Introduction
Aim of the study
Methods
Participants
Severity of depression
Outcomes
Predictors
Statistical analysis
Results
Characteristics
Characteristics | Depression | |||||
---|---|---|---|---|---|---|
Total N = 10,304 | No n = 7943 | Subsyndromal n = 1562 | Mild n = 346 | Moderate n = 196 | Severe n = 257 | |
Age, Mean (SD) | 41.4 (12.5) | 42.1 (12.5) | 38.2 (12.2) | 40.1 (12.2) | 39.1 (12.0) | 42.1 (11.2) |
Gender, n (%) | ||||||
Male | 4600 (44.6) | 3785 (47.7) | 557 (35.7) | 102 (29.5) | 61 (31.1) | 95 (37.0) |
Female | 5704 (55.4) | 4158 (52.3) | 1005 (64.3) | 244 (70.5) | 135 (68.9) | 162 (63.0) |
Education level, n (%) | ||||||
Primary | 1500 (14.6) | 1086 (13.7) | 238 (15.3) | 61 (17.7) | 41 (21.0) | 74 (29.2) |
Secondary | 4300 (41.9) | 3300 (41.7) | 673 (43.2) | 152 (44.1) | 83 (42.6) | 92 (36.4) |
Higher level | 4473 (43.5) | 3535 (44.6) | 648 (41.6) | 132 (38.3) | 71 (36.4) | 87 (34.4) |
Parental death, n (%) | 542 (5.3) | 388 (4.9) | 90 (5.8) | 22 (6.4) | 22 (11.2) | 20 (7.8) |
Familial hassles, n (%) | ||||||
No | 6600 (64.2) | 5415 (68.3) | 830 (53.3) | 170 (49.3) | 80 (41.0) | 105 (41.3) |
Small | 2431 (23.6) | 1756 (22.1) | 449 (28.8) | 96 (27.8) | 58 (29.7) | 72 (28.3) |
Severe | 1249 (12.1) | 758 (9.6) | 278 (17.9) | 79 (22.9) | 57 (29.2) | 77 (30.3) |
Negative coping, Mean (SD) | 2.2 (1.4) | 1.9 (1.3) | 2.8 (1.3) | 3.2 (1.3) | 3.2 (1.3) | 3.6 (1.3) |
Positive coping, Mean (SD) | 4.9 (1.5) | 5.1 (1.4) | 4.4 (1.6) | 3.8 (1.8) | 3.7 (1.6) | 3.4 (1.6) |
Social network, Mean (SD) | 27.3 (3.9) | 27.3 (3.9) | 27.0 (4.0) | 26.9 (4.5) | 27.2 (4.4) | 27.0 (4.3) |
Negative life events, Mean (SD) | 1.7 (1.7) | 1.4 (1.5) | 2.4 (1.8) | 2.8 (2.0) | 3.1 (2.1) | 3.9 (2.5) |
Psychiatric treatment history, n (%) | 629 (6.1) | 333 (4.2) | 161 (10.3) | 53 (15.3) | 27 (13.8) | 55 (21.4) |
Cumulative incidence, n (%) | ||||||
Hospitalizations | 416 (4.0) | 225 (2.8) | 98 (6.3) | 36 (10.4) | 16 (8.2) | 41 (16.0) |
Outpatient care | 1153 (11.2) | 623 (7.8) | 292 (18.7) | 90 (26.0) | 59 (30.1) | 94 (36.6) |
Antidepressants | 2258 (21.9) | 1354 (17.0) | 539 (34.5) | 143 (41.3) | 89 (45.4) | 133 (51.8) |
Incident rate per 1000 person-years | ||||||
Hospitalizations | 2.73 | 1.90 | 4.31 | 7.37 | 5.77 | 11.88 |
Outpatient care | 7.73 | 5.34 | 13.30 | 19.57 | 22.57 | 28.88 |
Antidepressants | 16.03 | 12.12 | 27.20 | 34.32 | 38.10 | 46.15 |
Cumulative incidence and incidence rates of outcomes
Predictors | Hospitalizations HR (95% CI) | Outpatient care HR (95% CI) | Antidepressants HR (95% CI) | |||
---|---|---|---|---|---|---|
Gender | Male | Female | Male | Female | Male | Female |
No depression | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
Subsyndromal | 2.48 (1.76,3.49)** | 2.25 (1.61,3.13)** | 2.34 (1.86,2.94)** | 2.65 (2.22,3.16)** | 2.26 (1.88,2.72)** | 2.11 (1.87,2.38)** |
Mild | 3.44 (1.86,6.37)** | 4.40 (2.84,6.82)** | 4.40 (3.04,6.37)** | 3.51 (2.66,4.63)** | 3.14 (2.24,4.41)** | 2.52 (2.06,3.08)** |
Moderate | 2.08 (0.77,5.64) | 3.82 (2.10,6.95)** | 4.19 (2.60,6.74)** | 4.40 (3.18,6.09)** | 2.69 (1.70,4.25)** | 3.07 (2.41,3.92)** |
Severe | 7.32 (4.57,11.74)** | 5.67 (3.54,9.08)** | 5.49 (3.85,7.84)** | 5.73 (4.35,7.55)** | 4.85 (3.58,6.56)** | 3.33 (2.67,4.15)** |
Psychiatric history | No | Yes | No | Yes | No | Yes |
No depression | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
Subsyndromal | 2.17 (1.65,2.84)** | 1.34 (0.81,2.22) | 2.46 (2.11,2.87)** | 1.61 (1.15,2.26)** | 2.19 (1.96,2.44)** | 1.67 (1.29,2.16)** |
Mild | 3.01 (1.92,4.72)** | 2.61 (1.44,4.73)** | 3.45 (2.67,4.47)** | 2.35 (1.50,3.69)** | 2.70 (2.22,3.28)** | 1.88 (1.29,2.74)** |
Moderate | 3.30 (1.88,5.78)** | 0.94 (0.29,3.03) | 4.12 (3.03,5.60)** | 2.41 (1.38,4.18)** | 3.10 (2.44,3.95)** | 1.83 (1.13,2.96)* |
Severe | 6.38 (4.31,9.43)** | 1.96 (1.03,3.74)* | 5.45 (4.22,7.04)** | 2.49 (1.62,3.84)** | 3.81 (3.10,4.69)** | 1.87 (1.30,2.69)** |
All the included factors | Crude | Adjusted | Crude | Adjusted | Crude | Adjusted |
No depression | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
Subsyndromal | 2.26 (1.78,2.86)** | 1.63 (1.26,2.11)** | 2.54 (2.21,2.92)** | 1.85 (1.59,2.16)** | 2.27 (2.06,2.51)** | 1.76 (1.58,1.96)** |
Mild | 3.83 (2.69,5.45)** | 2.42 (1.66,3.53)** | 3.77 (3.03,4.71)** | 2.50 (1.98,3.16)** | 2.88 (2.42,3.42)** | 1.86 (1.55,2.23)** |
Moderate | 3.00 (1.81,4.99)** | 1.68 (0.99,2.86) | 4.34 (3.32,5.66)** | 2.65 (2.00,3.53)** | 3.19 (2.58,3.96)** | 2.02 (1.61,2.53)** |
Severe | 6.13 (4.40,8.55)** | 2.46 (1.66,3.66)** | 5.65 (4.54,7.01)** | 2.85 (2.21,3.66)** | 3.93 (3.29,4.70)** | 2.06 (1.68,2.52)** |
Gender (female) | – | 0.67 (0.55,0.82)** | – | 0.94 (0.84,1.07) | – | 1.52 (1.39,1.67)** |
Psychiatric history (yes) | – | 3.07 (2.40,3.92)** | – | 2.52 (2.14,2.95)** | – | 2.26 (2.00,2.56)** |
Education level(1) | – | 0.64 (0.49,0.83)** | – | 0.86 (0.72,1.02) | – | 0.91 (0.82,1.04) |
Education level(2) | – | 0.57 (0.44,0.74)** | – | 0.86 (0.72,1.02) | – | 0.88 (0.78,0.99)* |
Age | – | 1.00 (0.99,1.01) | – | 0.99 (0.986,0.996)** | – | 1.01 (1.006,1.013)** |
Parent death in childhood | – | 1.04 (0.71,1.53) | – | 0.99 (0.78,1.27) | – | 1.05 (0.89,1.25) |
Disturbances in family(1) | – | 1.11 (0.87,1.42) | – | 1.17 (1.02,1.35)* | – | 1.19 (1.08,1.32)** |
Disturbances in family(2) | – | 1.75 (1.36,2.25)** | – | 1.46 (1.25,1.71)** | – | 1.33 (1.18,1.50)** |
Negative Coping | – | 1.04 (0.96,1.13) | – | 1.08 (1.03,1.13)** | – | 1.08 (1.05,1.12)** |
Positive Coping | – | 1.02 (0.95,1.09) | – | 0.99 (0.95,1.03) | – | 0.96 (0.93,0.99)** |
Social network | – | 0.95 (0.93,0.97)** | – | 0.97 (0.95,0.98)** | – | 0.98 (0.97,0.99)** |
Negative Life events | – | 1.15 (1.10,1.21)** | – | 1.09 (1.06,1.12)** | – | 1.05 (1.03,1.08)** |