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01.04.2016 | Note

Two new bicyclic sulfoxides from Welsh onion

verfasst von: Toshihiro Nohara, Yukio Fujiwara, Tsuyoshi Ikeda, Kotaro Murakami, Masateru Ono, Mona El-Aasr, Daisuke Nakano, Junei Kinjo

Erschienen in: Journal of Natural Medicines | Ausgabe 2/2016

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Abstract

Newly identified bicyclic sulfoxides, welsonins A₁ (1) and A₂ (2), were isolated from acetone extracts of the bulbs of the Welsh onion (Allium fistulosum). In this study, the structures of 1 and 2, which are tetrahydrothiophene-S-oxide derivatives, were characterized by spectroscopic analysis. These compounds appeared to be derived from the coupling of 1-propenyl sulfenic acid and uronic acid. Welsonin A₁ (1) showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of alternatively activated M2 macrophages.

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Titel: Two new bicyclic sulfoxides from Welsh onion
verfasst von: Toshihiro Nohara
Yukio Fujiwara
Tsuyoshi Ikeda
Kotaro Murakami
Masateru Ono
Mona El-Aasr
Daisuke Nakano
Junei Kinjo
Publikationsdatum: 01.04.2016
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 2/2016
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-015-0947-z

Springer Medizin

Abstract

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