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Seminars in Immunopathology

Erschienen in:

05.07.2018 | Review

Therapeutic cancer vaccine: building the future from lessons of the past

verfasst von: T. Tran, C. Blanc, C. Granier, A. Saldmann, C. Tanchot, Eric Tartour

Erschienen in: Seminars in Immunopathology | Ausgabe 1/2019

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Abstract

Anti-cancer vaccines have raised many hopes from the start of immunotherapy but have not yet been clinically successful. The few positive results of anti-cancer vaccines have been observed in clinical situations of low tumor burden or preneoplastic lesions. Several new concepts and new results reposition this therapeutic approach in the field of immunotherapy. Indeed, cancers that respond to anti-PD-1/PD-L1 (20–30%) are those that are infiltrated by anti-tumor T cells with an inflammatory infiltrate. However, 70% of cancers do not appear to have an anti-tumor immune reaction in the tumor microenvironment. To induce this anti-tumor immunity, therapeutic combinations between vaccines and anti-PD-1/PD-L1 are being evaluated. In addition, the identification of neoepitopes against which the immune system is less tolerated is giving rise to a new enthusiasm by the first clinical results of the vaccine including these neoepitopes in humans. The ability of anti-cancer vaccines to induce a population of anti-tumor T cells called memory resident T cells that play an important role in immunosurveillance is also a new criterion to consider in the design of therapeutic vaccines.

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Titel: Therapeutic cancer vaccine: building the future from lessons of the past
verfasst von: T. Tran
C. Blanc
C. Granier
A. Saldmann
C. Tanchot
Eric Tartour
Publikationsdatum: 05.07.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Seminars in Immunopathology / Ausgabe 1/2019
Print ISSN: 1863-2297
Elektronische ISSN: 1863-2300
DOI: https://doi.org/10.1007/s00281-018-0691-z

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