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Journal of Anesthesia
Erschienen in: Journal of Anesthesia 6/2016

09.08.2016 | Invited Review Article

TRPV4 ion channel as important cell sensors

verfasst von: Koji Shibasaki

Erschienen in: Journal of Anesthesia | Ausgabe 6/2016

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Abstract

This review provides a summary of the physiological significance of the TRPV4 ion channel. Although TRPV4 was initially characterized as an osmosensor, we found that TRPV4 can also act as a thermosensor or a mechanosensor in brain neurons or epithelial cells in the urinary bladder. Here, we summarize the newly characterized functions of TRPV4, including the research progress that has been made toward our understanding of TRPV4 physiology, and discuss other recent data pertaining to TRPV4. It is thought that TRPV4 may be an important drug target based on its broad expression patterns and important physiological functions. Possible associations between diseases and TRPV4 are also discussed.
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Metadaten
Titel
TRPV4 ion channel as important cell sensors
verfasst von
Koji Shibasaki
Publikationsdatum
09.08.2016
Verlag
Springer Japan
Erschienen in
Journal of Anesthesia / Ausgabe 6/2016
Print ISSN: 0913-8668
Elektronische ISSN: 1438-8359
DOI
https://doi.org/10.1007/s00540-016-2225-y

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