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Current Pain and Headache Reports
Erschienen in: Current Pain and Headache Reports 8/2013

01.08.2013 | Fibromyalgia (M Peres, Section Editor)

The Role of Vitamin D in Pathophysiology and Treatment of Fibromyalgia

Erschienen in: Current Pain and Headache Reports | Ausgabe 8/2013

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Abstract

Recent studies showed that most cells have receptors and enzymes responsible for metabolism of vitamin D. Several diseases have been linked to vitamin D deficiency, such as hypertension, diabetes, depression, Alzheimer's disease, Parkinson's disease, multiple sclerosis, and chronic pain syndromes such as fibromyalgia. The association between fibromyalgia and vitamin D deficiency is very controversial in the literature with conflicting studies and methodological problems, which leads to more questions than answers. The purpose of this article is to raise questions about the association of hypovitaminosis D with fibromyalgia considering causal relationships, treatment, and pathophysiological explanations.
Literatur
1.
• Abokrysha NT. Vitamin D deficiency in women with fibromyalgia in Saudi Arabia. Pain Medicine. 2012;13:452–8. This report consists of the prevalence of vitamin D deficiency among patients with fibromyalgia in a neurology clinic in the Kingdom of Saudi Arabia.PubMedCrossRef
2.
Mease P. Fibromyalgia syndrome: review of clinical presentation, pathogenesis, outcome measures, and treatment. J Rheumatol. 2005;75(Suppl):6–21.
3.
• Matthana MH. The relation between vitamin d deficiency and fibromyalgia syndrome in women. Saudi Med J. 2011;32:925–9. This article defines the relationship between vitamin D deficiency and fibromyalgia syndrome and evaluates the effect of replacement with vitamin D.PubMed
4.
Wolfe F, Ross K, Anderson J, et al. The prevalence and characteristics of fibromyalgia in the general population. Arthritis Rheum. 1995;38:19–28.PubMedCrossRef
5.
Arnson Y, Amital D, Amital H. The diverse world of vitamin D: does it also modulate pain sensation? IMAJ. 2009;11:371–2.PubMed
6.
Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain. Mayo Clin Proc. 2003;78:1463–70.PubMedCrossRef
7.
8.
Gloth III F, Lindsay JM, Zelesnick LB, et al. Can vitamin D deficiency produce an unusual pain syndrome? Arch Intern Med. 1991;151:1662–4.PubMedCrossRef
9.
Prabhala A, Garg R, Dandona P. Severe myopathy associated with vitamin D deficiency in Western New York. Arch Intern Med. 2000;160:1199–203.PubMedCrossRef
10.
Benson J, Wilson A, Stocks N, et al. Muscle pain as an indicator of vitamin D deficiency in an urban Australian Aboriginal population. Med J Aust. 2006;185:76–7.PubMed
11.
Lofti A, Abdel-Nasser AM, Hamdy A, et al. Hypovitaminosis D in female patients with chronic low back pain. Clin Rheumatol. 2007;26:1895–901.CrossRef
12.
Atherton K, Berry DJ, Parsons T, et al. Vitamin D and chronic widespread pain in a white middle-aged British population: evidence from a cross-sectional population survey. Ann Rheum Dis. 2009;68:817–22.PubMedCrossRef
13.
Badsha H, Daher M, Kong KO. Myalgias or nonspecific muscle pain in Arab or Indo-Pakistani patients may indicate vitamin D deficiency. Clin Rheumatol. 2009;28:971–3.PubMedCrossRef
14.
Schwalfenberg G. Improvement of chronic back pain or failed back surgery with vitamin D repletion: a case series. J Am Board Fam Med. 2009;22:69–74.PubMedCrossRef
15.
Saud AF, Khalaf AM. Vitamin D deficiency and chronic low back pain in Saudi Arabia. Spine. 2003;28:177–9.CrossRef
16.
Shinchuk L, Holick MF. Vitamin D and rehabilitation: improving functional outcomes. Nutr Clin Pract. 2007;22:297–304.PubMedCrossRef
17.
Armstrong DJ, Meenagh GK, Bickle I, et al. Vitamin D deficiency is associated with anxiety and depression in fibromyalgia. Clin Rheumatol. 2007;26:551–4.PubMedCrossRef
18.
Mouyis M, Ostor AJK, Crisp AJ, et al. Hypovitaminosis D among rheumatology outpatients in clinical practice. Rheumatology. 2008;47:1348–51.PubMedCrossRef
19.
•• McBeth J, Pye SR, O'Neill TW, et al. Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study. Ann Rheum Dis. 2010;69:1448–52. A study was undertaken to test the hypothesis that musculoskeletal pain is associated with low vitamin D levels but the relationship is explained by physical inactivity and/or other putative confounding factors.PubMedCrossRef
20.
•• Heidari B, Shirvani JS, Firouzjahi A, et al. Association between nonspecific skeletal pain and vitamin D deficiency. Int J Rheum Dis. 2010;13:340–6. The results of this study indicate a positive association of vitamin D deficiency with a variety of nonspecific bone pain, particularly in women.PubMedCrossRef
21.
• Olama SM, Senna MK, Elarman MM, et al. Serum vitamin D level and bone mineral density in premenopausal Egyptian women with fibromyalgia. Rheumatol Int. 2013;33:185–92.PubMedCrossRef
22.
23.
Glerup H, Mikkelsen K, Poulsen L, et al. Commonly recommended daily intake of vitamin D is not sufficient if sunlight exposure is limited. J Intern Med. 2000;247:260–8.PubMedCrossRef
24.
Bischoff HA, Stahelin HB, Dick W, et al. Effects of vitamin D and calcium supplementation on falls: a randomized controlled trial. J Bone Miner Res. 2003;18:343–51.PubMedCrossRef
25.
Al-Allaf AW, Mole PA, Paterson CR, et al. Bone heath in patients with fibromyalgia. Rheumatology. 2003;42:1202–6.PubMedCrossRef
26.
Block SR. Vitamin D, deficiency is not associated with nonspecific musculoskeletal pain syndromes including fibromyalgia. Mayo Clin Proc. 2004;79:1585–91.PubMedCrossRef
27.
Tandeter H, Grynbaum M, Zuili I, et al. Serum 25-OH vitamin D levels in patients with fibromyalgia. IMAJ. 2009;11:339–42.PubMed
28.
Huisman AM, White KP, Algra A. Vitamin D levels in women with systemic lupus erythematosus and fibromyalgia. J Rheumatol. 2001;28:2535–9.PubMed
29.
•• Daniel D, Pirotta MV. Fibromyalgia—should we be testing and treating for vitamin D deficiency? Aust Fam Physicia. 2011;40:712–6. This review aims to synthesize the evidence whether general practitioners should be testing and treating these patients for vitamin D deficiency in fibromyalgia.
30.
Warner AE, Arnspiger AS. Diffuse musculoskeletal pain is not associated with low vitamin D levels or improved by treatment with vitamin D. J Clin Rheumatol. 2008;14:12–6.PubMedCrossRef
31.
•• De Rezende Pena C, Grillo LP, Das Chagas Medeiros MM. Evaluation of 25-hydroxivitamin D serum levels in patients with fibromyalgia. J Clin Rheumatol. 2010;16:365–9. This study showed that light to moderate deficient and insufficient 25(OH)D levels are not found more commonly in patients with FM.PubMed
32.
33.
•• Lewis JM, Coley JLB, Frontrier TH. Fibromyalgia syndrome and vitamin D. J Musculoskeletal Pain. 2011;19:164–6. This article is an updated review on the association of fibromyalgia with hypovitaminosis D.CrossRef
34.
Martinez-Lavin M. Is fibromyalgia a generalized reflex sympathetic dystrophy? Clin Exp Rheumatol. 2001;19:1–3.PubMed
35.
Russell IJ. Fibromyalgia Syndrome. Bonica’s Management of Pain. Ed. Loeser J. Lippincott Williams & Wilkins, Philadelphia, 2001;pp.543–56.
36.
Bayliss DA, Millhorn DE. Central neural mechanisms of progesterone action: application to the respiratory system. J Appl Physiol. 1992;73:393–404.PubMed
37.
Schimitt CP, Obry J, Feneberg R, et al. Beta-1 adrenergic blockade augments pulsatile PTH secretion in humans. J Am Soc Nephrol. 2003;14:3245–50.CrossRef
38.
Mostellar ME, Tuttle EP. Effects of alkalosis on plasma concentration and urinary excretion of inorganic phosphate in man. J Clin Invest. 1964;43:138–49.PubMedCrossRef
39.
Valença MM, Medeiros FL, Martins HA, et al. Neuroendocrine dysfunction in fibromyalgia and migraine. Curr Pain Headache Rep. 2009;13:308–13.CrossRef
40.
Macedo JA, Hesse J, Turner JD, et al. Glucocorticoid sensitivity in fibromyalgia patients decreased expression of corticosteroid receptors and glucocorticoid-induced leucine zipper. Psychoneuroendocrinology. 2008;33:799–809.PubMedCrossRef
41.
Kuchinaid A, Schweinhardt P, Seminowicz DA, et al. Accelerated brain gray matter loss in fibromyalgia patients: premature aging of the brain? J Neurosci. 2007;27:4004–7.CrossRef
42.
Papageorgiou AC, Silman AJ, Macfarlane GJ. Chronic widespread pain in the population: a seven year follow-up study. Ann Rheum Dis. 2002;61:1071–4.PubMedCrossRef
43.
Nielsen G, Henriksson KG. Pathophysiological mechanisms in chronic musculoskeletal pain (fibromyalgia): the role of central and peripheral sensitization and pain disinhibition. Best Pract Res Clin Rheumatol. 2007;21:465–80.PubMedCrossRef
44.
Eyles DW, Smith S, Kinobe R, et al. Distribution of the vitamin D receptor and 1-alfa-hydroxylase in human brain. J Chem Neuroanat. 2005;29:21–30.PubMedCrossRef
45.
Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, et al. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metabol. 2002;13:100–5.CrossRef
46.
Bischoff-Ferrari HA, Thomas Dietrich T, Orav EJ, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > 60 years. Am J Clin Nutr. 2004;80:752–8.PubMed
47.
48.
Sorensen OH, Lund B, Saltin B, et al. Myopathy in bone loss of ageing: improvement by treatment with 1 alpha-hydroxycholecalciferol and calcium. Clin Sci (Colch). 1979;56:157–61.
49.
Simpson RU, Thomas GA, Arnold AJ. Identification of 1,25 dihydroxyvitamin D3 receptors and activities in muscle. J Biol Chem. 1985;260:8882–91.PubMed
50.
Bischoff HA, Borchers M, Gudat F, et al. In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J. 2001;33:19–24.PubMedCrossRef
51.
• Nimitphong H, Holick MF. Vitamin D, neurocognitive functioning and immunocompetence. Curr Op Clin Nutr Metabol Care. 2011;14:7–14. Low vitamin D status has been linked to poor performance in neurocognitive testing in elderly, depression, schizophrenia, Alzheimer's disease, multiple sclerosis, and a lower motor neuron-induced muscle atrophy.CrossRef
52.
Ceglia L. Vitamin D, and skeletal muscle tissue and function. Mol Aspects Med. 2008;29:407–14.PubMedCrossRef
53.
Dawson-Hughes B. Serum 25-hydroxyvitamin D and functional outcomes in the elderly. Am J Clin Nutr. 2008;88:537S–40S.PubMed
54.
Zehnder D, Bland R, Williams MC, et al. Extrarenal expression of 25-hydroxyvitam in d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab. 2001;86:888–94.PubMedCrossRef
55.
Diesel B, Radermacher J, Bureik M, et al. Vitamin D(3) metabolism in humanglioblastoma multiforme: functionality of CYP27B1 splice variants, metabolism of calcidiol, and effect of calcitriol. Clin Cancer Res. 2005;11:5370–80.PubMedCrossRef
56.
McCann JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J. 2008;22:982–1001.PubMedCrossRef
57.
Tommaso M, Sardaro M, Serpino C. Fibromyalgia comorbidity in primary headaches. Cephalalgia. 2009;29:453–64.PubMedCrossRef
58.
Peres MF, Young WB, Kaup AO, et al. Fibromyalgia is common in patients with transformed migraine. Neurology. 2001;57:1326–8.PubMedCrossRef
59.
Peres MF. Fibromyalgia, fatigue, and headache disorders. Curr Neurol Neurosci Rep. 2003;3:97–103.PubMedCrossRef
60.
Centonze V, Bassi A, Cassiano MA, et al. Migraine, daily chronic headache and fibromyalgia in the same patient: an evolutive ‘continuum’ of non organic chronic pain? About 100 clinical cases. Neurol Sci. 2004;25:S291–2.PubMedCrossRef
61.
Jesus CAS, Peres MFP. Low Vitamin D levels in migraine [Abstract]. International Headache Congress. Boston, USA. June 27–30, 2013.
Metadaten
Titel
The Role of Vitamin D in Pathophysiology and Treatment of Fibromyalgia
Publikationsdatum
01.08.2013
Erschienen in
Current Pain and Headache Reports / Ausgabe 8/2013
Print ISSN: 1531-3433
Elektronische ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-013-0355-6

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