Introduction
Materials/methods
Tissue collection and preparation
Biomechanical testing
Data analysis
Results
Overview of the results
Storage modulus
Diagnostic ability of a mechanical property-based discrimination between day 0 and the pooled data of days 1 to 3 or 4
Biomechanical property | Region | Cut-off value | Sensitivity (%) | 95% CI (%) | Specificity (%)* | Likelihood ratio |
---|---|---|---|---|---|---|
Storage modulus (Pa) | FL | < 1511 | 76.9 | 61.7–87.4 | 91.7 | 9.2 |
ADB | < 1627 | 81.8 | 68.0–90.5 | 91.7 | 9.8 | |
CB | < 1320 | 87.1 | 71.2–94.9 | 91.7 | 10.4 | |
Loss modulus (Pa) | FL | < 551.7 | 74.4 | 58.9–85.4 | 91.7 | 8.9 |
ADB | < 597.4 | 81.4 | 67.4–90.3 | 91.7 | 9.8 | |
CB | < 534.6 | 83.9 | 67.4–92.9 | 91.7 | 10.1 | |
Complex shear modulus (Pa) | FL | < 1607 | 74.4 | 58.9–85.4 | 91.7 | 8.9 |
ADB | < 1758 | 84.1 | 70.6–92.1 | 91.7 | 10.1 | |
CB | < 1461 | 90.3 | 75.1–96.7 | 91.7 | 10.8 |
Early post mortem biomechanical properties of ovine brain hemispheres, medulla oblongata, and cerebellum
Storage modulus | FL | ADB | PDB | PL | CB | M&P | SC |
---|---|---|---|---|---|---|---|
Average (Pa) | 1905 | 1927 | 1795 | 2033 | 1706 | 1924 | 1968 |
Median (Pa) | 1834 | 1948 | 1743 | 2002 | 1746 | 1953 | 2053 |
STDEV (Pa) | 360 | 293 | 307 | 220 | 286 | 413 | 389 |
Minimum (Pa) | 1338 | 1550 | 1322 | 1829 | 1215 | 1395 | 1507 |
Maximum (Pa) | 2613 | 2414 | 2414 | 2561 | 2143 | 2657 | 2389 |
n | 12 | 12 | 12 | 12 | 12 | 12 | 6 |
Loss modulus | FL | ADB | PDB | PL | CB | M&P | SC |
---|---|---|---|---|---|---|---|
Average (Pa) | 680 | 693 | 710 | 785 | 616 | 692 | 742 |
Median (Pa) | 567 | 679 | 705 | 783 | 599 | 639 | 711 |
STDEV (Pa) | 137 | 99 | 101 | 115 | 80 | 161 | 203 |
Minimum (Pa) | 456 | 514 | 557 | 638 | 514 | 474 | 483 |
Maximum (Pa) | 911 | 874 | 900 | 982 | 808 | 1046 | 1000 |
n | 12 | 12 | 12 | 12 | 12 | 12 | 6 |
Complex shear modulus | FL | ADB | PDB | PL | CB | M&P | SC |
---|---|---|---|---|---|---|---|
Average (Pa) | 2023 | 2048 | 1931 | 2181 | 1816 | 2046 | 2105 |
Median (Pa) | 1949 | 2072 | 1886 | 2126 | 1854 | 2071 | 2211 |
STDEV (Pa) | 383 | 306 | 317 | 236 | 285 | 436 | 430 |
Minimum (Pa) | 1414 | 1633 | 1469 | 1940 | 1334 | 1510 | 1583 |
Maximum (Pa) | 2757 | 2567 | 2576 | 2731 | 2230 | 2856 | 2590 |
n | 12 | 12 | 12 | 12 | 12 | 12 | 6 |