Ausgabe 1/2022
Inhalt (58 Artikel)
Translational Neurodegeneration in the era of fast growing international brain research
Jialin C. Zheng, Shengdi Chen
Neddylation-dependent protein degradation is a nexus between synaptic insulin resistance, neuroinflammation and Alzheimer’s disease
Alessandro Dario Confettura, Eleonora Cuboni, Mohamed Rafeet Ammar, Shaobo Jia, Guilherme M. Gomes, PingAn Yuanxiang, Rajeev Raman, Tingting Li, Katarzyna M. Grochowska, Robert Ahrends, Anna Karpova, Alexander Dityatev, Michael R. Kreutz
Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration
Manish Verma, Britney N. Lizama, Charleen T. Chu
Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential
Lina Gao, Yun Zhang, Keenan Sterling, Weihong Song
LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease
Shirley Yin-Yu Pang, Rachel Cheuk Nam Lo, Philip Wing-Lok Ho, Hui-Fang Liu, Eunice Eun Seo Chang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, Wing Yan Wong, Michelle Hiu-Wai Kung, David Boyer Ramsden, Shu-Leong Ho
Mechanisms of motor symptom improvement by long-term Tai Chi training in Parkinson’s disease patients
Gen Li, Pei Huang, Shi-Shuang Cui, Yu-Yan Tan, Ya-Chao He, Xin Shen, Qin-Ying Jiang, Ping Huang, Gui-Ying He, Bin-Yin Li, Yu-Xin Li, Jin Xu, Zheng Wang, Sheng-Di Chen
Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
Ivan Martinez-Valbuena, Naomi P. Visanji, Ain Kim, Heather H. C. Lau, Raphaella W. L. So, Sohaila Alshimemeri, Andrew Gao, Michael A. Seidman, Maria R. Luquin, Joel C. Watts, Anthony E. Lang, Gabor G. Kovacs
EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid
Hannes Devos, Kathleen Gustafson, Ke Liao, Pedram Ahmadnezhad, Bradley Estes, Laura E. Martin, Jonathan D. Mahnken, William M. Brooks, Jeffrey M. Burns
Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson’s disease
Elisabet Jakova, Mohamed Taha Moutaoufik, Jeremy S. Lee, Mohan Babu, Francisco S. Cayabyab
LRRK2 mutant knock-in mouse models: therapeutic relevance in Parkinson's disease
Eunice Eun Seo Chang, Philip Wing-Lok Ho, Hui-Fang Liu, Shirley Yin-Yu Pang, Chi-Ting Leung, Yasine Malki, Zoe Yuen-Kiu Choi, David Boyer Ramsden, Shu-Leong Ho
Prodromal Parkinson's disease: hype or hope for disease-modification trials?
Philipp Mahlknecht, Kathrin Marini, Mario Werkmann, Werner Poewe, Klaus Seppi
RNA targets of TDP-43: Which one is more important in neurodegeneration?
Dilara Halim, Fen-Biao Gao
Clinical and genetic characterization of a large cohort of patients with Wilson’s disease in China
Shijie Zhang, Wenming Yang, Xiang Li, Pei Pei, Ting Dong, Yue Yang, Jing Zhang
Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model
Yi-Qing Lv, Lin Yuan, Yan Sun, Hao-Wen Dou, Ji-Hui Su, Zhi-Pan Hou, Jia-Yi Li, Wen Li
Pathophysiological significance of increased α-synuclein deposition in sympathetic nerves in Parkinson’s disease: a post-mortem observational study
Risa Isonaka, Patti Sullivan, David S. Goldstein
Autologous treatment for ALS with implication for broad neuroprotection
Daehwan Kim, Subin Kim, Ashley Sung, Neetika Patel, Nathan Wong, Michael J. Conboy, Irina M. Conboy
Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis
Akram Zamani, Adam K. Walker, Ben Rollo, Katie L. Ayers, Raysha Farah, Terence J. O’Brien, David K. Wright
Immunotherapy for Alzheimer’s disease: targeting β-amyloid and beyond
Chenghuan Song, Jiyun Shi, Pingao Zhang, Yongfang Zhang, Jianrong Xu, Lanxue Zhao, Rui Zhang, Hao Wang, Hongzhuan Chen
Propagation of tau and α-synuclein in the brain: therapeutic potential of the glymphatic system
Douglas M. Lopes, Sophie K. Llewellyn, Ian F. Harrison
α-Synuclein arginylation in the human brain
Jun Zhao, Buyan Pan, Marie Fina, Yun Huang, Marie Shimogawa, Kelvin C. Luk, Elizabeth Rhoades, E. James Petersson, Dawei W. Dong, Anna Kashina
Genetic heterogeneity on sleep disorders in Parkinson’s disease: a systematic review and meta-analysis
Jingxuan Huang, Yangfan Cheng, Chunyu Li, Huifang Shang
Analysis of human brain tissue derived from DBS surgery
Salla M. Kangas, Jaakko Teppo, Maija J. Lahtinen, Anu Suoranta, Bishwa Ghimire, Pirkko Mattila, Johanna Uusimaa, Markku Varjosalo, Jani Katisko, Reetta Hinttala
Stepping up to meet the challenge of freezing of gait in Parkinson’s disease
Simon Lewis, Stewart Factor, Nir Giladi, Alice Nieuwboer, John Nutt, Mark Hallett
Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations
Federico Rodriguez-Porcel, Kathryn A. Wyman-Chick, Carla Abdelnour Ruiz, Jon B. Toledo, Daniel Ferreira, Prabitha Urwyler, Rimona S. Weil, Joseph Kane, Andrea Pilotto, Arvid Rongve, Bradley Boeve, John-Paul Taylor, Ian McKeith, Dag Aarsland, Simon J. G. Lewis
Advances in the development of new biomarkers for Alzheimer’s disease
Timofey O. Klyucherev, Pawel Olszewski, Alena A. Shalimova, Vladimir N. Chubarev, Vadim V. Tarasov, Misty M. Attwood, Stina Syvänen, Helgi B. Schiöth
Parvalbumin neuroplasticity compensates for somatostatin impairment, maintaining cognitive function in Alzheimer’s disease
Christopher Daniel Morrone, Aaron Yenhsin Lai, Jossana Bishay, Mary Elizabeth Hill, JoAnne McLaurin
Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer’s disease
Dongmei Chen, Guihua Lan, Ruomeng Li, Yingxue Mei, Xindong Shui, Xi Gu, Long Wang, Tao Zhang, Chen-Ling Gan, Yongfang Xia, Li Hu, Yuan Tian, Mi Zhang, Tae Ho Lee
A new paradigm for diagnosis of neurodegenerative diseases: peripheral exosomes of brain origin
Neelam Younas, Leticia Camila Fernandez Flores, Franziska Hopfner, Günter U. Höglinger, Inga Zerr
Correction: Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations
Federico Rodriguez-Porcel, Kathryn A. Wyman-Chick, Carla Abdelnour Ruiz, Jon B. Toledo, Daniel Ferreira, Prabitha Urwyler, Rimona S. Weil, Joseph Kane, Andrea Pilotto, Arvid Rongve, Bradley Boeve, John-Paul Taylor, Ian McKeith, Dag Aarsland, Simon J. G. Lewis
N-terminally truncated Aβ4-x proteoforms and their relevance for Alzheimer’s pathophysiology
Agueda Rostagno, Erwin Cabrera, Tammaryn Lashley, Jorge Ghiso
Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus–response in spinal muscular atrophy
Chunchu Deng, Sebastian Reinhard, Luisa Hennlein, Janna Eilts, Stefan Sachs, Sören Doose, Sibylle Jablonka, Markus Sauer, Mehri Moradi, Michael Sendtner
Defective mitophagy and the etiopathogenesis of Alzheimer’s disease
Kuan Zeng, Xuan Yu, Yacoubou Abdoul Razak Mahaman, Jian-Zhi Wang, Rong Liu, Yi Li, Xiaochuan Wang
Tauroursodeoxycholic acid: a potential therapeutic tool in neurodegenerative diseases
Kareem Khalaf, Paolo Tornese, Antoniangela Cocco, Alberto Albanese
Loss of tau expression attenuates neurodegeneration associated with α-synucleinopathy
Scott C. Vermilyea, Anne Christensen, Joyce Meints, Balvindar Singh, Héctor Martell-Martínez, Md. Razaul Karim, Michael K. Lee
Retraction Note: Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease
Haichen Niu, Lingyu Shen, Tongzhou Li, Chao Ren, Sheng Ding, Lei Wang, Zhonghai Zhang, Xiaoyu Liu, Qiang Zhang, Deqin Geng, Xiujuan Wu, Haiying Li
The use of fibroblasts as a valuable strategy for studying mitochondrial impairment in neurological disorders
Margrethe A. Olesen, Francisca Villavicencio-Tejo, Rodrigo A. Quintanilla
Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease
Matilde Bongianni, Mauro Catalan, Daniela Perra, Elena Fontana, Francesco Janes, Claudio Bertolotti, Luca Sacchetto, Stefano Capaldi, Matteo Tagliapietra, Paola Polverino, Valentina Tommasini, Giulia Bellavita, Elham Ataie Kachoie, Roberto Baruca, Andrea Bernardini, Mariarosaria Valente, Michele Fiorini, Erika Bronzato, Stefano Tamburin, Laura Bertolasi, Lorenzo Brozzetti, Maria Paola Cecchini, Gianluigi Gigli, Salvatore Monaco, Paolo Manganotti, Gianluigi Zanusso
Correction: Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease
Matilde Bongianni, Mauro Catalan, Daniela Perra, Elena Fontana, Francesco Janes, Claudio Bertolotti, Luca Sacchetto, Stefano Capaldi, Matteo Tagliapietra, Paola Polverino, Valentina Tommasini, Giulia Bellavita, Elham Ataie Kachoie, Roberto Baruca, Andrea Bernardini, Mariarosaria Valente, Michele Fiorini, Erika Bronzato, Stefano Tamburin, Laura Bertolasi, Lorenzo Brozzetti, Maria Paola Cecchini, Gianluigi Gigli, Salvatore Monaco, Paolo Manganotti, Gianluigi Zanusso
The emerging role of furin in neurodegenerative and neuropsychiatric diseases
Yi Zhang, Xiaoqin Gao, Xue Bai, Shanshan Yao, Yan-Zhong Chang, Guofen Gao
The COVID-19 pandemic and Alzheimer’s disease: mutual risks and mechanisms
Feng Chen, Yanting Chen, Yongxiang Wang, Qiongwei Ke, Lili Cui
CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s disease
Hanseul Park, Jaein Shin, Yunkyung Kim, Takashi Saito, Takaomi C. Saido, Jongpil Kim
A review of brain imaging biomarker genomics in Alzheimer’s disease: implementation and perspectives
Lanlan Li, Xianfeng Yu, Can Sheng, Xueyan Jiang, Qi Zhang, Ying Han, Jiehui Jiang
Why do ‘OFF’ periods still occur during continuous drug delivery in Parkinson’s disease?
Silvia Rota, Daniele Urso, Daniel J. van Wamelen, Valentina Leta, Iro Boura, Per Odin, Alberto J. Espay, Peter Jenner, K. Ray Chaudhuri
Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson’s disease in Drosophila
Wei Liu, Kah-Leong Lim, Eng-King Tan
APOE ε4-dependent effects on the early amyloid pathology in induced neurons of patients with Alzheimer’s disease
Hongwon Kim, Siyoung Kim, Byounggook Cho, Jaein Shin, Jongpil Kim
Association of variants in the KIF1A gene with amyotrophic lateral sclerosis
Panlin Liao, Yanchun Yuan, Zhen Liu, Xiaorong Hou, Wanzhen Li, Jin Wen, Kexuan Zhang, Bin Jiao, Lu Shen, Hong Jiang, Jifeng Guo, Beisha Tang, Zhuohua Zhang, Zhonghua Hu, Junling Wang
Myelin repair in Alzheimer’s disease: a review of biological pathways and potential therapeutics
Lauren Rose Hirschfeld, Shannon L. Risacher, Kwangsik Nho, Andrew J. Saykin
Deciphering lipid dysregulation in ALS: from mechanisms to translational medicine
Ira Agrawal, Yong Shan Lim, Shi-Yan Ng, Shuo-Chien Ling
Gut microbiome, cognitive function and brain structure: a multi-omics integration analysis
Xinxiu Liang, Yuanqing Fu, Wen-ting Cao, Zhihong Wang, Ke Zhang, Zengliang Jiang, Xiaofang Jia, Chun-ying Liu, Hong-rou Lin, Haili Zhong, Zelei Miao, Wanglong Gou, Menglei Shuai, Yujing Huang, Shengdi Chen, Bing Zhang, Yu-ming Chen, Ju-Sheng Zheng
Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic-therapeutic molecules
Francesca Natale, Salvatore Fusco, Claudio Grassi
Deep brain stimulation of the nucleus basalis of Meynert modulates hippocampal–frontoparietal networks in patients with advanced Alzheimer’s disease
Yin Jiang, Tian-Shuo Yuan, Ying-Chuan Chen, Peng Guo, Teng-Hong Lian, Yu-Ye Liu, Wei Liu, Yu-Tong Bai, Quan Zhang, Wei Zhang, Jian-Guo Zhang
Axonal degeneration in the anterior insular cortex is associated with Alzheimer’s co-pathology in Parkinson’s disease and dementia with Lewy bodies
Yasmine Y. Fathy, Laura E. Jonkman, John J. Bol, Evelien Timmermans, Allert J. Jonker, Annemieke J. M. Rozemuller, Wilma D. J. van de Berg
Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases
Xiaohuan Xia, Yi Wang, Jialin C. Zheng
Remodeling of astrocyte secretome in amyotrophic lateral sclerosis: uncovering novel targets to combat astrocyte-mediated toxicity
Winanto Ng, Shi-Yan Ng
ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein
Gillian Bonvicini, Stina Syvänen, Ken G. Andersson, Merja Haaparanta-Solin, Francisco López-Picón, Dag Sehlin
TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis
Sarah Lépine, Maria José Castellanos-Montiel, Thomas Martin Durcan
Enhanced delivery of a low dose of aducanumab via FUS in 5×FAD mice, an AD model
Chanho Kong, Eun-Jeong Yang, Jaewoo Shin, Junwon Park, Si-Hyun Kim, Seong-Wook Park, Won Seok Chang, Chang-Han Lee, Hyunju Kim, Hye-Sun Kim, Jin Woo Chang
Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer’s disease protects against mitochondrial dysfunction and mitigates brain pathology
Ankit Verma, Anna Shteinfer-Kuzmine, Nikita Kamenetsky, Srinivas Pittala, Avijit Paul, Edna Nahon Crystal, Alberto Ouro, Vered Chalifa-Caspi, Swaroop Kumar Pandey, Alon Monsonego, Noga Vardi, Shira Knafo, Varda Shoshan-Barmatz