nach oben

Social Psychiatry and Psychiatric Epidemiology

Erschienen in:

01.12.2015 | Original Paper

The role of allelic variation in estrogen receptor genes and major depression in the Nurses Health Study

verfasst von: K. Keyes, J. Agnew-Blais, A. L. Roberts, A. Hamilton, I. De Vivo, H. Ranu, K. Koenen

Erschienen in: Social Psychiatry and Psychiatric Epidemiology | Ausgabe 12/2015

Einloggen, um Zugang zu erhalten

Abstract

Purpose

The role of exogenous and endogenous sex hormones in the etiology of depression remains elusive, in part because sex hormone variation is often correlated with behaviors, life stage changes, and other factors that may influence depression. Estrogen receptor alpha (ESR1) and beta (ESR2) are known to regulate gene expression and estrogen response in areas of the brain associated with major depression and are unlikely to be correlated with exogenous factors that may influence depression.

Methods

We examined whether functional polymorphisms in these genes are associated with lifetime major depression and chronic major depression among a sample of women from the Nurses’ Health Study II (N = 2527). DSM-IV depressive disorder symptoms were assessed by structured interview in 2007. Genotyping was performed on DNA extracted from blood using Taq-man.

Results

Women with the AA alleles of ESR2 RS4986938 had the higher prevalence of lifetime major depression than women with other allele frequencies (36.7 % for those with AA versus 28.5 % with GA and 29.1 % with GG, p = 0.02) and chronic major depression (14.7 % for those with AA versus 9.3 % with GA and 9.1 % with GG, p = 0.01). History of post-menopausal hormone (PMH) use modified the association of ESR1 polymorphism RS2234693 with any lifetime depression; specifically, those with the TT allele had the highest risk of lifetime depression among PMH users, and the lowest risk of depression among non-PMH users (p value for interaction = 0.02). Further, carriers of the AA alleles in ESR1 polymorphism RS9340799 had increased prevalence of lifetime major depression only among lifetime PMH users (p = 0.007).

Conclusions

Our findings support the hypothesis that estrogen receptor polymorphisms influence risk for major depression; the role of estrogen receptors and other sex steroid-related genetic factors may provide unique insights into etiology.

Nur mit Berechtigung zugänglich

Hasin DS, Goodwin RD, Stinson FS, Grant BF (2005) Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Arch Gen Psychiatry 62(10):1097–1106. doi:10.1001/archpsyc.62.10.1097 CrossRefPubMed

Hays RD, Wells KB, Sherbourne CD, Rogers W, Spritzer K (1995) Functioning and well-being outcomes of patients with depression compared with chronic general medical illnesses. Arch Gen Psychiatry 52(1):11–19CrossRefPubMed

Zurück zum Zitat Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basanez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabe E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fevre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Laden F, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Levinson D, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mock C, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O’Donnell M, O’Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA 3rd, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Leon FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiebe N, Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, AlMazroa MA, Memish ZA (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2197–2223. doi:10.1016/s0140-6736(12)61689-4 CrossRefPubMed Murray CJ, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V, Abraham J, Ackerman I, Aggarwal R, Ahn SY, Ali MK, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Bahalim AN, Barker-Collo S, Barrero LH, Bartels DH, Basanez MG, Baxter A, Bell ML, Benjamin EJ, Bennett D, Bernabe E, Bhalla K, Bhandari B, Bikbov B, Bin Abdulhak A, Birbeck G, Black JA, Blencowe H, Blore JD, Blyth F, Bolliger I, Bonaventure A, Boufous S, Bourne R, Boussinesq M, Braithwaite T, Brayne C, Bridgett L, Brooker S, Brooks P, Brugha TS, Bryan-Hancock C, Bucello C, Buchbinder R, Buckle G, Budke CM, Burch M, Burney P, Burstein R, Calabria B, Campbell B, Canter CE, Carabin H, Carapetis J, Carmona L, Cella C, Charlson F, Chen H, Cheng AT, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahiya M, Dahodwala N, Damsere-Derry J, Danaei G, Davis A, De Leo D, Degenhardt L, Dellavalle R, Delossantos A, Denenberg J, Derrett S, Des Jarlais DC, Dharmaratne SD, Dherani M, Diaz-Torne C, Dolk H, Dorsey ER, Driscoll T, Duber H, Ebel B, Edmond K, Elbaz A, Ali SE, Erskine H, Erwin PJ, Espindola P, Ewoigbokhan SE, Farzadfar F, Feigin V, Felson DT, Ferrari A, Ferri CP, Fevre EM, Finucane MM, Flaxman S, Flood L, Foreman K, Forouzanfar MH, Fowkes FG, Fransen M, Freeman MK, Gabbe BJ, Gabriel SE, Gakidou E, Ganatra HA, Garcia B, Gaspari F, Gillum RF, Gmel G, Gonzalez-Medina D, Gosselin R, Grainger R, Grant B, Groeger J, Guillemin F, Gunnell D, Gupta R, Haagsma J, Hagan H, Halasa YA, Hall W, Haring D, Haro JM, Harrison JE, Havmoeller R, Hay RJ, Higashi H, Hill C, Hoen B, Hoffman H, Hotez PJ, Hoy D, Huang JJ, Ibeanusi SE, Jacobsen KH, James SL, Jarvis D, Jasrasaria R, Jayaraman S, Johns N, Jonas JB, Karthikeyan G, Kassebaum N, Kawakami N, Keren A, Khoo JP, King CH, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Laden F, Lalloo R, Laslett LL, Lathlean T, Leasher JL, Lee YY, Leigh J, Levinson D, Lim SS, Limb E, Lin JK, Lipnick M, Lipshultz SE, Liu W, Loane M, Ohno SL, Lyons R, Mabweijano J, MacIntyre MF, Malekzadeh R, Mallinger L, Manivannan S, Marcenes W, March L, Margolis DJ, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGill N, McGrath J, Medina-Mora ME, Meltzer M, Mensah GA, Merriman TR, Meyer AC, Miglioli V, Miller M, Miller TR, Mitchell PB, Mock C, Mocumbi AO, Moffitt TE, Mokdad AA, Monasta L, Montico M, Moradi-Lakeh M, Moran A, Morawska L, Mori R, Murdoch ME, Mwaniki MK, Naidoo K, Nair MN, Naldi L, Narayan KM, Nelson PK, Nelson RG, Nevitt MC, Newton CR, Nolte S, Norman P, Norman R, O’Donnell M, O’Hanlon S, Olives C, Omer SB, Ortblad K, Osborne R, Ozgediz D, Page A, Pahari B, Pandian JD, Rivero AP, Patten SB, Pearce N, Padilla RP, Perez-Ruiz F, Perico N, Pesudovs K, Phillips D, Phillips MR, Pierce K, Pion S, Polanczyk GV, Polinder S, Pope CA 3rd, Popova S, Porrini E, Pourmalek F, Prince M, Pullan RL, Ramaiah KD, Ranganathan D, Razavi H, Regan M, Rehm JT, Rein DB, Remuzzi G, Richardson K, Rivara FP, Roberts T, Robinson C, De Leon FR, Ronfani L, Room R, Rosenfeld LC, Rushton L, Sacco RL, Saha S, Sampson U, Sanchez-Riera L, Sanman E, Schwebel DC, Scott JG, Segui-Gomez M, Shahraz S, Shepard DS, Shin H, Shivakoti R, Singh D, Singh GM, Singh JA, Singleton J, Sleet DA, Sliwa K, Smith E, Smith JL, Stapelberg NJ, Steer A, Steiner T, Stolk WA, Stovner LJ, Sudfeld C, Syed S, Tamburlini G, Tavakkoli M, Taylor HR, Taylor JA, Taylor WJ, Thomas B, Thomson WM, Thurston GD, Tleyjeh IM, Tonelli M, Towbin JA, Truelsen T, Tsilimbaris MK, Ubeda C, Undurraga EA, van der Werf MJ, van Os J, Vavilala MS, Venketasubramanian N, Wang M, Wang W, Watt K, Weatherall DJ, Weinstock MA, Weintraub R, Weisskopf MG, Weissman MM, White RA, Whiteford H, Wiebe N, Wiersma ST, Wilkinson JD, Williams HC, Williams SR, Witt E, Wolfe F, Woolf AD, Wulf S, Yeh PH, Zaidi AK, Zheng ZJ, Zonies D, Lopez AD, AlMazroa MA, Memish ZA (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2197–2223. doi:10.1016/s0140-6736(12)61689-4 CrossRefPubMed

Wharton W, Gleason CE, Olson SR, Carlsson CM, Asthana S (2012) Neurobiological underpinnings of the estrogen—mood relationship. Curr Psychiatry Rev 8(3):247–256. doi:10.2174/157340012800792957 PubMedCentralCrossRefPubMed

Soares CN, Zitek B (2008) Reproductive hormone sensitivity and risk for depression across the female life cycle: a continuum of vulnerability? J Psychiatry Neurosci JPN 33(4):331–343PubMed

Freeman EW (2010) Associations of depression with the transition to menopause. Menopause (New York, NY) 17(4):823–827. doi:10.1097/gme.0b013e3181db9f8b CrossRef

Senie R, Senie RT (2014) Epidemiology of women’s health. Jones & Bartlett Learning, Burlington, MA

Dennerstein L, Lehert P, Heinemann K (2012) Epidemiology of premenstrual symptoms and disorders. Menopause Int 18(2):48–51. doi:10.1258/mi.2012.012013 PubMed

Rapkin AJ, Mikacich JA (2013) Premenstrual dysphoric disorder and severe premenstrual syndrome in adolescents. Paediatr Drugs 15(3):191–202. doi:10.1007/s40272-013-0018-4 CrossRefPubMed

10.

Vesga-Lopez O, Blanco C, Keyes K, Olfson M, Grant BF, Hasin DS (2008) Psychiatric disorders in pregnant and postpartum women in the United States. Arch Gen Psychiatry 65(7):805–815. doi:10.1001/archpsyc.65.7.805 PubMedCentralCrossRefPubMed

11.

Graziottin A, Serafini A (2009) Depression and the menopause: why antidepressants are not enough? Menopause Int 15(2):76–81. doi:10.1258/mi.2009.009021 PubMed

12.

Keyes KM, Cheslack-Postava K, Westhoff C, Heim CM, Haloossim M, Walsh K, Koenen K (2013) Association of hormonal contraceptive use with reduced levels of depressive symptoms: a national study of sexually active women in the United States. Am J Epidemiol 178(9):1378–1388. doi:10.1093/aje/kwt188 PubMedCentralCrossRefPubMed

13.

Ryan J, Carriere I, Scali J, Ritchie K, Ancelin ML (2008) Lifetime hormonal factors may predict late-life depression in women. Int Psychogeriatr IPA 20(6):1203–1218. doi:10.1017/s1041610208007412 CrossRef

14.

Brooks-Gunn J, Warren MP (1989) Biological and social contributions to negative affect in young adolescent girls. Child Dev 60(1):40–55CrossRefPubMed

15.

Hayward C, Gotlib IH, Schraedley PK, Litt IF (1999) Ethnic differences in the association between pubertal status and symptoms of depression in adolescent girls. J Adolesc Health Off Publ Soc Adolesc Med 25(2):143–149CrossRef

16.

Davey Smith G, Ebrahim S (2005) What can mendelian randomisation tell us about modifiable behavioural and environmental exposures? BMJ 330(7499):1076–1079. doi:10.1136/bmj.330.7499.1076 PubMedCentralCrossRefPubMed

17.

Smith GD (2010) Mendelian randomization for strengthening causal inference in observational studies: application to gene × environment interactions. Perspect Psychol Sci 5(5):527–545. doi:10.1177/1745691610383505 CrossRefPubMed

18.

Dey P, Barros RP, Warner M, Strom A, Gustafsson JA (2013) Insight into the mechanisms of action of estrogen receptor beta. J Mol Endocrinol. doi:10.1530/jme-13-0150 PubMed

19.

Guo H, Ming J, Liu C, Li Z, Zhang N, Cheng H, Wang W, Shi W, Shen N, Zhao Q, Li D, Yi P, Wang L, Wang R, Xin Y, Zhao X, Nie X, Huang T (2012) A common polymorphism near the ESR1 gene is associated with risk of breast cancer: evidence from a case–control study and a meta-analysis. PLoS One 7(12):e52445. doi:10.1371/journal.pone.0052445 PubMedCentralCrossRefPubMed

20.

Lipphardt MF, Deryal M, Ong MF, Schmidt W, Mahlknecht U (2013) ESR1 single nucleotide polymorphisms predict breast cancer susceptibility in the central European Caucasian population. Int J Clin Exp Med 6(4):282–288PubMedCentralPubMed

21.

Demissie S, Cupples LA, Shearman AM, Gruenthal KM, Peter I, Schmid CH, Karas RH, Housman DE, Mendelsohn ME, Ordovas JM (2006) Estrogen receptor-α variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study. Atherosclerosis 185(1):210–218. doi:10.1016/j.atherosclerosis.2005.06.008 CrossRefPubMed

22.

Ryan J, Canonico M, Carcaillon L, Carriere I, Scali J, Dartigues JF, Dufouil C, Ritchie K, Scarabin PY, Ancelin ML (2012) Hormone treatment, estrogen receptor polymorphisms and mortality: a prospective cohort study. PLoS One 7(3):e34112. doi:10.1371/journal.pone.0034112 PubMedCentralCrossRefPubMed

23.

Ryan J, Ancelin ML (2012) Polymorphisms of estrogen receptors and risk of depression: therapeutic implications. Drugs 72(13):1725–1738. doi:10.2165/11635960-000000000-00000 CrossRefPubMed

24.

Yalamanchili V, Gallagher JC (2012) Treatment with hormone therapy and calcitriol did not affect depression in older postmenopausal women: no interaction with estrogen and vitamin D receptor genotype polymorphisms. Menopause (New York, NY) 19(6):697–703. doi:10.1097/gme.0b013e31823bcec5 CrossRef

25.

Malacara JM, Perez-Luque EL, Martinez-Garza S, Sanchez-Marin FJ (2004) The relationship of estrogen receptor-alpha polymorphism with symptoms and other characteristics in post-menopausal women. Maturitas 49(2):163–169. doi:10.1016/j.maturitas.2004.01.002 CrossRefPubMed

26.

Comings DE, Muhleman D, Johnson P, MacMurray JP (1999) Potential role of the estrogen receptor gene (ESR1) in anxiety. Mol Psychiatry 4(4):374–377CrossRefPubMed

27.

Tiemeier H, Schuit SC, den Heijer T, van Meurs JB, van Tuijl HR, Hofman A, Breteler MM, Pols HA, Uitterlinden AG (2005) Estrogen receptor alpha gene polymorphisms and anxiety disorder in an elderly population. Mol Psychiatry 10(9):806–807. doi:10.1038/sj.mp.4001697 CrossRefPubMed

28.

Kishi T, Ikeda M, Kitajima T, Yamanouchi Y, Kinoshita Y, Kawashima K, Okochi T, Okumura T, Tsunoka T, Inada T, Ozaki N, Iwata N (2009) Association analysis of functional polymorphism in estrogen receptor alpha gene with schizophrenia and mood disorders in the Japanese population. Psychiatr Genet 19(4):217–218. doi:10.1097/YPG.0b013e32832cee98 CrossRefPubMed

29.

Mill J, Kiss E, Baji I, Kapornai K, Daroczy G, Vetro A, Kennedy J, Kovacs M, Barr C (2008) Association study of the estrogen receptor alpha gene (ESR1) and childhood-onset mood disorders. Am J Med Genet Part B Neuropsychiatr Genet Off Publ Int Soc Psychiatr Genet 147B(7):1323–1326. doi:10.1002/ajmg.b.30751 CrossRef

30.

Ryan J, Scali J, Carriere I, Peres K, Rouaud O, Scarabin PY, Ritchie K, Ancelin ML (2011) Oestrogen receptor polymorphisms and late-life depression. Br J Psychiatry J Mental Sci 199(2):126–131. doi:10.1192/bjp.bp.111.091751 CrossRef

31.

Kim JJ, Pae CU, Kim MR, Min JA, Kim KH, Lee CU, Lee C, Paik IH (2010) Association between estrogen receptor gene polymorphisms and depression in post-menopausal women: a preliminary study. Psychiatry Investig 7(3):224–227. doi:10.4306/pi.2010.7.3.224 PubMedCentralCrossRefPubMed

32.

Vermeersch H, T’Sjoen G, Kaufman JM, Van Houtte M (2013) ESR1 polymorphisms, daily hassles, anger expression, and depressive symptoms in adolescent boys and girls. Horm Behav 63(3):447–453. doi:10.1016/j.yhbeh.2012.11.017 CrossRefPubMed

33.

Fortier E, Noreau A, Lepore F, Boivin M, Perusse D, Rouleau GA, Beauregard M (2011) Early influence of the rs4675690 on the neural substrates of sadness. J Affect Disord 135(1–3):336–340. doi:10.1016/j.jad.2011.06.039 CrossRefPubMed

34.

Soares CN, Almeida OP, Joffe H, Cohen LS (2001) Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial. Arch Gen Psychiatry 58(6):529–534CrossRefPubMed

35.

Liukkonen T, Vanhala M, Jokelainen J, Keinänen-Kiukaanniemi S, Koponen H, Timonen M (2010) Effect of menopause and use of contraceptives/hormone therapy on association of C-reactive protein and depression: a population-based study. J Psychosom Res 68(6):573–579. doi:10.1016/j.jpsychores.2009.11.003 CrossRefPubMed

36.

Ryan J, Scali J, Carriere I, Scarabin PY, Ritchie K, Ancelin ML (2011) Estrogen receptor gene variants are associated with anxiety disorders in older women. Psychoneuroendocrinology 36(10):1582–1586. doi:10.1016/j.psyneuen.2011.04.011 CrossRefPubMed

37.

Kroenke K, Spitzer RL, Williams JB (2001) The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med 16(9):606–613PubMedCentralCrossRefPubMed

38.

Walter S, Glymour MM, Koenen K, Liang L, Tchetgen Tchetgen EJ, Cornelis M, Chang SC, Rewak M, Rimm E, Kawachi I, Kubzansky LD (2015) Do genetic risk scores for body mass index predict risk of phobic anxiety? Evidence for a shared genetic risk factor. Psychol Med 45(1):181–191. doi:10.1017/S0033291714001226 CrossRefPubMed

39.

Westberg L, Eriksson E (2008) Sex steroid-related candidate genes in psychiatric disorders. J Psychiatry Neurosci JPN 33(4):319–330PubMed

40.

Ryan J, Scali J, Carriere I, Peres K, Rouaud O, Scarabin PY, Ritchie K, Ancelin ML (2012) Estrogen receptor alpha gene variants and major depressive episodes. J Affect Disord 136(3):1222–1226. doi:10.1016/j.jad.2011.10.010 CrossRefPubMed

41.

Tsai SJ, Wang YC, Hong CJ, Chiu HJ (2003) Association study of oestrogen receptor alpha gene polymorphism and suicidal behaviours in major depressive disorder. Psychiatr Genet 13(1):19–22. doi:10.1097/01.ypg.0000051091.88669.17 CrossRefPubMed

42.

Hlatky MA, Boothroyd D, Vittinghoff E, Sharp P, Whooley MA, for the HRG (2002) Quality-of-life and depressive symptoms in postmenopausal women after receiving hormone therapy: results from the heart and estrogen/progestin replacement study (hers) trial. JAMA J Am Med Assoc 287(5):591–597. doi:10.1001/jama.287.5.591 CrossRef

43.

Resnick SM, Maki PM, Rapp SR, Espeland MA, Brunner R, Coker LH, Granek IA, Hogan P, Ockene JK, Shumaker SA (2006) Effects of combination estrogen plus progestin hormone treatment on cognition and affect. J Clin Endocrinol Metab 91(5):1802–1810. doi:10.1210/jc.2005-2097 CrossRefPubMed

44.

Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, Kotchen JM, Ockene J (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women’s Health Initiative randomized controlled trial. JAMA J Am Med Assoc 288(3):321–333CrossRef

45.

Shumaker SA, Legault C, Kuller L, Rapp SR, Thal L, Lane DS, Fillit H, Stefanick ML, Hendrix SL, Lewis CE, Masaki K, Coker LH (2004) Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: women’s Health Initiative Memory Study. JAMA J Am Med Assoc 291(24):2947–2958. doi:10.1001/jama.291.24.2947 CrossRef

46.

McIntyre RS, Konarski JZ, Grigoriadis S, Fan NC, Mancini DA, Fulton KA, Stewart DE, Kennedy SH (2005) Hormone replacement therapy and antidepressant prescription patterns: a reciprocal relationship. CMAJ 172(1):57–59. doi:10.1503/cmaj.1040517 PubMedCentralCrossRefPubMed

47.

Reynolds RF, Walker AM, Obermeyer CM, Rahman O, Guilbert D (2001) Discontinuation of postmenopausal hormone therapy in a Massachusetts HMO. J Clin Epidemiol 54(10):1056–1064CrossRefPubMed

48.

Phan KL, Wager T, Taylor SF, Liberzon I (2002) Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. NeuroImage 16(2):331–348. doi:10.1006/nimg.2002.1087 CrossRefPubMed

49.

Osterlund MK (2010) Underlying mechanisms mediating the antidepressant effects of estrogens. Biochim Biophys Acta 1800(10):1136–1144. doi:10.1016/j.bbagen.2009.11.001 CrossRefPubMed

50.

Rocha BA, Fleischer R, Schaeffer JM, Rohrer SP, Hickey GJ (2005) 17 Beta-estradiol-induced antidepressant-like effect in the forced swim test is absent in estrogen receptor-beta knockout (BERKO) mice. Psychopharmacology 179(3):637–643. doi:10.1007/s00213-004-2078-1 CrossRefPubMed

51.

Dey P, Barros RP, Warner M, Strom A, Gustafsson JA (2013) Insight into the mechanisms of action of estrogen receptor beta in the breast, prostate, colon, and CNS. J Mol Endocrinol 51(3):T61–T74. doi:10.1530/jme-13-0150 CrossRefPubMed

52.

Schuit SC, de Jong FH, Stolk L, Koek WN, van Meurs JB, Schoofs MW, Zillikens MC, Hofman A, van Leeuwen JP, Pols HA, Uitterlinden AG (2005) Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women. Eur J Endocrinol Eur Fed Endocr Soc 153(2):327–334. doi:10.1530/eje.1.01973 CrossRef

53.

Sowers MR, Jannausch ML, McConnell DS, Kardia SR, Randolph JF Jr (2006) Endogenous estradiol and its association with estrogen receptor gene polymorphisms. Am J Med 119(9 Suppl 1):S16–S22. doi:10.1016/j.amjmed.2006.07.002 CrossRefPubMed

54.

Yaffe K, Lui LY, Grady D, Stone K, Morin P (2002) Estrogen receptor 1 polymorphisms and risk of cognitive impairment in older women. Biol Psychiatry 51(8):677–682CrossRefPubMed

55.

Colditz GA, Hankinson SE (2005) The nurses’ health study: lifestyle and health among women. Nat Rev Cancer 5(5):388–396. doi:10.1038/nrc1608 CrossRefPubMed

56.

Wolf AM, Hunter DJ, Colditz GA, Manson JE, Stampfer MJ, Corsano KA, Rosner B, Kriska A, Willett WC (1994) Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol 23(5):991–999CrossRefPubMed

Titel: The role of allelic variation in estrogen receptor genes and major depression in the Nurses Health Study
verfasst von: K. Keyes
J. Agnew-Blais
A. L. Roberts
A. Hamilton
I. De Vivo
H. Ranu
K. Koenen
Publikationsdatum: 01.12.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Social Psychiatry and Psychiatric Epidemiology / Ausgabe 12/2015
Print ISSN: 0933-7954
Elektronische ISSN: 1433-9285
DOI: https://doi.org/10.1007/s00127-015-1087-1

Neu im Fachgebiet Psychiatrie

Demenzkranke durch Antipsychotika vielfach gefährdet

23.04.2024 Demenz Nachrichten

Wenn Demenzkranke aufgrund von Symptomen wie Agitation oder Aggressivität mit Antipsychotika behandelt werden, sind damit offenbar noch mehr Risiken verbunden als bislang angenommen.

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

23.04.2024 Depression antepartal oder postpartal Nachrichten

Bislang gibt es kein Medikament zur Prävention von Wochenbettdepressionen. Das Injektionsanästhetikum Esketamin könnte womöglich diese Lücke füllen.

„Psychotherapie ist auch bei sehr alten Menschen hochwirksam!“

22.04.2024 DGIM 2024 Kongressbericht

Die Kombination aus Medikamenten und Psychotherapie gilt als effektivster Ansatz bei Depressionen. Das ist bei betagten Menschen nicht anders, trotz Besonderheiten.

Auf diese Krankheiten bei Geflüchteten sollten Sie vorbereitet sein

22.04.2024 DGIM 2024 Nachrichten

Um Menschen nach der Flucht aus einem Krisengebiet bestmöglich medizinisch betreuen zu können, ist es gut zu wissen, welche Erkrankungen im jeweiligen Herkunftsland häufig sind. Dabei hilft eine Internetseite der CDC (Centers for Disease Control and Prevention).

Update Psychiatrie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2015

One-year incidence and prevalence of seclusion: Dutch findings in an international perspective

Study of resilience and environmental adversity in midlife health (STREAM)

Mother–infant interaction in schizophrenia: transmitting risk or resilience? A systematic review of the literature

‘Post-deployment appraisal’ and the relationship with stress and psychological health in Australian veterans