Diepstra, Marius C van den Heuvel, Peter Heeringa, Grietje Molema, Jan G Zijlstra, Matijs van Meurs
Erschienen in:
Critical Care
|
Ausgabe 2/2014
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Excerpt
Sepsis-induced multi-organ dysfunction syndrome (MODS) still has a high mortality. Improvements await a better understanding of the pathophysiological mechanisms. The angiopoietin (Ang)1/2 and Tie2 (tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2) ligand/receptor system is an important regulator of endothelial cell responses to severe insults [
1]. Plasma Ang2 levels are prognostic in sepsis, but data on Ang/Tie responses in organs in humans are lacking [
2‐
5]. We hypothesized that, in kidneys of patients who died of sepsis with acute kidney injury (AKI), the Ang/Tie signaling system is changed in such a way that microvessels become destabilized. …