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01.08.2010 | Commentary | Ausgabe 4/2010

Critical Care 4/2010

The role of inflammation in ICU-acquired weakness

Critical Care > Ausgabe 4/2010
Chris Winkelman
Wichtige Hinweise

Competing interests

CW has received research and travel funding from Hill-Rom. 2007-2009.


A pilot observational study by Weber-Carstens and colleagues contributes to a mechanistic explanation of the puzzling and complex phenomena of ICU-acquired weakness (ICU-AW). The authors suggest systemic, inflammatory-mediated pathology is the most significant risk factor for ICU-AW. While this finding is somewhat equivocal, it provides important direction for future investigations and illustrates the challenges of interpreting significance in small observational studies.

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