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Erschienen in: Die Dermatologie 1/2021

05.11.2020 | Varikosis | Leitlinien und Empfehlungen

Leitlinie Sklerosierungsbehandlung der Varikose

S2k-Leitlinie der Deutschen Gesellschaft für Phlebologie (DGP) in Kooperation mit folgenden Fachgesellschaften: DDG, DGA, DGG, BVP

verfasst von: Prof. Dr. med. E. Rabe, F. X. Breu, I. Flessenkämper, H. Gerlach, S. Guggenbichler, B. Kahle, R. Murena, S. Reich-Schupke, T. Schwarz, Prof. Dr. med. M. Stücker, E. Valesky, S. Werth, F. Pannier

Erschienen in: Die Dermatologie | Ausgabe 1/2021

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Bei der Sklerosierungsbehandlung handelt es sich um die gezielte chemische Ablation von Varizen durch die intravenöse Injektion eines flüssigen oder aufgeschäumten Sklerosierungsmittels [ 1, 2]. Die zu behandelnden Venen können intradermal, subkutan und/oder transfaszial (Perforansvenen) sowie als epi-, supra- und subfasziale Gefäße bei venösen Malformationen vorliegen. Das Sklerosierungsmittel zerstört das venöse Endothel und evtl. weitere Bereiche der Venenwand und wird durch Blutbestandteile und zirkulierende Zellen inaktiviert [ 1, 2]. Nach erfolgreicher Sklerosierung kommt es längerfristig zur Umwandlung der Varizen in einen bindegewebigen Strang, einem als Sklerose bekannten Prozess [ 36]. Ziel der Sklerosierungsbehandlung ist nicht die Thrombosierung der Venen, da die behandelten Venen rekanalisieren könnten, sondern die definitive Transformation der thrombosierten Vene in einen Bindegewebsstrang. Dieser kann nicht rekanalisieren und entspricht in seinem funktionellen Ergebnis der operativen Entfernung einer Varize oder der endovenösen thermischen Ablation. …
Literatur
1.
Zurück zum Zitat Rabe E, Breu FX, Cavezzi A, Coleridge Smith P, Frullini A, Gillet JL, Guex JJ, Hamel-Desnos C, Kern P, Partsch B, Ramelet AA, Tessari L, Pannier F, Guideline Group (2014) European guidelines for sclerotherapy in chronic venous disorders. Phlebology 29:338–354 PubMedCrossRef Rabe E, Breu FX, Cavezzi A, Coleridge Smith P, Frullini A, Gillet JL, Guex JJ, Hamel-Desnos C, Kern P, Partsch B, Ramelet AA, Tessari L, Pannier F, Guideline Group (2014) European guidelines for sclerotherapy in chronic venous disorders. Phlebology 29:338–354 PubMedCrossRef
2.
Zurück zum Zitat Connor DE, Cooley-Andrade O, Goh WX, Ma DDF, Parsi K (2015) Detergent sclerosants are deactivated and consumed by circulating blood cells. Eur J Vasc Endovasc Surg 49:426–431 PubMedCrossRef Connor DE, Cooley-Andrade O, Goh WX, Ma DDF, Parsi K (2015) Detergent sclerosants are deactivated and consumed by circulating blood cells. Eur J Vasc Endovasc Surg 49:426–431 PubMedCrossRef
3.
Zurück zum Zitat Drake LA, Dinehart SM, Goltz RW, Graham GF, Hordinsky MK, Lewis CW, Pariser DM, Skouge JW, Webster SB, Whitaker DC, Franceschi C (1996) Guidelines of care for sclerotherapy treatment of varicose and teleangiectatic leg veins. J Am Acad Dermatol 34:523–528 CrossRef Drake LA, Dinehart SM, Goltz RW, Graham GF, Hordinsky MK, Lewis CW, Pariser DM, Skouge JW, Webster SB, Whitaker DC, Franceschi C (1996) Guidelines of care for sclerotherapy treatment of varicose and teleangiectatic leg veins. J Am Acad Dermatol 34:523–528 CrossRef
4.
Zurück zum Zitat Rabe E, Pannier-Fischer F, Gerlach H, Breu FX, Guggenbichler S, Zabel M, German Society of Phlebology (2004) Guidelines for sclerotherapy of varicose veins. Dermatol Surg 30:687–693 PubMed Rabe E, Pannier-Fischer F, Gerlach H, Breu FX, Guggenbichler S, Zabel M, German Society of Phlebology (2004) Guidelines for sclerotherapy of varicose veins. Dermatol Surg 30:687–693 PubMed
5.
Zurück zum Zitat Hamel-Desnos C, Ouvry P, Benigni JP, Boitelle G, Schadeck M, Desnos P, Allaert FA (2007) Comparison of 1 % and 3 % polidocanol foam in ultrasound guided sclerotherapy of the great saphenous vein: a randomised, double-blind trial with 2 year-follow-up. “the 3/1 study”. Eur J Vasc Endovasc Surg 34:723–729 PubMedCrossRef Hamel-Desnos C, Ouvry P, Benigni JP, Boitelle G, Schadeck M, Desnos P, Allaert FA (2007) Comparison of 1 % and 3 % polidocanol foam in ultrasound guided sclerotherapy of the great saphenous vein: a randomised, double-blind trial with 2 year-follow-up. “the 3/1 study”. Eur J Vasc Endovasc Surg 34:723–729 PubMedCrossRef
6.
Zurück zum Zitat Chen C‑H, Chiu C‑S, Yang C‑H (2012) Ultrasound-guided foam sclerotherapy for treating incompetent great saphenous veins—results of 5 years of analysis and morphologic evolvement study. Dermatol Surg 38:851–857 PubMedCrossRef Chen C‑H, Chiu C‑S, Yang C‑H (2012) Ultrasound-guided foam sclerotherapy for treating incompetent great saphenous veins—results of 5 years of analysis and morphologic evolvement study. Dermatol Surg 38:851–857 PubMedCrossRef
7.
Zurück zum Zitat Hamel-Desnos C, Desnos P, Wollmann JC, Quvry P, Mako S, Allaert FA (2003) Evaluation of the efficacy of Polidocanol in the form of foam compared with liquid form in sclerotherapy of the long saphenous vein: Initial results. Dermatol Surg 29:1170–1175 PubMed Hamel-Desnos C, Desnos P, Wollmann JC, Quvry P, Mako S, Allaert FA (2003) Evaluation of the efficacy of Polidocanol in the form of foam compared with liquid form in sclerotherapy of the long saphenous vein: Initial results. Dermatol Surg 29:1170–1175 PubMed
8.
Zurück zum Zitat Alòs J, López JA, Estadella B, Serra-Prat M, Marinel-Lo J (2006) Efficacy and safety of sclerotherapy using Polidocanol foam: a controlled clinical trial. Eur J Vasc Endovasc Surg 31:101–107 PubMedCrossRef Alòs J, López JA, Estadella B, Serra-Prat M, Marinel-Lo J (2006) Efficacy and safety of sclerotherapy using Polidocanol foam: a controlled clinical trial. Eur J Vasc Endovasc Surg 31:101–107 PubMedCrossRef
9.
Zurück zum Zitat Ouvry P, Allaert FA, Desnos P, Hamel-Desnos C (2008) Efficacy of polidocanol foam versus liquid in Sclerotherapy of the great Saphenous vein: a multicenter randomised controlled trial with a 2-year follow-up. Eur J Vasc Surg 36:366–370 CrossRef Ouvry P, Allaert FA, Desnos P, Hamel-Desnos C (2008) Efficacy of polidocanol foam versus liquid in Sclerotherapy of the great Saphenous vein: a multicenter randomised controlled trial with a 2-year follow-up. Eur J Vasc Surg 36:366–370 CrossRef
10.
Zurück zum Zitat Rabe E, Otto J, Schliephake D, Pannier F (2008) Efficacy and safety of great Saphenous vein Sclerotherapy using Standardised polidocanol foam (ESAF): a randomised controlled multicentre clinical trial. Eur J Endovasc Vasc Surg 35:238–245 CrossRef Rabe E, Otto J, Schliephake D, Pannier F (2008) Efficacy and safety of great Saphenous vein Sclerotherapy using Standardised polidocanol foam (ESAF): a randomised controlled multicentre clinical trial. Eur J Endovasc Vasc Surg 35:238–245 CrossRef
11.
Zurück zum Zitat Rasmussen LH, Lawaetz M, Bjoern L, Vennits B, Blemings A, Eklof B (2011) Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins. Br J Surg 98:1079–1087 PubMedCrossRef Rasmussen LH, Lawaetz M, Bjoern L, Vennits B, Blemings A, Eklof B (2011) Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy and surgical stripping for great saphenous varicose veins. Br J Surg 98:1079–1087 PubMedCrossRef
12.
Zurück zum Zitat Shadid N, Ceulen R, Nelemans P, Dirksen C, Veraart J, Schurink GW, van Neer P, Vd Kley J, de Haan E, Sommer A (2012) Randomized clinical trial of ultrasound-guided foam sclerotherapy versus surgery for the incompetent great saphenous vein. Br J Surg 99:1062–1070 PubMedCrossRef Shadid N, Ceulen R, Nelemans P, Dirksen C, Veraart J, Schurink GW, van Neer P, Vd Kley J, de Haan E, Sommer A (2012) Randomized clinical trial of ultrasound-guided foam sclerotherapy versus surgery for the incompetent great saphenous vein. Br J Surg 99:1062–1070 PubMedCrossRef
13.
Zurück zum Zitat Williamsson C, Danielsson P, Smith L (2013) Catheter-directed foam sclerotherapy for insufficiency of the great saphenous vein: occlusion rates and patient satisfaction after one year. Phlebology 28:80–85 PubMedCrossRef Williamsson C, Danielsson P, Smith L (2013) Catheter-directed foam sclerotherapy for insufficiency of the great saphenous vein: occlusion rates and patient satisfaction after one year. Phlebology 28:80–85 PubMedCrossRef
14.
Zurück zum Zitat Davies HO, Popplewell M, Darvall K, Bate G, Bradbury AW (2016) A review of randomized controlled trials comparing ultrasound-guided foam sclerotherapy with endothermal ablation for the treatment of great saphenous varicose veins. Phlebology 31:234–240 PubMedCrossRef Davies HO, Popplewell M, Darvall K, Bate G, Bradbury AW (2016) A review of randomized controlled trials comparing ultrasound-guided foam sclerotherapy with endothermal ablation for the treatment of great saphenous varicose veins. Phlebology 31:234–240 PubMedCrossRef
15.
Zurück zum Zitat Venermo M, Saarinen J, Eskelinen E, Vähäaho S, Saarinen E, Railo M, Uurto I, Salenius J, Albäck A, Finnish Venous Study Collaborators (2016) Randomized clinical trial comparing surgery, endovenous laser ablation and ultrasound-guided foam sclerotherapy for the treatment of great saphenous varicose veins. Br J Surg 103:1438–1444 PubMedPubMedCentralCrossRef Venermo M, Saarinen J, Eskelinen E, Vähäaho S, Saarinen E, Railo M, Uurto I, Salenius J, Albäck A, Finnish Venous Study Collaborators (2016) Randomized clinical trial comparing surgery, endovenous laser ablation and ultrasound-guided foam sclerotherapy for the treatment of great saphenous varicose veins. Br J Surg 103:1438–1444 PubMedPubMedCentralCrossRef
16.
Zurück zum Zitat Lawaetz M, Serup J, Lawaetz B, Bjoern L, Blemings A, Eklof B, Rasmussen L (2017) Comparison of endovenous ablation techniques, foam sclerotherapy and surgical stripping for great saphenous varicose veins. Extended 5‑year follow-up of a RCT. Int Angiol 36:281–288 PubMed Lawaetz M, Serup J, Lawaetz B, Bjoern L, Blemings A, Eklof B, Rasmussen L (2017) Comparison of endovenous ablation techniques, foam sclerotherapy and surgical stripping for great saphenous varicose veins. Extended 5‑year follow-up of a RCT. Int Angiol 36:281–288 PubMed
17.
Zurück zum Zitat Brittenden J, Cotton SC, Elders A, Tassie E, Scotland G, Ramsay CR, Norrie J, Burr J, Francis J, Wileman S, Campbell B, Bachoo P, Chetter I, Gough M, Earnshaw J, Lees T, Scott J, Baker SA, MacLennan G, Prior M, Bolsover D, Campbell MK (2015) Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial. Health Technol Assess 19:1–342 PubMedPubMedCentralCrossRef Brittenden J, Cotton SC, Elders A, Tassie E, Scotland G, Ramsay CR, Norrie J, Burr J, Francis J, Wileman S, Campbell B, Bachoo P, Chetter I, Gough M, Earnshaw J, Lees T, Scott J, Baker SA, MacLennan G, Prior M, Bolsover D, Campbell MK (2015) Clinical effectiveness and cost-effectiveness of foam sclerotherapy, endovenous laser ablation and surgery for varicose veins: results from the Comparison of LAser, Surgery and foam Sclerotherapy (CLASS) randomised controlled trial. Health Technol Assess 19:1–342 PubMedPubMedCentralCrossRef
18.
Zurück zum Zitat Van der Velden SK, Biemans A, De Maeseneer M, Kockaert MA, Cuypers PW, Hollestein LM, Neumann HAM, Nijsten T, van den Bos RR (2015) Five-year results of a randomized clinical trial of conventional surgery, endovenous laser ablation and ultrasound-guided foam sclerotherapy in patients with great saphenous varicose veins. Br J Surg 102:1184–1194 PubMedCrossRef Van der Velden SK, Biemans A, De Maeseneer M, Kockaert MA, Cuypers PW, Hollestein LM, Neumann HAM, Nijsten T, van den Bos RR (2015) Five-year results of a randomized clinical trial of conventional surgery, endovenous laser ablation and ultrasound-guided foam sclerotherapy in patients with great saphenous varicose veins. Br J Surg 102:1184–1194 PubMedCrossRef
19.
Zurück zum Zitat Myers KA, Jolley D, Clough A, Kirwan J (2007) Outcome of ultrasound-guided sclerotherapy for varicose veins: medium-term results assessed by ultrasound surveillance. Eur J Vasc Endovasc Surg 33:116–121 PubMedCrossRef Myers KA, Jolley D, Clough A, Kirwan J (2007) Outcome of ultrasound-guided sclerotherapy for varicose veins: medium-term results assessed by ultrasound surveillance. Eur J Vasc Endovasc Surg 33:116–121 PubMedCrossRef
20.
Zurück zum Zitat Zhang J, Jing Z, Schliephake DE, Otto J, Malouf GM, Gu YQ (2012) Efficacy and safety of Aethoxysklerol® (polidocanol) 0.5 %, 1 % and 3 % in comparison with placebo solution for the treatment of varicose veins of the lower extremities in Chinese patients (ESA-China Study). Phlebology 27:184–190 PubMedCrossRef Zhang J, Jing Z, Schliephake DE, Otto J, Malouf GM, Gu YQ (2012) Efficacy and safety of Aethoxysklerol® (polidocanol) 0.5 %, 1 % and 3 % in comparison with placebo solution for the treatment of varicose veins of the lower extremities in Chinese patients (ESA-China Study). Phlebology 27:184–190 PubMedCrossRef
21.
Zurück zum Zitat Guex JJ (2000) Ultrasound guided Sclerotherapy (USGS) for perforating veins. Hawaii Med J 59:261–262 PubMed Guex JJ (2000) Ultrasound guided Sclerotherapy (USGS) for perforating veins. Hawaii Med J 59:261–262 PubMed
22.
Zurück zum Zitat Masuda EM, Kessler DM, Lurie F, Puggioni A, Kistner RL, Eklof B (2006) The effect of ultrasound guided sclerotherapy of incompetent perforator veins on venous clinical severity scores. J Vasc Surg 43:551–556 PubMedCrossRef Masuda EM, Kessler DM, Lurie F, Puggioni A, Kistner RL, Eklof B (2006) The effect of ultrasound guided sclerotherapy of incompetent perforator veins on venous clinical severity scores. J Vasc Surg 43:551–556 PubMedCrossRef
23.
Zurück zum Zitat Van Neer P, Veraart JCJM, Neumann H (2006) Posterolateral thigh perforator varicosities in 12 patients: a normal deep venous system and successful treatment with ultrasound-guided sclerotherapy. Dermatol Surg 32:1346–1352 PubMed Van Neer P, Veraart JCJM, Neumann H (2006) Posterolateral thigh perforator varicosities in 12 patients: a normal deep venous system and successful treatment with ultrasound-guided sclerotherapy. Dermatol Surg 32:1346–1352 PubMed
24.
Zurück zum Zitat Guzelmansur I, Oguzkurt L, Koca N, Andic C, Gedikoglu M, Ozkan U (2014) Endovenous laser ablation and sclerotherapy for incompetent vein of Giacomini. Phlebology 29(8):511–516 PubMedCrossRef Guzelmansur I, Oguzkurt L, Koca N, Andic C, Gedikoglu M, Ozkan U (2014) Endovenous laser ablation and sclerotherapy for incompetent vein of Giacomini. Phlebology 29(8):511–516 PubMedCrossRef
25.
Zurück zum Zitat Kahle B, Leng K (2004) Efficacy of sclerotherapy in varicose veins—a prospective, blinded placebocontrolled study. Dermatol Surg 30:723–728 PubMed Kahle B, Leng K (2004) Efficacy of sclerotherapy in varicose veins—a prospective, blinded placebocontrolled study. Dermatol Surg 30:723–728 PubMed
26.
Zurück zum Zitat Norris MJ, Carlin MC, Ratz JL (1989) Treatment of essential telangiectasias: effects of increasing concentrations of polidocanol. J Am Acad Dermatol 20:643–649 PubMedCrossRef Norris MJ, Carlin MC, Ratz JL (1989) Treatment of essential telangiectasias: effects of increasing concentrations of polidocanol. J Am Acad Dermatol 20:643–649 PubMedCrossRef
27.
Zurück zum Zitat Rabe E, Schliephake D, Otto J, Breu FX, Pannier F (2010) Sclerotherapy of telangiectasias and reticular veins: a double-blind, randomized, comparative clinical trial of polidocanol, sodium tetradecyl sulphate and isotonic saline (EASI study). Phlebology 25:124–131 PubMedCrossRef Rabe E, Schliephake D, Otto J, Breu FX, Pannier F (2010) Sclerotherapy of telangiectasias and reticular veins: a double-blind, randomized, comparative clinical trial of polidocanol, sodium tetradecyl sulphate and isotonic saline (EASI study). Phlebology 25:124–131 PubMedCrossRef
28.
Zurück zum Zitat Uncu H (2010) Sclerotherapy: a study comparing polidocanol in foam and liquid form. Phlebology 25:44–49 PubMedCrossRef Uncu H (2010) Sclerotherapy: a study comparing polidocanol in foam and liquid form. Phlebology 25:44–49 PubMedCrossRef
29.
Zurück zum Zitat Peterson JD, Goldman MP, Weiss RA, Duffy DM, Fabi SG, Weiss MA, Guiha I (2012) Treatment of reticular and telangiectatic leg veins: double-blind, prospective comparative trial of polidocanol and hypertonic saline. Dermatol Surg 38:1–9 CrossRef Peterson JD, Goldman MP, Weiss RA, Duffy DM, Fabi SG, Weiss MA, Guiha I (2012) Treatment of reticular and telangiectatic leg veins: double-blind, prospective comparative trial of polidocanol and hypertonic saline. Dermatol Surg 38:1–9 CrossRef
30.
Zurück zum Zitat Parlar B, Blazek C, Cazzaniga S, Naldi L, Kloetgen HW, Borradori L, Buettiker U (2015) Treatment of lower extremity telangiectasias in women by foam sclerotherapy vs. Nd:YAG laser: a prospective, comparative, randomized, open-label trial. J Eur Acad Dermatol Venereol 29:549–554 PubMedCrossRef Parlar B, Blazek C, Cazzaniga S, Naldi L, Kloetgen HW, Borradori L, Buettiker U (2015) Treatment of lower extremity telangiectasias in women by foam sclerotherapy vs. Nd:YAG laser: a prospective, comparative, randomized, open-label trial. J Eur Acad Dermatol Venereol 29:549–554 PubMedCrossRef
31.
Zurück zum Zitat Kakkos SK, Bountouroglou DG, Azzam M, Kalodiki E, Daskalopoulos M, Geroulakos G (2006) Effectiveness and safety of ultrasound-guided foam Sclerotherapy for recurrent varicose veins: immediate results. J Endovascular Ther 13:357–364 CrossRef Kakkos SK, Bountouroglou DG, Azzam M, Kalodiki E, Daskalopoulos M, Geroulakos G (2006) Effectiveness and safety of ultrasound-guided foam Sclerotherapy for recurrent varicose veins: immediate results. J Endovascular Ther 13:357–364 CrossRef
32.
Zurück zum Zitat McDonagh B, Sorenson S, Gray C, Huntley DE, Putterman P, King T, Eaton T, Martin C, Harry JL, Cohen A, Guptan RC (2003) Clinical spectrum of recurrent postoperative varicose veins and efficacy of sclerotherapy management using the compass technique. Phlebology 18:173–186 CrossRef McDonagh B, Sorenson S, Gray C, Huntley DE, Putterman P, King T, Eaton T, Martin C, Harry JL, Cohen A, Guptan RC (2003) Clinical spectrum of recurrent postoperative varicose veins and efficacy of sclerotherapy management using the compass technique. Phlebology 18:173–186 CrossRef
33.
Zurück zum Zitat Coleridge Smith P (2006) Chronic venous disease treated by ultrasound guided foam Sclerotherapy. Eur J Vasc Endovasc Surg 32:577–583 PubMedCrossRef Coleridge Smith P (2006) Chronic venous disease treated by ultrasound guided foam Sclerotherapy. Eur J Vasc Endovasc Surg 32:577–583 PubMedCrossRef
34.
Zurück zum Zitat Coleridge Smith P (2009) Sclerotherapy and foam sclerotherapy for varicose veins. Phlebology 24:260–269 PubMedCrossRef Coleridge Smith P (2009) Sclerotherapy and foam sclerotherapy for varicose veins. Phlebology 24:260–269 PubMedCrossRef
35.
Zurück zum Zitat Bradbury AW, Bate G, Pang K, Darvall KA, Adam DJ (2010) Ultrasound-guided foam sclerotherapy is a safe and clinically effective treatment for superficial venous reflux. J Vasc Surg 52:939–945 PubMedCrossRef Bradbury AW, Bate G, Pang K, Darvall KA, Adam DJ (2010) Ultrasound-guided foam sclerotherapy is a safe and clinically effective treatment for superficial venous reflux. J Vasc Surg 52:939–945 PubMedCrossRef
36.
Zurück zum Zitat Darvall KA, Bate GR, Adam DJ, Silverman SH, Bradbury AW (2011) Duplex ultrasound outcomes following ultrasound guided foam sclerotherapy of symptomatic recurrent great saphenous varicose veins. Eur J Vasc Endovasc Surg 42:107–114 PubMedCrossRef Darvall KA, Bate GR, Adam DJ, Silverman SH, Bradbury AW (2011) Duplex ultrasound outcomes following ultrasound guided foam sclerotherapy of symptomatic recurrent great saphenous varicose veins. Eur J Vasc Endovasc Surg 42:107–114 PubMedCrossRef
37.
Zurück zum Zitat Darvall KA, Bate GR, Adam DJ, Silverman SH, Bradbury A (2011) Duplex ultrasound outcomes following ultrasound-guided foam sclerotherapy of symptomatic recurrent great saphenous varicose veins. Eur J Vasc Endovasc Surg 42:107–114 PubMedCrossRef Darvall KA, Bate GR, Adam DJ, Silverman SH, Bradbury A (2011) Duplex ultrasound outcomes following ultrasound-guided foam sclerotherapy of symptomatic recurrent great saphenous varicose veins. Eur J Vasc Endovasc Surg 42:107–114 PubMedCrossRef
38.
Zurück zum Zitat De Maeseneer M (2011) Surgery for recurrent varicose veins: toward a less-invasive approach? Perspect Vasc Surg Endovasc Ther 23:244–249 PubMedCrossRef De Maeseneer M (2011) Surgery for recurrent varicose veins: toward a less-invasive approach? Perspect Vasc Surg Endovasc Ther 23:244–249 PubMedCrossRef
39.
Zurück zum Zitat Pavei P, Vecchiato M, Spreafico G, Giraldi E, Ferrini M, Baccaglini U, Ancona E (2008) Natural history of recurrent varices undergoing reintervention: a retrospective study. Dermatol Surg 34:1676–1682 PubMed Pavei P, Vecchiato M, Spreafico G, Giraldi E, Ferrini M, Baccaglini U, Ancona E (2008) Natural history of recurrent varices undergoing reintervention: a retrospective study. Dermatol Surg 34:1676–1682 PubMed
40.
Zurück zum Zitat Sukovatykh BS, Rodionov OA, Sukovatykh MB, Khodykin SP (2008) Diagnosis and treatment of atypical forms of varicose disease of pelvic veins. Vestnik Khirurgii Imeni Grekova 167:43–45 Sukovatykh BS, Rodionov OA, Sukovatykh MB, Khodykin SP (2008) Diagnosis and treatment of atypical forms of varicose disease of pelvic veins. Vestnik Khirurgii Imeni Grekova 167:43–45
41.
Zurück zum Zitat Paraskevas P (2011) Successful ultrasound-guided foam sclerotherapy for vulval and leg varicosities secondary to ovarian vein reflux: a case study. Phlebology 26:29–31 PubMedCrossRef Paraskevas P (2011) Successful ultrasound-guided foam sclerotherapy for vulval and leg varicosities secondary to ovarian vein reflux: a case study. Phlebology 26:29–31 PubMedCrossRef
42.
Zurück zum Zitat Herwig R, Sansalone S (2015) Venous leakage treatment revisited: Pelvic venoablation using Aethoxysclerol under air block technique and valsalva maneuver. Arch Ital Urol Androl 87:1–4 PubMedCrossRef Herwig R, Sansalone S (2015) Venous leakage treatment revisited: Pelvic venoablation using Aethoxysclerol under air block technique and valsalva maneuver. Arch Ital Urol Androl 87:1–4 PubMedCrossRef
43.
Zurück zum Zitat Stücker M, Reich S, Hermes N, Altmeyer P (2006) Safety and efficiency of perilesional sclerotherapy in leg ulcer patients with postthrombotic syndrome and/or oral anticoagulation with phenprocoumon. J Dtsch Dermatol Ges 4:734–738 PubMedCrossRef Stücker M, Reich S, Hermes N, Altmeyer P (2006) Safety and efficiency of perilesional sclerotherapy in leg ulcer patients with postthrombotic syndrome and/or oral anticoagulation with phenprocoumon. J Dtsch Dermatol Ges 4:734–738 PubMedCrossRef
44.
Zurück zum Zitat De Waard MM, Der Kinderen DJ (2005) Duplex ultrasonography-guided foam sclerotherapy of incompetent perforator veins in a patient with bilateral venous leg ulcers. Dermatol Surg 31:580–583 PubMedCrossRef De Waard MM, Der Kinderen DJ (2005) Duplex ultrasonography-guided foam sclerotherapy of incompetent perforator veins in a patient with bilateral venous leg ulcers. Dermatol Surg 31:580–583 PubMedCrossRef
45.
Zurück zum Zitat Hertzman PA, Owens R (2007) Rapid healing of chronic venous ulcers following ultrasound-guided foam sclerotherapy. Phlebology 22:34–39 PubMedCrossRef Hertzman PA, Owens R (2007) Rapid healing of chronic venous ulcers following ultrasound-guided foam sclerotherapy. Phlebology 22:34–39 PubMedCrossRef
46.
Zurück zum Zitat Pang KH, Bate GR, Darvall KAL, Adam DJ, Bradbury AW (2010) Healing and recurrence rates following ultrasound guided foam sclerotherapy of superficial venous reflux in patients with chronic venous ulceration. Eur J Vasc Endovasc Surg 40:790–795 PubMedCrossRef Pang KH, Bate GR, Darvall KAL, Adam DJ, Bradbury AW (2010) Healing and recurrence rates following ultrasound guided foam sclerotherapy of superficial venous reflux in patients with chronic venous ulceration. Eur J Vasc Endovasc Surg 40:790–795 PubMedCrossRef
47.
Zurück zum Zitat Williamsson C, Danielsson P, Smith L (2014) Catheter-directed foam sclerotherapy for chronic venous leg ulcers. Phlebology 29:688–693 PubMedCrossRef Williamsson C, Danielsson P, Smith L (2014) Catheter-directed foam sclerotherapy for chronic venous leg ulcers. Phlebology 29:688–693 PubMedCrossRef
48.
Zurück zum Zitat Campos W, Torres IO, da Silva ES, Casella IB, Puech-Leão P (2015) A prospective randomized study comparing polidocanol foam sclerotherapy with surgical treatment of patients with primary chronic venous insufficiency and ulcer. Ann Vasc Surg 29:1128–1135 PubMedCrossRef Campos W, Torres IO, da Silva ES, Casella IB, Puech-Leão P (2015) A prospective randomized study comparing polidocanol foam sclerotherapy with surgical treatment of patients with primary chronic venous insufficiency and ulcer. Ann Vasc Surg 29:1128–1135 PubMedCrossRef
49.
Zurück zum Zitat Lloret P, Redondo P, Cabrera J, Sierra A (2015) Treatment of venous leg ulcers with ultrasound-guided foam sclerotherapy: healing, long-term recurrence and quality of life evaluation. Wound Repair Regen 23:369–378 PubMedCrossRef Lloret P, Redondo P, Cabrera J, Sierra A (2015) Treatment of venous leg ulcers with ultrasound-guided foam sclerotherapy: healing, long-term recurrence and quality of life evaluation. Wound Repair Regen 23:369–378 PubMedCrossRef
50.
Zurück zum Zitat Neto FC, de Araújo GR, Kessler IM, de Amorim RFB, Falcão DP (2015) Treatment of severe chronic venous insufficiency with ultrasound-guided foam sclerotherapy: a two-year series in a single center in Brazil. Phlebology 30:113–118 PubMedCrossRef Neto FC, de Araújo GR, Kessler IM, de Amorim RFB, Falcão DP (2015) Treatment of severe chronic venous insufficiency with ultrasound-guided foam sclerotherapy: a two-year series in a single center in Brazil. Phlebology 30:113–118 PubMedCrossRef
51.
Zurück zum Zitat Yamaki T, Nozaki M, Sasaki K (2000) Color duplex-guided sclerotherapy for the treatment of venous malformations. Dermatol Surg 26:323–328 PubMedCrossRef Yamaki T, Nozaki M, Sasaki K (2000) Color duplex-guided sclerotherapy for the treatment of venous malformations. Dermatol Surg 26:323–328 PubMedCrossRef
52.
Zurück zum Zitat Yamaki T, Nozaki M, Sakurai H, Takeuchi M, Soejima K, Kono T (2008) Prospective randomized efficacy of ultrasound-guided foam sclerotherapy compared with ultrasound-guided liquid sclerotherapy in the treatment of symptomatic venous malformations. J Vasc Surg 47:578–584 PubMedCrossRef Yamaki T, Nozaki M, Sakurai H, Takeuchi M, Soejima K, Kono T (2008) Prospective randomized efficacy of ultrasound-guided foam sclerotherapy compared with ultrasound-guided liquid sclerotherapy in the treatment of symptomatic venous malformations. J Vasc Surg 47:578–584 PubMedCrossRef
53.
Zurück zum Zitat Blaise S, Charavin-Cocuzza M, Riom H, Brix M, Seinturier C, Diamand JM, Gachet G, Carpentier PH (2011) Treatment of low-flow vascular malformations by ultrasound-guided Sclerotherapy with Polidocanol foam: 24 cases and literature review. Eur J Vasc Endovasc Surg 41:412–417 PubMedCrossRef Blaise S, Charavin-Cocuzza M, Riom H, Brix M, Seinturier C, Diamand JM, Gachet G, Carpentier PH (2011) Treatment of low-flow vascular malformations by ultrasound-guided Sclerotherapy with Polidocanol foam: 24 cases and literature review. Eur J Vasc Endovasc Surg 41:412–417 PubMedCrossRef
54.
Zurück zum Zitat Markovic JN, Kim CY, Lidsky ME, Shortell CK (2012) A 6‑year experience treating vascular malformations with foam Sclerotherapy. Perspect Vasc Surg Endovasc Ther 24:70–79 PubMedCrossRef Markovic JN, Kim CY, Lidsky ME, Shortell CK (2012) A 6‑year experience treating vascular malformations with foam Sclerotherapy. Perspect Vasc Surg Endovasc Ther 24:70–79 PubMedCrossRef
55.
Zurück zum Zitat Van der Vleuten CJM, Kater A, Wijnen MHWA, Schultze Kool LJ, Rovers MM (2014) Effectiveness of Sclerotherapy, surgery, and laser therapy in patients with venous malformations: a systematic review. Cardiovasc Intervent Radiol 37:977–989 PubMed Van der Vleuten CJM, Kater A, Wijnen MHWA, Schultze Kool LJ, Rovers MM (2014) Effectiveness of Sclerotherapy, surgery, and laser therapy in patients with venous malformations: a systematic review. Cardiovasc Intervent Radiol 37:977–989 PubMed
56.
Zurück zum Zitat Chen AW, Liu YR, Zhang K, Wang T, Liu SH (2015) Efficacy of sclerotherapy with radio-opaque foam guided by digital subtraction angiography for the treatment of complex venous malformations of the head and neck. Br J Oral Maxillofac Surg 53:809–813 PubMedCrossRef Chen AW, Liu YR, Zhang K, Wang T, Liu SH (2015) Efficacy of sclerotherapy with radio-opaque foam guided by digital subtraction angiography for the treatment of complex venous malformations of the head and neck. Br J Oral Maxillofac Surg 53:809–813 PubMedCrossRef
57.
Zurück zum Zitat Horbach SER, Lokhorst MM, Saeed P, De Pontouraude CMF, Rothova A, Van der Horst CMAM (2016) Sclerotherapy for low-flow vascular malformations of the head and neck: a systematic Review of sclerosing agents. J Plast Reconstr Aesthet Surg 69(3):295–304 PubMedCrossRef Horbach SER, Lokhorst MM, Saeed P, De Pontouraude CMF, Rothova A, Van der Horst CMAM (2016) Sclerotherapy for low-flow vascular malformations of the head and neck: a systematic Review of sclerosing agents. J Plast Reconstr Aesthet Surg 69(3):295–304 PubMedCrossRef
58.
Zurück zum Zitat Kern P, Ramelet A‑A, Wutschert R, Bounameaux H, Hayoz D (2004) Single blind randomized study comparing chromated glycerin, polidocanol solution and polidocanol foam for treatment of telangiectactic leg veins. Dermatol Surg 30:367–372 PubMed Kern P, Ramelet A‑A, Wutschert R, Bounameaux H, Hayoz D (2004) Single blind randomized study comparing chromated glycerin, polidocanol solution and polidocanol foam for treatment of telangiectactic leg veins. Dermatol Surg 30:367–372 PubMed
59.
Zurück zum Zitat Rabe E, Pannier F, Gerlach H, Breu FX, Guggenbichler S, Wollmann JC (2008) Leitlinie Sklerosierungsbehandlung der Varikose. Phlebologie 37:27–34 CrossRef Rabe E, Pannier F, Gerlach H, Breu FX, Guggenbichler S, Wollmann JC (2008) Leitlinie Sklerosierungsbehandlung der Varikose. Phlebologie 37:27–34 CrossRef
60.
Zurück zum Zitat Rao J, Wildemore JK, Goldmann MP (2005) Double-blind prospective comparative trial between foamed and liquid Polidocanol and Natrium Tetradecyl Sulfate in the treatment of varicose and telangiectatic leg veins. Dermatol Surg 31:631–635 PubMedCrossRef Rao J, Wildemore JK, Goldmann MP (2005) Double-blind prospective comparative trial between foamed and liquid Polidocanol and Natrium Tetradecyl Sulfate in the treatment of varicose and telangiectatic leg veins. Dermatol Surg 31:631–635 PubMedCrossRef
61.
Zurück zum Zitat Bullens-Goessens YIJM, Mentink LF et al (2004) Ultrasound-guided sclerotherapy of the insufficient short saphenous vein. Phlebol Ger 33:89–91 CrossRef Bullens-Goessens YIJM, Mentink LF et al (2004) Ultrasound-guided sclerotherapy of the insufficient short saphenous vein. Phlebol Ger 33:89–91 CrossRef
62.
Zurück zum Zitat Schultz-Ehrenburg U, Tourbier H (1984) Doppler-kontrollierte Verödungsbehandlung der Vena saphena magna. Phlebol Proktol 13:117–122 Schultz-Ehrenburg U, Tourbier H (1984) Doppler-kontrollierte Verödungsbehandlung der Vena saphena magna. Phlebol Proktol 13:117–122
63.
Zurück zum Zitat Vin F (1997) Principes de la Sclérothéraphie des Troncs Saphènes Internes. Phlebologie 50:229–234 Vin F (1997) Principes de la Sclérothéraphie des Troncs Saphènes Internes. Phlebologie 50:229–234
64.
Zurück zum Zitat Gohel MS, Epstein DM, Davies AH (2010) Cost-effectiveness of traditional and endovenous treatments for varicose veins. Br J Surg 97:1815–1823 PubMedCrossRef Gohel MS, Epstein DM, Davies AH (2010) Cost-effectiveness of traditional and endovenous treatments for varicose veins. Br J Surg 97:1815–1823 PubMedCrossRef
65.
Zurück zum Zitat Biemans AAM, Kockaert M, Akkersdijk GP, van den Bos RR, de Maeseneer MGR, Cuypers P, Stijne T, Neumann MHA, Nijsten T (2013) Comparing endovenous laser ablation, foam sclerotherapy, and conventional surgery for great saphenous varicose veins. J Vasc Surg 58:727–734 PubMedCrossRef Biemans AAM, Kockaert M, Akkersdijk GP, van den Bos RR, de Maeseneer MGR, Cuypers P, Stijne T, Neumann MHA, Nijsten T (2013) Comparing endovenous laser ablation, foam sclerotherapy, and conventional surgery for great saphenous varicose veins. J Vasc Surg 58:727–734 PubMedCrossRef
66.
Zurück zum Zitat Rasmussen L, Lawaetz M, Serup J, Bjoern L, Vennits B, Blemings A, Eklof B (2013) Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy, and surgical stripping for great saphenous varicose veins with 3‑year follow-up. J Vasc Surg Venous Lymphat Disord 1:349–356 PubMedCrossRef Rasmussen L, Lawaetz M, Serup J, Bjoern L, Vennits B, Blemings A, Eklof B (2013) Randomized clinical trial comparing endovenous laser ablation, radiofrequency ablation, foam sclerotherapy, and surgical stripping for great saphenous varicose veins with 3‑year follow-up. J Vasc Surg Venous Lymphat Disord 1:349–356 PubMedCrossRef
67.
Zurück zum Zitat Carroll C, Hummel S, Leaviss J, Re S, Stevens JW, Cantrell A, Michaels J (2015) Systematic review, network meta-analysis and exploratory cost-effectiveness model of randomized trials of minimally invasive techniques versus surgery for varicose veins. Br J Surg 101:1040–1052 CrossRef Carroll C, Hummel S, Leaviss J, Re S, Stevens JW, Cantrell A, Michaels J (2015) Systematic review, network meta-analysis and exploratory cost-effectiveness model of randomized trials of minimally invasive techniques versus surgery for varicose veins. Br J Surg 101:1040–1052 CrossRef
69.
Zurück zum Zitat National Institute for Health and Care of Excellence (2013) Ultrasound-guided foam sclerotherapy for varicose veins. NICE interventional procedure guidance [IPG440] National Institute for Health and Care of Excellence (2013) Ultrasound-guided foam sclerotherapy for varicose veins. NICE interventional procedure guidance [IPG440]
70.
Zurück zum Zitat Siribumrungwong B, Noorit P, Wilasrusmee C, Leelahavarong P, Thakkinstian A, Teerawattananon Y (2016) Cost-utility analysis of great saphenous vein ablation with radiofrequency, foam and surgery in the emerging health-care setting of Thailand. Phlebology 31:573–581 PubMedCrossRef Siribumrungwong B, Noorit P, Wilasrusmee C, Leelahavarong P, Thakkinstian A, Teerawattananon Y (2016) Cost-utility analysis of great saphenous vein ablation with radiofrequency, foam and surgery in the emerging health-care setting of Thailand. Phlebology 31:573–581 PubMedCrossRef
71.
Zurück zum Zitat Varisolve European Phase III Investigators Group, Wright D, Gobin JP, Bradbury AW et al (2006) Varisolve® polidocanol microfoam compared with surgery or sclerotherapy in the management of varicose veins in the presence of trunk vein incompetence: European randomized controlled trial. Phlebology 21:180–190 CrossRef Varisolve European Phase III Investigators Group, Wright D, Gobin JP, Bradbury AW et al (2006) Varisolve® polidocanol microfoam compared with surgery or sclerotherapy in the management of varicose veins in the presence of trunk vein incompetence: European randomized controlled trial. Phlebology 21:180–190 CrossRef
72.
Zurück zum Zitat Cavezzi A, Frullini A, Ricci S, Tessari L (2002) Treatment of varicose veins by foam sclerotherapy: two clinical series. Phlebology 17:13–18 CrossRef Cavezzi A, Frullini A, Ricci S, Tessari L (2002) Treatment of varicose veins by foam sclerotherapy: two clinical series. Phlebology 17:13–18 CrossRef
73.
Zurück zum Zitat Hamel-Desnos C, Ouvry P, Desnos P et al (2003) Sclérothérapie et thrombophilie: Démarche pour un consensus dans la sclérothérapie chez les thrombophiles. Phlebologie 56:165–169 Hamel-Desnos C, Ouvry P, Desnos P et al (2003) Sclérothérapie et thrombophilie: Démarche pour un consensus dans la sclérothérapie chez les thrombophiles. Phlebologie 56:165–169
74.
Zurück zum Zitat Gohel MS, Heatley F, Liu X, Bradbury A, Bulbulia R, Cullum N, Epstein DM, Nyamekye I, Poskitt KR, Renton S, Warwick J, Davies AH (2018) A randomized trial of early endovenous ablationin venous ulceration. N Eng J Med 378:2105–2114 CrossRef Gohel MS, Heatley F, Liu X, Bradbury A, Bulbulia R, Cullum N, Epstein DM, Nyamekye I, Poskitt KR, Renton S, Warwick J, Davies AH (2018) A randomized trial of early endovenous ablationin venous ulceration. N Eng J Med 378:2105–2114 CrossRef
75.
Zurück zum Zitat Breu FX, Guggenbichler S, Wollmann JC (2008) 2nd European Consensus Meeting on Foam Sclerotherapy, 28–30 April 2006, Tegernsee, Germany. Vasa 37(Supplement 71):1–32 PubMedCrossRef Breu FX, Guggenbichler S, Wollmann JC (2008) 2nd European Consensus Meeting on Foam Sclerotherapy, 28–30 April 2006, Tegernsee, Germany. Vasa 37(Supplement 71):1–32 PubMedCrossRef
76.
Zurück zum Zitat Guex JJ (2005) Les contre-indications de la sclérothérapie, mise à jour 2005. J Mal Vasc 30:144–149 PubMedCrossRef Guex JJ (2005) Les contre-indications de la sclérothérapie, mise à jour 2005. J Mal Vasc 30:144–149 PubMedCrossRef
77.
Zurück zum Zitat Hamel-Desnos CM, Gillet J‑L, Desnos PR, Allaert FA (2009) Sclerotherapy of varicose veins in patients with documented thrombophilia: a prospective controlled randomized study of 105 cases. Phlebology 24:176–182 PubMedCrossRef Hamel-Desnos CM, Gillet J‑L, Desnos PR, Allaert FA (2009) Sclerotherapy of varicose veins in patients with documented thrombophilia: a prospective controlled randomized study of 105 cases. Phlebology 24:176–182 PubMedCrossRef
78.
Zurück zum Zitat Gachet G, Spini L (2002) Sclérothérapie des varices sous anticoagulants. Phlebologie 55:41–44 Gachet G, Spini L (2002) Sclérothérapie des varices sous anticoagulants. Phlebologie 55:41–44
79.
Zurück zum Zitat Rathbun S, Norris A, Stoner J (2012) Efficacy and safety of endovenous foam sclerotherapy: meta-analysis for treatment of venous disorders. Phlebology 27:105–117 PubMedCrossRef Rathbun S, Norris A, Stoner J (2012) Efficacy and safety of endovenous foam sclerotherapy: meta-analysis for treatment of venous disorders. Phlebology 27:105–117 PubMedCrossRef
80.
Zurück zum Zitat Guex JJ, Allaert F‑A, Gillet J‑L (2005) Immediate and midterm complications of sclerotherapy: report of a prospective multicenter registry of 12,173 sclerotherapy sessions. Dermatol Surg 31:123–128 PubMedCrossRef Guex JJ, Allaert F‑A, Gillet J‑L (2005) Immediate and midterm complications of sclerotherapy: report of a prospective multicenter registry of 12,173 sclerotherapy sessions. Dermatol Surg 31:123–128 PubMedCrossRef
81.
82.
Zurück zum Zitat Munavalli GS, Weiss RA (2007) Complications of sclerotherapy. Semin Cutan Med Surg 26:22–28 PubMedCrossRef Munavalli GS, Weiss RA (2007) Complications of sclerotherapy. Semin Cutan Med Surg 26:22–28 PubMedCrossRef
83.
Zurück zum Zitat Weiss RA, Weiss MA (1990) Incidence of side effects in the treatment of telangiectasias by compression Sclerotherapy: hypertonics saline vs. polidocanol. J Dermatol Surg Oncol 16:800–804 PubMedCrossRef Weiss RA, Weiss MA (1990) Incidence of side effects in the treatment of telangiectasias by compression Sclerotherapy: hypertonics saline vs. polidocanol. J Dermatol Surg Oncol 16:800–804 PubMedCrossRef
84.
Zurück zum Zitat Gillet JL, Guedes JM, Guex JJ et al (2009) Side effects and complications of foam sclerotherapy of the great and small saphenous veins: a controlled multicentre prospective study including 1025 patients. Phlebology 24:131–138 PubMedCrossRef Gillet JL, Guedes JM, Guex JJ et al (2009) Side effects and complications of foam sclerotherapy of the great and small saphenous veins: a controlled multicentre prospective study including 1025 patients. Phlebology 24:131–138 PubMedCrossRef
85.
Zurück zum Zitat Cavezzi A, Parsi K (2012) Complications of foam sclerotherapy. Phlebology 27(Suppl 1):46–51 PubMedCrossRef Cavezzi A, Parsi K (2012) Complications of foam sclerotherapy. Phlebology 27(Suppl 1):46–51 PubMedCrossRef
86.
Zurück zum Zitat Sarvananthan T, Shepherd AC, Willenberg T, Davies AH (2012) Neurological complications of sclerotherapy for varicose veins. J Vasc Surg 55:243–251 PubMedCrossRef Sarvananthan T, Shepherd AC, Willenberg T, Davies AH (2012) Neurological complications of sclerotherapy for varicose veins. J Vasc Surg 55:243–251 PubMedCrossRef
87.
Zurück zum Zitat Feied CF, Jackson JJ, Bren TS, Bond OB, Fernando CE, Young VC, Hashemiyoon RB (1994) Allergic reactions to Polidocanol for vein sclerosis. J Dermatol Surg Oncol 20:466–468 PubMedCrossRef Feied CF, Jackson JJ, Bren TS, Bond OB, Fernando CE, Young VC, Hashemiyoon RB (1994) Allergic reactions to Polidocanol for vein sclerosis. J Dermatol Surg Oncol 20:466–468 PubMedCrossRef
88.
Zurück zum Zitat Pradalier A, Vincent D, Hentschel V et al (1995) Allergie aux sclérosants des varices. Rev Fr Allergol 35:440–443 Pradalier A, Vincent D, Hentschel V et al (1995) Allergie aux sclérosants des varices. Rev Fr Allergol 35:440–443
89.
Zurück zum Zitat Hannaford PKP (2016) Intra-arterial injection of sclerosants: report of three cases treated with systemic steroids. Phlebology 31:241–250 PubMedCrossRef Hannaford PKP (2016) Intra-arterial injection of sclerosants: report of three cases treated with systemic steroids. Phlebology 31:241–250 PubMedCrossRef
90.
Zurück zum Zitat Oesch A, Stirnemann P, Mahler F (1984) The acute Ischemic syndrome of the foot after Sclerotherapy of varicose veins. Schweiz Med Wochenschr 114:1155–1158 PubMed Oesch A, Stirnemann P, Mahler F (1984) The acute Ischemic syndrome of the foot after Sclerotherapy of varicose veins. Schweiz Med Wochenschr 114:1155–1158 PubMed
91.
Zurück zum Zitat Grommes J, Franzen EL, Binnebösel M, Toonder IM, Wittens C, Jacobs M, Greiner A (2010) Inadvertent arterial injection using catheter-assisted sclerotherapy resulting in amputation. Dermatol Surg 37:536–538 PubMedCrossRef Grommes J, Franzen EL, Binnebösel M, Toonder IM, Wittens C, Jacobs M, Greiner A (2010) Inadvertent arterial injection using catheter-assisted sclerotherapy resulting in amputation. Dermatol Surg 37:536–538 PubMedCrossRef
92.
Zurück zum Zitat Hafner F, Fröhlich H, Gary T, Brodmann M (2013) Intra-arterial injection, a rare but serious complication of sclerotherapy. Phlebology 28:64–73 PubMedCrossRef Hafner F, Fröhlich H, Gary T, Brodmann M (2013) Intra-arterial injection, a rare but serious complication of sclerotherapy. Phlebology 28:64–73 PubMedCrossRef
93.
Zurück zum Zitat Goldman MP, Sadick NS, Weiss RA (1995) Cutaneous necrosis, telangiectatic matting and hyperpigmentation following Sclerotherapy. Dermatol Surg 21:19–29 PubMedCrossRef Goldman MP, Sadick NS, Weiss RA (1995) Cutaneous necrosis, telangiectatic matting and hyperpigmentation following Sclerotherapy. Dermatol Surg 21:19–29 PubMedCrossRef
94.
Zurück zum Zitat Schuller-Petrović S, Brunner F, Neuhold N, Pavlović MD, Wölkart G (2011) Subcutaneous injection of liquid and foamed polidocanol: extravasation is not responsible for skin necrosis during reticular and spider vein sclerotherapy. J Eur Acad Dermatol Venereol 25:983–986 PubMedCrossRef Schuller-Petrović S, Brunner F, Neuhold N, Pavlović MD, Wölkart G (2011) Subcutaneous injection of liquid and foamed polidocanol: extravasation is not responsible for skin necrosis during reticular and spider vein sclerotherapy. J Eur Acad Dermatol Venereol 25:983–986 PubMedCrossRef
95.
Zurück zum Zitat Bergan JJ, Weiss RA, Goldman MP (2000) Extensive tissue necrosis following high concentration sclerotherapy for varicose veins. Dermatol Surg 26:535–542 PubMedCrossRef Bergan JJ, Weiss RA, Goldman MP (2000) Extensive tissue necrosis following high concentration sclerotherapy for varicose veins. Dermatol Surg 26:535–542 PubMedCrossRef
96.
Zurück zum Zitat Bihari I, Magyar É (2001) Reasons for ulceration after injection treatment of telangiectasia. Dermatol Surg 27:133–136 PubMed Bihari I, Magyar É (2001) Reasons for ulceration after injection treatment of telangiectasia. Dermatol Surg 27:133–136 PubMed
97.
Zurück zum Zitat Geukens J, Rabe E, Bieber T (1999) Embolia cutis medicamentosa of the foot after sclerotherapy. Eur J Dermatol 9:132–133 PubMed Geukens J, Rabe E, Bieber T (1999) Embolia cutis medicamentosa of the foot after sclerotherapy. Eur J Dermatol 9:132–133 PubMed
98.
Zurück zum Zitat Ramelet AA, Parmentier L (2010) Delayed Nicolau’s Livedoid dermatitis after ultrasound-guided Sclerotherapy. Dermatol Surg 36:155–158 PubMedCrossRef Ramelet AA, Parmentier L (2010) Delayed Nicolau’s Livedoid dermatitis after ultrasound-guided Sclerotherapy. Dermatol Surg 36:155–158 PubMedCrossRef
99.
Zurück zum Zitat Van der Plas JPL, Lambers JC, van Wersch JW, Koehler PJ (1994) Reversible ischaemic neurological deficit after sclerotherapy of varicose veins. Lancet 343:428 PubMedCrossRef Van der Plas JPL, Lambers JC, van Wersch JW, Koehler PJ (1994) Reversible ischaemic neurological deficit after sclerotherapy of varicose veins. Lancet 343:428 PubMedCrossRef
100.
Zurück zum Zitat Künzelberger B, Pieck C, Altmeyer P, Stücker M (2006) Migraine ophthalmique with reversible scotomas after sclerotherapy with liquid 1 % polidocanol. Derm Surg 32:1410 Künzelberger B, Pieck C, Altmeyer P, Stücker M (2006) Migraine ophthalmique with reversible scotomas after sclerotherapy with liquid 1 % polidocanol. Derm Surg 32:1410
101.
Zurück zum Zitat Hill DA (2014) Neurological and chest symptoms following sclerotherapy: a single centre experience. Phlebology 29:619–627 PubMedCrossRef Hill DA (2014) Neurological and chest symptoms following sclerotherapy: a single centre experience. Phlebology 29:619–627 PubMedCrossRef
102.
Zurück zum Zitat Willenberg T, Smith PC, Shepherd A, Davies AH (2013) Visual disturbance following sclerotherapy for varicose veins, reticular veins and telangiectasias: a systematic literature review. Phlebology 28:123–131 PubMedCrossRef Willenberg T, Smith PC, Shepherd A, Davies AH (2013) Visual disturbance following sclerotherapy for varicose veins, reticular veins and telangiectasias: a systematic literature review. Phlebology 28:123–131 PubMedCrossRef
103.
104.
Zurück zum Zitat Parsi K (2011) Venous gas embolism during foam sclerotherapy of saphenous veins despite recommended treatment modifications. Phlebology 26:140–147 PubMedCrossRef Parsi K (2011) Venous gas embolism during foam sclerotherapy of saphenous veins despite recommended treatment modifications. Phlebology 26:140–147 PubMedCrossRef
105.
Zurück zum Zitat Morrison N, Cavezzi A, Bergan J, Partsch H (2006) Regarding “stroke after varicose vein foam injection sclerotherapy”. J Vasc Surg 44:224–225 PubMedCrossRef Morrison N, Cavezzi A, Bergan J, Partsch H (2006) Regarding “stroke after varicose vein foam injection sclerotherapy”. J Vasc Surg 44:224–225 PubMedCrossRef
106.
Zurück zum Zitat Passariello F (2007) Sclerosing foam and patent foramen ovale. The final report. In: Word Congress of the International Union of Phlebology; Int Angiol, Bd. 26, S 87 Passariello F (2007) Sclerosing foam and patent foramen ovale. The final report. In: Word Congress of the International Union of Phlebology; Int Angiol, Bd. 26, S 87
107.
Zurück zum Zitat Wagdi P (2006) Migräne und offenes Foramen Ovale: nur ein vorübergehender Hoffnungsschimmer? Kardiovasc Med 9:32–36 Wagdi P (2006) Migräne und offenes Foramen Ovale: nur ein vorübergehender Hoffnungsschimmer? Kardiovasc Med 9:32–36
108.
Zurück zum Zitat Gillet JL, Donnet A, Lausecker M, Guedes JM, Guex JJ, Lehmann P (2010) Pathophysiology of visual disturbances occurring after foam sclerotherapy. Phlebology 25:261–266 PubMedCrossRef Gillet JL, Donnet A, Lausecker M, Guedes JM, Guex JJ, Lehmann P (2010) Pathophysiology of visual disturbances occurring after foam sclerotherapy. Phlebology 25:261–266 PubMedCrossRef
109.
Zurück zum Zitat Zouitina TM, Hyra M, Seryer D, Chillon J‑M, Bugnicourt J‑M (2014) Prolonged acute migraine with aura and reversible brain MRI abnormalities after liquid sclerotherapy. J Headache Pain 15:1–4 CrossRef Zouitina TM, Hyra M, Seryer D, Chillon J‑M, Bugnicourt J‑M (2014) Prolonged acute migraine with aura and reversible brain MRI abnormalities after liquid sclerotherapy. J Headache Pain 15:1–4 CrossRef
110.
Zurück zum Zitat Frullini A, Felice F, Burchielli S, Di Stefano R (2011) High production of endothelin after foam sclerotherapy: a new pathogenetic hypothesis for neurological and visual disturbances after sclerotherapy. Phlebology 26:203–208 PubMedCrossRef Frullini A, Felice F, Burchielli S, Di Stefano R (2011) High production of endothelin after foam sclerotherapy: a new pathogenetic hypothesis for neurological and visual disturbances after sclerotherapy. Phlebology 26:203–208 PubMedCrossRef
111.
Zurück zum Zitat Frullini A, Barsotti MC, Santoni T, Duranti E, Burchielli S, Di Stefano R (2012) Significant endothelin release in patients treated with foam sclerotherapy. Dermatol Surg 38:741–747 PubMedCrossRef Frullini A, Barsotti MC, Santoni T, Duranti E, Burchielli S, Di Stefano R (2012) Significant endothelin release in patients treated with foam sclerotherapy. Dermatol Surg 38:741–747 PubMedCrossRef
112.
Zurück zum Zitat Yamaki T, Nozaki M, Sakurai H, Takeuchi M, Soejima K, Kono T (2008) Multiple Small-Dose Injections can reduce the passage of sclerosant foam into deep veins during foam sclerotherapy for varicose veins. Eur J Vasc Endovasc Surg 37:343–348 PubMedCrossRef Yamaki T, Nozaki M, Sakurai H, Takeuchi M, Soejima K, Kono T (2008) Multiple Small-Dose Injections can reduce the passage of sclerosant foam into deep veins during foam sclerotherapy for varicose veins. Eur J Vasc Endovasc Surg 37:343–348 PubMedCrossRef
113.
Zurück zum Zitat Forlee MV, Grouden M, Moore DJ, Shanik G (2006) Stroke after varicose vein foam injection sclerotherapy. J Vasc Surg 43:162–164 PubMedCrossRef Forlee MV, Grouden M, Moore DJ, Shanik G (2006) Stroke after varicose vein foam injection sclerotherapy. J Vasc Surg 43:162–164 PubMedCrossRef
114.
Zurück zum Zitat Busch RG, Derrick M, Manjoney D (2008) Major neurological events following foam sclerotherapy. Phlebology 23:189–192 CrossRef Busch RG, Derrick M, Manjoney D (2008) Major neurological events following foam sclerotherapy. Phlebology 23:189–192 CrossRef
115.
Zurück zum Zitat Leslie-Mazwi TM, Avery LL, Sims JR (2009) Intra-arterial air thrombogenesis after cerebral air embolism complicating lower extremity sclerotherapy. Neurocrit Care 11:97–100 PubMedCrossRef Leslie-Mazwi TM, Avery LL, Sims JR (2009) Intra-arterial air thrombogenesis after cerebral air embolism complicating lower extremity sclerotherapy. Neurocrit Care 11:97–100 PubMedCrossRef
116.
Zurück zum Zitat De Laney MC, Bowe CT, Higgins GL III (2010) Acute stroke from air embolism after leg Sclerotherapy. West J Emerg Med 11:397 De Laney MC, Bowe CT, Higgins GL III (2010) Acute stroke from air embolism after leg Sclerotherapy. West J Emerg Med 11:397
117.
Zurück zum Zitat Ma RWL, Pilotelle A, Paraskevas P, Parsi K (2011) Three cases of stroke following peripheral venous interventions. Phlebology 26:280–284 PubMedCrossRef Ma RWL, Pilotelle A, Paraskevas P, Parsi K (2011) Three cases of stroke following peripheral venous interventions. Phlebology 26:280–284 PubMedCrossRef
118.
Zurück zum Zitat Harzheim M, Becher H, Klockgether T (2000) Brain infarct from a paradoxical embolism following a varices operation. Dtsch Med Wochenschr 125:794–796 PubMedCrossRef Harzheim M, Becher H, Klockgether T (2000) Brain infarct from a paradoxical embolism following a varices operation. Dtsch Med Wochenschr 125:794–796 PubMedCrossRef
119.
Zurück zum Zitat Caggiati A, Franceschini M (2010) Stroke following endovenous laser treatment of varicose veins. J Vasc Surg 51:218–220 PubMedCrossRef Caggiati A, Franceschini M (2010) Stroke following endovenous laser treatment of varicose veins. J Vasc Surg 51:218–220 PubMedCrossRef
120.
Zurück zum Zitat Gillet JL (2011) Neurological complications of foam sclerotherapy: fears and reality. Phlebology 26:277–279 PubMedCrossRef Gillet JL (2011) Neurological complications of foam sclerotherapy: fears and reality. Phlebology 26:277–279 PubMedCrossRef
121.
Zurück zum Zitat Deichman B, Blum G (1995) Cerebrovascular accident after sclerotherapy. Phlebologie 24:148–152 Deichman B, Blum G (1995) Cerebrovascular accident after sclerotherapy. Phlebologie 24:148–152
122.
Zurück zum Zitat Kas A, Begue M, Nifle C, Gil R, Neau JP (2000) Infarctus cérébelleux après sclérothérapie de varicosités des membres inférieurs. Presse Med 29:1935 PubMed Kas A, Begue M, Nifle C, Gil R, Neau JP (2000) Infarctus cérébelleux après sclérothérapie de varicosités des membres inférieurs. Presse Med 29:1935 PubMed
123.
Zurück zum Zitat Hanisch F, Müller T, Krivocuca M, Winterholler M (2004) Stroke following variceal sclerotherapy. Eur J Med Res 9:282–284 PubMed Hanisch F, Müller T, Krivocuca M, Winterholler M (2004) Stroke following variceal sclerotherapy. Eur J Med Res 9:282–284 PubMed
124.
Zurück zum Zitat Picard C, Deltombe B, Duru C, Godefroy O, Bugnicourt JM (2010) Foam sclerotherapy: a possible cause of ischaemic stroke? J Neurol Neurosurg Psychiatry 81:582–583 PubMedCrossRef Picard C, Deltombe B, Duru C, Godefroy O, Bugnicourt JM (2010) Foam sclerotherapy: a possible cause of ischaemic stroke? J Neurol Neurosurg Psychiatry 81:582–583 PubMedCrossRef
125.
Zurück zum Zitat Hahn M, Shulz T, Juenger M (2010) Late stroke after foam sclerotherapy. Vasa 39:108–110 PubMedCrossRef Hahn M, Shulz T, Juenger M (2010) Late stroke after foam sclerotherapy. Vasa 39:108–110 PubMedCrossRef
126.
Zurück zum Zitat Guex JJ (1996) Thombotic complications of the varicose disease. J Dermatol Surg 22:378–382 Guex JJ (1996) Thombotic complications of the varicose disease. J Dermatol Surg 22:378–382
127.
Zurück zum Zitat Hamel-Desnos C, Desnos P, Ferré B, Le Querrec A (2011) In vivo biological effects of foam sclerotherapy. Eur J Vasc Endovasc Surg 42:238–245 PubMedCrossRef Hamel-Desnos C, Desnos P, Ferré B, Le Querrec A (2011) In vivo biological effects of foam sclerotherapy. Eur J Vasc Endovasc Surg 42:238–245 PubMedCrossRef
128.
Zurück zum Zitat Fabi SG, Peterson JD, Goldman MP, Guiha I (2012) An investigation of coagulation cascade activation and induction of Fibrinolysis using foam Sclerotherapy of reticular veins. Dermatol Surg 38:367–372 PubMedCrossRef Fabi SG, Peterson JD, Goldman MP, Guiha I (2012) An investigation of coagulation cascade activation and induction of Fibrinolysis using foam Sclerotherapy of reticular veins. Dermatol Surg 38:367–372 PubMedCrossRef
129.
Zurück zum Zitat Jia X, Mowatt G, Burr JM, Cassar K, Cooke J, Fraser C (2007) Systematic review of foam sclerotherapy for varicose veins. Br J Surg 94:925–936 PubMedCrossRef Jia X, Mowatt G, Burr JM, Cassar K, Cooke J, Fraser C (2007) Systematic review of foam sclerotherapy for varicose veins. Br J Surg 94:925–936 PubMedCrossRef
130.
Zurück zum Zitat Dermody M, Schul MW, O’Donnell TF (2015) Thromboembolic complications of endovenous thermal ablation and foam sclerotherapy in the treatment of great saphenous vein insufficiency. Phlebology 30:357–364 PubMedCrossRef Dermody M, Schul MW, O’Donnell TF (2015) Thromboembolic complications of endovenous thermal ablation and foam sclerotherapy in the treatment of great saphenous vein insufficiency. Phlebology 30:357–364 PubMedCrossRef
131.
Zurück zum Zitat Myers KA, Jolley D (2008) Factors affecting the risk of deep venous occlusion after ultrasound-guided Sclerotherapy for varicose vein. Eur J Vasc Endovasc Surg 36:602–605 PubMedCrossRef Myers KA, Jolley D (2008) Factors affecting the risk of deep venous occlusion after ultrasound-guided Sclerotherapy for varicose vein. Eur J Vasc Endovasc Surg 36:602–605 PubMedCrossRef
132.
Zurück zum Zitat Reich-Schupke S, Doerler M, Altmeyer P, Stücker M (2013) Foam sclerotherapy with enoxaparin prophylaxis in high-risk patients with postthrombotic syndrome. Vasa 42:50–55 PubMedCrossRef Reich-Schupke S, Doerler M, Altmeyer P, Stücker M (2013) Foam sclerotherapy with enoxaparin prophylaxis in high-risk patients with postthrombotic syndrome. Vasa 42:50–55 PubMedCrossRef
133.
Zurück zum Zitat Zipper SG (2000) Nervus peronäus-Schaden nach Varizensklerosierung mit Aethoxysklerol. Versicherungsmedizin 4:185–187 Zipper SG (2000) Nervus peronäus-Schaden nach Varizensklerosierung mit Aethoxysklerol. Versicherungsmedizin 4:185–187
134.
Zurück zum Zitat Reich-Schupke S, Weyer K, Altmeyer P, Stücker M (2010) Treatment of varicose tributaries with sclerotherapy with polidocanol 0.5 % foam. Vasa 39:169–174 PubMedCrossRef Reich-Schupke S, Weyer K, Altmeyer P, Stücker M (2010) Treatment of varicose tributaries with sclerotherapy with polidocanol 0.5 % foam. Vasa 39:169–174 PubMedCrossRef
135.
Zurück zum Zitat Georgiev MJ (1990) Postsclerotherapy hyperpigmentations: a one-year follow-up. Dermatol Surg Oncol 16:608–610 CrossRef Georgiev MJ (1990) Postsclerotherapy hyperpigmentations: a one-year follow-up. Dermatol Surg Oncol 16:608–610 CrossRef
136.
Zurück zum Zitat Scultetus AH, Villavicencio JL, Kao TC, Gillespie DL, Ketron GD, Iafrati MD, Pikoulis E, Eifert S (2003) Microthrombectomy reduces postsclerotherapy pigmentation: multicenter randomized trial. J Vasc Surg 38:896–903 PubMedCrossRef Scultetus AH, Villavicencio JL, Kao TC, Gillespie DL, Ketron GD, Iafrati MD, Pikoulis E, Eifert S (2003) Microthrombectomy reduces postsclerotherapy pigmentation: multicenter randomized trial. J Vasc Surg 38:896–903 PubMedCrossRef
137.
Zurück zum Zitat Goldman MP, Kaplan RP, Duffy DM (1987) Postsclerotherapy hyperpigmentation: a histologic evaluation. J Dermatol Surg Oncol 13:547–550 PubMedCrossRef Goldman MP, Kaplan RP, Duffy DM (1987) Postsclerotherapy hyperpigmentation: a histologic evaluation. J Dermatol Surg Oncol 13:547–550 PubMedCrossRef
138.
Zurück zum Zitat Davis LT, Duffy DM (1990) Cutaneous necrosis, telangiectatic matting, and hyperpigmentation following sclerotherapy. Etiology, prevention, and treatment. J Dermatol Surg Oncol 16:327–330 PubMedCrossRef Davis LT, Duffy DM (1990) Cutaneous necrosis, telangiectatic matting, and hyperpigmentation following sclerotherapy. Etiology, prevention, and treatment. J Dermatol Surg Oncol 16:327–330 PubMedCrossRef
139.
Zurück zum Zitat Ramelet A‑A (2010) Phlébologie esthétique. Télangiectasies : possibilités thérapeutiques. Cosmétologie et Dermatologie esthétique. EMC (Elsevier Masson SAS), Paris Ramelet A‑A (2010) Phlébologie esthétique. Télangiectasies : possibilités thérapeutiques. Cosmétologie et Dermatologie esthétique. EMC (Elsevier Masson SAS), Paris
140.
Zurück zum Zitat Morrison N, Neuhardt DL, Rogers CR, McEown J, Morrison T, Johnson E, Salles-Cunha SX (2008) Comparisons of side effects using air and carbon dioxide foam for endovenous chemical ablation. J Vasc Surg 47:830–836 PubMedCrossRef Morrison N, Neuhardt DL, Rogers CR, McEown J, Morrison T, Johnson E, Salles-Cunha SX (2008) Comparisons of side effects using air and carbon dioxide foam for endovenous chemical ablation. J Vasc Surg 47:830–836 PubMedCrossRef
141.
Zurück zum Zitat Morrison N, Neuhardt DL, Rogers CR, McEown J, Morrison T, Johnson E, Salles-Cunha SX (2010) Incidence of side effects using carbon dioxide oxygen foam for chemical ablation of superficial veins of the lower extremity. Eur J Vasc Endovasc Surg 40:407–413 PubMedCrossRef Morrison N, Neuhardt DL, Rogers CR, McEown J, Morrison T, Johnson E, Salles-Cunha SX (2010) Incidence of side effects using carbon dioxide oxygen foam for chemical ablation of superficial veins of the lower extremity. Eur J Vasc Endovasc Surg 40:407–413 PubMedCrossRef
142.
Zurück zum Zitat Beckitt T, Elstone A, Ashley S (2011) Air versus physiological gas for ultrasound guided foam Sclerotherapy treatment of varicose veins. Eur J Vasc Endovasc Surg 42:115–119 PubMedCrossRef Beckitt T, Elstone A, Ashley S (2011) Air versus physiological gas for ultrasound guided foam Sclerotherapy treatment of varicose veins. Eur J Vasc Endovasc Surg 42:115–119 PubMedCrossRef
143.
Zurück zum Zitat Hesse G, Breu FX, Kuschmann A, Hartmann K, Salomon N (2012) Sclerotherapy using air- or CO2-O2-foam: post-approval study. Phlebologie 41:77–88 CrossRef Hesse G, Breu FX, Kuschmann A, Hartmann K, Salomon N (2012) Sclerotherapy using air- or CO2-O2-foam: post-approval study. Phlebologie 41:77–88 CrossRef
144.
Zurück zum Zitat Mercer KG, Scott DJ, Berridge DC (1998) Preoperative duplex imaging is required before all operations for primary varicose veins. Br J Surg 85:1495–1497 PubMedCrossRef Mercer KG, Scott DJ, Berridge DC (1998) Preoperative duplex imaging is required before all operations for primary varicose veins. Br J Surg 85:1495–1497 PubMedCrossRef
145.
Zurück zum Zitat Blomgren L, Johansson G, Bergquist D (2005) Randomized clinical trial of routine preoperative duplex imaging before varicose vein surgery. Br J Surg 92:688–694 PubMedCrossRef Blomgren L, Johansson G, Bergquist D (2005) Randomized clinical trial of routine preoperative duplex imaging before varicose vein surgery. Br J Surg 92:688–694 PubMedCrossRef
146.
Zurück zum Zitat Coleridge-Smith P, Labropoulos N, Partsch H, Myers K, Nicolaides A, Cavezzi A (2006) Duplex ultrasound investigation of the veins in chronic venous disease of the lower limbs—UIP consensus document. Part I. Basic principles. Eur J Vasc Endovasc Surg 31:83–92 PubMedCrossRef Coleridge-Smith P, Labropoulos N, Partsch H, Myers K, Nicolaides A, Cavezzi A (2006) Duplex ultrasound investigation of the veins in chronic venous disease of the lower limbs—UIP consensus document. Part I. Basic principles. Eur J Vasc Endovasc Surg 31:83–92 PubMedCrossRef
147.
Zurück zum Zitat De Maeseneer M, Pichot O, Cavezzi A, Earnshaw J, van Rij A, Lurie F, Smith PC (2011) Duplex ultrasound investigation of the veins of the lower limbs after treatment for varicose veins—UIP consensus document. Eur J Vasc Endovasc Surg 42:89–102 PubMedCrossRef De Maeseneer M, Pichot O, Cavezzi A, Earnshaw J, van Rij A, Lurie F, Smith PC (2011) Duplex ultrasound investigation of the veins of the lower limbs after treatment for varicose veins—UIP consensus document. Eur J Vasc Endovasc Surg 42:89–102 PubMedCrossRef
148.
Zurück zum Zitat Rautio T, Perälä J, Biancari F, Wiik H, Ohtonen P, Haukipuro K, Juvonen T (2002) Accuracy of hand-held Doppler in planning the operation for primary varicose veins. Eur J Vasc Endovasc Surg 24:450–455 PubMedCrossRef Rautio T, Perälä J, Biancari F, Wiik H, Ohtonen P, Haukipuro K, Juvonen T (2002) Accuracy of hand-held Doppler in planning the operation for primary varicose veins. Eur J Vasc Endovasc Surg 24:450–455 PubMedCrossRef
149.
Zurück zum Zitat Franco G (1998) Explorations ultrasonographiques des récidives variqueuses post-chirurgicales. Phlebologie 51:403–413 Franco G (1998) Explorations ultrasonographiques des récidives variqueuses post-chirurgicales. Phlebologie 51:403–413
150.
Zurück zum Zitat Jiang P, van Rij AM, Christie R, Hill G, Solomon C, Thomson I (1999) Recurrent varicose veins: patterns of reflux and clinical severity. Cardiovasc Surg 7:332–339 PubMedCrossRef Jiang P, van Rij AM, Christie R, Hill G, Solomon C, Thomson I (1999) Recurrent varicose veins: patterns of reflux and clinical severity. Cardiovasc Surg 7:332–339 PubMedCrossRef
151.
Zurück zum Zitat Lee BB, Do YS, Byun HS, Choo IW, Kim DI, Huh SH (2003) Advanced management of venous malformation with ethanol sclerotherapy: mid-term results. J Vasc Surg 37:533–538 PubMedCrossRef Lee BB, Do YS, Byun HS, Choo IW, Kim DI, Huh SH (2003) Advanced management of venous malformation with ethanol sclerotherapy: mid-term results. J Vasc Surg 37:533–538 PubMedCrossRef
152.
Zurück zum Zitat Bihari I, Tasnadi G, Bihari P (2003) Importance of subfascial collaterals in deep-vein malformations. Dermatol Surg 29:146–149 PubMed Bihari I, Tasnadi G, Bihari P (2003) Importance of subfascial collaterals in deep-vein malformations. Dermatol Surg 29:146–149 PubMed
153.
Zurück zum Zitat Brunken A, Rabe E, Pannier F (2009) Changes in venous function after foam sclerotherapy of varicose veins. Phlebology 24:145–150 PubMedCrossRef Brunken A, Rabe E, Pannier F (2009) Changes in venous function after foam sclerotherapy of varicose veins. Phlebology 24:145–150 PubMedCrossRef
154.
Zurück zum Zitat Darvall KAL, Sam RC, Bate GR, Adam DJ, Bradbury AW (2010) Photoplethysmographic venous refilling times following ultrasound guided foam Sclerotherapy for symptomatic superficial venous reflux: relationship with clinical outcomes. Eur J Vasc Endovasc Surg 40:267–272 PubMedCrossRef Darvall KAL, Sam RC, Bate GR, Adam DJ, Bradbury AW (2010) Photoplethysmographic venous refilling times following ultrasound guided foam Sclerotherapy for symptomatic superficial venous reflux: relationship with clinical outcomes. Eur J Vasc Endovasc Surg 40:267–272 PubMedCrossRef
155.
Zurück zum Zitat Kreussler: Fachinformationen Aethoxysklerol® 0,25 %/0,5 %/1 %/2 %/3 % Stand August 2015, Chemische Fabrik Kreussler & Co GmbH Kreussler: Fachinformationen Aethoxysklerol® 0,25 %/0,5 %/1 %/2 %/3 % Stand August 2015, Chemische Fabrik Kreussler & Co GmbH
156.
Zurück zum Zitat Wollmann JC (2004) The history of sclerosing foams. Dermatol Surg 30:694–703 PubMed Wollmann JC (2004) The history of sclerosing foams. Dermatol Surg 30:694–703 PubMed
157.
Zurück zum Zitat Sadoun S, Benigni JP, Sica M (2002) Étude prospective de l’efficacité de la mousse de sclérosant dans le traitement des varices tronculaires des membres inférieurs. Phlebologie 55:259–262 Sadoun S, Benigni JP, Sica M (2002) Étude prospective de l’efficacité de la mousse de sclérosant dans le traitement des varices tronculaires des membres inférieurs. Phlebologie 55:259–262
158.
Zurück zum Zitat Tessari L, Cavezzi A, Frullini A (2001) Preliminary experience with a new sclerosing foam in the treatment of varicose veins. Dermatol Surg 27:58–60 PubMed Tessari L, Cavezzi A, Frullini A (2001) Preliminary experience with a new sclerosing foam in the treatment of varicose veins. Dermatol Surg 27:58–60 PubMed
159.
Zurück zum Zitat De Roos KP, Groen L, Leenders AC (2011) Foam sclerotherapy: investigating the need for sterile air. Dermatol Surg 37:1119–1124 PubMedCrossRef De Roos KP, Groen L, Leenders AC (2011) Foam sclerotherapy: investigating the need for sterile air. Dermatol Surg 37:1119–1124 PubMedCrossRef
160.
Zurück zum Zitat Guex JJ, Hamel-Desnos C, Gillet JL, Chleir F, Perrin M (2008) Sclérothérapie des varices par mousse écho-guidée: techniques de mise en œuvre, indications, résultats publiés. Phlebologie 61:261–270 Guex JJ, Hamel-Desnos C, Gillet JL, Chleir F, Perrin M (2008) Sclérothérapie des varices par mousse écho-guidée: techniques de mise en œuvre, indications, résultats publiés. Phlebologie 61:261–270
161.
Zurück zum Zitat Yamaki T, Hamahata A, Soejima K, Kono T, Nozaki M, Sakurai H (2012) Prospective randomised comparative study of visual foam Sclerotherapy alone or in combination with ultrasound-guided foam sclerotherapy for treatment of superficial venous insufficiency: preliminary report. Eur J Vasc Endovasc Surg 43:343–347 PubMedCrossRef Yamaki T, Hamahata A, Soejima K, Kono T, Nozaki M, Sakurai H (2012) Prospective randomised comparative study of visual foam Sclerotherapy alone or in combination with ultrasound-guided foam sclerotherapy for treatment of superficial venous insufficiency: preliminary report. Eur J Vasc Endovasc Surg 43:343–347 PubMedCrossRef
162.
Zurück zum Zitat Blaise S, Bosson JL, Diamand JM (2010) Ultrasound-guided sclerotherapy of the great saphenous vein with 1 % vs. 3 % Polidocanol foam: a multicentre double-blind randomised trial with 3‑year follow-up. Eur J Vasc Endovasc Surg 39:779–786 PubMedCrossRef Blaise S, Bosson JL, Diamand JM (2010) Ultrasound-guided sclerotherapy of the great saphenous vein with 1 % vs. 3 % Polidocanol foam: a multicentre double-blind randomised trial with 3‑year follow-up. Eur J Vasc Endovasc Surg 39:779–786 PubMedCrossRef
163.
Zurück zum Zitat Ceulen RPM, Bullens-Goessens YIJM, Pi-Van De Venne SJA (2007) Outcomes and side effects of duplex-guided sclerotherapy in the treatment of great saphenous veins with 1 % versus 3 % Polidocanol foam: Results of a randomized controlled trial with 1‑year follow-up. Dermatol Surg 33:276–281 PubMed Ceulen RPM, Bullens-Goessens YIJM, Pi-Van De Venne SJA (2007) Outcomes and side effects of duplex-guided sclerotherapy in the treatment of great saphenous veins with 1 % versus 3 % Polidocanol foam: Results of a randomized controlled trial with 1‑year follow-up. Dermatol Surg 33:276–281 PubMed
164.
Zurück zum Zitat Yamaki T, Nozaki M, Iwasaka S (2004) Comparative study of duplex-guided foam sclerotherapy and duplex-guided liquid sclerotherapy for the treatment of superficial venous insufficiency. Dermatol Surg 30:718–722 PubMed Yamaki T, Nozaki M, Iwasaka S (2004) Comparative study of duplex-guided foam sclerotherapy and duplex-guided liquid sclerotherapy for the treatment of superficial venous insufficiency. Dermatol Surg 30:718–722 PubMed
165.
Zurück zum Zitat Kanter A, Thibault P (1996) Saphenofemoral incompetence treated by ultrasound-guided sclerotherapy. Dermatol Surg 22:648–652 PubMed Kanter A, Thibault P (1996) Saphenofemoral incompetence treated by ultrasound-guided sclerotherapy. Dermatol Surg 22:648–652 PubMed
166.
Zurück zum Zitat Grondin L, Young R, Wouters L (1997) Sclérothérapie écho-guidée et sécurité: comparaison des techniques. Phlebologie 50:241–245 Grondin L, Young R, Wouters L (1997) Sclérothérapie écho-guidée et sécurité: comparaison des techniques. Phlebologie 50:241–245
167.
Zurück zum Zitat Schadeck M, Allaert FA (1997) Résultats à long terme de la Sclérothérapie des Saphènes internes. Phlebologie 50(2):257–262 Schadeck M, Allaert FA (1997) Résultats à long terme de la Sclérothérapie des Saphènes internes. Phlebologie 50(2):257–262
168.
Zurück zum Zitat Elias S, Raines JK (2012) Mechanochemical tumescentless endovenous ablation: final results of the initial clinical trial. Phlebology 27:67–72 PubMedPubMedCentralCrossRef Elias S, Raines JK (2012) Mechanochemical tumescentless endovenous ablation: final results of the initial clinical trial. Phlebology 27:67–72 PubMedPubMedCentralCrossRef
169.
Zurück zum Zitat Whiteley MS, Dos SSJ, Lee CT, Li JM (2017) Mechanochemical ablation causes endothelial and medial damage to the vein wall resulting in deeper penetration of sclerosant compared with sclerotherapy alone in extrafascial great saphenous vein using an ex vivo model. J Vasc Surg Venous Lymphat Disord 5:370–377 PubMedCrossRef Whiteley MS, Dos SSJ, Lee CT, Li JM (2017) Mechanochemical ablation causes endothelial and medial damage to the vein wall resulting in deeper penetration of sclerosant compared with sclerotherapy alone in extrafascial great saphenous vein using an ex vivo model. J Vasc Surg Venous Lymphat Disord 5:370–377 PubMedCrossRef
172.
Zurück zum Zitat Ramon R, van Eekeren JP, Boersma D, Konijn V, de Vries JP, Reijnen MM (2013) Postoperative pain and early quality of life after radiofrequency ablation and mechanochemical endovenous ablation of incompetent great saphenous veins. J Vasc Surg 57:445–450 CrossRef Ramon R, van Eekeren JP, Boersma D, Konijn V, de Vries JP, Reijnen MM (2013) Postoperative pain and early quality of life after radiofrequency ablation and mechanochemical endovenous ablation of incompetent great saphenous veins. J Vasc Surg 57:445–450 CrossRef
174.
Zurück zum Zitat van Eekeren RR, Boersma D, Konijn V, de Vries JP, Reijnen MM (2013) Postoperative pain and early quality of life after radiofrequency ablation and mechanochemical endovenous ablation of incompetent great saphenous veins. J Vasc Surg 57:445–450 PubMedCrossRef van Eekeren RR, Boersma D, Konijn V, de Vries JP, Reijnen MM (2013) Postoperative pain and early quality of life after radiofrequency ablation and mechanochemical endovenous ablation of incompetent great saphenous veins. J Vasc Surg 57:445–450 PubMedCrossRef
175.
Zurück zum Zitat Witte ME, Holewijn S, van Eekeren RR, de Vries JP, Zeebregts CJ, Reijnen MM (2017) Midterm outcome of mechanochemical endovenous ablation for the treatment of great Saphenous vein insufficiency. J Endovasc Ther 24:149–155 PubMedCrossRef Witte ME, Holewijn S, van Eekeren RR, de Vries JP, Zeebregts CJ, Reijnen MM (2017) Midterm outcome of mechanochemical endovenous ablation for the treatment of great Saphenous vein insufficiency. J Endovasc Ther 24:149–155 PubMedCrossRef
176.
Zurück zum Zitat Lane T, Bootun R, Dharmarajah B, Lim CS, Najem M, Renton S, Sritharan K, Davies AH (2017) A multi-centre randomised controlled trial comparing radiofrequency and mechanical occlusion chemically assisted ablation of varicose veins—Final results of the Venefit versus Clarivein for varicose veins trial. Phlebology 32:89–98 PubMedCrossRef Lane T, Bootun R, Dharmarajah B, Lim CS, Najem M, Renton S, Sritharan K, Davies AH (2017) A multi-centre randomised controlled trial comparing radiofrequency and mechanical occlusion chemically assisted ablation of varicose veins—Final results of the Venefit versus Clarivein for varicose veins trial. Phlebology 32:89–98 PubMedCrossRef
177.
Zurück zum Zitat Devereux N, Recke AL, Westermann L, Recke A, Kahle B (2014) Catheter-directed foam Sclerotherapy of great Saphenous veins in combination with pre-treatment reduction of the diameter employing the principals of perivenous tumescent local anesthesia. Eur J Vasc Endovasc Surg 47:187–195 PubMedCrossRef Devereux N, Recke AL, Westermann L, Recke A, Kahle B (2014) Catheter-directed foam Sclerotherapy of great Saphenous veins in combination with pre-treatment reduction of the diameter employing the principals of perivenous tumescent local anesthesia. Eur J Vasc Endovasc Surg 47:187–195 PubMedCrossRef
178.
Zurück zum Zitat Ceulen RPM, Jagtmann EA, Sommer A, Teule GJJ, Schurink GWH, Kemerink GJ (2010) Blocking the saphenafemoral junction during ultrasound guided foam sclerotherapy—assessment of a presumed safety-measure procedure. Eur J Vasc Endovasc Surg 40:772–776 PubMedCrossRef Ceulen RPM, Jagtmann EA, Sommer A, Teule GJJ, Schurink GWH, Kemerink GJ (2010) Blocking the saphenafemoral junction during ultrasound guided foam sclerotherapy—assessment of a presumed safety-measure procedure. Eur J Vasc Endovasc Surg 40:772–776 PubMedCrossRef
179.
Zurück zum Zitat Brodersen JP (2007) Catheter-assisted vein sclerotherapy: a new approach for sclerotherapy of the greater saphenous vein with a double-lumen balloon catheter. Dermatol Surg 33:469–475 PubMed Brodersen JP (2007) Catheter-assisted vein sclerotherapy: a new approach for sclerotherapy of the greater saphenous vein with a double-lumen balloon catheter. Dermatol Surg 33:469–475 PubMed
180.
Zurück zum Zitat Wildenhues B (2005) Catheter-assisted foam sclerotherapy. A new minimally invasive method for the treatment of trunk varicosis of the long and short saphenous veins. Phlebologie 34:165–170 CrossRef Wildenhues B (2005) Catheter-assisted foam sclerotherapy. A new minimally invasive method for the treatment of trunk varicosis of the long and short saphenous veins. Phlebologie 34:165–170 CrossRef
181.
Zurück zum Zitat Hahn M, Schulz T, Jünger M (2007) Sonographically guided, transcatheter foam sclerotherapy of the great saphenous vein. Medical and oeconomic aspects. Phlebologie 36:309–312 CrossRef Hahn M, Schulz T, Jünger M (2007) Sonographically guided, transcatheter foam sclerotherapy of the great saphenous vein. Medical and oeconomic aspects. Phlebologie 36:309–312 CrossRef
182.
Zurück zum Zitat Bidwai A, Beresford T, Dialynas M, Prionidis J, Panayiotopoulos Y, Bowne TF (2007) Balloon control of the saphenofemoral junction during foam sclerotherapy : proposed innovation. J Vasc Surg 46:145–147 PubMedCrossRef Bidwai A, Beresford T, Dialynas M, Prionidis J, Panayiotopoulos Y, Bowne TF (2007) Balloon control of the saphenofemoral junction during foam sclerotherapy : proposed innovation. J Vasc Surg 46:145–147 PubMedCrossRef
183.
Zurück zum Zitat Kölbel T, Hinchliffe RJ, Lindbal B (2007) Catheter-directed foam sclerotherapy of axial saphenous reflux. Early results. Phlebology 22:219–222 PubMedCrossRef Kölbel T, Hinchliffe RJ, Lindbal B (2007) Catheter-directed foam sclerotherapy of axial saphenous reflux. Early results. Phlebology 22:219–222 PubMedCrossRef
185.
Zurück zum Zitat Cavezzi A, Tessari L (2009) Foam sclerotherapy techniques: different gases and methods of preparation, catheter versus direct injection. Phlebology 24:247–251 PubMedCrossRef Cavezzi A, Tessari L (2009) Foam sclerotherapy techniques: different gases and methods of preparation, catheter versus direct injection. Phlebology 24:247–251 PubMedCrossRef
186.
Zurück zum Zitat Chapman-Smith P, Browne A (2009) Prospective five year study of ultrasound guided foam sclerotherapy in the treatment of great saphenous vein reflux. Phlebology 24:183–188 PubMedCrossRef Chapman-Smith P, Browne A (2009) Prospective five year study of ultrasound guided foam sclerotherapy in the treatment of great saphenous vein reflux. Phlebology 24:183–188 PubMedCrossRef
187.
Zurück zum Zitat Kern P, Ramelet AA, Wütschert R, Hayoz D (2007) Compression after sclerotherapy for telangiectasiastelangiectasias and reticular leg veins. A randomized controlled study. J Vasc Surg 45:1212–1216 PubMedCrossRef Kern P, Ramelet AA, Wütschert R, Hayoz D (2007) Compression after sclerotherapy for telangiectasiastelangiectasias and reticular leg veins. A randomized controlled study. J Vasc Surg 45:1212–1216 PubMedCrossRef
188.
Zurück zum Zitat Weiss RA, Sadick NS, Goldman MP, Weiss MA (1999) Post-sclerotherapy compression: controlled comparative study of duration of compression and its effects on clinical outcome. Dermatol Surg 25:105–108 PubMedCrossRef Weiss RA, Sadick NS, Goldman MP, Weiss MA (1999) Post-sclerotherapy compression: controlled comparative study of duration of compression and its effects on clinical outcome. Dermatol Surg 25:105–108 PubMedCrossRef
189.
Zurück zum Zitat Goldman MP, Beaudoing D, Marley W, Lopez L, Butie A (1990) Compression in the treatment of leg teleangiectasia: a preliminary report. J Dermatol Surg Oncol 16:322–325 PubMedCrossRef Goldman MP, Beaudoing D, Marley W, Lopez L, Butie A (1990) Compression in the treatment of leg teleangiectasia: a preliminary report. J Dermatol Surg Oncol 16:322–325 PubMedCrossRef
190.
Zurück zum Zitat Nootheti PK, Cadag KM, Magpantay A, Goldman MP (2009) Efficacy of graduated compression stockings for an additional 3 weeks after sclerotherapy treatment of reticular and telangiectatic leg veins. Dermatol Surg 35:53–58 PubMed Nootheti PK, Cadag KM, Magpantay A, Goldman MP (2009) Efficacy of graduated compression stockings for an additional 3 weeks after sclerotherapy treatment of reticular and telangiectatic leg veins. Dermatol Surg 35:53–58 PubMed
191.
Zurück zum Zitat Hamel-Desnos C, Guias BJ, Desnos PR, Mesgard A (2010) Foam sclerotherapy of the saphenous veins. Randomised controlled trial with or without compression. Eur J Vasc Endovasc Surg 39:500–507 PubMedCrossRef Hamel-Desnos C, Guias BJ, Desnos PR, Mesgard A (2010) Foam sclerotherapy of the saphenous veins. Randomised controlled trial with or without compression. Eur J Vasc Endovasc Surg 39:500–507 PubMedCrossRef
192.
Zurück zum Zitat El-Sheikha J, Carradice D, Nandhra S, Leung HC, Smith GE, Campbell B, Chetter IC (2015) Systematic review of compression following treatment for varicose veins. Br J Surg 102:719–725 PubMedCrossRef El-Sheikha J, Carradice D, Nandhra S, Leung HC, Smith GE, Campbell B, Chetter IC (2015) Systematic review of compression following treatment for varicose veins. Br J Surg 102:719–725 PubMedCrossRef
193.
Zurück zum Zitat Zarca C, Bailly C, Gachet G, Spini L (2012) ClassMousse 1 study: compression hosiery and foam Sclerotherapy. Phlebologie 65:11–20 Zarca C, Bailly C, Gachet G, Spini L (2012) ClassMousse 1 study: compression hosiery and foam Sclerotherapy. Phlebologie 65:11–20
194.
Zurück zum Zitat Ferrara F, Bernbach HR (2009) La compression écho-guidée après sclérothérapie. Phlebologie 62:36–41 Ferrara F, Bernbach HR (2009) La compression écho-guidée après sclérothérapie. Phlebologie 62:36–41
195.
Zurück zum Zitat Stanley PRW, Bickerton DR, Campbell WB (1991) Injection sclerotherapy for varicose veins—a comparison of materials for applying local compression. Phlebology 6:37–39 CrossRef Stanley PRW, Bickerton DR, Campbell WB (1991) Injection sclerotherapy for varicose veins—a comparison of materials for applying local compression. Phlebology 6:37–39 CrossRef
196.
Zurück zum Zitat Friedmann DP, Liolios AM, Wu DC, Goldman MP, Eimpunth S (2015) A randomized, double-blind, placebo-controlled study of the effect of a high-potency topical corticosteroid after Sclerotherapy for reticular and telangiectatic veins of the lower extremities. Dermatol Surg 41:1158–1163 PubMedCrossRef Friedmann DP, Liolios AM, Wu DC, Goldman MP, Eimpunth S (2015) A randomized, double-blind, placebo-controlled study of the effect of a high-potency topical corticosteroid after Sclerotherapy for reticular and telangiectatic veins of the lower extremities. Dermatol Surg 41:1158–1163 PubMedCrossRef
Metadaten
Titel
Leitlinie Sklerosierungsbehandlung der Varikose
S2k-Leitlinie der Deutschen Gesellschaft für Phlebologie (DGP) in Kooperation mit folgenden Fachgesellschaften: DDG, DGA, DGG, BVP
verfasst von
Prof. Dr. med. E. Rabe
F. X. Breu
I. Flessenkämper
H. Gerlach
S. Guggenbichler
B. Kahle
R. Murena
S. Reich-Schupke
T. Schwarz
Prof. Dr. med. M. Stücker
E. Valesky
S. Werth
F. Pannier
Publikationsdatum
05.11.2020
Verlag
Springer Medizin
Erschienen in
Die Dermatologie / Ausgabe 1/2021
Print ISSN: 2731-7005
Elektronische ISSN: 2731-7013
DOI
https://doi.org/10.1007/s00105-020-04707-y

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