nach oben

Cellular Oncology

Erschienen in:

02.03.2023 | Review

The role of pyroptosis in hepatocellular carcinoma

verfasst von: Zhimiao Zou, Minghui Zhao, Yang Yang, Yalong Xie, Zeyang Li, Liang Zhou, Runshi Shang, Ping Zhou

Erschienen in: Cellular Oncology | Ausgabe 4/2023

Einloggen, um Zugang zu erhalten

Abstract

Hepatocellular carcinoma (HCC) is the main histologic type of liver cancer. It accounts for the majority of all diagnoses and deaths due to liver cancer. The induction of tumor cell death is an effective strategy to control tumor development. Pyroptosis is an inflammatory programmed cell death caused by microbial infection, accompanied by activation of inflammasomes and release of pro-inflammatory cytokines, interleukin-1β (IL-1β), and interleukin-18 (IL-18). The cleavage of gasdermins (GSDMs) promotes the occurrence of pyroptosis leading to cell swelling, lysis, and death. Accumulating evidence has indicated that pyroptosis influences the progression of HCC by regulating immune-mediated tumor cell death. Currently, some researchers hold the view that inhibition of pyroptosis-related components may prevent the incidence of HCC, but more researchers have the view that activation of pyroptosis exerts a tumor-inhibitory effect. Growing evidence indicates that pyroptosis can prevent or promote tumor development depending on the type of tumor. In this review, pyroptosis pathways and pyroptosis-related components were discussed. Next, the role of pyroptosis and its components in HCC was described. Finally, the therapeutic significance of pyroptosis in HCC was discussed.

A. Vogel, T. Meyer, G. Sapisochin, R. Salem, A. Saborowski, Lancet 400, 1345–1362 (2022). https://doi.org/10.1016/S0140-6736(22)01200-4CrossRefPubMed

H. Sung, J. Ferlay, R.L. Siegel, M. Laversanne, I. Soerjomataram, A. Jemal, F. Bray, CA Cancer J Clin 71, 209–249 (2021). https://doi.org/10.3322/caac.21660CrossRefPubMed

C.H. Zhang, Y. Cheng, S. Zhang, J. Fan, Q. Gao, Liver Int. 42, 2029–2041 (2022). https://doi.org/10.1111/liv.15251CrossRefPubMed

T. Torimura, H. Iwamoto, Liver Int. 42, 2042–2054 (2022). https://doi.org/10.1111/liv.15130CrossRefPubMed

H.C. Sun, J. Zhou, Z. Wang, X. Liu, Q. Xie, W. Jia, M. Zhao, X. Bi, G. Li, X. Bai, Y. Ji, L. Xu, X.D. Zhu, D. Bai, Y. Chen, Y. Chen, C. Dai, R. Guo, W. Guo, C. Hao, T. Huang, Z. Huang, D. Li, G. Li, T. Li, X. Li, G. Li, X. Liang, J. Liu, F. Liu, S. Lu, Z. Lu, W. Lv, Y. Mao, G. Shao, Y. Shi, T. Song, G. Tan, Y. Tang, K. Tao, C. Wan, G. Wang, L. Wang, S. Wang, T. Wen, B. Xing, B. Xiang, S. Yan, D. Yang, G. Yin, T. Yin, Z. Yin, Z. Yu, B. Zhang, J. Zhang, S. Zhang, T. Zhang, Y. Zhang, Y. Zhang, A. Zhang, H. Zhao, L. Zhou, W. Zhang, Z. Zhu, S. Qin, F. Shen, X. Cai, G. Teng, J. Cai, M. Chen, Q. Li, L. Liu, W. Wang, T. Liang, J. Dong, X. Chen, X. Wang, S. Zheng, J. Fan and C.o.L.C. o.t.C.A-C.A. Alliance of liver cancer conversion therapy. Hepatobiliary Surg. Nutr. 11, 227–252 (2022). https://doi.org/10.21037/hbsn-21-328

C. Yang, H. Zhang, L. Zhang, A.X. Zhu, R. Bernards, W. Qin, C. Wang, Nat. Rev. Gastroenterol. Hepatol. (2022). https://doi.org/10.1038/s41575-022-00704-9CrossRefPubMedPubMedCentral

J.M. Llovet, R. Pinyol, R.K. Kelley, A. El-Khoueiry, H.L. Reeves, X.W. Wang, G.J. Gores, A. Villanueva, Nat. Cancer 3, 386–401 (2022). https://doi.org/10.1038/s43018-022-00357-2CrossRefPubMedPubMedCentral

Y. Chen, H.N. Chen, K. Wang, L. Zhang, Z. Huang, J. Liu, Z. Zhang, M. Luo, Y. Lei, Y. Peng, Z.G. Zhou, Y. Wei, C. Huang, J. Hepatol. 70, 66–77 (2019). https://doi.org/10.1016/j.jhep.2018.09.022CrossRefPubMed

C. Lu, D. Rong, B. Zhang, W. Zheng, X. Wang, Z. Chen, W. Tang, Mol. Cancer. 18, (2019). https://doi.org/10.1186/s12943-019-1047-6

10.

Q. Xu, J. Tu, C. Dou, J. Zhang, L. Yang, X. Liu, K. Lei, Z. Liu, Y. Wang, L. Li, H. Bao, J. Wang, K. Tu, Mol. Cancer 16, 178 (2017). https://doi.org/10.1186/s12943-017-0748-yCrossRefPubMedPubMedCentral

11.

X. Wei, F. Xie, X. Zhou, Y. Wu, H. Yan, T. Liu, J. Huang, F. Wang, F. Zhou, L. Zhang, Cell. Mol. Immunol. 19, 971–992 (2022). https://doi.org/10.1038/s41423-022-00905-xCrossRefPubMedPubMedCentral

12.

Y. Zhao, Q. Song, F. Xu, Y. Zhou, X. Zuo, Z. Zhang, Front. Genet. 13, 823443 (2022). https://doi.org/10.3389/fgene.2022.823443CrossRefPubMedPubMedCentral

13.

J. Shi, Y. Zhao, K. Wang, X. Shi, Y. Wang, H. Huang, Y. Zhuang, T. Cai, F. Wang, F. Shao, Nature 526, 660–665 (2015). https://doi.org/10.1038/nature15514CrossRefPubMed

14.

K. Wang, Q. Sun, X. Zhong, M. Zeng, H. Zeng, X. Shi, Z. Li, Y. Wang, Q. Zhao, F. Shao, J. Ding, Cell. 180, 941–955 e920 (2020). https://doi.org/10.1016/j.cell.2020.02.002

15.

M.A. Brennan, B.T. Cookson, Mol. Microbiol. 38, 31–40 (2000). https://doi.org/10.1046/j.1365-2958.2000.02103.xCrossRefPubMed

16.

B.T. Cookson, M.A. Brennan, Trends Microbiol. 9, 113–114 (2001). https://doi.org/10.1016/s0966-842x(00)01936-3CrossRefPubMed

17.

D.R. Green, Cell 177, 1094–1107 (2019). https://doi.org/10.1016/j.cell.2019.04.024CrossRefPubMedPubMedCentral

18.

H. Shi, Y. Gao, Z. Dong, J. Yang, R. Gao, X. Li, S. Zhang, L. Ma, X. Sun, Z. Wang, F. Zhang, K. Hu, A. Sun, J. Ge, Circ. Res. 129, 383–396 (2021). https://doi.org/10.1161/CIRCRESAHA.120.318629CrossRefPubMedPubMedCentral

19.

C. Aluganti Narasimhulu, D.K. Singla, J. Cachexia Sarcopeni. 12, 403–420 (2021). https://doi.org/10.1002/jcsm.12662CrossRefPubMedPubMedCentral

20.

E.H. Koh, J.E. Yoon, M.S. Ko, J. Leem, J.Y. Yun, C.H. Hong, Y.K. Cho, S.E. Lee, J.E. Jang, J.Y. Baek, H.J. Yoo, S.J. Kim, C.O. Sung, J.S. Lim, W.I. Jeong, S.H. Back, I.J. Baek, S. Torres, E. Solsona-Vilarrasa,. A.E. Garcia-Ruiz, J.C. Feldstein, Fernandez-Checa, K.U. Lee, L. Conde de la Rosa, C. Gut 70, 1954–1964 (2021). https://doi.org/10.1136/gutjnl-2020-322509CrossRefPubMed

21.

X. Ma, J. Hao, J. Wu, Y. Li, X. Cai, Y. Zheng, Adv. Mater. e2106723 (2022). https://doi.org/10.1002/adma.202106723

22.

L. Li, M. Jiang, L. Qi, Y. Wu, D. Song, J. Gan, Y. Li, Y. Bai, Cancer Sci. 112, 3979–3994 (2021). https://doi.org/10.1111/cas.15059CrossRefPubMedPubMedCentral

23.

D.C. Johnson, C.Y. Taabazuing, M.C. Okondo, A.J. Chui, S.D. Rao, F.C. Brown, C. Reed, E. Peguero, E. de Stanchina, A. Kentsis, D.A. Bachovchin, Nat. Med. 24, 1151–1156 (2018). https://doi.org/10.1038/s41591-018-0082-yCrossRefPubMedPubMedCentral

24.

B. Xie, T. Liu, S. Chen, Y. Zhang, D. He, Q. Shao, Z. Zhang, C. Wang, Nanoscale 13, 18608–18615 (2021). https://doi.org/10.1039/d1nr05001jCrossRefPubMed

25.

Y. Yang, P.Y. Liu, W. Bao, S.J. Chen, F.S. Wu, P.Y. Zhu, BMC Cancer 20, 28 (2020). https://doi.org/10.1186/s12885-019-6491-6CrossRefPubMedPubMedCentral

26.

A. Zychlinsky, M.C. Prevost, P.J. Sansonetti, Nature 358, 167–169 (1992). https://doi.org/10.1038/358167a0CrossRefPubMed

27.

C.A. D’Souza, J. Heitman, Trends Microbiol. 9, 112–113 (2001). https://doi.org/10.1016/s0966-842x(00)01945-4CrossRefPubMed

28.

L. Xiaodong, X. Xuejun, Int. Ophthalmol. (2022). https://doi.org/10.1007/s10792-022-02506-zCrossRefPubMed

29.

N.M. de Vasconcelos, N. Van Opdenbosch, H. Van Gorp, E. Parthoens, M. Lamkanfi, Cell. Death Differ. 26, 146–161 (2019). https://doi.org/10.1038/s41418-018-0106-7CrossRefPubMed

30.

R.A. Aglietti, A. Estevez, A. Gupta, M.G. Ramirez, P.S. Liu, N. Kayagaki, C. Ciferri, V.M. Dixit, E.C. Dueber, Proc. Natl. Acad. Sci. U S A 113, 7858–7863 (2016). https://doi.org/10.1073/pnas.1607769113CrossRefPubMedPubMedCentral

31.

J. Shi, Y. Zhao, Y. Wang, W. Gao, J. Ding, P. Li, L. Hu, F. Shao, Nature 514, 187–192 (2014). https://doi.org/10.1038/nature13683CrossRefPubMed

32.

S.B. Kovacs, E.A. Miao, Trends Cell. Biol. 27, 673–684 (2017). https://doi.org/10.1016/j.tcb.2017.05.005CrossRefPubMedPubMedCentral

33.

Z. Rao, Y. Zhu, P. Yang, Z. Chen, Y. Xia, C. Qiao, W. Liu, H. Deng, J. Li, P. Ning, Z. Wang, Theranostics. 12, 4310–4329 (2022). https://doi.org/10.7150/thno.71086

34.

X. Xia, X. Wang, Z. Cheng, W. Qin, L. Lei, J. Jiang, J. Hu, Cell. Death Dis. 10, 650 (2019). https://doi.org/10.1038/s41419-019-1883-8CrossRefPubMedPubMedCentral

35.

D. Frank, J.E. Vince, Cell. Death Differ. 26, 99–114 (2019). https://doi.org/10.1038/s41418-018-0212-6CrossRefPubMed

36.

V.I. Maltez, A.L. Tubbs, K.D. Cook, Y. Aachoui, E.L. Falcone, S.M. Holland, J.K. Whitmire, E.A. Miao, Immunity 43, 987–997 (2015). https://doi.org/10.1016/j.immuni.2015.10.010CrossRefPubMedPubMedCentral

37.

S.M. Man, R. Karki, T.D. Kanneganti, Immunol. Rev. 277, 61–75 (2017). https://doi.org/10.1111/imr.12534CrossRefPubMedPubMedCentral

38.

T. Strowig, J. Henao-Mejia, E. Elinav, R. Flavell, Nature 481, 278–286 (2012). https://doi.org/10.1038/nature10759CrossRefPubMed

39.

A. Liston, S.L. Masters, Nat. Rev. Immunol. 17, 208–214 (2017). https://doi.org/10.1038/nri.2016.151CrossRefPubMed

40.

M. Lamkanfi, V.M. Dixit, Cell 157, 1013–1022 (2014). https://doi.org/10.1016/j.cell.2014.04.007CrossRefPubMed

41.

D.E. Place, T.D. Kanneganti, Curr. Opin. Immunol. 50, 32–38 (2018). https://doi.org/10.1016/j.coi.2017.10.011CrossRefPubMed

42.

T. Bergsbaken, S.L. Fink, B.T. Cookson, Nat. Rev. Microbiol. 7, 99–109 (2009). https://doi.org/10.1038/nrmicro2070CrossRefPubMedPubMedCentral

43.

E.A. Miao, I.A. Leaf, P.M. Treuting, D.P. Mao, M. Dors, A. Sarkar, S.E. Warren, M.D. Wewers, A. Aderem, Nat. Immunol. 11, 1136–1142 (2010). https://doi.org/10.1038/ni.1960CrossRefPubMedPubMedCentral

44.

T. Fernandes-Alnemri, J.W. Yu, P. Datta, J. Wu, E.S. Alnemri, Nature 458, 509–513 (2009). https://doi.org/10.1038/nature07710CrossRefPubMedPubMedCentral

45.

F. Martinon, V. Petrilli, A. Mayor, A. Tardivel, J. Tschopp, Nature 440, 237–241 (2006). https://doi.org/10.1038/nature04516CrossRefPubMed

46.

X. Chen, W.T. He, L. Hu, J. Li, Y. Fang, X. Wang, X. Xu, Z. Wang, K. Huang, J. Han, Cell. Res. 26, 1007–1020 (2016). https://doi.org/10.1038/cr.2016.100CrossRefPubMedPubMedCentral

47.

S. Nystrom, D.J. Antoine, P. Lundback, J.G. Lock, A.F. Nita, K. Hogstrand, A. Grandien, H. Erlandsson-Harris, U. Andersson, S.E. Applequist, EMBO J. 32, 86–99 (2013). https://doi.org/10.1038/emboj.2012.328CrossRefPubMed

48.

V.A. Rathinam, K.A. Fitzgerald, Cell 165, 792–800 (2016). https://doi.org/10.1016/j.cell.2016.03.046CrossRefPubMedPubMedCentral

49.

J. von Moltke, J.S. Ayres, E.M. Kofoed, J. Chavarria-Smith, R.E. Vance, Annu. Rev. Immunol. 31, 73–106 (2013). https://doi.org/10.1146/annurev-immunol-032712-095944CrossRef

50.

J.A. Duncan, S.W. Canna, Immunol. Rev. 281, 115–123 (2018). https://doi.org/10.1111/imr.12607CrossRefPubMedPubMedCentral

51.

P.M. Ridker, B.M. Everett, T. Thuren, J.G. MacFadyen, W.H. Chang, C. Ballantyne, F. Fonseca, J. Nicolau, W. Koenig, S.D. Anker, J.J.P. Kastelein, J.H. Cornel, P. Pais, D. Pella, J. Genest, R. Cifkova, A. Lorenzatti, T. Forster, Z. Kobalava, L. Vida-Simiti, M. Flather, H. Shimokawa, H. Ogawa, M. Dellborg, P.R.F. Rossi, R.P.T. Troquay, P. Libby, R.J. Glynn, C.T. Group, N. Engl. J. Med. 377, 1119–1131 (2017). https://doi.org/10.1056/NEJMoa1707914CrossRefPubMed

52.

F. Martinon, K. Burns, J. Tschopp, Mol. Cell. 10, 417–426 (2002). https://doi.org/10.1016/s1097-2765(02)00599-3CrossRefPubMed

53.

J. Chavarria-Smith, R.E. Vance, Immunol. Rev. 265, 22–34 (2015). https://doi.org/10.1111/imr.12283CrossRefPubMed

54.

S. Bauernfried, M.J. Scherr, A. Pichlmair, K.E. Duderstadt, V. Hornung, Science 371 (2021). https://doi.org/10.1126/science.abd0811

55.

K.V. Swanson, M. Deng, J.P. Ting, Nat. Rev. Immunol. 19, 477–489 (2019). https://doi.org/10.1038/s41577-019-0165-0CrossRefPubMedPubMedCentral

56.

E.A. Miao, D.P. Mao, N. Yudkovsky, R. Bonneau, C.G. Lorang, S.E. Warren, I.A. Leaf, A. Aderem, Proc. Natl. Acad. Sci. U S A 107, 3076–3080 (2010). https://doi.org/10.1073/pnas.0913087107CrossRefPubMedPubMedCentral

57.

J. Lugrin, F. Martinon, Immunol. Rev. 281, 99–114 (2018). https://doi.org/10.1111/imr.12618CrossRefPubMed

58.

S.M. Man, T.D. Kanneganti, Nat. Rev. Immunol. 16, 7–21 (2016). https://doi.org/10.1038/nri.2015.7CrossRefPubMed

59.

L. Luo, M. Liu, Y. Fan, J. Zhang, L. Liu, Y. Li, Q. Zhang, H. Xie, C. Jiang, J. Wu, X. Xiao, Y. Wu, J. Neuroinflammation 19, 141 (2022). https://doi.org/10.1186/s12974-022-02501-2CrossRefPubMedPubMedCentral

60.

X. Jin, X. Dong, Y. Sun, Z. Liu, L. Liu, H. Gu, Oxid Med Cell Longev 2022, 3711371 (2022). https://doi.org/10.1155/2022/3711371

61.

F.G. Bauernfeind, G. Horvath, A. Stutz, E.S. Alnemri, K. MacDonald, D. Speert, T. Fernandes-Alnemri, J. Wu, B.G. Monks, K.A. Fitzgerald, V. Hornung, E. Latz, J. Immunol. 183, 787–791 (2009). https://doi.org/10.4049/jimmunol.0901363CrossRefPubMed

62.

E.I. Elliott, F.S. Sutterwala, Immunol. Rev. 265, 35–52 (2015). https://doi.org/10.1111/imr.12286CrossRefPubMedPubMedCentral

63.

J. Ding, F. Shao, Cell 168, 544–544 e541 (2017). https://doi.org/10.1016/j.cell.2017.01.008

64.

N. Kayagaki, S. Warming, M. Lamkanfi, L. Vande Walle, S. Louie, J. Dong, K. Newton, Y. Qu, J. Liu, S. Heldens, J. Zhang, W.P. Lee, M. Roose-Girma, V.M. Dixit, Nature 479, 117–121 (2011). https://doi.org/10.1038/nature10558CrossRefPubMed

65.

N. Kayagaki, I.B. Stowe, B.L. Lee, K. O’Rourke, K. Anderson, S. Warming, T. Cuellar, B. Haley, M. Roose-Girma, Q.T. Phung, P.S. Liu, J.R. Lill, H. Li, J. Wu, S. Kummerfeld, J. Zhang, W.P. Lee, S.J. Snipas, G.S. Salvesen, L.X. Morris, L. Fitzgerald, Y. Zhang, E.M. Bertram, C.C. Goodnow, V.M. Dixit, Nature 526, 666–671 (2015). https://doi.org/10.1038/nature15541CrossRefPubMed

66.

H.M. Kim, Y.M. Kim, Immunity 49, 582–584 (2018). https://doi.org/10.1016/j.immuni.2018.09.021CrossRefPubMed

67.

S. Ruhl, P. Broz, Eur. J. Immunol. 45, 2927–2936 (2015). https://doi.org/10.1002/eji.201545772CrossRefPubMed

68.

Y. Wang, W. Gao, X. Shi, J. Ding, W. Liu, H. He, K. Wang, F. Shao, Nature 547, 99–103 (2017). https://doi.org/10.1038/nature22393CrossRefPubMed

69.

P. Orning, D. Weng, K. Starheim, D. Ratner, Z. Best, B. Lee, A. Brooks, S. Xia, H. Wu, M.A. Kelliher, S.B. Berger, P.J. Gough, J. Bertin, M.M. Proulx, J.D. Goguen, N. Kayagaki, K.A. Fitzgerald, E. Lien, Science 362, 1064–1069 (2018). https://doi.org/10.1126/science.aau2818CrossRefPubMedPubMedCentral

70.

J. Sarhan, B.C. Liu, H.I. Muendlein, P. Li, R. Nilson, A.Y. Tang, A. Rongvaux, S.C. Bunnell, F. Shao, D.R. Green, A. Poltorak, Proc. Natl. Acad. Sci. U S A 115, E10888–E10897 (2018). https://doi.org/10.1073/pnas.1809548115CrossRefPubMedPubMedCentral

71.

J. Hou, R. Zhao, W. Xia, C.W. Chang, Y. You, J.M. Hsu, L. Nie, Y. Chen, Y.C. Wang, C. Liu, W.J. Wang, Y. Wu, B. Ke, J.L. Hsu, K. Huang, Z. Ye, Y. Yang, X. Xia, Y. Li, C.W. Li, B. Shao, J.A. Tainer, M.C. Hung, Nat. Cell. Biol. 22, 1264–1275 (2020). https://doi.org/10.1038/s41556-020-0575-zCrossRefPubMedPubMedCentral

72.

Z. Zhou, H. He, K. Wang, X. Shi, Y. Wang, Y. Su, Y. Wang, D. Li, W. Liu, Y. Zhang, L. Shen, W. Han, L. Shen, J. Ding, F. Shao, Science 368, (2020). https://doi.org/10.1126/science.aaz7548

73.

Q. Chu, Y. Jiang, W. Zhang, C. Xu, W. Du, G. Tuguzbaeva, Y. Qin, A. Li, L. Zhang, G. Sun, Y. Cai, Q. Feng, G. Li, Y. Li, Z. Du, Y. Bai, B. Yang, Oncotarget 7, 84658–84665 (2016). https://doi.org/10.18632/oncotarget.12384CrossRefPubMedPubMedCentral

74.

D.L. Elion, M.E. Jacobson, D.J. Hicks, B. Rahman, V. Sanchez, P.I. Gonzales-Ericsson, O. Fedorova, A.M. Pyle, J.T. Wilson, R.S. Cook, Cancer Res. 78, 6183–6195 (2018). https://doi.org/10.1158/0008-5472.CAN-18-0730CrossRefPubMed

75.

M. Wu, Y. Wang, D. Yang, Y. Gong, F. Rao, R. Liu, D. Yeerken, J. Li, J. Fan, J. Chen, W. Zhang, Q. Zhan, EBioMedicine 63, 103041 (2021). https://doi.org/10.1016/j.ebiom.2020.103041

76.

X. Chen, H. Chen, H. Yao, K. Zhao, Y. Zhang, D. He, Y. Zhu, Y. Cheng, R. Liu, R. Xu, K. Cao, Oncogene 40, 6381–6393 (2021). https://doi.org/10.1038/s41388-021-02024-9CrossRefPubMed

77.

G. Tan, C. Huang, J. Chen, F. Zhi, J. Hematol. Oncol. 13, 149 (2020). https://doi.org/10.1186/s13045-020-00985-0CrossRefPubMedPubMedCentral

78.

A.E.E. El-Sisi, S.S. Sokar, A.M. Shebl, D.Z. Mohamed, S.E. Abu-Risha, Toxicol. Appl. Pharmacol. 410, 115340 (2021). https://doi.org/10.1016/j.taap.2020.115340CrossRefPubMed

79.

S.J. Kim, S.M. Lee, Free Radic. Biol. Med. 65, 997–1004 (2013). https://doi.org/10.1016/j.freeradbiomed.2013.08.178CrossRefPubMed

80.

J. Knorr, A. Wree, F. Tacke, A.E. Feldstein, Semin. Liver Dis. 40, 298–306 (2020). https://doi.org/10.1055/s-0040-1708540CrossRefPubMed

81.

Q. Wei, K. Mu, T. Li, Y. Zhang, Z. Yang, X. Jia, W. Zhao, W. Huai, P. Guo, L. Han, Lab. Invest. 94, 52–62 (2014). https://doi.org/10.1038/labinvest.2013.126CrossRefPubMed

82.

Q. Wei, P. Guo, K. Mu, Y. Zhang, W. Zhao, W. Huai, Y. Qiu, T. Li, X. Ma, Y. Liu, X. Chen, L. Han, Lab. Invest. 95, 804–816 (2015). https://doi.org/10.1038/labinvest.2015.63CrossRefPubMed

83.

Q. Wei, R. Zhu, J. Zhu, R. Zhao, M. Li, Oncol. Res. 27, 827–834 (2019). https://doi.org/10.3727/096504018X15462920753012CrossRefPubMedPubMedCentral

84.

Y. Zhang, H. Yang, M. Sun, T. He, Y. Liu, X. Yang, X. Shi, X. Liu, Pharmacol. Rep. 72, 1370–1382 (2020). https://doi.org/10.1007/s43440-020-00064-8CrossRefPubMed

85.

W. Chen, T. Wei, Y. Chen, L. Yang, X. Wu, Onco Targets Ther. 13, 12787–12796 (2020). https://doi.org/10.2147/OTT.S260793CrossRefPubMedPubMedCentral

86.

P. Li, Y. Liu, Q. He, Drug Des. Devel Ther. 14, 1609–1620 (2020). https://doi.org/10.2147/DDDT.S243383CrossRefPubMedPubMedCentral

87.

L. Zitvogel, O. Kepp, L. Galluzzi, G. Kroemer, Nat. Immunol. 13, 343–351 (2012). https://doi.org/10.1038/ni.2224CrossRefPubMed

88.

C. Brenner, L. Galluzzi, O. Kepp, G. Kroemer, J. Hepatol. 59, 583–594 (2013). https://doi.org/10.1016/j.jhep.2013.03.033CrossRefPubMed

89.

R.N. Winter, A. Kramer, A. Borkowski, N. Kyprianou, Cancer Res. 61, 1227–1232 (2001)PubMed

90.

B. Hu, E. Elinav, S. Huber, C.J. Booth, T. Strowig, C. Jin, S.C. Eisenbarth, R.A. Flavell, Proc. Natl. Acad. Sci. U S A 107, 21635–21640 (2010). https://doi.org/10.1073/pnas.1016814108CrossRefPubMedPubMedCentral

91.

W. Yan, Y. Chang, X. Liang, J.S. Cardinal, H. Huang, S.H. Thorne, S.P. Monga, D.A. Geller, M.T. Lotze, A. Tsung, Hepatology 55, 1863–1875 (2012). https://doi.org/10.1002/hep.25572CrossRefPubMed

92.

J. Li, Y. Zhang, R. Ruan, W. He, Y. Qian, Cell. Death Dis. 11, 961 (2020). https://doi.org/10.1038/s41419-020-03158-6CrossRefPubMedPubMedCentral

93.

T. Zhou, T. Wang, K. Zeng, R. Qin, Y. Jin, P. Chen, G. Ju, Gene 819, 146243 (2022). https://doi.org/10.1016/j.gene.2022.146243CrossRefPubMed

94.

S.I. Grivennikov, F.R. Greten, M. Karin, Cell 140, 883–899 (2010). https://doi.org/10.1016/j.cell.2010.01.025CrossRefPubMedPubMedCentral

95.

J.M. Henderson, M.S.W. Xiang, J.C. Huang, S. Wetzel, L. Jiang, J.H. Lai, W. Wu, J.G. Kench, W.W. Bachovchin, B. Roediger, G.W. McCaughan, H.E. Zhang, M.D. Gorrell, Cancers (Basel) 13, (2021). https://doi.org/10.3390/cancers13215495

96.

F. Sonohara, Y. Inokawa, M. Kanda, Y. Nishikawa, S. Yamada, T. Fujii, H. Sugimoto, Y. Kodera, S. Nomoto, Anticancer Res. 37, 293–300 (2017). https://doi.org/10.21873/anticanres.11320CrossRefPubMed

97.

X. Ma, P. Guo, Y. Qiu, K. Mu, L. Zhu, W. Zhao, T. Li, L. Han, Oncotarget 7, 36185–36197 (2016). https://doi.org/10.18632/oncotarget.9154CrossRefPubMedPubMedCentral

98.

X. Shi, L. Wang, L. Ren, J. Li, S. Li, Q. Cui, S. Li, Phytother Res. 33, 1413–1425 (2019). https://doi.org/10.1002/ptr.6332CrossRefPubMed

99.

S.L. Chen, L.L. Liu, S.X. Lu, R.Z. Luo, C.H. Wang, H. Wang, S.H. Cai, X. Yang, D. Xie, C.Z. Zhang, J.P. Yun, Mol. Oncol. 11, 1225–1240 (2017). https://doi.org/10.1002/1878-0261.12090CrossRefPubMedPubMedCentral

100.

C. Martinez-Cardona, B. Lozano-Ruiz, V. Bachiller, G. Peiro, F. Algaba-Chueca, I. Gomez-Hurtado, J. Such, P. Zapater, R. Frances, J.M. Gonzalez-Navajas, Int. J. Cancer 143, 2997–3007 (2018). https://doi.org/10.1002/ijc.31827CrossRefPubMed

101.

B. Lozano-Ruiz, J.M. Gonzalez-Navajas, Int. J. Mol. Sci. 21, (2020). https://doi.org/10.3390/ijms21186535

102.

W.T. He, H. Wan, L. Hu, P. Chen, X. Wang, Z. Huang, Z.H. Yang, C.Q. Zhong, J. Han, Cell. Res. 25, 1285–1298 (2015). https://doi.org/10.1038/cr.2015.139CrossRefPubMedPubMedCentral

103.

J. Ding, K. Wang, W. Liu, Y. She, Q. Sun, J. Shi, H. Sun, D.C. Wang, F. Shao, Nature 535, 111–116 (2016). https://doi.org/10.1038/nature18590CrossRefPubMed

104.

J. Lin, Chem. Biol. Interact. 345, 109551 (2021). https://doi.org/10.1016/j.cbi.2021.109551CrossRefPubMed

105.

L. Li, Y. Li, Y. Bai, Cancer Manag. Res. 12, 3033–3043 (2020). https://doi.org/10.2147/CMAR.S246948CrossRefPubMedPubMedCentral

106.

C. Shen, A. Pandey, S.M. Man, Cell. Res. 30, 463–464 (2020). https://doi.org/10.1038/s41422-020-0316-7CrossRefPubMedPubMedCentral

107.

K. Hu, Z. Xu, L. Yao, Y. Yan, L. Zhou, J. Li, Aging (Albany NY) 13, 24117–24135 (2021). https://doi.org/10.18632/aging.203669CrossRefPubMed

108.

Z. Zhang, Y. Zhang, S. Xia, Q. Kong, S. Li, X. Liu, C. Junqueira, K.F. Meza-Sosa, T.M.Y. Mok, J. Ansara, S. Sengupta, Y. Yao, H. Wu, J. Lieberman, Nature 579, 415–420 (2020). https://doi.org/10.1038/s41586-020-2071-9CrossRefPubMedPubMedCentral

109.

X. Zhang, P. Zhang, L. An, N. Sun, L. Peng, W. Tang, D. Ma, J. Chen, Acta Pharm. Sin. B 10, 1397–1413 (2020). https://doi.org/10.1016/j.apsb.2020.06.015CrossRefPubMedPubMedCentral

110.

S. Qiu, Y. Hu, S. Dong, Int. Immunopharmacol. 101, 108270 (2021). https://doi.org/10.1016/j.intimp.2021.108270CrossRefPubMed

111.

H. Morishita, N. Mizushima, Annu. Rev. Cell. Dev. Biol. 35, 453–475 (2019). https://doi.org/10.1146/annurev-cellbio-100818-125300CrossRefPubMed

112.

H. Xia, D.R. Green, W. Zou, Nat. Rev. Cancer 21, 281–297 (2021). https://doi.org/10.1038/s41568-021-00344-2CrossRefPubMedPubMedCentral

113.

J. Levy, W. Cacheux, M.A. Bara, A. L’Hermitte, P. Lepage, M. Fraudeau, C. Trentesaux, J. Lemarchand, A. Durand, A.M. Crain, C. Marchiol, G. Renault, F. Dumont, F. Letourneur, M. Delacre, A. Schmitt, B. Terris, C. Perret, M. Chamaillard, J.P. Couty, B. Romagnolo, Nat. Cell. Biol. 17, 1062–1073 (2015). https://doi.org/10.1038/ncb3206CrossRefPubMed

114.

A. Yang, G. Herter-Sprie, H. Zhang, E.Y. Lin, D. Biancur, X. Wang, J. Deng, J. Hai, S. Yang, K.K. Wong, A.C. Kimmelman, Cancer Discov 8, 276–287 (2018). https://doi.org/10.1158/2159-8290.CD-17-0952CrossRefPubMedPubMedCentral

115.

K. Yamamoto, A. Venida, J. Yano, D.E. Biancur, M. Kakiuchi, S. Gupta, A.S.W. Sohn, S. Mukhopadhyay, E.Y. Lin, S.J. Parker, R.S. Banh, J.A. Paulo, K.W. Wen, J. Debnath, G.E. Kim, J.D. Mancias, D.T. Fearon, R.M. Perera, A.C. Kimmelman, Nature 581, 100–105 (2020). https://doi.org/10.1038/s41586-020-2229-5CrossRefPubMedPubMedCentral

116.

W. Guo, W. Zhong, L. Hao, H. Dong, X. Sun, R. Yue, T. Li, Z. Zhou, Cell. Mol. Gastroenterol. Hepatol. 12, 1599–1615 (2021). https://doi.org/10.1016/j.jcmgh.2021.07.002CrossRefPubMedPubMedCentral

117.

J. Kim, E. Seki, Cell. Mol. Gastroenterol. Hepatol. 12, 1877–1878 (2021). https://doi.org/10.1016/j.jcmgh.2021.08.006CrossRefPubMedPubMedCentral

118.

X. Jin, J. Gao, R. Zheng, M. Yu, Y. Ren, T. Yan, Y. Huang, Y. Li, Cell. Death Dis. 11, 123 (2020). https://doi.org/10.1038/s41419-020-2293-7CrossRefPubMedPubMedCentral

119.

H.M. Ni, A. Bockus, N. Boggess, H. Jaeschke, W.X. Ding, Hepatology 55, 222–232 (2012). https://doi.org/10.1002/hep.24690CrossRefPubMed

120.

D. Sir, C. Liang, W.L. Chen, J.U. Jung, J.H. Ou, Autophagy 4, 830–831 (2008). https://doi.org/10.4161/auto.6566CrossRefPubMed

121.

D. Sir, Y. Tian, W.L. Chen, D.K. Ann, T.S. Yen, J.H. Ou, Proc. Natl. Acad. Sci. U S A 107, 4383–4388 (2010). https://doi.org/10.1073/pnas.0911373107CrossRefPubMedPubMedCentral

122.

S.Y. Wu, S.H. Lan, S.R. Wu, Y.C. Chiu, X.Z. Lin, I.J. Su, T.F. Tsai, C.J. Yen, T.H. Lu, F.W. Liang, C.Y. Li, H.J. Su, C.L. Su, H.S. Liu, Hepatology 68, 141–154 (2018). https://doi.org/10.1002/hep.29781CrossRefPubMed

123.

F. Huang, B.R. Wang, Y.G. Wang, World J. Gastroenterol. 24, 4643–4651 (2018). https://doi.org/10.3748/wjg.v24.i41.4643CrossRefPubMedPubMedCentral

124.

L. Poillet-Perez, X. Xie, L. Zhan, Y. Yang, D.W. Sharp, Z.S. Hu, X. Su, A. Maganti, C. Jiang, W. Lu, H. Zheng, M.W. Bosenberg, J.M. Mehnert, J.Y. Guo, E. Lattime, J.D. Rabinowitz, E. White, Nature 563, 569–573 (2018). https://doi.org/10.1038/s41586-018-0697-7CrossRefPubMedPubMedCentral

125.

W.P. Xu, J.P. Liu, J.F. Feng, C.P. Zhu, Y. Yang, W.P. Zhou, J. Ding, C.K. Huang, Y.L. Cui, C.H. Ding, X. Zhang, B. Lu, W.F. Xie, Gut 69, 1309–1321 (2020). https://doi.org/10.1136/gutjnl-2019-318830CrossRefPubMed

126.

Y.Y. Chen, Y.H. Lee, B.J. Wang, R.J. Chen, Y.J. Wang, Part. Fibre Toxicol. 19(2), (2022). https://doi.org/10.1186/s12989-021-00443-w

127.

M.Y. Jiang, Z.D. Han, W. Li, F. Yue, J. Ye, B. Li, Z. Cai, J.M. Lu, W. Dong, X. Jiang, W. Zhong, H. He, L. Liu, Oncotarget 8, 80295–80302 (2017). https://doi.org/10.18632/oncotarget.17927CrossRefPubMedPubMedCentral

128.

X. Zhu, S. Li, Q. Lin, X. Shao, J. Wu, W. Zhang, H. Cai, W. Zhou, N. Jiang, Z. Zhang, J. Shen, Q. Wang, Z. Ni, Pharmacol. Res. 167, 105531 (2021). https://doi.org/10.1016/j.phrs.2021.105531CrossRefPubMed

129.

X. Qu, H. Gao, L. Tao, Y. Zhang, J. Zhai, Y. Song, S. Zhang, J. Biochem. Mol. Toxicol. e22208 (2018). https://doi.org/10.1002/jbt.22228

130.

K. Nakahira, J.A. Haspel, V.A. Rathinam, S.J. Lee, T. Dolinay, H.C. Lam, J.A. Englert, M. Rabinovitch, M. Cernadas, H.P. Kim, K.A. Fitzgerald, S.W. Ryter, A.M. Choi, Nat. Immunol. 12, 222–230 (2011). https://doi.org/10.1038/ni.1980CrossRefPubMed

131.

Y.P. Chang, S.M. Ka, W.H. Hsu, A. Chen, L.K. Chao, C.C. Lin, C.C. Hsieh, M.C. Chen, H.W. Chiu, C.L. Ho, Y.C. Chiu, M.L. Liu, K.F. Hua, J. Cell. Physiol. 230, 1567–1579 (2015). https://doi.org/10.1002/jcp.24903CrossRefPubMed

132.

M.Y. Li, X.L. Zhu, B.X. Zhao, L. Shi, W. Wang, W. Hu, S.L. Qin, B.H. Chen, P.H. Zhou, B. Qiu, Y. Gao, B.L. Liu, Cell. Death Dis. 10, 489 (2019). https://doi.org/10.1038/s41419-019-1728-5CrossRefPubMedPubMedCentral

133.

X. Wang, L. Jiang, L. Shi, K. Yao, X. Sun, G. Yang, L. Jiang, C. Zhang, N. Wang, H. Zhang, Y. Wang, X. Liu, Toxicology 428, 152304 (2019). https://doi.org/10.1016/j.tox.2019.152304CrossRefPubMed

134.

M.E. Ahmed, S. Iyer, R. Thangavel, D. Kempuraj, G.P. Selvakumar, S.P. Raikwar, S. Zaheer, A. Zaheer, J. Alzheimers Dis. 60, 1143–1160 (2017). https://doi.org/10.3233/JAD-170634CrossRefPubMedPubMedCentral

135.

Z. Xue, Z. Zhang, H. Liu, W. Li, X. Guo, Z. Zhang, Y. Liu, L. Jia, Y. Li, Y. Ren, H. Yang, L. Zhang, Q. Zhang, Y. Da, J. Hao, Z. Yao, R. Zhang, Cell. Death Differ. 26, 130–145 (2019). https://doi.org/10.1038/s41418-018-0105-8CrossRefPubMed

136.

L. Liu, J.Z. Liao, X.X. He, P.Y. Li, Oncotarget 8, 57707–57722 (2017). https://doi.org/10.18632/oncotarget.17202CrossRefPubMedPubMedCentral

137.

K. Sun, X.L. Guo, Q.D. Zhao, Y.Y. Jing, X.R. Kou, X.Q. Xie, Y. Zhou, N. Cai, L. Gao, X. Zhao, S.S. Zhang, J.R. Song, D. Li, W.J. Deng, R. Li, M.C. Wu, L.X. Wei, Cell. Death Dis. 4, e501 (2013). https://doi.org/10.1038/cddis.2013.35

138.

C. Hage, S. Hoves, L. Strauss, S. Bissinger, Y. Prinz, T. Pöschinger, F. Kiessling, C.H. Ries, Hepatology 70, 1280–1297 (2019). https://doi.org/10.1002/hep.30666CrossRefPubMed

139.

Z. Shen, H. Zhou, A. Li, T. Wu, X. Ji, L. Guo, X. Zhu, D. Zhang, X. He, Aging (Albany NY) 13, 22120–22133 (2021). https://doi.org/10.18632/aging.203464CrossRefPubMed

140.

Z. Yan, Q. Da, Z. Li, Q. Lin, J. Yi, Y. Su, G. Yu, Q. Ren, X. Liu, Z. Lin, J. Qu, W. Yin, J. Liu, Front. Oncol. 12, 812655 (2022). https://doi.org/10.3389/fonc.2022.812655CrossRefPubMedPubMedCentral

141.

J. Hu, Y. Dong, L. Ding, Y. Dong, Z. Wu, W. Wang, M. Shen, Y. Duan, Signal. Transduct. Target. Ther. 4, 28 (2019). https://doi.org/10.1038/s41392-019-0062-9CrossRefPubMedPubMedCentral

142.

W.F. Liang, Y.X. Gong, H.F. Li, F.L. Sun, W.L. Li, D.Q. Chen, D.P. Xie, C.X. Ren, X.Y. Guo, Z.Y. Wang, T. Kwon, H.N. Sun, In Vivo 35, 249–257 (2021). https://doi.org/10.21873/invivo.12253CrossRefPubMedPubMedCentral

143.

S. Fulda, Semin Cancer Biol 31, 84–88 (2015). https://doi.org/10.1016/j.semcancer.2014.05.002CrossRefPubMed

Titel: The role of pyroptosis in hepatocellular carcinoma
verfasst von: Zhimiao Zou
Minghui Zhao
Yang Yang
Yalong Xie
Zeyang Li
Liang Zhou
Runshi Shang
Ping Zhou
Publikationsdatum: 02.03.2023
Verlag: Springer Netherlands
Erschienen in: Cellular Oncology / Ausgabe 4/2023
Print ISSN: 2211-3428
Elektronische ISSN: 2211-3436
DOI: https://doi.org/10.1007/s13402-023-00787-9

Springer Medizin

The role of pyroptosis in hepatocellular carcinoma

Abstract

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 4/2023

The composition and roles of gastric stem cells in epithelial homeostasis, regeneration, and tumorigenesis

Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner

Atp8a1 deletion increases the proliferative activity of hematopoietic stem cells by impairing PTEN function

Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner

The autocrine glycosylated-GREM1 interacts with TGFB1 to suppress TGFβ/BMP/SMAD-mediated EMT partially by inhibiting MYL9 transactivation in urinary carcinoma

Lenalidomide overcomes the resistance to third-generation CD19-CAR-T cell therapy in preclinical models of diffuse large B-cell lymphoma

Neu im Fachgebiet Pathologie

Molekularpathologische Untersuchungen im Wandel der Zeit

Vergleichende Pathologie in der onkologischen Forschung

Gastrointestinale Stromatumoren

Personalisierte Medizin in der Onkologie