Ausgabe 1/2023
Inhalt (59 Artikel)
p85S6K sustains synaptic GluA1 to ameliorate cognitive deficits in Alzheimer’s disease
Jia-Bing Li, Xiao-Yu Hu, Mu-Wen Chen, Cai-Hong Xiong, Na Zhao, Yan-Hui Ge, Hao Wang, Xiao-Ling Gao, Nan-Jie Xu, Lan-Xue Zhao, Zhi-Hua Yu, Hong-Zhuan Chen, Yu Qiu
Correction: Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer’s disease protects against mitochondrial dysfunction and mitigates brain pathology
Ankit Verma, Anna Shteinfer-Kuzmine, Nikita Kamenetsky, Srinivas Pittala, Avijit Paul, Edna Nahon Crystal, Alberto Ouro, Vered Chalifa-Caspi, Swaroop Kumar Pandey, Alon Monsonego, Noga Vardi, Shira Knafo, Varda Shoshan-Barmatz
Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson’s disease dementia
Irene Frigerio, Max A. Laansma, Chen-Pei Lin, Emma J. M. Hermans, Maud M. A. Bouwman, John G. J. M. Bol, Yvon Galis-de Graaf, Dagmar H. Hepp, Annemieke J. M. Rozemuller, Frederik Barkhof, Wilma D. J. van de Berg, Laura E. Jonkman
Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial
Burak Yulug, Ozlem Altay, Xiangyu Li, Lutfu Hanoglu, Seyda Cankaya, Simon Lam, Halil Aziz Velioglu, Hong Yang, Ebru Coskun, Ezgi Idil, Rahim Nogaylar, Ahmet Ozsimsek, Cemil Bayram, Ismail Bolat, Sena Oner, Ozlem Ozdemir Tozlu, Mehmet Enes Arslan, Ahmet Hacimuftuoglu, Serkan Yildirim, Muhammad Arif, Saeed Shoaie, Cheng Zhang, Jens Nielsen, Hasan Turkez, Jan Borén, Mathias Uhlén, Adil Mardinoglu
Links between COVID-19 and Parkinson’s disease/Alzheimer’s disease: reciprocal impacts, medical care strategies and underlying mechanisms
Pei Huang, Lin-Yuan Zhang, Yu-Yan Tan, Sheng-Di Chen
Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer’s disease
Luis Enrique Arroyo-García, Sara Bachiller, Rocío Ruiz, Antonio Boza-Serrano, Antonio Rodríguez-Moreno, Tomas Deierborg, Yuniesky Andrade-Talavera, André Fisahn
Employing nanoparticle tracking analysis of salivary neuronal exosomes for early detection of neurodegenerative diseases
Vaibhav Sharma, Fredrik Nikolajeff, Saroj Kumar
Circadian disruption and sleep disorders in neurodegeneration
Yun Shen, Qian-kun Lv, Wei-ye Xie, Si-yi Gong, Sheng Zhuang, Jun-yi Liu, Cheng-jie Mao, Chun-feng Liu
Recent advances on the molecular mechanisms of exercise-induced improvements of cognitive dysfunction
Yi Lu, Fa-Qian Bu, Fang Wang, Li Liu, Shuai Zhang, Guan Wang, Xiu-Ying Hu
Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis
Cristina de Dios, Xenia Abadin, Vicente Roca-Agujetas, Marina Jimenez-Martinez, Albert Morales, Ramon Trullas, Montserrat Mari, Anna Colell
Alleviating the unwanted effects of oxidative stress on Aβ clearance: a review of related concepts and strategies for the development of computational modelling
Sarawoot Somin, Don Kulasiri, Sandhya Samarasinghe
α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies
Matthias Schmitz, Niccolò Candelise, Sezgi Canaslan, Hermann C. Altmeppen, Jakob Matschke, Markus Glatzel, Neelam Younas, Saima Zafar, Peter Hermann, Inga Zerr
Seed amplification assay of nasal swab extracts for accurate and non-invasive molecular diagnosis of neurodegenerative diseases
Suying Duan, Jing Yang, Zheqing Cui, Jiaqi Li, Honglin Zheng, Taiqi Zhao, Yanpeng Yuan, Yutao Liu, Lu Zhao, Yangyang Wang, Haiyang Luo, Yuming Xu
Toward a biomarker panel measured in CNS-originating extracellular vesicles for improved differential diagnosis of Parkinson’s disease and multiple system atrophy
Hash Brown Taha, Simon Hornung, Suman Dutta, Leony Fenwick, Otmane Lahgui, Kathryn Howe, Nour Elabed, Irish del Rosario, Darice Y. Wong, Aline Duarte Folle, Daniela Markovic, Jose-Alberto Palma, Un Jung Kang, Roy N. Alcalay, Miriam Sklerov, Horacio Kaufmann, Brent L. Fogel, Jeff M. Bronstein, Beate Ritz, Gal Bitan
Modulating arousal to overcome gait impairments in Parkinson’s disease: how the noradrenergic system may act as a double-edged sword
Anouk Tosserams, Bastiaan R. Bloem, Kaylena A. Ehgoetz Martens, Rick C. Helmich, Roy P. C. Kessels, James M. Shine, Natasha L. Taylor, Gabriel Wainstein, Simon J. G. Lewis, Jorik Nonnekes
Argyrophilic grain disease is common in older adults and may be a risk factor for suicide: a study of Japanese forensic autopsy cases
Koji Yoshida, Yukiko Hata, Shojiro Ichimata, Keitaro Okada, Naoki Nishida
Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients
Xavier Sánchez-Sáez, Isabel Ortuño-Lizarán, Carla Sánchez-Castillo, Pedro Lax, Nicolás Cuenca
Redox dysregulation as a driver for DNA damage and its relationship to neurodegenerative diseases
Sina Shadfar, Sonam Parakh, Md Shafi Jamali, Julie D. Atkin
An AARS1 variant identified to cause adult-onset leukoencephalopathy with neuroaxonal spheroids and pigmented glia
Jingying Wu, Taotao Liu, Benyan Zhang, Chang Liu, Xinghua Luan, Li Cao
Microtubule acetylation dyshomeostasis in Parkinson’s disease
Padmashri Naren, Khan Sabiya Samim, Kamatham Pushpa Tryphena, Lalitkumar K. Vora, Saurabh Srivastava, Shashi Bala Singh, Dharmendra Kumar Khatri
Correction: Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia
Nuole Zhu, Miguel Santos-Santos, Ignacio Illán-Gala, Victor Montal, Teresa Estellés, Isabel Barroeta, Miren Altuna, Javier Arranz, Laia Muñoz, Olivia Belbin, Isabel Sala, Maria Belén Sánchez-Saudinós, Andrea Subirana, Laura Videla, Jordi Pegueroles, Rafael Blesa, Jordi Clarimón, Maria Carmona-Iragui, Juan Fortea, Alberto Lleó, Daniel Alcolea
Correction: Starburst amacrine cells, involved in visual motion perception, lose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson’s disease patients
Xavier Sánchez‑Sáez, Isabel Ortuño‑Lizarán, Carla Sánchez‑Castillo, Pedro Lax, Nicolás Cuenca
Correction: Links between COVID-19 and Parkinson’s disease/Alzheimer’s disease: reciprocal impacts, medical care strategies and underlying mechanisms
Pei Huang, Lin-Yuan Zhang, Yu-Yan Tan, Sheng-Di Chen
A phase 1b randomized clinical trial of CT1812 to measure Aβ oligomer displacement in Alzheimer’s disease using an indwelling CSF catheter
Kelsie M. LaBarbera, Yvette I. Sheline, Nicholas J. Izzo, Carla M. Yuede, Lora Waybright, Raymond Yurko, Hannah M. Edwards, Woodrow D. Gardiner, Kaj Blennow, Henrik Zetterberg, Anne Börjesson-Hanson, Roger Morgan, Charles S. Davis, Robert J. Guttendorf, Lon S. Schneider, Steven DeKosky, Harry LeVine III, Michael Grundman, Anthony O. Caggiano, John R. Cirrito, Susan M. Catalano, Mary E. Hamby
Early life adversity as a risk factor for cognitive impairment and Alzheimer’s disease
Zhihai Huang, J. Dedrick Jordan, Quanguang Zhang
An open-label multiyear study of sargramostim-treated Parkinson’s disease patients examining drug safety, tolerability, and immune biomarkers from limited case numbers
Katherine E. Olson, Mai M. Abdelmoaty, Krista L. Namminga, Yaman Lu, Helen Obaro, Pamela Santamaria, R. Lee Mosley, Howard E. Gendelman
Longitudinal evolution of cortical thickness signature reflecting Lewy body dementia in isolated REM sleep behavior disorder: a prospective cohort study
Jung Hwan Shin, Heejung Kim, Yu Kyeong Kim, Eun Jin Yoon, Hyunwoo Nam, Beomseok Jeon, Jee-Young Lee
Cognitive dysfunction of patients infected with SARS-CoV-2 omicron variant in Shanghai, China
Ping Yuan, Yong Bi, Yu Luo, Quan Tao, Sugang Gong, Yi Wang, Lize Xiong, Xiaohuan Xia, Jialin C. Zheng
Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases
Chih Hung Lo, Jialiu Zeng
Perivascular spaces relate to the course and cognition of Huntington’s disease
Xiao-Yan Li, Juan-Juan Xie, Jin-Hong Wang, Yu-Feng Bao, Yi Dong, Bin Gao, Ting Shen, Pei-Yu Huang, Hao-Chao Ying, Han Xu, Anna Wang Roe, Hsin-Yi Lai, Zhi-Ying Wu
Reciprocal effects of alpha-synuclein aggregation and lysosomal homeostasis in synucleinopathy models
Alice Drobny, Fanni Annamária Boros, Denise Balta, Susy Prieto Huarcaya, Deniz Caylioglu, Niyeti Qazi, Julia Vandrey, Yanni Schneider, Jan Philipp Dobert, Caleb Pitcairn, Joseph Robert Mazzulli, Friederike Zunke
Update on the pathological roles of prostaglandin E2 in neurodegeneration in amyotrophic lateral sclerosis
Hiroshi Nango, Komugi Tsuruta, Hiroko Miyagishi, Yuri Aono, Tadashi Saigusa, Yasuhiro Kosuge
Brain metabolism in Alzheimer’s disease: biological mechanisms of exercise
Longfei Xu, Ran Liu, Yingkai Qin, Tianhui Wang
Head-to-head comparison of plasma and PET imaging ATN markers in subjects with cognitive complaints
Jiaying Lu, Xiaoxi Ma, Huiwei Zhang, Zhenxu Xiao, Ming Li, Jie Wu, Zizhao Ju, Li Chen, Li Zheng, Jingjie Ge, Xiaoniu Liang, Weiqi Bao, Ping Wu, Ding Ding, Tzu-Chen Yen, Yihui Guan, Chuantao Zuo, Qianhua Zhao, Keliang Chen, Langfeng Shi, Wanqing Wu, Yan Zhou, Yan Zhang, Fang Pei
Impact of seed amplification assay and surface-enhanced Raman spectroscopy combined approach on the clinical diagnosis of Alzheimer’s disease
Cristiano D’Andrea, Federico Angelo Cazzaniga, Edoardo Bistaffa, Andrea Barucci, Marella de Angelis, Martina Banchelli, Edoardo Farnesi, Panagis Polykretis, Chiara Marzi, Antonio Indaco, Pietro Tiraboschi, Giorgio Giaccone, Paolo Matteini, Fabio Moda
Animal models of Parkinson’s disease: bridging the gap between disease hallmarks and research questions
Axelle Dovonou, Cyril Bolduc, Victoria Soto Linan, Charles Gora, Modesto R. Peralta III, Martin Lévesque
Clinical evidence of human pathogens implicated in Alzheimer’s disease pathology and the therapeutic efficacy of antimicrobials: an overview
Celso S. G. Catumbela, Vijayasree V. Giridharan, Tatiana Barichello, Rodrigo Morales
Multidimensional biomarkers for multiple system atrophy: an update and future directions
Linlin Wan, Sudan Zhu, Zhao Chen, Rong Qiu, Beisha Tang, Hong Jiang
The potential impact of clinical factors on blood-based biomarkers for Alzheimer’s disease
Fengfeng Pan, Yan Lu, Qi Huang, Fang Xie, Jingye Yang, Qihao Guo
α-Synuclein-carrying astrocytic extracellular vesicles in Parkinson pathogenesis and diagnosis
Pan Wang, Guoyu Lan, Bin Xu, Zhenwei Yu, Chen Tian, Xia Lei, Wassilios G. Meissner, Tao Feng, Ying Yang, Jing Zhang
Early GCase activity is a predictor of long-term cognitive decline in Parkinson’s disease
Linn Oftedal, Johannes Lange, Kenn Freddy Pedersen, Aleksander Hagen Erga, Ingvild Dalen, Ole-Bjørn Tysnes, Guido Alves, Jodi Maple-Grødem
Large-scale proximity extension assay reveals CSF midkine and DOPA decarboxylase as supportive diagnostic biomarkers for Parkinson’s disease
Wojciech Paslawski, Shervin Khosousi, Ellen Hertz, Ioanna Markaki, Adam Boxer, Per Svenningsson
Research progress on the role of extracellular vesicles in neurodegenerative diseases
Zhengzhe Li, Xiaoling Wang, Xiaoxing Wang, Xiaomei Yi, Yin Kwan Wong, Jiyang Wu, Fangfang Xie, Die Hu, Qi Wang, Jigang Wang, Tianyu Zhong
Role of dopamine in the pathophysiology of Parkinson’s disease
Zhi Dong Zhou, Ling Xiao Yi, Dennis Qing Wang, Tit Meng Lim, Eng King Tan
Patient-derived iPSC models of Friedreich ataxia: a new frontier for understanding disease mechanisms and therapeutic application
Saumya Maheshwari, Gabriela Vilema-Enríquez, Richard Wade-Martins
Pathological insights from amyotrophic lateral sclerosis animal models: comparisons, limitations, and challenges
Longhong Zhu, Shihua Li, Xiao-Jiang Li, Peng Yin
Janus kinase inhibitors are potential therapeutics for amyotrophic lateral sclerosis
Peter J. Richardson, Daniel P. Smith, Alex de Giorgio, Xenia Snetkov, Joshua Almond-Thynne, Sara Cronin, Richard J. Mead, Christopher J. McDermott, Pamela J. Shaw
Metabolic regulation of microglial phagocytosis: Implications for Alzheimer's disease therapeutics
Izabela Lepiarz-Raba, Ismail Gbadamosi, Roberta Florea, Rosa Chiara Paolicelli, Ali Jawaid
NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
Yi Xu, Yanling Yang, Xi Chen, Danling Jiang, Fei Zhang, Yao Guo, Bin Hu, Guohai Xu, Shengliang Peng, Lidong Wu, Jialing Hu
Intranasal administration of induced pluripotent stem cell-derived cortical neural stem cell-secretome as a treatment option for Alzheimer’s disease
Hyunkyung Mo, Juryun Kim, Jennifer Yejean Kim, Jang Woon Kim, Heeju Han, Si Hwa Choi, Yeri Alice Rim, Ji Hyeon Ju
A novel transgenic mouse line with hippocampus-dominant and inducible expression of truncated human tau
Yang Gao, Yuying Wang, Huiyang Lei, Zhendong Xu, Shihong Li, Haitao Yu, Jiazhao Xie, Zhentao Zhang, Gongping Liu, Yao Zhang, Jie Zheng, Jian-Zhi Wang
Oligodendrocyte progenitor cells in Alzheimer’s disease: from physiology to pathology
Peibin Zou, Chongyun Wu, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang
N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease
Xiong Wang, Jiazhao Xie, Lu Tan, Yanjun Lu, Na Shen, Jiaoyuan Li, Hui Hu, Huijun Li, Xiaoguang Li, Liming Cheng
A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease
Alireza Faridar, Abdulmunaim M. Eid, Aaron D. Thome, Weihua Zhao, David R. Beers, Maria B. Pascual, Mohammad O. Nakawah, Gustavo C. Roman, Charles S. Davis, Michael Grundman, Joseph C. Masdeu, Stanley H. Appel
Neuronal and synaptic adaptations underlying the benefits of deep brain stimulation for Parkinson's disease
Wenying Xu, Jie Wang, Xin-Ni Li, Jingxue Liang, Lu Song, Yi Wu, Zhenguo Liu, Bomin Sun, Wei-Guang Li
Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model
Carolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R. Joe, Rana Rais, Norman J. Haughey, Dimitrios Kapogiannis, Barbara S. Slusher
Novel data-driven subtypes and stages of brain atrophy in the ALS–FTD spectrum
Ting Shen, Jacob W. Vogel, Jeffrey Duda, Jeffrey S. Phillips, Philip A. Cook, James Gee, Lauren Elman, Colin Quinn, Defne A. Amado, Michael Baer, Lauren Massimo, Murray Grossman, David J. Irwin, Corey T. McMillan
Supplementation with high-GABA-producing Lactobacillus plantarum L5 ameliorates essential tremor triggered by decreased gut bacteria-derived GABA
Hao-Jie Zhong, Si-Qi Wang, Ruo-Xin Zhang, Yu-Pei Zhuang, Longyan Li, Shuo-Zhao Yi, Ying Li, Lei Wu, Yu Ding, Jumei Zhang, Xinqiang Xie, Xing-Xiang He, Qingping Wu
Parkinson’s disease and gut microbiota: from clinical to mechanistic and therapeutic studies
Xuxiang Zhang, Beisha Tang, Jifeng Guo