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Neuropsychology Review

Erschienen in:

01.12.2015 | Review

The Subthalamic Nucleus, Limbic Function, and Impulse Control

verfasst von: P. Justin Rossi, Aysegul Gunduz, Michael S. Okun

Erschienen in: Neuropsychology Review | Ausgabe 4/2015

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Abstract

It has been well documented that deep brain stimulation (DBS) of the subthalamic nucleus (STN) to address some of the disabling motor symptoms of Parkinson’s disease (PD) can evoke unintended effects, especially on non-motor behavior. This observation has catalyzed more than a decade of research concentrated on establishing trends and identifying potential mechanisms for these non-motor effects. While many issues remain unresolved, the collective result of many research studies and clinical observations has been a general recognition of the role of the STN in mediating limbic function. In particular, the STN has been implicated in impulse control and the related construct of valence processing. A better understanding of STN involvement in these phenomena could have important implications for treating impulse control disorders (ICDs). ICDs affect up to 40% of PD patients on dopamine agonist therapy and approximately 15% of PD patients overall. ICDs have been reported to be associated with STN DBS. In this paper we will focus on impulse control and review pre-clinical, clinical, behavioral, imaging, and electrophysiological studies pertaining to the limbic function of the STN.

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Titel: The Subthalamic Nucleus, Limbic Function, and Impulse Control
verfasst von: P. Justin Rossi
Aysegul Gunduz
Michael S. Okun
Publikationsdatum: 01.12.2015
Verlag: Springer US
Erschienen in: Neuropsychology Review / Ausgabe 4/2015
Print ISSN: 1040-7308
Elektronische ISSN: 1573-6660
DOI: https://doi.org/10.1007/s11065-015-9306-9

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